Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
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Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Colore e forma:Odour SolidN6-Methyladenine
CAS:<p>N6-Methyladenine (6-(Methylamino)Purine) is a modified purine commonly found in genomes of prokaryotes, protists, and plants.</p>Formula:C6H7N5Purezza:99.78%Colore e forma:SolidPeso molecolare:149.15N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>Formula:C21H35N12O17P3Colore e forma:SolidPeso molecolare:820.49STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Purezza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:Odour Liquid3'-β-C-Methyl-2-thiouridine
3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies.Formula:C10H14N2O5SColore e forma:SolidPeso molecolare:274.29Vasoactive intestinal contractor
CAS:<p>Vasoactive intestinal contractor, a novel member of the endothelin family, stimulates a rapid increase in intracellular Ca2+ concentration in fura-2-overexpressed Swiss 3T3 cells [1.</p>Formula:C116H161N27O32S4Colore e forma:SolidPeso molecolare:2573.94LEB-03-146
CAS:<p>LEB-03-146: WEE1 DUBTAC linking AZD1775 to OTUB1 via PEG2; stabilizes WEE1 in HEP3B cells.</p>Formula:C46H57N11O8Colore e forma:SolidPeso molecolare:892.01MS133
<p>MS133 is a human bispecific antibody targeting CD133/PROM1 and CD3E. It is used in the study of colon cancer.</p>Colore e forma:Odour LiquidRTDLDSLRTYTL
CAS:RTDLDSLRTYTL is a high-affinity and specific inhibitor of Alpha (v) beta (6) integrin (avb6). By binding to the avb6 integrin, this peptide sequence activates T cell cytotoxicity and cytokine production, such as interferon-γ. Through the design of chimeric T cell antigen receptors (CAR), RTDLDSLRTYTL enables T cells to be redirected, allowing them to specifically recognize and attack tumor cells. It is used in research for cancer immunotherapy and the development of targeted drugs.Formula:C62H104N18O22Colore e forma:SolidPeso molecolare:1453.60HSDVHK-NH2 TFA
<p>HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [</p>Formula:C32H49F3N12O11Colore e forma:SolidPeso molecolare:834.8wrwycr-NH2 TFA
wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.Colore e forma:Odour Solid3'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Colore e forma:Odour SolidXT17
XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.Colore e forma:Odour SolidThailanstatin C
CAS:Thailanstatin C from Burkholderia thailandensis blocks pre-mRNA splicing, IC50 6.84 μM.Formula:C30H46ClNO9Colore e forma:SolidPeso molecolare:600.15Py-MAA-Val-Cit-PAB-DX8951
CAS:Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].Formula:C57H66FN11O13SColore e forma:SolidPeso molecolare:1164.26N1-Benzoyl pseudouridine
N1-Benzoyl pseudouridine, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.Formula:C16H16N2O7Colore e forma:SolidPeso molecolare:348.31ML-60218
CAS:<p>ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.</p>Formula:C19H15Cl2N3O2S2Purezza:98.1%Colore e forma:SolidPeso molecolare:452.38Uridine triphosphate 13C9,15N2 sodium
CAS:Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.Formula:C9H1415N2NaO15P3Colore e forma:SolidPeso molecolare:517.04Dafsolimab
CAS:Dafsolimab (SPV-T3a), an IgG2a murine monoclonal antibody (anti-CD3), induces cell death by modulating and activating the CD3/T cell receptor complex and isColore e forma:LiquidNUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formula:C25H30N6OColore e forma:SolidPeso molecolare:430.545CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Formula:C24H22FN7O2Colore e forma:SolidPeso molecolare:459.48TS-002266
CAS:TS-0022666 is a selective TUT4/7 inhibitor, antiproliferative and anti-leukaemic in vivo and in vitro, cancers with FOCAD deficiency.Formula:C31H32Cl2N6O5Purezza:98.18%Colore e forma:SoildPeso molecolare:639.53CDK4/6-IN-23
CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.Formula:C32H34FN7O4Colore e forma:SolidPeso molecolare:599.6558-iso Prostaglandin F1β
CAS:8-iso Prostaglandin F1β,inducet vasoconstrictor effects in (PA), (PV) and (MA) through the activation of TXA2R, tyrosine kinase and Rho kinase.Formula:C20H36O5Colore e forma:SolidPeso molecolare:356.5Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Purezza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Colore e forma:LiquidAdenosine 5′-O-1-thiotriphosphate (disodium)
