Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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Cyclothialidine
CAS:<p>Cyclothialidine is an inhibitor of DNA gyrase.</p>Formula:C26H35N5O12SColore e forma:SolidPeso molecolare:641.652-Amino-6-O-methyl-2'-O-methyl purine riboside
2-Amino-6-O-methyl-2’-O-methyl purine riboside, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoidFormula:C12H17N5O5Colore e forma:SolidPeso molecolare:311.29Solidagonic acid
CAS:Solidagonic acid inhibits HSET, prevents fission yeast cell death, and hinders L. sativa and L. multiflorum seedling growth.Formula:C22H34O4Colore e forma:SolidPeso molecolare:362.5Fradafiban hydrochloride
Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.Formula:C20H22ClN3O4Colore e forma:SolidPeso molecolare:403.86Catumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Purezza:95%Colore e forma:LiquidSD49-7
CAS:<p>SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.</p>Formula:C18H14N2O3Purezza:99.91%Colore e forma:SoildPeso molecolare:306.32ROCK-IN-5
CAS:<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Formula:C16H11ClFN3OSPurezza:99.72% - 99.83%Colore e forma:SolidPeso molecolare:347.79JB-11 isethionate
CAS:JB-11 isethionate is a bioactive chemical.Formula:C21H29N5O7SColore e forma:SolidPeso molecolare:495.55JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formula:C21H26N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:338.445'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Formula:C44H49F2N4O7PColore e forma:SolidPeso molecolare:814.85αvβ5 integrin-IN-1
CAS:αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.Formula:C25H28F3N3O3Colore e forma:SolidPeso molecolare:475.512Guanosine 5'-triphosphate trisodium salt hydrate
CAS:5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.Formula:C10H18N5NaO15P3Purezza:98%Colore e forma:SolidPeso molecolare:564.185Dafsolimab
CAS:Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and isColore e forma:LiquidLSN3106729 hydrochloride
CAS:LSN3106729 hydrochloride, an Abemaciclib metabolite, is a CDK-inhibiting antitumor PROTAC CDK4/6 degrader.Formula:C25H29ClF2N8OColore e forma:SoildPeso molecolare:531.00K34c hydrochloride
CAS:<p>K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.</p>Formula:C26H30ClN3O4Purezza:99.76% - 99.89%Colore e forma:SoildPeso molecolare:483.99N6-Ethyl-2'-β-C-ethynyl adenosine
N6-Ethyl-2’-beta-C-ethynyl adenosine is a purine nucleoside analog.Formula:C14H17N5O4Colore e forma:SolidPeso molecolare:319.326-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS:6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, exhibits a broad spectrum of biochemical andFormula:C11H15N5O4Colore e forma:SolidPeso molecolare:281.27LXY3
CAS:LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.Formula:C32H43N11O15S2Colore e forma:SolidPeso molecolare:885.88SMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formula:C20H21NO5Purezza:98.29%Colore e forma:SoildPeso molecolare:355.38Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Colore e forma:Odour Solid1-(b-D-Xylofuranosyl)-N6-(p-methoxybenzyl) adenine
1-(β-D-Xylofuranosyl)adenine is a purine analog with antitumor activity, inhibiting DNA synthesis and inducing apoptosis.Formula:C18H21N5O5Colore e forma:SolidPeso molecolare:387.39Ganodermaones B
Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .Formula:C21H26O5Colore e forma:SolidPeso molecolare:358.43Farletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.36 kDaCDK9 ligand 3
CAS:<p>CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.</p>Formula:C18H18BrCl2N5O3Colore e forma:SolidPeso molecolare:503.177CTP Synthetase-IN-1 Ammonium salt
<p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>Formula:C20H22F3N7O3S2Purezza:99.97%Colore e forma:SolidPeso molecolare:529.56CDK1-IN-2
CAS:CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Formula:C17H11ClN2OPurezza:98.53%Colore e forma:SoildPeso molecolare:294.73KWR137
<p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>Formula:C33H31ClF3N9O4Colore e forma:SolidPeso molecolare:710.105PROTAC CDK9 degrader-8
<p>PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].</p>Formula:C44H52Cl2N10O7Purezza:98%Colore e forma:SolidPeso molecolare:903.85N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Formula:C10H13Li4N2O15P3Colore e forma:SolidPeso molecolare:521.923-Oxa-OSW-1
