CymitQuimica logo
Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

Mostrare 10 più sottocategorie

Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"

Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
prodotti per pagina.
  • 2′-F-UDP
    Targetmol
    + Info

    2′-F-UDP

    CAS:
    2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.
    Formula:C9H13FN2O11P2
    Colore e forma:Solid
    Peso molecolare:406.15

    Ref: TM-TSW-00958

  • Bersiporocin
    Targetmol
    + Info

    Bersiporocin

    CAS:
    <p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>
    Formula:C15H19Cl2N3O
    Purezza:98.88% - 99.79%
    Colore e forma:Solid
    Peso molecolare:328.24

    Ref: TM-T39739

  • Logo CymitQuimica
    Targetmol
    + Info

    CYP2C19-IN-1

    CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.
    Formula:C26H26N2O6S
    Colore e forma:Solid
    Peso molecolare:494.56

    Ref: TM-T63337

  • CDK12/13 ligand 1
    Targetmol
    + Info

    CDK12/13 ligand 1

    CAS:
    ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.
    Formula:C26H26BrN5O
    Colore e forma:Solid
    Peso molecolare:504.42

    Ref: TM-T201159

  • Polθ-IN-6
    Targetmol
    + Info

    Polθ-IN-6

    CAS:
    Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.
    Formula:C25H23N3O3S
    Colore e forma:Solid
    Peso molecolare:445.53

    Ref: TM-T200918

  • WRN inhibitor 12
    Targetmol
    + Info

    WRN inhibitor 12

    CAS:
    WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.
    Formula:C33H33ClF3N9O5
    Colore e forma:Solid
    Peso molecolare:728.12

    Ref: TM-T201316

  • Lobucavir
    Targetmol
    + Info

    Lobucavir

    CAS:
    <p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>
    Formula:C11H15N5O3
    Colore e forma:Solid
    Peso molecolare:265.27

    Ref: TM-T200820

  • DNA Gyrase-IN-13
    Targetmol
    + Info

    DNA Gyrase-IN-13

    CAS:
    <p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>
    Formula:C15H21N3O3S
    Colore e forma:Solid
    Peso molecolare:323.41

    Ref: TM-T201341

  • WRN inhibitor 11
    Targetmol
    + Info

    WRN inhibitor 11

    CAS:
    WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.
    Formula:C34H35ClF3N9O5
    Colore e forma:Solid
    Peso molecolare:742.15

    Ref: TM-T201262

  • LNA-CTP
    Targetmol
    + Info

    LNA-CTP

    CAS:
    <p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Formula:C10H16N3O14P3
    Colore e forma:Solid
    Peso molecolare:495.17

    Ref: TM-TSW-00954

  • WEE1-IN-11
    Targetmol
    + Info

    WEE1-IN-11

    CAS:
    WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.
    Formula:C26H29FN8OS2
    Colore e forma:Solid
    Peso molecolare:552.69

    Ref: TM-T200924

  • CDK2-IN-31
    Targetmol
    + Info

    CDK2-IN-31

    CAS:
    CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.
    Formula:C37H52N6O5
    Colore e forma:Solid
    Peso molecolare:660.85

    Ref: TM-T201156

  • BWC0977
    Targetmol
    + Info

    BWC0977

    CAS:
    BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.
    Formula:C22H21FN6O5
    Colore e forma:Solid
    Peso molecolare:468.44

    Ref: TM-T201074

  • SGC-CLK-1
    Targetmol
    + Info

    SGC-CLK-1

    CAS:
    SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.
    Formula:C19H15F3N6O2
    Colore e forma:Solid
    Peso molecolare:416.36

    Ref: TM-T201181

  • Polθ-IN-5
    Targetmol
    + Info

    Polθ-IN-5

    CAS:
    Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.
    Formula:C23H18ClF2N7O3S
    Colore e forma:Solid
    Peso molecolare:545.95

    Ref: TM-T200913

  • Dyrk1A-IN-4
    Targetmol
    + Info

    Dyrk1A-IN-4

    CAS:
    Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.
    Formula:C14H13F3N6
    Colore e forma:Solid
    Peso molecolare:322.29

    Ref: TM-T60867

  • 12(S)-HETE
    Targetmol
    + Info

    12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Formula:C20H32O3
    Colore e forma:Solid
    Peso molecolare:320.47

    Ref: TM-T37047

  • PD-L1-IN-7
    Targetmol
    + Info

    PD-L1-IN-7

    CAS:
    PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.
    Formula:C46H50N6O7
    Colore e forma:Solid
    Peso molecolare:798.93

    Ref: TM-T89952

  • GTSE1-IN-1
    Targetmol
    + Info

    GTSE1-IN-1

    CAS:
    GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.
    Formula:C21H24FN7
    Colore e forma:Solid
    Peso molecolare:393.46

    Ref: TM-T200127

  • TY-011
    Targetmol
    + Info

    TY-011

    CAS:
    TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.
    Formula:C18H16ClN5
    Colore e forma:Solid
    Peso molecolare:337.81

    Ref: TM-T89833