Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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SHP2/CDK4-IN-1
CAS:SHP2/CDK4-IN-1: dual inhibitor, oral, potent (IC50: SHP2 4.3 nM, CDK4 18.2 nM), hinders TNBC growth, strong antitumor effects in mice.Formula:C33H35ClF2N10OSColore e forma:SolidPeso molecolare:693.21Raluridine
CAS:Raluridine is an HIV treatment inhibiting RNA-directed DNA polymerase with IC50 of 1.8 microM, compared to FLT, AZT, ddI, and ddC.Formula:C9H10ClFN2O4Purezza:98%Colore e forma:SolidPeso molecolare:264.64USP7-IN-12
CAS:<p>USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].</p>Formula:C29H28ClFN4O2SColore e forma:SolidPeso molecolare:551.07CDK4/6-IN-17
CAS:CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formula:C27H28F4N8Purezza:98%Colore e forma:SolidPeso molecolare:540.56GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formula:C19H16N6OPeso molecolare:344.37Gly-Arg-Gly-Asp-Ser TFA
CAS:Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Formula:C19H31F3N8O11Colore e forma:SolidPeso molecolare:604.49Aurora kinase inhibitor-8
CAS:Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formula:C30H29N7O3Colore e forma:SolidPeso molecolare:535.6Anti-hepatic fibrosis agent 2
CAS:Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting theFormula:C26H41N3OColore e forma:SolidPeso molecolare:411.623-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormula:C13H8O3Purezza:98%Colore e forma:SolidPeso molecolare:212.2H3B-968
CAS:H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonucleaseFormula:C22H18F6N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:548.46Mps1-IN-10
CAS:Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFormula:C24H27N7O2Colore e forma:SolidPeso molecolare:445.52HQ005
CAS:HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader.Formula:C15H15N5O2S2Colore e forma:SolidPeso molecolare:361.44TNH
CAS:TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].Formula:C39H57ClN6O13Colore e forma:SolidPeso molecolare:853.36PD-321852
CAS:PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Formula:C24H19Cl2N3O3Colore e forma:SolidPeso molecolare:468.33BMT-090605 hydrochloride
CAS:BMT-090605 HCl: AAK1 inhibitor (IC50=0.6 nM), also targets BIKE (IC50=45 nM) & GAK (IC50=60 nM), with potential in neuropathic pain research.Formula:C21H25ClN4O2Colore e forma:SolidPeso molecolare:400.91(S)-Cdc7-IN-18
CAS:'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47DNA Gyrase-IN-8
CAS:DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].Formula:C19H14BrN5OPurezza:98%Colore e forma:SolidPeso molecolare:408.25CCT-271850
CAS:CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.Formula:C24H29N7OPurezza:98%Colore e forma:SolidPeso molecolare:431.53CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purezza:99%Colore e forma:SolidPeso molecolare:425.93RAD51-IN-4
CAS:RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.Formula:C31H34FN5O5S2Colore e forma:SolidPeso molecolare:639.76PLK1-IN-7
CAS:PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1].Formula:C24H24F4N8O2Colore e forma:SolidPeso molecolare:532.49Lotrafiban hydrochloride
CAS:Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.Formula:C23H33ClN4O4Colore e forma:SolidPeso molecolare:464.99Balapiravir hydrochloride
CAS:Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.Formula:C21H31ClN6O8Colore e forma:SolidPeso molecolare:530.96Lotrafiban
CAS:Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.Formula:C23H32N4O4Colore e forma:SolidPeso molecolare:428.52Lerociclib
CAS:<p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>Formula:C26H34N8OPurezza:99%Colore e forma:SolidPeso molecolare:474.6DAM-IN-1
CAS:DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Formula:C16H17NO4Purezza:98%Colore e forma:SolidPeso molecolare:287.31CDK9-IN-19
CAS:CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.Formula:C26H22F2N4O5Colore e forma:SolidPeso molecolare:508.47BIO-7662
