Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(224 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(86 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(284 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
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Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"
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MtTMPK-IN-9
MtTMPK-IN-9 moderately inhibits MtbTMPK (IC50: 48 μM), has submicromolar Mycobacterium activity, and is non-toxic, aiding tuberculosis research.Formula:C25H26N6O7Colore e forma:SolidPeso molecolare:522.515'-DMT-5-F-2'-dU Phosphoramidite
CAS:5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.Formula:C39H46FN4O8PColore e forma:SolidPeso molecolare:748.777Antitumor agent-75
Antitumor agent-75 is a novel and potent antitumor agent.Formula:C26H23FN6Colore e forma:SolidPeso molecolare:438.54,5'-Dimethylangelicin-NHS
NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.Formula:C21H19NO7SColore e forma:SolidPeso molecolare:429.44DYRKs-IN-1 hydrochloride
CAS:DYRKs-IN-1 HCl inhibits DYRK1A (5 nM IC50) & DYRK1B (8 nM IC50) with antitumor properties.Formula:C30H31Cl2N7O4Colore e forma:SolidPeso molecolare:624.52Chk1-IN-5
CAS:Chk1-IN-5 inhibits Chk1, blocking phosphorylation and suppressing colon cancer growth.Formula:C18H18FN7O2Colore e forma:SolidPeso molecolare:383.38GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formula:C27H36FN3O4Colore e forma:SolidPeso molecolare:485.59Rhodblock 1a
CAS:<p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>Formula:C20H16N2O2Colore e forma:SolidPeso molecolare:316.353CDK9-IN-13
CDK9-IN-13 is a potent and selective CDK inhibitor (IC50<3 nM). CDK9-IN-13 has a very short half-life in rodents.Formula:C27H35N5O2Colore e forma:SolidPeso molecolare:461.6CDK2/4-IN-2
CAS:CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Formula:C18H20F3N7O3S2Colore e forma:SolidPeso molecolare:503.52LNA-GTP
CAS:LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.Formula:C11H16N5O14P3Colore e forma:SolidPeso molecolare:535.19DNA gyrase B-IN-1
DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.Formula:C23H18ClF3N6O4SColore e forma:SolidPeso molecolare:566.942'-O-MOE-GMP
CAS:<p>2'-O-MOE-GMP is a nucleotide analogue that can be utilized in the synthesis of oligonucleotides.</p>Formula:C13H20N5O9PColore e forma:SolidPeso molecolare:421.30WEE1/PKMYT1-IN-1
CAS:<p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>Formula:C16H16N4O3Colore e forma:SolidPeso molecolare:312.323SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formula:C23H27F2N5O4Colore e forma:SolidPeso molecolare:475.49PCNA-IN-1
CAS:PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.Formula:C19H18I3NO3Colore e forma:SolidPeso molecolare:689.065N-Isobutyryl-2', 3'-acetyl-guanosine
CAS:N-Isobutyryl-2', 3'-acetyl-guanosine is a derivative of guanosine.Formula:C18H23N5O8Colore e forma:SolidPeso molecolare:437.4042-CEES
CAS:2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.Formula:C4H9ClSColore e forma:SolidPeso molecolare:124.632Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formula:C29H33ClN4O3SColore e forma:SolidPeso molecolare:553.12DDO-6079
CAS:DDO-6079 is an efficient CDC37 inhibitor. It suppresses the HSP90-CDC37 and CDC37-CDK4/6 chaperone complexes by binding to an allosteric site on CDC37. Additionally, DDO-6079 reduces the thermal stability of CDK6.Formula:C18H13ClN2O3Colore e forma:SolidPeso molecolare:340.76USP7-IN-10
CAS:USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Formula:C26H29ClN4O3SColore e forma:SolidPeso molecolare:513.05Z4P
CAS:Z4P, an IRE1 inhibitor with blood-brain barrier permeability (BBB), inhibited glioblastoma growth and recurrence in combination with Temozolomide.Formula:C19H24N2O2Purezza:98.99%Colore e forma:SolidPeso molecolare:312.41WEE1-IN-10
CAS:WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.Formula:C28H30Cl2N8OPurezza:98.18%Colore e forma:SolidPeso molecolare:565.5IIP0943
CAS:IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.Formula:C26H28N6O3SColore e forma:SolidPeso molecolare:504.604NusB-IN-1