CAS:23-Oxa-OSW-1 (SBF-1), a derivative of OSW-1, serves as a potent inhibitor of the osterol-binding protein (OSBP) with demonstrated antitumor activity [1] [2].Formula:C54H82O16Colore e forma:SolidPeso molecolare:987.22AV-153
CAS:AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.Formula:C14H19NNaO6Colore e forma:SolidPeso molecolare:320.297Endo-1,4-β-xylanase
CAS:Endo-1,4-β-xylanase (CtXyn11A) is a type of xylan hydrolase that hydrolyzes the β-1,4-glycosidic bond of the xylan molecule.Colore e forma:SolidEchistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formula:C217H341N71O74S9Purezza:98%Colore e forma:SolidPeso molecolare:5417.1Nusinersen
CAS:<p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>Purezza:98.62%Colore e forma:SolidClofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formula:C10H13ClFN5O9P2Colore e forma:SolidPeso molecolare:463.64N1-Benzoyl pseudouridine
N1-Benzoyl pseudouridine, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.Formula:C16H16N2O7Colore e forma:SolidPeso molecolare:348.31Ceftriaxone
CAS:Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Formula:C18H18N8O7S3Purezza:96.08%Colore e forma:SolidPeso molecolare:554.58KGDS
CAS:KGDS is a synthetic peptide that targets the integrin GPIIb-IIIa on the membrane of activated human platelets, with the amino acid sequence Lys-Gly-Asp-Ser [1].Formula:C15H27N5O8Colore e forma:SolidPeso molecolare:405.44-Amino-1-(2-C-methyl-β-D-ribofuranosyl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
CAS:4-Amino-5-cyano-1-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine, a purine nucleoside analogue, exhibits widespread antitumor efficacy,Formula:C13H15N5O4Colore e forma:SolidPeso molecolare:305.29N2-Acetylguanine
CAS:Compound 19962-37-9, with CAS No. 19962-37-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 19962-37-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C7H7N5O2Purezza:99.90%Colore e forma:White SolidPeso molecolare:193.166PD-1/PD-L1-IN-51
<p>PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.</p>Colore e forma:Odour SolidLys-Gln-Ala-Gly-Asp-Val
CAS:KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.Formula:C25H44N8O10Colore e forma:SolidPeso molecolare:616.66CDK2/4-IN-1
CDK2/4-IN-1 (compound B-4a) serves as both a CDK2/4 inhibitor and a microtubule polymerization inhibitor, making it useful in cancer research.Colore e forma:Odour SolidCHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is a highly selective and orally active checkpoint kinase 1 (CHK1) inhibitor, demonstrating an in vitro enzyme IC50 of ≤10 nM and a cellular IC50 of ≤50 nM. This compound suppresses the phosphorylation activity of CHK1 kinase, disrupts DNA damage response pathways, and induces tumor cell cycle arrest and apoptosis. CHK1-IN-12 shows promise for cancer research applications.Formula:C19H19N7O2Colore e forma:SolidPeso molecolare:377.16002Methylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Colore e forma:Odour SolidDSPE-PEG2000-cRGD
DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.Colore e forma:Odour SolidDSPE-PEG5000-cRGD
DSPE-PEG5000-cRGD is a PEG compound composed of DSPE and an αvβ3 targeting peptide (cRGD). The cRGD peptide has the ability to specifically bind to the αvβ3 present on the surfaces of numerous cancer cells and new vascular cells. DSPE-PEG5000-cRGD is useful for drug delivery applications.Colore e forma:Odour SolidIV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Formula:C23H32FN5O2SiColore e forma:SolidPeso molecolare:457.625LDV FITC
CAS:fluorescent ligand that binds to the α4β1 integrin (VLA-4)Formula:C69H81N11O17SPurezza:98%Colore e forma:SolidPeso molecolare:1368.53GS-443902 trisodium
CAS:<p>GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.</p>Formula:C12H16N5O13P3·xNaColore e forma:SolidDNA Gyrase-IN-12
<p>DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.</p>Colore e forma:Odour SolidCDK9/EZH2-IN-1
CAS:CDK9/EZH2-IN-1 is a dual-target inhibitor of CDK9 and EZH2 with IC50 values of 83.9 nM and 108.6 nM, respectively. It induces apoptosis and causes DNA double-strand breaks (DSB). Additionally, CDK9/EZH2-IN-1 inhibits the proliferation of MKN45, MDA-MB-453, and SW620 cancer cells, with respective IC50 values of 136.3 nM, 171.3 nM, and 315.7 nM.Formula:C47H59N11O4S2Colore e forma:SolidPeso molecolare:906.17CDK9 degrader-1
