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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"

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  • Haspin-IN-2
    Targetmol
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    Haspin-IN-2

    CAS:
    Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).
    Formula:C12H8N4O3
    Colore e forma:Solid
    Peso molecolare:256.22

    Ref: TM-T60394

  • CDK4/6-IN-13
    Targetmol
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    CDK4/6-IN-13

    CAS:
    Compounds 10B and 10C: potent cdk4/6 inhibitors with low nM activity, great antiproliferative effects, excellent metabolism, and good pharmacokinetics.
    Formula:C25H29N7O
    Colore e forma:Solid
    Peso molecolare:443.54

    Ref: TM-T62605

  • Antimalarial agent 44
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    Antimalarial agent 44

    Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.
    Formula:C37H37N5O7
    Colore e forma:Solid
    Peso molecolare:663.72

    Ref: TM-T201453

  • Logo CymitQuimica
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    α5β1 integrin agonist-1

    CAS:
    α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.
    Formula:C24H26FN5O9
    Colore e forma:Solid
    Peso molecolare:547.49

    Ref: TM-T63868

  • Logo CymitQuimica
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    Zalunfiban dihydrochloride

    Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.
    Formula:C16H20Cl2N8O2S
    Colore e forma:Solid
    Peso molecolare:459.35

    Ref: TM-T62878

  • FR-145715
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    FR-145715

    CAS:
    FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.
    Formula:C16H21N5O2S
    Colore e forma:Solid
    Peso molecolare:347.44

    Ref: TM-T201582

  • β-catenin-IN-8
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    β-catenin-IN-8

    CAS:
    β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.
    Formula:C15H12ClN3O2S
    Colore e forma:Solid
    Peso molecolare:333.79

    Ref: TM-T201581

  • Logo CymitQuimica
    Targetmol
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    MtTMPK-IN-7

    MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.
    Formula:C27H29ClN6O3
    Colore e forma:Solid
    Peso molecolare:521.01

    Ref: TM-T63639

  • PNR-3-80
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    PNR-3-80

    CAS:
    PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.
    Formula:C24H14ClN3O3S
    Colore e forma:Solid
    Peso molecolare:459.90

    Ref: TM-T212403

  • CHK1-IN-11
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    CHK1-IN-11

    CAS:
    CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.
    Formula:C20H22N8O2
    Colore e forma:Solid
    Peso molecolare:406.44

    Ref: TM-T207353

  • Logo CymitQuimica
    Targetmol
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    Aurora/LIM kinase-IN-1

    Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.
    Formula:C16H20N6O
    Colore e forma:Solid
    Peso molecolare:312.37

    Ref: TM-T60783

  • Cdc7-IN-8
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    Cdc7-IN-8

    CAS:
    Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)
    Formula:C19H21N5O2
    Colore e forma:Solid
    Peso molecolare:351.40

    Ref: TM-T61224

  • OPN expression inhibitor 1
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    OPN expression inhibitor 1

    CAS:
    OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.
    Formula:C25H33N3O5
    Purezza:99.78%
    Colore e forma:Solid
    Peso molecolare:455.55

    Ref: TM-T62820

  • BRD-7880
    Targetmol
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    BRD-7880

    CAS:
    BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.
    Formula:C32H38N4O7
    Colore e forma:Solid
    Peso molecolare:590.67

    Ref: TM-T70600

  • CD 10899
    Targetmol
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    CD 10899

    CAS:
    CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].
    Formula:C34H50N8O4
    Colore e forma:Solid
    Peso molecolare:634.81

    Ref: TM-T86023

  • Logo CymitQuimica
    Targetmol
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    Dyrk1A/B-IN-1

    Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.
    Formula:C21H17N3O2S2
    Colore e forma:Solid
    Peso molecolare:407.51

    Ref: TM-T62043

  • Logo CymitQuimica
    Targetmol
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    Sovesudil hydrochloride

    Sovesudil (PHP-201) HCl: potent local ROCK inhibitor; targets ROCK I/II (IC50: 3.7/2.3 nM); lowers IOP, non-congesting.
    Formula:C23H23ClFN3O3
    Colore e forma:Solid
    Peso molecolare:443.9

    Ref: TM-T62608

  • L-I-OddU
    Targetmol
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    L-I-OddU

    CAS:
    L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).
    Formula:C8H9IN2O5
    Colore e forma:Solid
    Peso molecolare:340.07

    Ref: TM-T61080

  • Logo CymitQuimica
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    TH9619

    CAS:
    TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). Anticancer.
    Formula:C17H18FN7O7
    Purezza:98.07%
    Peso molecolare:451.37

    Ref: TM-T87512

  • CDK9 autophagic degrader 1
    Targetmol
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    CDK9 autophagic degrader 1

    CAS:
    CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.
    Formula:C34H39N7O4S2
    Colore e forma:Solid
    Peso molecolare:673.848

    Ref: TM-T204672