CAS:BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.Formula:C38H48N6O8SPurezza:98%Colore e forma:SolidPeso molecolare:748.89FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formula:C25H29N5OSColore e forma:SolidPeso molecolare:447.6TC-I 15
CAS:α2β1 integrin inhibitorFormula:C23H28N4O6S2Purezza:98%Colore e forma:SolidPeso molecolare:520.62Riviciclib
CAS:Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.Formula:C21H20ClNO5Purezza:98%Colore e forma:SolidPeso molecolare:401.84ML 315 hydrochloride
CAS:<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Formula:C18H14Cl3N3O2Colore e forma:SolidPeso molecolare:410.682CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H27FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:442.48TNP-351
CAS:Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.Formula:C21H24N6O5Colore e forma:SolidPeso molecolare:440.45CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formula:C21H23ClN6OPurezza:99.07%Colore e forma:SolidPeso molecolare:410.9NU6300
CAS:NU6300 is a covalent CDK2 inhibitor exhibiting irreversible and ATP-competitive properties and also functions as a GSDMD (Gasdermin D) inhibitor.Formula:C20H23N5O3SPurezza:96.08%Colore e forma:SolidPeso molecolare:413.49Phototrexate
CAS:Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).Formula:C20H19N7O5Colore e forma:SolidPeso molecolare:437.41DDD85646
CAS:DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.Formula:C21H24Cl2N6O2SPurezza:97.8% - 99.76%Colore e forma:SolidPeso molecolare:495.43Sovesudil
CAS:Sovesudil (PHP-201) is a potent ROCK inhibitor with IC50 of 3.7 nM/2.3 nM for ROCK-I/II; lowers IOP without hyperemia.Formula:C23H22FN3O3Colore e forma:SolidPeso molecolare:407.445'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt N-Bzm5 C Phosphoramidite is a strong modified nucleic acid analog for antisense oligos.</p>Formula:C49H56N5O9PColore e forma:SolidPeso molecolare:889.97ROCK-IN-9
CAS:<p>ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.</p>Formula:C20H20FN5O2Purezza:98%Colore e forma:SolidPeso molecolare:381.4L-739758
CAS:L-739758 is a glycoprotein IIb/IIIa inhibitor.Formula:C22H26N4O5S3Colore e forma:SolidPeso molecolare:522.66GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Formula:C28H30N4O3Purezza:98.24%Colore e forma:SolidPeso molecolare:470.56WRN inhibitor 4
CAS:<p>WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Formula:C16H14N2O5SColore e forma:SolidPeso molecolare:346.36WRN inhibitor 3
CAS:WRN Inhibitor 3 (example 110), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).Formula:C20H20N2O5SColore e forma:SolidPeso molecolare:400.45CDK-IN-11
CAS:CDK-IN-11, a heterocyclic compound, promotes cardiomyocyte maturation [1].Formula:C25H21BrN4O2Colore e forma:SolidPeso molecolare:489.36XL413 hydrochloride
CAS:XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.Formula:C14H13Cl2N3O2Purezza:98.81% - 99.8%Colore e forma:SolidPeso molecolare:326.18USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Formula:C27H24F3N7OColore e forma:SolidPeso molecolare:519.52c-Myc inhibitor 8
CAS:c-Myc inhibitor 8 suppresses cell growth in various cancers and is used in research.Formula:C19H12BrClF3NO3S2Colore e forma:SolidPeso molecolare:538.79UNC2170 maleate
CAS:53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.Formula:C14H21BrN2OC4H4O4Colore e forma:SolidPeso molecolare:429.31PF-6808472
CAS:PF-6808472 is a cell-permeable covalent kinase probe, reacts with conserved lysine residues within the ATP-binding site of kinases.Formula:C25H27FN8O3SPurezza:99.02%Colore e forma:SolidPeso molecolare:538.6Integrin Antagonists 27
CAS:Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Formula:C24H20N4O5Colore e forma:SolidPeso molecolare:444.44N-desmethyl Netupitant
CAS:<p>N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.</p>Formula:C29H30F6N4OPurezza:98%Colore e forma:SolidPeso molecolare:564.57OXA-06 hydrochloride
CAS:OXA-06 hydrochloride, an ATP-competitive ROCK inhibitor, impedes anchorage-dependent growth and invasion in non-small cell lung cancer cell lines. It effectively inhibits cofilin phosphorylation without inducing apoptosis [1].Formula:C21H20Cl2FN3Colore e forma:SolidPeso molecolare:404.31Galidesivir hydrochloride