CDK9degrader-1 is a selective CDK9 degrader (DC50: 0.4073 µM). It recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuse with lysosomes to degrade CDK9 and its partner protein, Cyclin T1 (DC50: 1.215 µM). CDK9degrader-1 induces caspase 3-mediated apoptosis and exhibits antitumor activity in a mouse HCT116 xenograft model.Formula:C32H34Cl2N6O4Colore e forma:SolidPeso molecolare:637.56DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Colore e forma:Odour SolidIRE1-IN-2
IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.Formula:C16H20O6Colore e forma:SolidPeso molecolare:308.12599TFMU-ADPr triethylamine
<p>TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.</p>Formula:C25H26F3N5O16P2·5C6H15NColore e forma:SolidPeso molecolare:1024.428-NH2-ATP
CAS:8-NH2-ATP is an inactive derivative of adenosine triphosphate (ATP), synthesized from 8-NH2-Ado.Formula:C10H17N6O13P3Colore e forma:SolidPeso molecolare:522.20YKL-5-124 TFA
CAS:YKL-5-124 TFA is a potent CDK7 inhibitor (IC50: 53.5 nM), more than 100x selective over CDK9/2, not active on CDK12/13, and disrupts the cell cycle.Formula:C30H34F3N7O5Colore e forma:SolidPeso molecolare:629.63MS133
<p>MS133 is a human bispecific antibody targeting CD133/PROM1 and CD3E. It is used in the study of colon cancer.</p>Colore e forma:Odour LiquidDitercalinium chloride
CAS:Ditercalinium chloride, an anticancer agent, inhibits human DNA polymerase gamma activity and can deplete mitochondrial DNA in both mouse and human cells. Additionally, Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein [1] [2].Formula:C46H50Cl2N6O2Colore e forma:SolidPeso molecolare:789.83HSDVHK-NH2 TFA
<p>HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [</p>Formula:C32H49F3N12O11Colore e forma:SolidPeso molecolare:834.8N3,5-Dimethyl-2'-O-(2-methoxyethyl) uridine
<p>N3,5-Dimethyl-2’-O-(2-methoxyethyl) uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formula:C14H22N2O7Colore e forma:SolidPeso molecolare:330.33N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-deoxycytidine
N4-Acetyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-deoxycytidine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolentFormula:C33H35N3O7Colore e forma:SolidPeso molecolare:585.65CDK-IN-12
CAS:CDK-IN-12 (Example 20), a CDK inhibitor, effectively inhibits CDK4/6, demonstrating IC50 values below 20 nM [1].Formula:C26H29FN6OSColore e forma:SolidPeso molecolare:492.61LY243246
CAS:LY249543, the S-isomer of lometrexol, is an inhibitor of Methylenetetrahydrofolate Dehydrogenase/Cycl.Formula:C21H25N5O6Colore e forma:SolidPeso molecolare:443.4516,16-dimethyl Prostaglandin A1
CAS:16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Formula:C22H36O4Colore e forma:SolidPeso molecolare:364.5265'-O-TBDMS-Bz-dA
CAS:5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.Formula:C23H31N5O4SiColore e forma:SolidPeso molecolare:469.617O-Glycoprotease
O-Glycoprotease is a specific endoprotease for O-glycoproteins, capable of catalyzing the hydrolysis of peptide bonds directly adjacent to O-glycan structures in natural mucin-type O-glycosylated proteins. The sequence of O-Glycoprotease is derived from Akkermansia muciniphila, and it is recombinantly expressed in E. coli with a C-terminal 6×His tag. This enzyme maintains high activity within a pH range of 5.5 to 7.5, is resistant to 1 M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn2+.Colore e forma:Odour SolidViquidacin
CAS:NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.Formula:C25H29FN2O4S2Colore e forma:SolidPeso molecolare:504.64(S)-Monastrol
CAS:Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formula:C14H16N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:292.35BLINK15
BLINK15 is a blood-brain barrier-permeable Cdk5 inhibitor. It reduces CDK5 activity in CDK5/p35 (IC50= 29.34 nM) and CDK5/p25 (IC50= 12.08 nM) complexes. Additionally, BLINK15 exhibits antidiabetic and neuroprotective effects. It lowers blood glucose levels in type 2 diabetes (T2D) mice, enhances cognitive abilities, and diminishes neurodegenerative lesions.Colore e forma:Odour Solid5'-O-DMT-Bz-rC
CAS:<p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formula:C37H35N3O8Colore e forma:SolidPeso molecolare:649.69DHFR-IN-16
DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 0.199 μM, and is valuable for anti-infection research.Formula:C32H34N4O4SPeso molecolare:570.23008TS-002266
