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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"

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  • CDK8-IN-5
    Targetmol
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    CDK8-IN-5

    CAS:
    CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.
    Formula:C26H22N2O4
    Colore e forma:Solid
    Peso molecolare:426.46

    Ref: TM-T62310

  • Adafosbuvir
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    Adafosbuvir

    CAS:
    Adafosbuvir has antiviral activity.
    Formula:C22H29FN3O10P
    Colore e forma:Solid
    Peso molecolare:545.457

    Ref: TM-T26560

  • Morpholino U subunit
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    Morpholino U subunit

    CAS:
    Morpholino U subunit is one of the fundamental components of morpholino oligonucleotides, capable of pairing with adenine in target RNA.
    Formula:C30H32ClN4O5P
    Colore e forma:Solid
    Peso molecolare:595.03

    Ref: TM-TSW-01102

  • Logo CymitQuimica
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    Dyrk1A/α-synuclein-IN-1

    Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).
    Formula:C20H21N5O3S
    Colore e forma:Solid
    Peso molecolare:411.48

    Ref: TM-T62096

  • Deoxythymidine-5'-triphosphate-d15
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    Deoxythymidine-5'-triphosphate-d15

    CAS:
    Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.
    Formula:C10H15Li2N2O14P3
    Colore e forma:Solid
    Peso molecolare:509.13

    Ref: TM-T211806

  • 3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
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    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite

    CAS:
    3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer featuring protective group modifications, suitable for RNA oligonucleotide synthesis.
    Formula:C42H51N8O5P
    Colore e forma:Solid
    Peso molecolare:778.88

    Ref: TM-TSW-01143

  • Antifolate agent 1
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    Antifolate agent 1

    CAS:
    Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.
    Formula:C19H19N5O6
    Colore e forma:Solid
    Peso molecolare:413.38

    Ref: TM-T212452

  • 6K465
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    6K465

    CAS:
    6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.
    Formula:C26H33ClFN9O
    Purezza:99.78%
    Colore e forma:Solid
    Peso molecolare:542.05

    Ref: TM-T85508

  • DHICA
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    DHICA

    CAS:
    DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.
    Formula:C9H7NO4
    Colore e forma:Solid
    Peso molecolare:193.16

    Ref: TM-T201499

  • PKMYT1-IN-9
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    PKMYT1-IN-9

    CAS:
    PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.
    Formula:C17H14FN5O
    Colore e forma:Solid
    Peso molecolare:323.324

    Ref: TM-T206301

  • CDK9/PARP-IN-1
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    CDK9/PARP-IN-1

    CAS:
    CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.
    Formula:C38H34F2N8O3
    Colore e forma:Solid
    Peso molecolare:688.725

    Ref: TM-T205731

  • PARG-IN-6
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    PARG-IN-6

    CAS:
    PARG-IN-6 (Compound 2) is an orally bioavailable PARG inhibitor with an IC50 of 0.3 nM. It exhibits significant anticancer activity against cancer cells, with an IC50 of 0.0368 μM for HCC1395 cells. PARG-IN-6 shows potential for research in colon cancer, appendiceal cancer, and pancreatic cancer.
    Formula:C24H25F4N7O4S3
    Colore e forma:Solid
    Peso molecolare:647.69

    Ref: TM-T210766

  • Logo CymitQuimica
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    c-Myc inhibitor 4

    Potent oral c-Myc inhibitor 4 reduces the proto-oncogene linked to tumor development.
    Formula:C26H33FN6O3
    Colore e forma:Solid
    Peso molecolare:496.58

    Ref: TM-T63359

  • Logo CymitQuimica
    Targetmol
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    CDK/HDAC-IN-1

    CDK/HDAC-IN-1 inhibits CDK2/4/6 & HDAC6 with IC50s: 60.9, 276, 27.2, and 128.6 nM respectively.
    Formula:C20H18N4O4
    Colore e forma:Solid
    Peso molecolare:378.38

    Ref: TM-T61583

  • BRD-7880
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    BRD-7880

    CAS:
    BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.
    Formula:C32H38N4O7
    Colore e forma:Solid
    Peso molecolare:590.67

    Ref: TM-T70600

  • ROCK-IN-11
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    ROCK-IN-11

    CAS:
    ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.
    Formula:C22H20N4O4S
    Colore e forma:Solid
    Peso molecolare:436.484

    Ref: TM-T204468

  • Mitotic kinesin-IN-1 hydrochloride
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    Mitotic kinesin-IN-1 hydrochloride

    CAS:
    Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.
    Formula:C22H26ClF2N3OS
    Colore e forma:Solid
    Peso molecolare:453.98

    Ref: TM-T212561

  • 2′-OMe-ADP
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    2′-OMe-ADP

    CAS:
    <p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>
    Formula:C11H17N5O10P2
    Colore e forma:Solid
    Peso molecolare:441.23

    Ref: TM-TSW-00949

  • Logo CymitQuimica
    Targetmol
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    Dyrk1A/B-IN-1

    Dyrk1A/B-IN-1 (3n) is a potent DYRK1A/B inhibitor, cell-permeable, with Ki values of 67.8 nM (1A) and 237.9 nM (1B), IC50s of 1.1 and 0.8 μM.
    Formula:C21H17N3O2S2
    Colore e forma:Solid
    Peso molecolare:407.51

    Ref: TM-T62043

  • PD-1-IN-17
    Targetmol
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    PD-1-IN-17

    CAS:
    PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.
    Formula:C13H22N6O7
    Purezza:99.6%
    Colore e forma:Solid
    Peso molecolare:374.35

    Ref: TM-T12377