CAS:Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.Formula:C11H16ClN5O3Purezza:98%Colore e forma:SolidPeso molecolare:301.73CDK9-IN-9
CAS:<p>CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).</p>Formula:C22H23F2N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:459.51GSK2646264
CAS:<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formula:C24H26N2O2Colore e forma:SolidPeso molecolare:374.48Carotegrast
CAS:Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Formula:C27H24Cl2N4O5Colore e forma:SolidPeso molecolare:555.415-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormula:C16H10IN3O2Colore e forma:SolidPeso molecolare:403.17USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Formula:C29H27F3N8OColore e forma:SolidPeso molecolare:560.57CDK8-IN-3
CAS:CDK8-IN-3 is an inhibitor of CDK8.Formula:C22H23N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.45CDK7-IN-22
CAS:CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].Formula:C22H25F3N6Purezza:98%Colore e forma:SolidPeso molecolare:430.47hDHODH-IN-1
CAS:hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Formula:C17H14N2O2Purezza:99.97%Colore e forma:SolidPeso molecolare:278.31PD-1/PD-L1-IN-33
CAS:PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM.Formula:C26H27N5OPurezza:98%Colore e forma:SolidPeso molecolare:425.53DNA gyrase B-IN-3
CAS:DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against GramFormula:C14H9Cl2N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:386.21RNA polymerase II-IN-1
CAS:RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.Formula:C38H53N11O12SPurezza:98%Colore e forma:SolidPeso molecolare:887.96PD-1/PD-L1-IN-34
CAS:PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1Formula:C35H33ClN2O3Purezza:98%Colore e forma:SolidPeso molecolare:565.1Aurora Kinases-IN-4
CAS:<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Formula:C26H28N8OPurezza:98%Colore e forma:SolidPeso molecolare:468.55PD-1/PD-L1-IN-26
CAS:PD-1/PD-L1-IN-26 is a strong inhibitor with IC50 of 0.0380 μM that may boost immune response in cancer by aiding CD4+ T cell entry to tumors.Formula:C43H52N4O8Purezza:98%Colore e forma:SolidPeso molecolare:752.89PD-1/PD-L1-IN-27
CAS:PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.Formula:C44H35NO6Purezza:98%Colore e forma:SolidPeso molecolare:673.75CDK9-IN-29
CAS:<p>CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.</p>Formula:C29H33F2N5O4Purezza:98%Colore e forma:SolidPeso molecolare:553.6CDK7-IN-14
CAS:<p>CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).</p>Formula:C22H24F3N6OPColore e forma:SolidPeso molecolare:476.43USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFormula:C27H23F3N8OColore e forma:SolidPeso molecolare:532.52Cdc7-IN-7
CAS:<p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>Formula:C21H22N4O5Purezza:98.78%Colore e forma:SolidPeso molecolare:410.42αvβ1 integrin-IN-2
CAS:<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Formula:C29H38N4O4Purezza:98%Colore e forma:SolidPeso molecolare:506.648-Azahypoxanthine
CAS:8-Azahypoxanthine (NSC-22709) inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase and has antimalarial properties.Formula:C4H3N5OPurezza:99.66%Colore e forma:Light Yellow To Light Beige Fine CrystallinePeso molecolare:137.1DNA polymerase-IN-3
CAS:DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications inFormula:C13H12O4Purezza:98%Colore e forma:SolidPeso molecolare:232.23Tirofiban HCl
CAS:<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Formula:C22H37ClN2O5SPurezza:98%Colore e forma:SolidPeso molecolare:477.068-NH2-ATP tetrasodium
CAS:<p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>Formula:C10H13N6Na4O13P3Colore e forma:SolidPeso molecolare:610.12KY386
CAS:KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.Formula:C21H19N5O2SColore e forma:SolidPeso molecolare:405.47Palmitoyl 3-carbacyclic phosphatidic acid