CAS:TS-0022666 is a selective TUT4/7 inhibitor, antiproliferative and anti-leukaemic in vivo and in vitro, cancers with FOCAD deficiency.Formula:C31H32Cl2N6O5Purezza:98.18%Colore e forma:SoildPeso molecolare:639.53THK01
CAS:<p>THK01: ROCK2 inhibitor (IC50=5.7nM), less effective on ROCK1 (923nM). Hinders breast cancer spread via ROCK2-STAT3. For cancer research.</p>Formula:C20H13N3O2Colore e forma:SolidPeso molecolare:327.348-iso Prostaglandin F1α
CAS:8-iso Prostaglandin F1α induces vasoconstrictor effects in (PA),(PV) and (MA) through activation of TXA2R, tyrosine kinases and Rho kinases.Formula:C20H36O5Colore e forma:SolidPeso molecolare:356.5PROTAC CDK9 degrader-11
CAS:PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formula:C39H48Cl2N10O5Colore e forma:SolidPeso molecolare:807.768TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Formula:C37H50F2N12O13Colore e forma:SolidPeso molecolare:908.86DSPE-PEG1000-iRGD
DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.Colore e forma:Odour SolidN7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>Formula:C21H35N12O17P3Colore e forma:SolidPeso molecolare:820.49(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Formula:C25H34O10Colore e forma:SolidPeso molecolare:494.537dsDNase
dsDNase is a highly specific endonuclease for double-stranded DNA (dsDNA) that can rapidly and efficiently eliminate contaminant DNA from PCR master mixes.LDV-FITC TFA
<p>LDV-FITC TFA is a fluorescent peptide, specifically an FITC-conjugated LDV peptide. This compound binds to the α4β1 integrin with high affinity, displaying a Kd of 0.3 nM in the presence of Mn2+ and 12 nM in its absence, when binding to U937 cells. LDV-FITC TFA is useful for assessing α4β1 integrin affinity.</p>Formula:C69H81N11O17S·xC2HF3O25'-DMTr-3'dA(Bz)-methylphosphonami dite
5’-DMTr-3’dA(Bz)-methylphosphonamidite, a purine nucleoside analog, exhibits wide-ranging antitumor activity, specifically targeting indolent lymphoidFormula:C45H51N6O6PColore e forma:SolidPeso molecolare:802.9dUTP trisodium
CAS:<p>dUTP trisodium (Deoxyuridine triphosphate) is a deoxyuridine phosphate having a triphosphate group at the 5'-position and can be used for PCR.</p>Formula:C9H12N2Na3O14P3Purezza:100.00%Colore e forma:SolidPeso molecolare:534.09LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Formula:C10H12N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:284.29CDK2-IN-43
CDK2-IN-43 (Compound 3a) is a CDK2-cyclin E2 inhibitor with an IC50 value of 6.0 nM. It is applicable to cancer research.Formula:C19H27N7OColore e forma:SolidPeso molecolare:369.464WRN inhibitor 17
CAS:<p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>Formula:C33H34F4N4O6SColore e forma:SolidPeso molecolare:690.71CAM2602
<p>CAM2602 is an inhibitor of Aurora A-TPX2 interaction, demonstrating a binding affinity of 19 nM with Aurora A. This compound has been shown to inhibit the growth of pancreatic cancer cells. In solid tumor xenograft models, CAM2602 increases the proportion of PH3-positive cells while decreasing the ratio of P-Thr288Aurora A-positive cells, ultimately inhibiting tumor growth.</p>Colore e forma:Odour SolidN-Methylisatoic anhydride
CAS:<p>N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs.</p>Formula:C9H7NO3Purezza:95.27%Colore e forma:Brownish ChunksPeso molecolare:177.16PROTAC CDK9 degrader-7
CAS:PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (Formula:C43H50Cl2N8O9Colore e forma:SoildPeso molecolare:893.81Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Formula:C21H25FN4O2Colore e forma:SolidPeso molecolare:384.455'-O-DMT-rU
CAS:5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.Formula:C30H30N2O8Colore e forma:SolidPeso molecolare:546.57m7GpppCmpG
CAS:m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.Formula:C31H43N13O25P4Colore e forma:SolidPeso molecolare:1121.64PROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Formula:C44H38N6O8Colore e forma:SolidPeso molecolare:778.27511BAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Formula:C24H28F3N5O2SColore e forma:SolidPeso molecolare:507.57Pyrindamycin A
CAS:Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.Formula:C26H26ClN3O8Purezza:98%Colore e forma:SolidPeso molecolare:543.955'-O-TBDMS-N2-ibu-dG
