Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
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Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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3'-Deoxy-3'-fluoro-xyloadenosine
CAS:3'-Deoxy-3'-fluoro-xyloadenosine is a Nucleoside Derivative - Xylo-nucleoside, Fluoro-modified nucleoside, 3'-Modified nucleoside.Formula:C10H12FN5O3Colore e forma:SolidPeso molecolare:269.232',3'-Dideoxy-5-fluorocytidine
CAS:Nucleoside Derivatives - 2’,3’-Dideoxy-nucleoside; Fluoro-modified nucleoside; Drugs and Inhibitors; HIV-1 inhibitorsFormula:C9H12FN3O3Colore e forma:SolidPeso molecolare:229.215'-Amino-5'-deoxythymidine
CAS:5'-Amino-5'-deoxythymidine is a thymidine derivative widely used in biochemical experiments and drug synthesis research.Formula:C10H15N3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:241.242-Amino-6-chloropurine-9-β-D-(2'-deoxy)riboside
CAS:2-Amino-6-chloropurine-9-beta-D-(2'-deoxy)riboside is a 2'-Deoxy nucleoside; Halo-nucleoside.Formula:C10H12ClN5O3Colore e forma:SolidPeso molecolare:285.693',5'-Di-O-acetyl-2'-deoxy-N3-methyl uridine
CAS:3',5'-Di-O-acetyl-2'-deoxy-N3-methyl uridine is a Nucleoside Derivative - N-Alkylated nucleoside.Formula:C14H18N2O7Colore e forma:SolidPeso molecolare:326.33'-β-C-Methyl-5-methylcytidine
3'-beta-C-Methyl-5-methylcytidine is a Nucleoside Derivative - 3'-Modified nucleoside.Colore e forma:Soild2'-O-Phthalimidopropyl cytidine
CAS:2’-O-Phthalimidopropyl cytidine is a useful organic compound for research related to life sciences.Formula:C20H22N4O7Colore e forma:SolidPeso molecolare:430.413'-Deoxy-5-methoxyuridine
CAS:Nucleoside Derivatives - 3’-Deoxy nucleosides, 5-Modified pyrimidine nucleosidesFormula:C10H14N2O6Colore e forma:SolidPeso molecolare:258.23N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine
CAS:N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine is a Nucleoside Derivative - C-nucleoside; N-Alkylated nucleoside.Formula:C23H37N3O10Colore e forma:SolidPeso molecolare:515.55α-inosine
CAS:Alpha-inosine is a useful organic compound for research related to life sciences. The catalog number is TNU1638 and the CAS number is 38183-47-0.Formula:C10H12N4O5Colore e forma:SolidPeso molecolare:268.237,8-Dihydro-8-oxo-7-propargyl-3'-deoxy-3'-fluoro-xylo-guanosine
CAS:7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro-xylo-guanosine is a useful organic compound for research related to life sciences.Formula:C13H14FN5O5Colore e forma:SolidPeso molecolare:339.282'-Deoxy-2'-fluoro-ara-uridine
2'-Deoxy-2'-fluoro-ara-uridine is a Nucleoside Derivative - 2'-Modified nucleoside, Fluoro-modified nucleoside, N-Methylated/ alkylated nucleoside.Colore e forma:Soild4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
CAS:4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 7-deaza-8-aza purine nucleoside.Formula:C10H14N6O4Colore e forma:SolidPeso molecolare:282.265'-Azido-5'-deoxy-2'-O-methyl-5-methyluridine
CAS:Nucleoside Derivatives - 5’-Modified nucleosides, Azido-nucleosides, 2’-Modified nucleosidesFormula:C11H15N5O5Colore e forma:SolidPeso molecolare:297.272'-O-MOE-A(Bz)-3'-phosphoramidite
CAS:2'-O-MOE-A(Bz)-3'-phosphoramidite is a Nucleoside Phosphoramidite;Nucleoside Derivative - 2'-Modified nucleoside;.Formula:C50H58N7O9PColore e forma:SolidPeso molecolare:932.013'-β-C-Ethynyl-N6,N6-dimethyladenosine
CAS:Nucleoside Derivatives - 3’-Modified purine nucleosides; 6-Modified purine nucleosidesFormula:C14H17N5O4Colore e forma:SolidPeso molecolare:319.325'-O-DMT-2'-TBDMS-Uridine
CAS:5’-O-DMT-2’-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.Formula:C36H44N2O8SiColore e forma:SolidPeso molecolare:660.83N1-(N,N-Dimethylaminocarbonyl)-pseudouridine