NusB-IN-1 (22r) is an oral bacterial rRNA inhibitor, effective against MRSA and VRSA.Formula:C21H16N2O3Colore e forma:SolidPeso molecolare:344.363-deoxy-3-fluoro-β-D-Ribofuranose 25
CAS:Compound 25, β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate), exhibits strong activity in inhibiting the growth of tumor cells [1].Formula:C17H19FO7Peso molecolare:354.33Antitumor agent-74
Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.Formula:C26H23FN6Colore e forma:SolidPeso molecolare:438.5Aurora A inhibitor 4
CAS:Aurora A inhibitor4 (compound C9) is a potent inhibitor of Aurora A, with GI50 values of 4.26 μM in DU 145 cells and 7.08 μM in HT-29 cells.Formula:C22H23N5O3Peso molecolare:405.45CLK1/4-IN-1
CLK1/4-IN-1 inhibits Clk1/4 (IC50: 9.7/6.6 nM), curbing T24 cell growth (GI50: 1.1 μM). Potential cancer research tool.Formula:C18H14ClNO4SColore e forma:SolidPeso molecolare:375.83RNAP-σ interaction inhibitor-2
CAS:RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.Formula:C27H19Cl3N2O6S2Colore e forma:SolidPeso molecolare:637.939PD-1/PD-L1-IN-53
CAS:<p>PD-1/PD-L1-IN-53 (compound B3) serves as an inhibitor targeting both the PD-1/PD-L1 and VISTA signaling pathways. It is utilized in cancer research.</p>Formula:C31H37N3O4Colore e forma:SolidPeso molecolare:515.64(R)-Atuveciclib
CAS:Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].Formula:C18H18FN5O2SPurezza:98%Colore e forma:SolidPeso molecolare:387.43MtTMPK-IN-1
MtTMPK-IN-1 inhibits MtTMPK with 2.5 μM IC50, shows moderate anti-tuberculosis activity, and is low in cytotoxicity.Formula:C22H24N4O3Colore e forma:SolidPeso molecolare:392.45Protein kinase inhibitor 14
CAS:Protein kinase inhibitor 14 (Compound 13) exhibits inhibitory effects on various serine/threonine kinases and receptor/non-receptor tyrosine kinases.Formula:C22H22F2N6OPeso molecolare:424.447CDK2-IN-30
CAS:CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC50 of ≤20 nM, utilized primarily in tumor research.Formula:C18H25N7O3SColore e forma:SolidPeso molecolare:419.50Tetrahydrouridine dihydrate
THU dihydrate, a potent CDA inhibitor, outperforms cytidine by blocking the enzyme's active site.Formula:C9H20N2O8Colore e forma:SolidPeso molecolare:284.26Anti-neuroinflammation agent 3
CAS:Compound A.10.3 (Anti-neuroinflammation agent 3) exhibits inhibitory activity against various Ser/Thr kinases or receptor/non-receptor tyrosine kinases.Formula:C22H23FN6O2Peso molecolare:422.455RMS-07
CAS:RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Formula:C35H40N8O2Colore e forma:SolidPeso molecolare:604.74PKMYT1-IN-7
CAS:PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM for PKMYT1 and 0.06 μM for pCDK1. It inhibits the phosphorylation of CDK1 at T14 and Y15 sites and exhibits anticancer activity both in vitro and in vivo.Formula:C17H18FN5O3Colore e forma:SolidPeso molecolare:359.355MtTMPK-IN-2
CAS:MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).Formula:C23H24ClN3O3Colore e forma:SolidPeso molecolare:425.91ART615
ART615 is a related isomer of ART558. ART615 inhibits Polθ by <10% at 12 μM and is able to act as a control for ART558 (IC50:7.9 nM).Formula:C21H21F3N4O2Colore e forma:SolidPeso molecolare:418.412'-(2-Nitrobenzyl)-ATP
CAS:2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.Formula:C17H21N6O15P3Colore e forma:SolidPeso molecolare:642.305-Iminodaunorubicin hydrochloride
CAS:5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.Formula:C27H31ClN2O9Colore e forma:SolidPeso molecolare:563.00Ladirubicin
CAS:Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.Formula:C29H31NO11SColore e forma:SolidPeso molecolare:601.62BAY-364
CAS:BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+Formula:C23H19N3O4Colore e forma:SolidPeso molecolare:401.41CDK6-IN-1
CAS:CDK6-IN-1 (compound 4i) is an inhibitor of CDK6 that suppresses cell growth and induces cell cycle arrest at the G1 phase.Formula:C30H23N5Colore e forma:SolidPeso molecolare:453.54CDK7-IN-31
CAS:CDK7-IN-31 (compound 13) is an effective and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) with a dissociation constant (Kd) of 0.18 nM. This compound exhibits anticancer activity.Formula:C27H32F5N6O2PColore e forma:SolidPeso molecolare:598.55Ascofuranone
