Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
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Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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FRα-targeting peptide C7 TFA
<p>FRα-targeting peptide C7 TFA is a selective peptide ligand for the folate receptor alpha (FRα) that specifically binds to FRα-expressing cells and has tumor-targeting capabilities in vivo. It is applicable in research related to tumor diagnosis and therapy.</p>Colore e forma:Odour SolidSD49-7
CAS:<p>SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.</p>Formula:C18H14N2O3Purezza:99.91%Colore e forma:SoildPeso molecolare:306.32Mps1-IN-6
Mps1-IN-6 is a potent Mps1 inhibitor that demonstrates antiproliferative and antitumor activities, exhibiting an IC50 of 2.596 nM [1].Formula:C35H39N9O3Colore e forma:SolidPeso molecolare:633.74Py-MAA-Val-Cit-PAB-DX8951
CAS:Py-MAA-Val-Cit-PAB-DX8951, a purine toxin, serves as an intermediate in the synthesis of antibody-drug conjugates [1].Formula:C57H66FN11O13SColore e forma:SolidPeso molecolare:1164.261-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine
1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog.Formula:C18H21N5O5Colore e forma:SolidPeso molecolare:387.392'-Deoxytubercidin 5'-triphosphate sodium
2'-Deoxytubercidin 5'-triphosphate (C7dATP) sodium is a deoxyadenosine triphosphate (dATP) analog designed to reduce electrophoretic mobility anomalies caused by compression at G or A residues, thereby enhancing the quality of DNA sequencing data.Formula:C11H13N4Na4O12P3Peso molecolare:577.93336HEMTAC WEE1 degrader-1
CAS:HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC50 of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.Formula:C57H71N15O6Colore e forma:SolidPeso molecolare:1062.27Batifiban
CAS:Batifiban, a glycoprotein IIb/IIIa antagonist, is used potentially for the treatment of coronary artery disease.Formula:C34H47N11O9S2Colore e forma:SolidPeso molecolare:817.93CDK12-Cyclin K Ligand-Linker Conjugates 1
CDK12-Cyclin K Ligand-Linker Conjugates 1 is a Target Protein Ligand-Linker Conjugate that includes a CDK12-Cyclin K ligand and a PROTAC linker, which can recruit E3 ligase. CDK12-Cyclin K Ligand-Linker Conjugates 1 is applicable for the synthesis of PROTACPP-C8.Colore e forma:Odour SolidNelvutamig
CAS:Nelvutamig is a humanized immunoglobulin antibody (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3) designed to target ENPP3/CD203c and CD3E. The corresponding isotype control is Human immunoglobulin (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3).Colore e forma:LiquidCatumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Purezza:95%Colore e forma:LiquidEndonuclease IV
CAS:Endonuclease IV is an apurinic/apyrimidinic (AP) endonuclease that functions as a DNA repair enzyme. It exhibits endonuclease activity at AP sites, possesses 3' phosphodiesterase activity (allowing it to remove various blocking lesions at the 3' end of DNA), and demonstrates endonuclease activity against oxidative DNA damage, as well as 3' to 5' exonuclease activity.Colore e forma:SolidT4 endonuclease VII
T4endonucleaseVII exhibits broad substrate specificity, enabling it to bind and cleave both DNA duplexes and single-base mismatches in three- and four-way branched DNA structures.Colore e forma:Odour SolidAdeninobananin
CAS:Adeninobananin, a negative control tool, exhibits no inhibitory activity against the SARS Coronavirus helicase.Formula:C19H19ClN6O9Colore e forma:SolidPeso molecolare:510.84N1-Methyl-2'-β-C-methyl inosine
N1-Methyl-2’-beta-C-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies through mechanisms thatFormula:C12H16N4O5Colore e forma:SolidPeso molecolare:296.28N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Formula:C10H13Li4N2O15P3Colore e forma:SolidPeso molecolare:521.9N1-Methylxylo-guanosine
N1-Methylxylo-guanosine, a purine analog, targets lymphoid cancer via DNA synthesis inhibition and apoptosis.Formula:C11H15N5O5Colore e forma:SolidPeso molecolare:297.275'-O-DMTr-2'-O-TBDMS-5-Me-U-3'-CE Phosphoramidite
CAS:5'-O-DMTr-2'-O-TBDMS-5-Me-U-3'-CE Phosphoramidite is a nucleoside phosphoramidite monomer modified with protective groups, suitable for RNA oligonucleotide synthesis.Formula:C46H63N4O9PSiColore e forma:SolidPeso molecolare:875.07JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formula:C21H26N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:338.44Ceftriaxone
CAS:Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.Formula:C18H18N8O7S3Purezza:96.08%Colore e forma:SolidPeso molecolare:554.58Rp-dCTPαS tetrasodium
Rp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP.Colore e forma:Odour Solid7-TFA-ap-7-Deaza-ddA
CAS:Compound 19c is a nucleotide derivative for DNA sequencing dye terminators.Formula:C16H16F3N5O3Colore e forma:SolidPeso molecolare:383.331CW-2
CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).Formula:C43H42Cl2FN11O10PtColore e forma:SolidPeso molecolare:1156.21251Besufetamig
CAS:Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Colore e forma:LiquidGuanosine 5'-triphosphate trisodium salt hydrate
CAS:5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.Formula:C10H18N5NaO15P3Purezza:98%Colore e forma:SolidPeso molecolare:564.185m7GpppUmpG