CAS:<p>5'-O-TBDMS-N2-ibu-dG: a nucleoside derivative with strong anti-BVDV activity, useful in lead compound synthesis.</p>Formula:C20H33N5O5SiColore e forma:SolidPeso molecolare:451.59[pSer2, pSer5, pSer7]-CTD TFA
Substrate '[pSer2, pSer5, pSer7]-CTD (TFA)' for CDK7 phosphorylates RNA Pol II CTD at ser2, 5, 7.Formula:C98H138F3N21O39Purezza:98%Colore e forma:SolidPeso molecolare:2291.25HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt
CAS:HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.Formula:C57H62N8O10SColore e forma:SolidPeso molecolare:1051.21Erythromycin thiocyanate
CAS:Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.Formula:C38H68N2O13SPurezza:98%Colore e forma:SolidPeso molecolare:793.02DENV-IN-2
CAS:DENV-IN-2 inhibits dengue virus replication (EC50: 0.016 nM), affects all serotypes (EC50: 0.013-0.029 nM). Derived from WO2018215315A1 6AB.Formula:C29H26ClF3N2O6Colore e forma:SolidPeso molecolare:590.982'-Deoxy-2'-fluoro-N3-(n-dodecyl)uridine
<p>2’-Deoxy-2’-fluoro-N3-(n-dodecyl)uridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.</p>Formula:C21H35FN2O5Colore e forma:SolidPeso molecolare:414.511-(β-D-Xylofuranosyl)-N6-Isopentenyladenine
<p>1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog.</p>Formula:C15H21N5O4Colore e forma:SolidPeso molecolare:335.36ROCK-IN-32
CAS:ROCK-IN-32 is an effective Rho-kinase inhibitor.Formula:C20H17Cl2N3O2Purezza:98%Colore e forma:SolidPeso molecolare:402.277-Deazaxanthine
CAS:<p>7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase) and reduces TPase activity in a concentration-dependent manner, with an IC50 value of 40 μM. Additionally, 7-Deazaxanthine exhibits significant anti-angiogenic properties.</p>Formula:C6H5N3O2Colore e forma:SolidPeso molecolare:151.12Vanoxonin
CAS:Vanoxonin is a new thymidylate synthetase inhibitor.Formula:C18H25N3O9Purezza:98%Colore e forma:SolidPeso molecolare:427.41Erythromycin glutamate
CAS:Erythromycin glutamate is a macrolide bacteriostatic antibiotic. This antibiotic is metabolized through the liver and inhibits cytochrome enzyme P450A 3A41.Formula:C42H76N2O17Purezza:98%Colore e forma:SolidPeso molecolare:881.067Carboxy pyridostatin trifluoroacetate salt
Carboxy pyridostatin trifluoroacetate salt exhibits higher molecular specificity for RNA over DNA G4s.Formula:C37H35F3N10O9Purezza:98%Colore e forma:SolidPeso molecolare:820.73Mumefural
CAS:<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Formula:C12H12O9Colore e forma:SolidPeso molecolare:300.22CDK8-IN-12
CAS:CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Formula:C21H20ClN3O2Purezza:98.55% - 99.22%Colore e forma:SoildPeso molecolare:381.86TMX-2138
CAS:TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.Formula:C40H43BrFN9O11SColore e forma:SolidPeso molecolare:956.791Cy5-dATP
<p>Cy5-dATP is a Cy5 -labeled dATP . Cy5-dATP can be incorporated into a DNA primer [1] [2] .</p>Formula:C47H58N7O19P3S2Colore e forma:SolidPeso molecolare:1182.05Nocarnickelamides B
<p>Nocarnickelamides B (Compound 2) is a linear peptide and an inhibitor of ROCK1/2. It exhibits dual inhibitory activity against ROCK1 and ROCK2, with IC50 values of 14.9 μM and 21.9 μM, respectively. This compound binds to the ATP binding site and inhibits ROCK-mediated cytoskeletal contraction markers, such as myosin light chain activation. Nocarnickelamides B can be utilized in glaucoma research.</p>Formula:C29H42N6O9Colore e forma:Odour SolidPeso molecolare:618.68EC0489
CAS:EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (Formula:C111H156N22O43S2Purezza:98%Colore e forma:SolidPeso molecolare:2550.7Cdk2/Cyclin Inhibitory Peptide I
CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.Formula:C111H196N48O23Purezza:98%Colore e forma:SolidPeso molecolare:2571.05AR-13324 analog mesylate
AR-13324 analog mesylate is an inhibitor of Rho-kinase and a norepinephrine transporter and reduces intraocular pressure in normotensive monkey eyes.Formula:C29H33N3O9S2Purezza:98%Colore e forma:SolidPeso molecolare:631.72Tirandamycin A
Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.Formula:C22H27NO7Colore e forma:SolidPeso molecolare:417.458SP27
<p>SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].</p>Formula:C40H40F2N12O5Purezza:98%Colore e forma:SolidPeso molecolare:806.82DG1
DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressingFormula:C19H17N5O5SColore e forma:SolidPeso molecolare:427.43Anti-MRSA agent 7
Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.Formula:C22H20BrF2N3O4Colore e forma:SolidPeso molecolare:508.31Dihydro-5-azacytidine
CAS:Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.Formula:C8H14N4O5Purezza:>99.99%Colore e forma:SolidPeso molecolare:246.22CDK12-IN-2
CAS:<p>CDK12-IN-2 selectively inhibits CDK12 (IC50: 52 nM) with minimal effect on CDK2, CDK7, and CDK9, useful for CDK12 research.</p>Formula:C32H32N6O2Purezza:99.31%Colore e forma:SolidPeso molecolare:532.643,6-DMAD hydrochloride
3,6-DMAD hydrochloride functions as an inhibitor for the IRE1α-XBP1 pathway within the unfolded protein response mechanism.Formula:C22H31N5xHClPurezza:98%Colore e forma:SolidPeso molecolare:365.52N1-(2-Methyl)propyl pseudouridine
N1-(2-Methyl)propyl pseudouridine, a purine analog, targets lymphoid cancer by inhibiting DNA synthesis and inducing apoptosis.Formula:C13H20N2O6Colore e forma:SolidPeso molecolare:300.313'-β-C-Methyl-2-thiouridine
3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies.Formula:C10H14N2O5SColore e forma:SolidPeso molecolare:274.29CDK12-IN-6
CAS:CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).Formula:C20H21F2N9Colore e forma:SolidPeso molecolare:425.448ONX 0801 trisodium
CAS:<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>Formula:C32H30N5Na3O10Colore e forma:SolidPeso molecolare:713.58Xylocytidine
CAS:Xylocytidine is a biochemical.Formula:C9H13N3O5Colore e forma:SolidPeso molecolare:243.22CDK6/9-IN-1
CAS:<p>CDK6/9-IN-1, an oral dual inhibitor of CDK6/9, has IC50s of 40.5nM (CDK6) and 39.5nM (CDK9).</p>Formula:C22H25ClN8OColore e forma:SolidPeso molecolare:452.95PD-1/PD-L1-IN-52
<p>PD-1/PD-L1-IN-52 (Compound Ⅲ-5) is an orally active inhibitor of PD-1/PD-L1 interaction, exhibiting an IC50 of 109.9 nM. It demonstrates antitumor activity in a C57BL/6 mouse model of MC38 colon carcinoma cells expressing human PD-1, achieving a tumor growth inhibition (TGI) rate of 49.6%.</p>Colore e forma:Odour SolidBiotin-PEG7-C2-S-Vidarabine
Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.Formula:C36H60N8O12S2Colore e forma:SolidPeso molecolare:861.04CDK7-IN-7
CAS:<p>CDK7-IN-7: Selective CDK7 inhibitor, IC50 < 50 nM (Patent CN112661745A).</p>Formula:C20H20BrF3N6O2Colore e forma:SolidPeso molecolare:513.319PP-C8
PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.Formula:C43H51FN12O7Colore e forma:SolidPeso molecolare:866.94CDK9 inhibitor HH1
CAS:<p>CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.</p>Formula:C13H15N3OSPurezza:99.92%Colore e forma:SolidPeso molecolare:261.34GSK299423
CAS:GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.Formula:C25H27N5O2SPurezza:97.34%Colore e forma:SolidPeso molecolare:461.58Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Purezza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Colore e forma:LiquidN7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Formula:C14H21N5O6Colore e forma:SolidPeso molecolare:355.35Ac-dA Phosphoramidite
CAS:Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Formula:C42H50N7O7PColore e forma:SolidPeso molecolare:795.878HSDVHK-NH2
CAS:Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.Formula:C30H48N12O9Purezza:98%Colore e forma:SolidPeso molecolare:720.78IBU-DC Phosphoramidite
CAS:IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.Formula:C43H54N5O8PColore e forma:SolidPeso molecolare:799.906GSK270822A
CAS:<p>GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.</p>Formula:C24H20N4O2Purezza:98.64% - 99.78%Colore e forma:SolidPeso molecolare:396.44α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFormula:C14H22N4O9Purezza:98%Colore e forma:SolidPeso molecolare:390.355'-O-DMT-ibu-dC
CAS:5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Formula:C34H37N3O7Colore e forma:SolidPeso molecolare:599.67Carboxy-pyridostatin
CAS:<p>Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.</p>Formula:C35H34N10O7Colore e forma:SolidPeso molecolare:706.712'-Deoxy-2'-fluoroguanosine 5'-monophosphate triethyl ammonium
2’-Deoxy-2’-fluoroguanosine 5’-monophosphate triethyl ammonium, a purine nucleoside analog, exhibits broad antitumor activity specifically targeting indolentFormula:C22H43FN7O7PColore e forma:SolidPeso molecolare:567.59Erythromycin A dihydrate