CAS:Ascofuranone is an inhibitor of the ubiquinol oxidase activity of Trypanosoma brucei mitochondrial alternative oxidase (TAO), as well as an inhibitor of HsDHODHFormula:C23H29ClO5Colore e forma:SolidPeso molecolare:420.93RAD51-IN-7
CAS:RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)Formula:C25H31N5O4S2Colore e forma:SolidPeso molecolare:529.67CDK9-IN-11
CAS:CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Formula:C20H25N3O4Purezza:98%Colore e forma:SolidPeso molecolare:371.43β-catenin-IN-8
CAS:β-catenin-IN-8 (Compound 25) is an inhibitor of β-catenin. It effectively lowers the levels of both β-catenin and c-Myc proteins and suppresses Wnt target genes (Fgf20 and Sall4). Additionally, β-catenin-IN-8 exhibits anticancer activity against colorectal cancer and possesses metabolic stability.Formula:C15H12ClN3O2SColore e forma:SolidPeso molecolare:333.79Plevitrexed
CAS:Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.Formula:C26H25FN8O4Purezza:98%Colore e forma:SolidPeso molecolare:532.53UM-C162
CAS:UM-C162, a benzimidazole derivative, offers protection to nematodes from Staphylococcus aureus infections. It inhibits biofilm formation without impairing bacterial viability. Additionally, UM-C162 disrupts the production of Staphylococcus aureus hemolysins, proteases, and coagulases. This compound holds potential as an antivirulence agent for managing Staphylococcus aureus infections.Formula:C30H25N3O4Peso molecolare:491.54Cdc7-IN-11
CAS:Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.Formula:C20H22F2N4O2SColore e forma:SolidPeso molecolare:420.48CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formula:C21H22N4OColore e forma:SolidPeso molecolare:346.432′-OMe-UMP
CAS:2′-OMe-UMP is a nucleotide analog used in the synthesis of oligonucleotides.Formula:C10H15N2O9PPeso molecolare:338.21TMX-3013
CAS:TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Formula:C17H14BrFN6O3SColore e forma:SolidPeso molecolare:481.3WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Formula:C30H31N5O3Colore e forma:SolidPeso molecolare:509.62′-F-UDP
CAS:2′-F-UDP is a nucleotide analogue used in the synthesis of oligonucleotides.Formula:C9H13FN2O11P2Colore e forma:SolidPeso molecolare:406.15RAD51-IN-8
RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.Formula:C16H14Cl2FN3O2Colore e forma:SolidPeso molecolare:370.21T-2513 hydrochloride
CAS:T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.Formula:C25H28ClN3O5Colore e forma:SolidPeso molecolare:485.96LIMK1 inhibitor 2
CAS:LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.Formula:C10H11N3OSColore e forma:SolidPeso molecolare:221.279Antibacterial agent 110
Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).Formula:C22H21N5O4SColore e forma:SolidPeso molecolare:451.5Dyrk1A-IN-2
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.Formula:C27H32N6O4Colore e forma:SolidPeso molecolare:504.58L-Tyrosyl-L-glutamic acid
CAS:L-Tyrosyl-L-glutamic acid acts as an inhibitor of the amino acid permease GAP1.Formula:C14H18N2O6Colore e forma:SolidPeso molecolare:310.3ROCK/HDAC-IN-1
ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.Formula:C19H22N4O3SColore e forma:SolidPeso molecolare:386.47D-G23
CAS:<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Formula:C19H22N4O3Colore e forma:SolidPeso molecolare:354.403Tizolemide
CAS:Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Formula:C11H14ClN3O3S2Colore e forma:SolidPeso molecolare:335.83Xanthosine-5'-Triphosphate trisodium
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>Formula:C10H12N4Na3O15P3Colore e forma:SolidPeso molecolare:590.111LNA-GMP
CAS:LNA-GMP, a nucleotide analogue, is utilized in the synthesis of oligonucleotides.Formula:C11H14N5O8PColore e forma:SolidPeso molecolare:375.23GSK_WRN4
CAS:<p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>Formula:C16H20N2O4SPurezza:99.95%Colore e forma:SolidPeso molecolare:336.41Cimpuciclib tosylate
CAS:Cimpuciclib tosylate, a selective CDK4 inhibitor (IC50: 0.49 nM), exhibits anti-tumor activity.Formula:C37H43FN8O4SColore e forma:SolidPeso molecolare:714.85CDK12/13 ligand 1
