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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"

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  • GSK_WRN4
    Targetmol
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    GSK_WRN4

    CAS:
    GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research
    Formula:C16H20N2O4S
    Purezza:99.95%
    Colore e forma:Solid
    Peso molecolare:336.41

    Ref: TM-T200332

  • BBI-355
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    BBI-355

    CAS:
    BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.
    Formula:C19H19N7O2
    Colore e forma:Solid
    Peso molecolare:377.40

    Ref: TM-T207786

  • KI-CDK9d-32
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    KI-CDK9d-32

    CAS:
    <p>KI-CDK9d-32 is a CDK9 PROTAC degrader with a DC50 of 0.89 nM. It facilitates the ubiquitination and degradation of CDK9, inhibits the MYC pathway, and disrupts nucleolar homeostasis. KI-CDK9d-32 demonstrates anticancer activity.</p>
    Formula:C39H45N9O4
    Colore e forma:Solid
    Peso molecolare:703.83

    Ref: TM-T207184

  • 2'-O-MOE-GTP
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    2'-O-MOE-GTP

    CAS:
    2'-O-MOE-GTP is a nucleotide analog utilized in the synthesis of oligonucleotides.
    Formula:C13H22N5O15P3
    Colore e forma:Solid
    Peso molecolare:581.26

    Ref: TM-TSW-00970

  • DNA ligase-IN-2
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    DNA ligase-IN-2

    CAS:
    <p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is &gt;64 μg/mL.</p>
    Formula:C13H8FN3O3
    Colore e forma:Solid
    Peso molecolare:273.219

    Ref: TM-T204415

  • ROCK-IN-11
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    ROCK-IN-11

    CAS:
    ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.
    Formula:C22H20N4O4S
    Colore e forma:Solid
    Peso molecolare:436.484

    Ref: TM-T204468

  • CDK8-IN-14
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    CDK8-IN-14

    CAS:
    <p>CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].</p>
    Formula:C18H13N3O2
    Colore e forma:Solid
    Peso molecolare:303.31

    Ref: TM-T86031

  • Aurora A inhibitor 1
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    Aurora A inhibitor 1

    CAS:
    Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)
    Formula:C25H28ClF2N5O2
    Colore e forma:Solid
    Peso molecolare:503.97

    Ref: TM-T63436

  • Logo CymitQuimica
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    8-Azakinetin riboside

    CAS:
    8-Azakinetin riboside, a structural analog of kinetin riboside, exhibits cytotoxic activity [1].
    Formula:C14H16N6O5
    Peso molecolare:348.31

    Ref: TM-T85526

  • 2′-O-MOE-CMP
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    2′-O-MOE-CMP

    CAS:
    2′-O-MOE-CMP is a nucleotide analogue utilized in the synthesis of oligonucleotides.
    Formula:C12H20N3O9P
    Colore e forma:Solid
    Peso molecolare:381.28

    Ref: TM-TSW-00960

  • TA-316
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    TA-316

    CAS:
    Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.
    Formula:C28H25BrN4O5S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:641.56

    Ref: TM-T13769

  • N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
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    N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine

    CAS:
    N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that resembles the natural nucleotide adenosine in structure. It acts as an activator of ribonucleotide reductase, facilitating the conversion of ribonucleotides into deoxyribonucleotides.
    Formula:C38H35N5O6
    Colore e forma:Solid
    Peso molecolare:657.714

    Ref: TM-T206424

  • LNA-CTP
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    LNA-CTP

    CAS:
    <p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Formula:C10H16N3O14P3
    Colore e forma:Solid
    Peso molecolare:495.17

    Ref: TM-TSW-00954

  • WEE1/PKMYT1-IN-1
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    WEE1/PKMYT1-IN-1

    CAS:
    <p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>
    Formula:C16H16N4O3
    Colore e forma:Solid
    Peso molecolare:312.323

    Ref: TM-T204368

  • WEE1-IN-11
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    WEE1-IN-11

    CAS:
    WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.
    Formula:C26H29FN8OS2
    Colore e forma:Solid
    Peso molecolare:552.69

    Ref: TM-T200924

  • CDK2-IN-31
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    CDK2-IN-31

    CAS:
    CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.
    Formula:C37H52N6O5
    Colore e forma:Solid
    Peso molecolare:660.85

    Ref: TM-T201156

  • Logo CymitQuimica
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    NusB-IN-1

    NusB-IN-1 (22r) is an oral bacterial rRNA inhibitor, effective against MRSA and VRSA.
    Formula:C21H16N2O3
    Colore e forma:Solid
    Peso molecolare:344.36

    Ref: TM-T61121

  • BWC0977
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    BWC0977

    CAS:
    BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.
    Formula:C22H21FN6O5
    Colore e forma:Solid
    Peso molecolare:468.44

    Ref: TM-T201074

  • SGC-CLK-1
    Targetmol
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    SGC-CLK-1

    CAS:
    SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.
    Formula:C19H15F3N6O2
    Colore e forma:Solid
    Peso molecolare:416.36

    Ref: TM-T201181

  • Logo CymitQuimica
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    2'-F-UMP

    CAS:
    <p>2'-F-UMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Formula:C9H12FN2O8P
    Peso molecolare:326.17

    Ref: TM-TSW-00948