CAS:Palmitoyl 3-carbacyclic phosphatidic acid, a palmitoylated Carba-like cyclophosphatidic acid and LPA (lysophosphatidic acid) analog, possesses distinct biological activities compared to LPA, including the inhibition of RhoA activation and melanoma cell migration. This compound has demonstrated efficacy in inhibiting experimental lung metastasis and reducing tumor nodule counts in a B16-F0 xenograft mouse model [1].Formula:C20H39O5PColore e forma:SolidPeso molecolare:390.49WEE1-IN-4
CAS:Wee1 Inhibitor I is an ATP-binding site-targeting Wee1 inhibitor.Formula:C20H11ClN2O3Colore e forma:SolidPeso molecolare:362.77WRN inhibitor 5
CAS:WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).Formula:C23H20N2O6SColore e forma:SolidPeso molecolare:452.48LDC3140
CAS:LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Formula:C23H33N7OPurezza:98%Colore e forma:SolidPeso molecolare:423.55CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFormula:C25H29N5O2SColore e forma:SolidPeso molecolare:463.6TC-A 2317 hydrochloride
CAS:<p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>Formula:C19H29ClN6OPurezza:98%Colore e forma:SolidPeso molecolare:392.93Zaurategrast
CAS:Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.Formula:C26H25BrN4O3Purezza:98%Colore e forma:SolidPeso molecolare:521.41ML-099
CAS:ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.Formula:C14H13NO2SPurezza:99.73%Colore e forma:SolidPeso molecolare:259.32NVS-SM2
CAS:NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.Formula:C23H30N6OColore e forma:SolidPeso molecolare:406.52PLK1/p38γ-IN-1
CAS:<p>PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular</p>Formula:C21H26ClN3O2Purezza:98%Colore e forma:SolidPeso molecolare:387.9Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurezza:99.18%Colore e forma:SolidPeso molecolare:512.46SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Formula:C22H24F3N3O4Purezza:98%Colore e forma:SolidPeso molecolare:451.445'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].</p>Formula:C42H51N4O9PColore e forma:SolidPeso molecolare:786.853-Cyanovinylcarbazole phosphoramidite
CAS:3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.Formula:C50H53N4O6PColore e forma:SolidPeso molecolare:836.95BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formula:C32H26Cl2FN7O3Purezza:98%Colore e forma:SolidPeso molecolare:646.55'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].</p>Formula:C49H54N7O8PColore e forma:SolidPeso molecolare:899.97JNJ-26076713
CAS:JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Formula:C29H38N4O3Purezza:98%Colore e forma:SolidPeso molecolare:490.64VER-00158411
CAS:VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).Formula:C31H34N6O3Purezza:98%Colore e forma:SolidPeso molecolare:538.64L-Methioninamide hydrochloride
CAS:L-Methioninamide hydrochloride is a potent inhibitor of methionyl-tRNA synthetase that reduces the toxicity of CDDP.Formula:C5H13ClN2OSPurezza:99.93%Colore e forma:SolidPeso molecolare:184.69Mevociclib
CAS:Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formula:C31H35ClN8O2Purezza:98.02% - 98.02%Colore e forma:SolidPeso molecolare:587.11Litronesib
CAS:Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.Formula:C23H37N5O4S2Purezza:98%Colore e forma:SolidPeso molecolare:511.7PDD00031705
CAS:PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.Formula:C20H22N6O3S3Purezza:98%Colore e forma:SolidPeso molecolare:490.62LX7101 hydrochloride
CAS:LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Formula:C23H29N7O3HClColore e forma:SolidPeso molecolare:488ICAM-1-IN-1
CAS:<p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>Formula:C15H11BrN2O2SPurezza:99.67%Colore e forma:SolidPeso molecolare:363.23ROCK2-IN-7
CAS:<p>ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.</p>Formula:C26H28FN5OPurezza:98%Colore e forma:SolidPeso molecolare:445.53DHODH-IN-14
CAS:DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Formula:C15H7F4N3O3Purezza:99.81%Colore e forma:SolidPeso molecolare:353.23TAK 029
CAS:TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Formula:C19H23N5O7Colore e forma:SolidPeso molecolare:433.42AR-13503