CAS:ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Formula:C26H26BrN5OColore e forma:SolidPeso molecolare:504.42Polθ-IN-6
CAS:Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.Formula:C25H23N3O3SColore e forma:SolidPeso molecolare:445.536-B345TTQ
CAS:6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.Formula:C22H20BrNO4Colore e forma:SolidPeso molecolare:442.303WRN inhibitor 12
CAS:WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formula:C33H33ClF3N9O5Colore e forma:SolidPeso molecolare:728.12Lobucavir
CAS:<p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>Formula:C11H15N5O3Colore e forma:SolidPeso molecolare:265.27DNA Gyrase-IN-13
CAS:<p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>Formula:C15H21N3O3SColore e forma:SolidPeso molecolare:323.41WRN inhibitor 11
CAS:WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formula:C34H35ClF3N9O5Colore e forma:SolidPeso molecolare:742.15Cdc7-IN-10
CAS:Cdc7-IN-10 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in studies of proliferative diseases.Formula:C20H22F2N4O2SColore e forma:SolidPeso molecolare:420.48CDK4-IN-1
CAS:CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formula:C22H29ClN8Purezza:98%Colore e forma:SolidPeso molecolare:440.97WEE1-IN-11
CAS:WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Formula:C26H29FN8OS2Colore e forma:SolidPeso molecolare:552.69CDK2-IN-31
CAS:CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Formula:C37H52N6O5Colore e forma:SolidPeso molecolare:660.85BWC0977
CAS:BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.Formula:C22H21FN6O5Colore e forma:SolidPeso molecolare:468.44SGC-CLK-1
CAS:SGC-CLK-1 is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. It effectively inhibits the growth of melanoma and glioblastoma cells.Formula:C19H15F3N6O2Colore e forma:SolidPeso molecolare:416.36Galidesivir
CAS:Galidesivir (BCX4430) is an antiviral compound that inhibits viral RNA-dependent RNA polymerase (RdRp) activity and reduces lung infections in infected animals.Formula:C11H15N5O3Purezza:96.73% - 99.13%Colore e forma:SolidPeso molecolare:265.27Polθ-IN-5
CAS:Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.Formula:C23H18ClF2N7O3SColore e forma:SolidPeso molecolare:545.95TASIN-30
CAS:<p>TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.</p>Formula:C18H30N2O3SColore e forma:SolidPeso molecolare:354.51Werner syndrome RecQ helicase-IN-2
CAS:Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formula:C32H34F3N9O5Purezza:99.02%Colore e forma:SolidPeso molecolare:681.67DYRK1-IN-1
CAS:DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.Formula:C12H12N6Colore e forma:SolidPeso molecolare:240.2612(S)-HETE
CAS:<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Formula:C20H32O3Colore e forma:SolidPeso molecolare:320.47Glycyl H-1152 hydrochloride
CAS:Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Formula:C18H26Cl2N4O3SColore e forma:SolidPeso molecolare:449.39Haspin-IN-2
CAS:Haspin-IN-2 is a potent haspin inhibitor (IC50: 50 nM) and also inhibits CLK1 (IC50: 445 nM) and DYRK1A (IC50: 917 nM).Formula:C12H8N4O3Colore e forma:SolidPeso molecolare:256.22APE1-IN-3
CAS:<p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>Formula:C17H16O4Colore e forma:SolidPeso molecolare:284.3114α-Demethylase/DNA Gyrase-IN-1
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formula:C26H22N4O4Colore e forma:SolidPeso molecolare:454.48TY-011
CAS:<p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>Formula:C18H16ClN5Colore e forma:SolidPeso molecolare:337.81Pseudouridine 5'-OTBDPS
CAS:<p>Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.</p>Formula:C25H30N2O6SiColore e forma:SolidPeso molecolare:482.60Valopicitabine
CAS:<p>Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic</p>Formula:C15H24N4O6Purezza:98%Colore e forma:SolidPeso molecolare:356.37GHP-88309
CAS:<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Formula:C16H11FN2OColore e forma:SolidPeso molecolare:266.27DS96432529