CAS:m7GpppUmpG, a trinucleotide cap analogue, enables RNA synthesis with cap 0 or 1 structures.Formula:C31H42N12O26P4Colore e forma:SolidPeso molecolare:1122.63Anti-MRSA agent 7
Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.Formula:C22H20BrF2N3O4Colore e forma:SolidPeso molecolare:508.31BIO-2007817
BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.Formula:C32H36N6O3Colore e forma:SolidPeso molecolare:552.67N6-Ethyl-2'-β-C-ethynyl adenosine
N6-Ethyl-2’-beta-C-ethynyl adenosine is a purine nucleoside analog.Formula:C14H17N5O4Colore e forma:SolidPeso molecolare:319.32T5 Exonuclease
CAS:T5 Exonuclease is a DNA exonuclease that exhibits 5′-3′ exonuclease activity on both single-stranded and double-stranded DNA. It also possesses single-strand endonuclease and 5′-flap endonuclease activity.Colore e forma:SolidROCK-IN-5
CAS:<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Formula:C16H11ClFN3OSPurezza:99.72% - 99.83%Colore e forma:SolidPeso molecolare:347.79Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formula:C23H20F2N2O4Purezza:98%Colore e forma:SolidPeso molecolare:426.41N1-Benzoyl pseudouridine
N1-Benzoyl pseudouridine, a purine nucleoside analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.Formula:C16H16N2O7Colore e forma:SolidPeso molecolare:348.31AV-153
CAS:AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.Formula:C14H19NNaO6Colore e forma:SolidPeso molecolare:320.2976-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS:6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, exhibits a broad spectrum of biochemical andFormula:C11H15N5O4Colore e forma:SolidPeso molecolare:281.27(E)-5-(2-Bromovinyl)uracil
CAS:BVU, a pyrimidine and inactive sorivudine metabolite, inactivates DPD, boosts 5-fluorouracil efficacy in leukemia, and may convert back to BVDU in vivo.Formula:C6H5BrN2O2Colore e forma:SolidPeso molecolare:217.02N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-deoxycytidine
N4-Acetyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-deoxycytidine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolentFormula:C33H35N3O7Colore e forma:SolidPeso molecolare:585.65c-Myc inhibitor 5
DA3: Fluorescent c-Myc inhibitor, targets c-MYC G-quadruplex (K D 16 μM), selective, suppresses c-MYC expression.Formula:C30H46N12Colore e forma:SolidPeso molecolare:574.77SMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formula:C20H21NO5Purezza:98.29%Colore e forma:SoildPeso molecolare:355.38TMX-2039
CAS:TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Formula:C17H20BrFN6O3SColore e forma:SolidPeso molecolare:487.347Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Colore e forma:Odour SolidRNA recruiter 2
RNA recruiter 2 serves as a QSOX1mRNA ligand. This compound functions as a target RNA ligand (RIBOTAC's target RNA ligand) and aids in developing RIBOTAC RNA degraders with antitumor activity. Additionally, RNA recruiter 2 is utilized in the synthesis of F1-RIBOTAC.Formula:C20H16FNO4SColore e forma:SolidPeso molecolare:385.409DNA Gyrase-IN-15
DNA Gyrase-IN-15 (Compound 11) is an antibacterial agent that inhibits both DHPS and DNA gyrase, with IC50 values of 1.73 and 0.07 µM, respectively. It shows antimicrobial activity against Enterococcus faecium (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus. Additionally, DNA Gyrase-IN-15 exhibits antibiofilm activity against Enterococcus faecium.Formula:C31H26N4O4S2Colore e forma:SolidPeso molecolare:582.693Tilatamig samrotecan
Tilatamig samrotecan (AZD9592) is an antibody-drug conjugate (ADC) designed to deliver a topoisomerase I inhibitor (TOP1i). It targets epidermal growth factor receptor (EGFR) and c-MET and demonstrates antitumor activity. The compound induces DNA double-strand breaks, elevates pRAD50 and γH2AX expression, and inhibits the growth of non-small cell lung cancer.Colore e forma:Odour SolidMU1920
<p>MU1920 is an ATP-competitive, selective inhibitor of haspin with an IC50 of 6 nM. In mouse plasma and microsomes, it demonstrates favorable pharmacokinetic properties and metabolic stability. Although it lacks significant anticancer activity, MU1920 is suitable for developing chemical probes.</p>Formula:C17H15N5SColore e forma:SolidPeso molecolare:321.4c-Myc inhibitor 10
CAS:<p>c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.</p>Formula:C28H38N6O3Colore e forma:SolidPeso molecolare:506.64Confidential-2
Confidential-2: a purine nucleoside analog with antitumor effects on lymphoid cancers, inhibits DNA synthesis, induces apoptosis.Formula:C20H25N5O8Colore e forma:SolidPeso molecolare:463.44LSN3106729 hydrochloride
CAS:LSN3106729 hydrochloride, an Abemaciclib metabolite, is a CDK-inhibiting antitumor PROTAC CDK4/6 degrader.Formula:C25H29ClF2N8OColore e forma:SoildPeso molecolare:531.00CDK9 ligand 3
CAS:<p>CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.</p>Formula:C18H18BrCl2N5O3Colore e forma:SolidPeso molecolare:503.177WRN inhibitor 10
WRN inhibitor 10 (Compound P24) is an inhibitor of the Werner helicase WRN, with an IC50 of 1.1 nM. It effectively inhibits the proliferation of SW48 cancer cells, with an IC50 of 39 nM. WRN inhibitor 10 exhibits favorable liver microsomal stability and membrane permeability, and demonstrates good pharmacokinetic properties in CD-1 mice.Formula:C31H29BrClN9O5SPeso molecolare:753.08843
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