CAS:AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.Formula:C19H19N3O2Colore e forma:SolidPeso molecolare:321.37EHT 5372
CAS:EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.Formula:C17H11Cl2N5OSColore e forma:SolidPeso molecolare:404.27CCT241533 hydrochloride
CAS:CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Formula:C23H28ClFN4O4Purezza:97.13%Colore e forma:SolidPeso molecolare:478.95T521
CAS:T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Formula:C17H14FNO5S2Purezza:99.71%Colore e forma:SolidPeso molecolare:395.43Voruciclib hydrochloride
CAS:Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Formula:C22H20Cl2F3NO5Purezza:98%Colore e forma:SolidPeso molecolare:506.3Sapacitabine
CAS:Sapacitabine (CS682) is a nucleoside analog precursor with anticancer activity used in the study of leukemia.Formula:C26H42N4O5Purezza:98.82%Colore e forma:SolidPeso molecolare:490.64CDK9-IN-8
CAS:<p>CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).</p>Formula:C31H32FN7O3Purezza:99.54%Colore e forma:SolidPeso molecolare:569.63ATN-161
CAS:ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Formula:C23H35N9O8SPurezza:98%Colore e forma:SolidPeso molecolare:597.64Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Purezza:95%Colore e forma:LiquidNetropsin dihydrochloride
CAS:Netropsin dihydrochloride, a small MGB, blocks topoisomerase I/II, hindering cleavable complex stabilization.Formula:C18H28Cl2N10O3Purezza:98%Colore e forma:SolidPeso molecolare:503.39AVG-233
CAS:AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.Formula:C26H22ClN5O3Purezza:99%Colore e forma:SolidPeso molecolare:487.94Senexin A hydrochloride
CAS:Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].Formula:C17H15ClN4Colore e forma:SolidPeso molecolare:310.78DHX9-IN-6
CAS:DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.Formula:C23H18ClFN4O4S2Purezza:99.71%Colore e forma:SolidPeso molecolare:533CCG-232964
CAS:CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].Formula:C15H15ClN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:338.81Senexin C
CAS:Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formula:C28H27N5OPurezza:98.06%Colore e forma:SolidPeso molecolare:449.55DHX9-IN-4
CAS:DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.Formula:C21H22ClN5O4S2Purezza:98.12%Colore e forma:SolidPeso molecolare:508.01KSP-IA
CAS:KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.Formula:C21H22F2N2OPurezza:98%Colore e forma:SolidPeso molecolare:356.41ON 108600
CAS:ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.Formula:C22H14Cl2N2O6S2Purezza:98%Colore e forma:SolidPeso molecolare:537.39Halofuginone hydrochloride
CAS:Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.Formula:C16H18BrCl2N3O3Colore e forma:SolidPeso molecolare:451.14PLK4-IN-4
CAS:<p>PLK4-IN-4 (compound 22), a potent inhibitor of PLK4, exhibits an IC50 value of 7.9 nM, suggesting its potential use in cancer research [1].</p>Formula:C21H23F2N9Colore e forma:SolidPeso molecolare:439.46BMT-090605
CAS:BMT-090605: AAK1 inhibitor (IC50=0.6 nM), also affects BIKE (45 nM) and GAK (60 nM), has antinociceptive properties.Formula:C21H24N4O2Purezza:98%Colore e forma:SolidPeso molecolare:364.44Pencitabine
CAS:Pen is an oral cancer drug that blocks DNA synthesis by inhibiting key enzymes and integrating into DNA.Formula:C15H20F3N3O6Colore e forma:SolidPeso molecolare:395.33Mefenidil
CAS:Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.Formula:C12H11N3Purezza:98.27%Colore e forma:SolidPeso molecolare:197.24WRN inhibitor 2
CAS:WRN Inhibitor 2 (example 118), a potent inhibitor of the WRN (Werner Syndrome ATP-dependent helicase enzyme), exhibits a pIC50 value of 7.0 or greater [1].Formula:C15H11F3N2O5S2Purezza:98%Colore e forma:SolidPeso molecolare:420.38CDK9-IN-23
CAS:CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].Formula:C22H25ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:428.91QR-6401
CAS:<p>QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/</p>Formula:C19H23N5O3Purezza:98%Colore e forma:SolidPeso molecolare:369.42Tacaciclib