DS96432529 is a potent and orally active bone anabolic agent through CDK8 inhibition.Formula:C18H26N4O3SColore e forma:SoildPeso molecolare:378.49Kolavenic acid analog
CAS:KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formula:C25H38O4Colore e forma:SolidPeso molecolare:402.57CHK1-IN-4
CAS:<p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>Formula:C18H18BrN7O2Purezza:98%Colore e forma:SolidPeso molecolare:444.29CDK7/12-IN-1
CAS:CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.Formula:C25H34N8OColore e forma:SolidPeso molecolare:462.59GTSE1-IN-1
CAS:GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Formula:C21H24FN7Colore e forma:SolidPeso molecolare:393.46PD-L1-IN-7
CAS:PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Formula:C46H50N6O7Colore e forma:SolidPeso molecolare:798.93CDK7-IN-17
CAS:CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.Formula:C24H26F3N6OPPurezza:99.60%Colore e forma:SolidPeso molecolare:502.47Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.Formula:C16H20N6OColore e forma:SolidPeso molecolare:312.37PolQi1
CAS:<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Formula:C18H14ClF5N4O2Purezza:98.97%Colore e forma:SolidPeso molecolare:448.77PLK1-IN-11
CAS:PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.Formula:C12H11N5OColore e forma:SolidPeso molecolare:241.249Epolactaene
CAS:Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.Formula:C21H27NO6Colore e forma:SolidPeso molecolare:389.44LIMK-IN-2
CAS:<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Formula:C28H27N5O2Colore e forma:SolidPeso molecolare:465.55Mps1-IN-8
CAS:Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].Formula:C35H47N8O6PColore e forma:SolidPeso molecolare:706.77iPAF1C
CAS:<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formula:C27H26BrFN4OColore e forma:SolidPeso molecolare:521.42CD 10899
CAS:CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].Formula:C34H50N8O4Colore e forma:SolidPeso molecolare:634.81FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Formula:C21H19N5O2Colore e forma:SolidPeso molecolare:373.41LY 254155
CAS:LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.Formula:C19H23N5O6SPurezza:98%Colore e forma:SolidPeso molecolare:449.48CHK1-IN-11
CAS:CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.Formula:C20H22N8O2Colore e forma:SolidPeso molecolare:406.44Dyrk1A-IN-8
CAS:Dyrk1A-IN-8 is an active molecule that can be used in life science related research. The CAS number of Dyrk1A-IN-8 is 101578-13-6.Formula:C17H21N3OColore e forma:SolidPeso molecolare:283.37PLK1-IN-5
CAS:PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].Formula:C28H39N7O3Colore e forma:SolidPeso molecolare:521.65YKL-1-116
CAS:YKL-1-116 is an effective, selective, and covalent CDK7 inhibitor.Formula:C34H38N8O3Purezza:98%Colore e forma:SolidPeso molecolare:606.72Haspin-IN-1
Haspin-IN-1 blocks haspin (IC50: 119 nM) and inhibits CLK1, DYRK1A, CDK9 with potential as an anticancer drug.Formula:C12H8N4O2SColore e forma:SolidPeso molecolare:272.28HRO761
CAS:HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.Formula:C31H31ClF3N9O5Purezza:98.74% - 99.62%Colore e forma:SolidPeso molecolare:702.08CTPS1-IN-1
CAS:CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.Formula:C21H22N6O4S2Purezza:99.46%Colore e forma:SolidPeso molecolare:486.57Elacytarabine
CAS:Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.Formula:C27H45N3O6Purezza:97.69%Colore e forma:SolidPeso molecolare:507.66GFB-12811
CAS:GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Formula:C22H23F4N5OPurezza:98.88%Colore e forma:SolidPeso molecolare:449.44VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Formula:C13H15ClN2O2Purezza:99.3%Colore e forma:SolidPeso molecolare:266.72SR 11302
CAS:SR 11302 is an inhibitor of activator protein-1 (AP-1).Formula:C26H32O2Purezza:98.65%Colore e forma:SolidPeso molecolare:376.53LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Formula:C16H14FN5O2Purezza:98.43%Colore e forma:SolidPeso molecolare:327.31INCB086550
CAS:INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.Formula:C41H39N7O4Purezza:98.49%Colore e forma:SolidPeso molecolare:693.79Bicyclomycin benzoate