Adenosine 5′-O-(1-thiotriphosphate) (disodium) is an adenosine nucleotide modified at the alpha-phosphate.Formula:C10H14N5Na2O12P3SPeso molecolare:566.936793'-Deoxyuridine-5'-triphosphate trisodium
3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).Formula:C9H12N2Na3O14P3Colore e forma:SoildPeso molecolare:534.08DSPE-PEG2000-cRGD
DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.Colore e forma:Odour SolidBarasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurezza:99.92% - 99.97%Colore e forma:SolidPeso molecolare:587.54DHFR-IN-18
<p>DHFR-IN-18 (compound 19D) is a DHFR inhibitor utilized in leukemia-related research.</p>Formula:C24H22ClN7Peso molecolare:443.16252Nusinersen
CAS:<p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>Purezza:98.62%Colore e forma:Solid5'(R)-C-Methyl-5-fluorouridine
5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.Formula:C10H13FN2O6Colore e forma:SolidPeso molecolare:276.22(S)-DI-87
CAS:<p>(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor，reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.</p>Formula:C23H30N6O3S2Purezza:99.42%Colore e forma:SoildPeso molecolare:502.65Biotin-PEG7-C2-S-Vidarabine
Biotin-PEG7-C2-S-Vidarabine: PEG linker with antiviral adenosine analog effective against herpes and zoster.Formula:C36H60N8O12S2Colore e forma:SolidPeso molecolare:861.045'-O-TBDMS-Bz-dA
CAS:5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.Formula:C23H31N5O4SiColore e forma:SolidPeso molecolare:469.6175'-O-DMT-PAC-dA
CAS:<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>Formula:C39H37N5O7Colore e forma:SolidPeso molecolare:687.746-Thioguanosine
CAS:6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside and low molecular weight gel.6-Thioguanosine has immunosuppressive properties.Formula:C10H13N5O4SPurezza:97.05%Colore e forma:Yellow-Green PowderPeso molecolare:299.31m7GpppUmpG
CAS:m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.Formula:C31H42N12O26P4Colore e forma:SolidPeso molecolare:1122.63Flurocitabine HCl
CAS:Fluorocitabine HCl, a cytarabine analog, hydrolyzes into ara-FC and ara-FU, showing antitumor effects in leukemia and solid cancers.Formula:C9H11ClFN3O4Purezza:99.23% - 99.76%Colore e forma:SoildPeso molecolare:279.65Ceftriaxone
CAS:Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Formula:C18H18N8O7S3Purezza:96.08%Colore e forma:SolidPeso molecolare:554.58Cytarabine triphosphate
CAS:Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.Formula:C9H16N3O14P3Colore e forma:SolidPeso molecolare:483.16THK01
CAS:<p>THK01: ROCK2 inhibitor (IC50=5.7nM), less effective on ROCK1 (923nM). Hinders breast cancer spread via ROCK2-STAT3. For cancer research.</p>Formula:C20H13N3O2Colore e forma:SolidPeso molecolare:327.34LL-K8-22
LL-K8-22: potent CDK8/cyclin C degrader; DC50 ~2.5μM; hinders STAT1 phosphorylation; curbs E2F/MYC cancer pathways; for TNBC study.Formula:C37H43N5OColore e forma:SolidPeso molecolare:573.77A-130A
CAS:A-130A is a polycyclic polyether compound belonging to the nigericin group of antibiotics generated by Streptomyces hygroscopicus strain.Formula:C47H78O13Purezza:98%Colore e forma:SolidPeso molecolare:851.11N-Methylisatoic anhydride
CAS:<p>N-Methylisatoic anhydride is a 2'-OH selective acylation agent of RNAs.</p>Formula:C9H7NO3Purezza:95.27%Colore e forma:Brownish ChunksPeso molecolare:177.16USP7-IN-16
CAS:<p>USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.</p>Formula:C43H45N7O6SColore e forma:SolidPeso molecolare:787.93CDK9 inhibitor HH1
CAS:<p>CDK9 inhibitor HH1 (8019-9719) is an inhibitor of the human CDK2-cyclin A2 complex with an IC50 value of 2 μM.</p>Formula:C13H15N3OSPurezza:99.92%Colore e forma:SolidPeso molecolare:261.34Ribonuclease T1
CAS:<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>Colore e forma:SolidCPS2
CAS:CPS2: potent, selective PROTAC CDK2 degrader. IC50=24nM, targets acute myeloid leukemia research.Formula:C38H42N12O10S2Colore e forma:SolidPeso molecolare:890.94WAY-230563
CAS:<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Formula:C17H12N2O2SPurezza:98.40%Colore e forma:SolidPeso molecolare:308.35