CAS:Tacaciclib is a cyclin-dependent kinase (CDK) inhibitor with observed antineoplastic activity [1].Formula:C30H36N6O3Purezza:98%Colore e forma:SolidPeso molecolare:528.65Palbociclib orotate
CAS:<p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>Formula:C29H33N9O6Purezza:98%Colore e forma:SolidPeso molecolare:603.63Butylparaben sodium
CAS:Butylparaben sodium significantly impacts the later phases of spermatogenesis in the testes by impairing hormonal regulation and/or RNA and protein synthesis [1Formula:C11H13NaO3Purezza:98%Colore e forma:SolidPeso molecolare:216.21CDK4-IN-2
CAS:CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].Formula:C22H26F2N6O4SPurezza:98%Colore e forma:SolidPeso molecolare:508.54Thymidine-5'-O-(α,β-methylene)diphosphate sodium
CAS:Thymidine-5’-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM).Formula:C11H15N2O10P2·3NaColore e forma:SolidPeso molecolare:466.16pppApG
CAS:pppApG serves as an initial substrate for the synthesis of vRNA (viral RNA) and cRNA (complementary RNA), with applications in influenza virus research [1].Formula:C20H28N10O20P4Colore e forma:SolidPeso molecolare:852.39Bexotegrast HCl
CAS:Bexotegrast (PLN-74809) inhibits αVβ1/αVβ6 integrins, preventing TGF-β1 activation to treat IPF and PSC.Formula:C27H38Cl2N6O3Colore e forma:SolidPeso molecolare:565.54RIOK2-IN-1
CAS:RIOK2-IN-1 (com 4) is a selective RIOK2 inhibitor with a Kd of 150 nM, though it demonstrates low cellular activity with an IC50 of 14,600 nM.Formula:C18H16N2OColore e forma:SolidPeso molecolare:276.33GSPT1 degrader-2
CAS:GSPT1 degrader-2 is a potent degrader of GSPT1 [1].Formula:C22H20ClN3O5Colore e forma:SolidPeso molecolare:441.86(±)9(10)-DiHOME
CAS:(±)9(10)-DiHOME, the diol derivative of (±)9(10)-EpOME—a cytochrome P450-derived epoxide of linoleic acid also known as leukotoxin—is formed through the action of soluble epoxide hydrolase (sEH) in neutrophils. It exhibits toxicity towards Sf21 cells expressing sEH as well as tolacZ-expressing control cells, differing from leukotoxin which only harms sEH-containing cells. Furthermore, combined exposure to 9(10)- and 12(13)-DiHOME leads to cell death in rabbit renal proximal tubule cells by disrupting mitochondrial respiration, and causes lung injury, respiratory distress, and mortality in mice, highlighting its role as a toxic lipid mediator. Specifically, 9(10)-DiHOME has been associated with acute respiratory distress syndrome (ARDS), a severe and often deadly complication in patients with major burns. Elevated levels of this compound have been detected in the bronchoalveolar lavage fluid (BALF) of women, but not men, with chronic obstructive pulmonary disease (COPD), and its levels are also increased in patients with allergic asthma, indicating its significance in respiratory conditions.Formula:C18H34O4Colore e forma:SolidPeso molecolare:314.5Abetimus
CAS:Abetimus (LJP 394 free base), an immunosuppressant composed of four double-stranded DNA (dsDNA) oligonucleotides, can crosslink anti-dsDNA antibodies on B cellFormula:C11H18N4O7Colore e forma:SolidPeso molecolare:318.28PD 121373
CAS:PD 121373, a Benzothiopyrano-indazole, inhibits nucleic acid synthesis, equally affecting DNA/RNA.Formula:C21H27N5OSColore e forma:SolidPeso molecolare:397.54NSC15520
CAS:NSC15520 is an RPA inhibitor that inhibits helical destabilization of double-stranded DNA oligonucleotides and can be used to study DNA damage repair.Formula:C24H34O6Colore e forma:SolidPeso molecolare:418.52KIF18A-IN-7
CAS:KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependentFormula:C27H35N3O5S2Colore e forma:SoildPeso molecolare:545.71Leucettinib-92
CAS:Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μMFormula:C21H22N4OSPurezza:98%Colore e forma:SolidPeso molecolare:378.49L 738167
CAS:L 738167 is a potent antagonist of the long-acting fibrinogen receptor.Formula:C25H34N6O6SColore e forma:SolidPeso molecolare:546.64DCB-3503