CAS:Bicyclomycin benzoate (BCM benzoate, FR2054) is a broad-spectrum antibiotic and selective Rho protein inhibitor active against Gram-negative bacteria.Formula:C19H22N2O8Colore e forma:SolidPeso molecolare:406.39Troxacitabine
CAS:Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.Formula:C8H11N3O4Purezza:98%Colore e forma:SolidPeso molecolare:213.192'-Deoxy-2'-fluoro-5-iodouridine
CAS:2'-Deoxy-2'-fluoro-5-iodouridine is a nucleoside, specifically a fluoro-modified and halo-nucleoside.Formula:C9H10FIN2O5Colore e forma:SolidPeso molecolare:372.095'-O-DMT-N6-ibu-dA
CAS:5'-O-DMT-N6-ibu-dA can be utilized in the synthesis of oligodeoxyribonucleotides.Formula:C35H37N5O6Colore e forma:SolidPeso molecolare:623.71Formycin A
CAS:Formycin A shows antitumor and antiviral activities. Formycin A , a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM.Formula:C10H13N5O4Purezza:98%Colore e forma:SolidPeso molecolare:267.24Tanuxiciclib
CAS:Tanuxiciclib is a cyclin dependent kinase (CDK) inhibitor, specifically designed to interfere with cell cycle progression by inhibiting the activity of CDKs, which are crucial regulators of cell division.Formula:C15H13FN6OColore e forma:SolidPeso molecolare:312.308PLK1-IN-6
<p>PLK1-IN-6: potent, selective PLK1 inhibitor, IC50 = 0.45 nM, hinders cancer cell growth.</p>Formula:C28H37N9O3Colore e forma:SolidPeso molecolare:547.65Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Formula:C11H13N3O5Purezza:98%Colore e forma:SolidPeso molecolare:267.245'-DMT-3'-TBDMS-ibu-rG
CAS:5'-DMT-3'-TBDMS-ibu-rG is a modified nucleoside employed in deoxyribonucleic acid (DNA) synthesis.Formula:C41H51N5O8SiColore e forma:SolidPeso molecolare:769.96N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine
CAS:N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine, catalog number T66118 and CAS number 64325-78-6, is a valuable organic compound for life sciences research.Formula:C38H35N5O6Colore e forma:SolidPeso molecolare:657.727NSC639828
CAS:NSC639828 is an efficient inhibitor of DNA polymerase α, exhibiting a remarkable IC50 value of 70 μM. Additionally, NSC639828 demonstrates substantial antitumor activity, making it a promising candidate for cancer research.Formula:C18H13BrClN5O3Colore e forma:SolidPeso molecolare:462.693BrB-PP1
CAS:3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase, particularly effective against protein kinases with mutations in the ATP-binding pocket, such as the Thr97 mutation within Sty1's ATP-binding pocket.Formula:C16H18BrN5Colore e forma:SolidPeso molecolare:360.259GSK-3/CDK5/CDK2-IN-1
CAS:GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].Formula:C21H22N4O2Colore e forma:SolidPeso molecolare:362.433PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formula:C23H25F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:474.48MitoE10
CAS:MitoE10 is an effective mitochondrial targeting antioxidant.Formula:C42H55O5PSColore e forma:SolidPeso molecolare:702.92Ref: TM-T33406
Prodotto fuori produzioneRibocil-C
CAS:Ribocil-C is a selective inhibitor of the bacterial riboflavin riboswitch, a synthetic analogue of flavin mononucleotide (FMN), inhibits bacterial cell growth.Formula:C21H21N7OSPurezza:98%Colore e forma:SolidPeso molecolare:419.56-Amino-5-nitropyridin-2-one
CAS:6-Amino-5-nitropyridin-2-one, a pyridine derivative, serves as a nucleobase within hachimoji DNA, where it is specifically paired with 5-aza-7-deazaguanine.Formula:C5H5N3O3Purezza:98%Colore e forma:SolidPeso molecolare:155.11Tibremciclib
CAS:<p>Tibremciclib is a cyclin-dependent kinase 4 (CDK4) inhibitor that exhibits antineoplastic properties [1].</p>Formula:C28H32F2N8Purezza:98%Colore e forma:SolidPeso molecolare:518.6PHI-101
CAS:<p>PHI-101 is a checkpoint kinase 2 (Chk2) inhibitor that can be used for the study of refractory acute myeloid leukemia (AML) and ovarian cancer.</p>Formula:C19H19FN4O2SPurezza:99.4%Colore e forma:SolidPeso molecolare:386.44YK-2168
CAS:<p>YK-2168 is a differentiated selective inhibitor of CDK9.</p>Formula:C16H18ClN5Colore e forma:SolidPeso molecolare:315.80Ref: TM-T200769
Prodotto fuori produzione