CAS:Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.Formula:C37H69NO14Colore e forma:SolidPeso molecolare:751.94TTK/PLK1-IN-1
CAS:TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Formula:C30H33N7O2Purezza:97.39%Colore e forma:SolidPeso molecolare:523.635'-ODMT cEt G Phosphoramidite (Amidite)
CAS:5'-ODMT cEt G Amidite is a safe, effective nucleic acid analog with strong antisense activity.Formula:C46H56N7O9PColore e forma:SolidPeso molecolare:881.95PLK1-IN-2
CAS:PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM.Formula:C24H27FN8OSColore e forma:SolidPeso molecolare:494.59Guanosine triphosphate
CAS:Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].Formula:C10H16N5O14P3Colore e forma:SolidPeso molecolare:523.18CDK9-IN-25
<p>CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM.</p>Formula:C15H16FN5Purezza:98%Colore e forma:SolidPeso molecolare:285.325'-O-DMT-N4-Bz-2'-F-dC
CAS:5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.Formula:C37H34FN3O7Colore e forma:SolidPeso molecolare:651.685'-O-DMT-N2-DMF-dG
CAS:5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.Formula:C34H36N6O6Colore e forma:SolidPeso molecolare:624.698DSPE-PEG1000-cRGD
DSPE-PEG1000-cRGD is a PEG compound composed of DSPE and the αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to the αvβ3 receptors present on the surfaces of various cancer cells and angiogenic vascular cells. DSPE-PEG1000-cRGD is applicable in drug delivery.Colore e forma:Odour Solid5'-O-TBDMS-dG
CAS:5’-O-TBDMS-dG is a modified nucleoside. 5’-O-DMT-2’-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.Formula:C16H27N5O4SiColore e forma:SolidPeso molecolare:381.502'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS:dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.Formula:C10H14N5Na2O8PColore e forma:SolidPeso molecolare:409.202DHODH-IN-16
CAS:DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).Formula:C24H25FN4O3Purezza:99.64%Colore e forma:SolidPeso molecolare:436.48Apcin A HCL
CAS:<p>Apcin A HCL is an Apcin-derived APC inhibitor that binds Cdc20 and hinders ubiquitination, useful for synthesizing PROTAC CP5V.</p>Formula:C10H15Cl4N5O2Purezza:99.59%Colore e forma:SolidPeso molecolare:379.07GK13S
<p>G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.</p>Formula:C21H22N6O2Colore e forma:SolidPeso molecolare:390.44SR15006
CAS:SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).Formula:C16H20ClN3O4SPurezza:99.87%Colore e forma:SoildPeso molecolare:385.87AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Formula:C137H215IN30O45SColore e forma:SolidPeso molecolare:3161.32CCT241533 dihydrochloride
CAS:Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.Formula:C23H29Cl2FN4O4Colore e forma:SolidPeso molecolare:515.41TLR7 agonist 12
CAS:TLR7 agonist 12, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis in lymphoid cancers.Formula:C14H19N5O8Colore e forma:SolidPeso molecolare:385.33Antibacterial agent 144
Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.Formula:C26H23N7O3Colore e forma:SolidPeso molecolare:481.51Emofolin sodium
CAS:Emofolin sodium, a synthetic folate analogue, inhibits DNA/RNA/protein synthesis by blocking dihydrofolate reductase.Formula:C21H25N7Na2O6Purezza:98%Colore e forma:SolidPeso molecolare:517.45Deoxythymidine-5'-triphosphate
CAS:<p>Deoxythymidine-5'-triphosphate (dTTP) is a nucleoside triphosphate involved in DNA synthesis.</p>Formula:C10H17N2O14P3Colore e forma:SolidPeso molecolare:482.167CDK7-IN-5
CAS:CDK7-IN-5, a CDK7 inhibitor with an IC 50 value of less than 100 nM, exhibits potent anticancer properties (WO2015154022A1, Compound 104).Formula:C34H45N9O2Colore e forma:SolidPeso molecolare:611.795PROTAC CDK9 degrader-2
CAS:PROTAC CDK9 degrader-2, potent, selective, IC50 17 μM in MCF-7, wogonin-derived, targets CRBN.Formula:C39H36N6O10Purezza:98%Colore e forma:SolidPeso molecolare:748.74wrwycr-NH2 TFA
wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.Colore e forma:Odour SolidCPS2
CAS:CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.Formula:C38H42N12O10S2Colore e forma:SolidPeso molecolare:890.94Aclacinomycin A
CAS:Aclacinomycin A has a wide range of applications in life science related research.Formula:C42H53NO15Purezza:99.43%Colore e forma:SolidPeso molecolare:811.87CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Colore e forma:SolidFlurocitabine HCl