CAS:DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.Formula:C24H27NO5Colore e forma:SolidPeso molecolare:409.47Cytidine 3'-monophosphate
CAS:Cytidine 3'-monophosphate, a ribonucleotide, results from the hydrolysis of cytidine 2',3'-cyclic monophosphate via RNase—a process that cytidine 3'-monophosphate itself inhibits. Additionally, it can be dephosphorylated to cytidine by 3'-nucleotidase.Formula:C9H14N3O8PColore e forma:SolidPeso molecolare:323.2CCT239065
CAS:CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor.Formula:C29H29N7O3SColore e forma:SolidPeso molecolare:555.65Fosfluridine tidoxil
CAS:Fosfluridine tidoxil, a thymidylate synthase inhibitor, is used potentially for the treatment of colorectal cancer, and breast cancer.Formula:C34H62FN2O10PSColore e forma:SolidPeso molecolare:740.9UNC-2170
CAS:UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.Formula:C14H21BrN2OPurezza:97.44%Colore e forma:SolidPeso molecolare:313.23SC-52012
CAS:<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Formula:C25H30N4O6Purezza:97.20%Colore e forma:SolidPeso molecolare:482.53GSK2850163
CAS:GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).Formula:C24H29Cl2N3OPurezza:99.04%Colore e forma:SolidPeso molecolare:446.41NTRC 0066-0
CAS:NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.Formula:C33H39N7O2Purezza:98.30%Colore e forma:SolidPeso molecolare:565.71α7β1 integrin modulator-1
CAS:α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Formula:C23H29N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:475.56Votoplam
CAS:Votoplam functions as a gene splicing modulator, employed in the inhibition of Huntington's disease [1].Formula:C21H25N9OPurezza:98%Colore e forma:SolidPeso molecolare:419.48Lamifiban
CAS:Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Formula:C24H28N4O6Purezza:98%Colore e forma:SolidPeso molecolare:468.5Spirofylline
CAS:Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.Formula:C24H28N6O5Purezza:98%Colore e forma:SolidPeso molecolare:480.52TAS-114
CAS:<p>TAS-114 is a dUTPase and DPD inhibitor that modulates catabolic pathways to improve systemic availability of 5-FU.</p>Formula:C21H29N3O6SPurezza:99.76%Colore e forma:SolidPeso molecolare:451.54IIIM-290
CAS:IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).Formula:C23H21Cl2NO5Purezza:98%Colore e forma:SolidPeso molecolare:462.32BVDU 5′-Triphosphate
CAS:BVDU 5′-Triphosphate is an antiviral agent labeled with 5′-Triphosphate that specifically targets viral DNA polymerase.Formula:C11H16BrN2O14P3Purezza:98%Colore e forma:SolidPeso molecolare:573.08ASC-69
CAS:ASC-69 (APY69) is a promising potent inhibitor of the PD-1/PD-L1 signaling pathway, classified as a small-molecule compound [1].Formula:C19H19N7Purezza:98%Colore e forma:SolidPeso molecolare:345.4Debio-0123
CAS:Debio-0123: potent, specific oral WEE1 inhibitor; IC50 in low nanomolar; boosts DNA damage & Carboplatin's anti-cancer effects.Formula:C26H28Cl2N6OPurezza:99.93%Colore e forma:SolidPeso molecolare:511.45Gossypolone
CAS:Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.Formula:C30H26O10Purezza:99.15%Colore e forma:SolidPeso molecolare:546.52Cdk1/2 Inhibitor III
CAS:<p>Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.</p>Formula:C15H13F2N7O2S2Purezza:99.07%Colore e forma:SolidPeso molecolare:425.44B I09
CAS:B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.Formula:C16H17NO5Purezza:99.64%Colore e forma:SolidPeso molecolare:303.31LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formula:C24H26ClF2N5O2Purezza:99.68%Colore e forma:SolidPeso molecolare:489.95(R)-Simurosertib
CAS:<p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>Formula:C17H19N5OSPurezza:99.89%Colore e forma:SolidPeso molecolare:341.43BDP9066
CAS:BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formula:C20H24N6Purezza:98.18%Colore e forma:SolidPeso molecolare:348.44PD-L1-IN-3
CAS:PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.Formula:C19H15ClFN2OSPurezza:99.47%Colore e forma:SoildPeso molecolare:373.85CCT129202
CAS:CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formula:C23H25ClN8OSPurezza:98.14%Colore e forma:SolidPeso molecolare:497.02DHX9-IN-2
CAS:<p>DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.</p>Formula:C18H16ClN3O3S2Purezza:98%Colore e forma:SolidPeso molecolare:421.92Thymectacin
CAS:Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.Formula:C21H25BrN3O9PPurezza:97.05% - 99.49%Colore e forma:SolidPeso molecolare:574.32CFI-402257
CAS:<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Formula:C28H30N6O3Purezza:96.66% - 99.51%Colore e forma:SolidPeso molecolare:498.58αvβ1 integrin-IN-1
CAS:<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Formula:C26H34N6O6SPurezza:99.74% - >99.99%Colore e forma:SolidPeso molecolare:558.65Roxifiban acetate
CAS:Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFormula:C23H33N5O8Purezza:97.91% - 98.36%Colore e forma:SolidPeso molecolare:507.54Plogosertib
CAS:<p>Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.</p>Formula:C34H48N8O3Purezza:99.22% - 99.85%Colore e forma:SolidPeso molecolare:616.797CF53
CAS:CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.Formula:C24H25N7O2Purezza:99.72%Colore e forma:SolidPeso molecolare:443.5AZD4573
CAS:AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies.Formula:C22H28ClN5O2Purezza:99% - 99.51%Colore e forma:SolidPeso molecolare:429.94LNA-Adenosine
CAS:LNA-Adenosine (LNA-A) is a nucleoside analogue that acts as a ligand for adenosine A3 receptors.Formula:C11H13N5O4Purezza:99.15%Colore e forma:SolidPeso molecolare:279.25SMN-C3
CAS:SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).Formula:C24H28N6OPurezza:99.01% - 99.05%Colore e forma:SolidPeso molecolare:416.52Lomibuvir
CAS:Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.Formula:C25H35NO4SPurezza:99.83%Colore e forma:SolidPeso molecolare:445.61Sorivudine
CAS:Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.Formula:C11H13BrN2O6Purezza:99.74%Colore e forma:SolidPeso molecolare:349.13Galidesivir
CAS:Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.Formula:C11H15N5O3Purezza:96.73% - 99.13%Colore e forma:SolidPeso molecolare:265.27PolQi1
CAS:<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Formula:C18H14ClF5N4O2Purezza:98.97%Colore e forma:SolidPeso molecolare:448.77DIDS
CAS:DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.Formula:C16H10N2O6S4Purezza:98%Colore e forma:SolidPeso molecolare:454.52BBI-355
CAS:BBI-355 is an oral, potent, and selective small molecule CHK1 inhibitor with an IC50 of 0.3 nM. It exhibits significant antitumor activity, both as a monotherapy and in combination with targeted therapies, across various ecDNA+ oncogene-amplified tumor models.Formula:C19H19N7O2Colore e forma:SolidPeso molecolare:377.40Bersiporocin
CAS:<p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>Formula:C15H19Cl2N3OPurezza:98.88% - 99.79%Colore e forma:SolidPeso molecolare:328.24DYRK1-IN-1
CAS:DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.Formula:C12H12N6Colore e forma:SolidPeso molecolare:240.26SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formula:C20H26N8OSPurezza:98%Colore e forma:SolidPeso molecolare:426.54CLK1/2-IN-1
CAS:CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.Formula:C21H20F3N7OPurezza:98%Colore e forma:SolidPeso molecolare:443.42Pseudouridine 5'-OTBDPS
CAS:<p>Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.</p>Formula:C25H30N2O6SiColore e forma:SolidPeso molecolare:482.60FT709
CAS:FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.Formula:C23H22N4O7SColore e forma:SolidPeso molecolare:498.51DNA polymerase-IN-6
CAS:DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.Formula:C26H28ClFN8O4Colore e forma:SolidPeso molecolare:571.0038-Azakinetin riboside
CAS:8-Azakinetin riboside, a structural analog of kinetin riboside, exhibits cytotoxic activity [1].Formula:C14H16N6O5Peso molecolare:348.31WRN inhibitor 13
CAS:WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.Formula:C16H20N2O5SColore e forma:SolidPeso molecolare:352.4052'-F-UMP
CAS:<p>2'-F-UMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>Formula:C9H12FN2O8PPeso molecolare:326.17