CAS:Fluorocitabine HCl, a cytarabine analog, hydrolyzes into ara-FC and ara-FU, showing antitumor effects in leukemia and solid cancers.Formula:C9H11ClFN3O4Purezza:99.23% - 99.76%Colore e forma:SoildPeso molecolare:279.65Lorutengitide
CAS:<p>Lorutengitide is a transcription-regulating peptide with antiproliferative activity.</p>Formula:C30H50N8O12Colore e forma:SolidPeso molecolare:714.764Pseudorabies virus-IN-1
<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>Formula:C27H23ClF2N4O2Colore e forma:SolidPeso molecolare:508.947Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidCDK2/PIM1-IN-1
<p>CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.</p>Colore e forma:Odour Solid11H-Benzo[a]carbazole
CAS:11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.Formula:C16H11NPurezza:99.14%Colore e forma:SolidPeso molecolare:217.27PROTAC CDK9 degrader-5
CAS:PROTAC CDK9 degrader-5 selectively degrades CDK9 isoforms 42, 55 with DC50 of 0.10μM, 0.14μM via proteasome.Formula:C42H48Cl2N8O9Purezza:98%Colore e forma:SolidPeso molecolare:879.78Biotin-PEG8-Vidarabine
Biotin-PEG8-Vidarabine is an antiviral PEG linker targeting herpes and varicella zoster with adenosine analog Vidarabine.Formula:C36H60N8O13SColore e forma:SolidPeso molecolare:844.975'-O-DMT-2'-O-TBDMS-Ac-rC
CAS:5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.Formula:C38H47N3O8SiColore e forma:SolidPeso molecolare:701.8925-Caroxy uracil-1-yl acetic acid benzyl ester
5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.Formula:C14H12N2O6Colore e forma:SolidPeso molecolare:304.25dAURK-4
CAS:dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H52ClFN8O12Colore e forma:SolidPeso molecolare:1035.476-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue with broad antitumor activity, particularly againstFormula:C10H15N7O4Colore e forma:SolidPeso molecolare:297.27Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Formula:C49H58N5O10PColore e forma:SolidPeso molecolare:907.997-TFA-ap-7-Deaza-ddA
CAS:Compound 19c is a nucleotide derivative for DNA sequencing dye terminators.Formula:C16H16F3N5O3Colore e forma:SolidPeso molecolare:383.331Besufetamig
CAS:Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Colore e forma:LiquidKIF2C-IN-1
<p>KIF2C-IN-1 (Compound 7S9) is a selective and potent small molecule inhibitor of KIF2C. It stabilizes the interaction between KIF2C and microtubule proteins, preventing the depolymerization of polyglutamylated microtubules. KIF2C-IN-1 enhances the cytotoxicity of Paclitaxel in Paclitaxel-resistant triple-negative breast cancer (TNBC) cells and, when combined with Paclitaxel, significantly reduces tumor growth in mouse models.</p>Formula:C36H39ClN4O9SColore e forma:SolidPeso molecolare:738.212631-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine
1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog.Formula:C18H21N5O5Colore e forma:SolidPeso molecolare:387.393'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Colore e forma:Odour SolidNogalamycin
CAS:Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.Formula:C39H49NO16Purezza:98%Colore e forma:SolidPeso molecolare:787.812DHFR-IN-8
DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.Formula:C18H14N6SColore e forma:SolidPeso molecolare:346.41GRGDSP
CAS:<p>Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.</p>Formula:C22H37N9O10Purezza:98%Colore e forma:SolidPeso molecolare:587.5813-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Formula:C12H19F2N6O12P3Colore e forma:SolidPeso molecolare:570.23IRE1α kinase-IN-6
CAS:IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.Formula:C25H23Cl2FN6O3S2Colore e forma:SolidPeso molecolare:609.52Adenosine-2-carboxy methyl amide
Adenosine-2-carboxy methyl amide: a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis.Formula:C12H16N6O5Colore e forma:SolidPeso molecolare:324.29Isocytosine
CAS:Compound PDK0016, with CAS No. 108-53-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0016 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C4H5N3OColore e forma:White To Off-White SolidPeso molecolare:111.1PAT-LM1
PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.Colore e forma:Odour LiquidUnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Formula:C39H35NO10C6H15NColore e forma:SolidPeso molecolare:778.34655
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