N1-(N,N-Dimethylaminocarbonyl)-pseudouridine is a Nucleoside Derivative - C-nucleoside.Colore e forma:Soild2'-Deoxy-2'-fluoro-N3-(n-dodecyl)-β-D-arabinouridine
CAS:2'-Deoxy-2'-fluoro-N3-(n-dodecyl)-beta-D-arabinouridine is a Nucleoside Derivative - Fluoro-modified nucleoside,Arabino-nucleoside, 2'-Modified nucleoside.Formula:C21H35FN2O5Colore e forma:SolidPeso molecolare:414.513'-O-(2-Methoxyethyl)uridine
CAS:3'-O-(2-Methoxyethyl)uridine is a Nucleoside Derivative - 3'-Modified nucleoside.Formula:C12H18N2O7Colore e forma:SolidPeso molecolare:302.281,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-xylofuranose
CAS:1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-xylofuranose is a Carbohydrate Derivative.Formula:C16H17FO7Colore e forma:SolidPeso molecolare:340.3360A
CAS:<p>360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).</p>Formula:C27H23N5O2Purezza:98.68%Colore e forma:SolidPeso molecolare:449.5Dasabuvir
CAS:<p>Dasabuvir (ABT-333) blocks HCV replication by inhibiting the essential NS5B RNA polymerase.</p>Formula:C26H27N3O5SPurezza:99.54% - 99.62%Colore e forma:SolidPeso molecolare:493.57Apcin
CAS:Apcin: potent APC/C(Cdc20) E3 ligase inhibitor, blocks substrate recognition & mitosis, synergizes with Ts-Arg-OMe.Formula:C13H14Cl3N7O4Purezza:96.74%Colore e forma:SolidPeso molecolare:438.65Preq1-Dihydrochloride
CAS:Preq1-Dihydrochloride, a queuosine pathway intermediate, binds strongly to PreQ1 riboswitch aptamer, suppressing protein expression.Formula:C7H11Cl2N5OPurezza:99.46%Colore e forma:SolidPeso molecolare:252.1TH588
CAS:TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.Formula:C13H12Cl2N4Purezza:96.05% - 99.82%Colore e forma:SolidPeso molecolare:295.17Besifloxacin Hydrochloride
CAS:Besifloxacin Hydrochloride (BOL-303224-A) is a fourth-generation fluoroquinolone antibiotic.Formula:C19H21ClFN3O3·HClPurezza:99.20%Colore e forma:Pale Yellow SolidPeso molecolare:430.3TH287 hydrochloride
CAS:<p>TH287 inhibits MTH1 (IC50: 0.8 nM), causing DNA damage in cancer cells through oxidized dNTP incorporation, leading to cytotoxicity in mouse xenografts.</p>Formula:C11H11Cl3N4Purezza:>99.99%Colore e forma:SolidPeso molecolare:305.59FUBP1-IN-1
CAS:FUBP1-in-1: Potent FUBP1 inhibitor with 11.0 M IC50, disrupts FUBP1-DNA binding.Formula:C19H14F3N3O2SPurezza:99.7%Colore e forma:SolidPeso molecolare:405.39(1E)-CFI-400437 dihydrochloride
CAS:(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) is a selective and potent polo-like kinase 4 (PLK4) inhibitor.Formula:C29H30Cl2N6O2Purezza:97.08%Colore e forma:SolidPeso molecolare:565.5APY29
CAS:APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.Formula:C17H16N8Purezza:96.51% - 98.46%Colore e forma:SolidPeso molecolare:332.36TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Formula:C24H26N2O3SPurezza:98.23%Colore e forma:SolidPeso molecolare:422.54CRT0044876
CAS:CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.Formula:C9H6N2O4Purezza:98.27% - 98.98%Colore e forma:Brown PowderPeso molecolare:206.15URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formula:C27H27N5Purezza:99.32% - 99.98%Colore e forma:SolidPeso molecolare:421.54Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Formula:C27H32N8O2Purezza:98.65% - 99.86%Colore e forma:SolidPeso molecolare:500.6SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formula:C18H15ClN6OS2·CH4O3SPurezza:99.44% - 99.92%Colore e forma:SolidPeso molecolare:527.04ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formula:C10H12N6OPurezza:99.69%Colore e forma:SolidPeso molecolare:232.24XMD8-92
CAS:XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).Formula:C26H30N6O3Purezza:98.21%Colore e forma:SolidPeso molecolare:474.55Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Formula:C25H31ClN6O2Colore e forma:SolidPeso molecolare:483.015-Fluoroorotic acid
CAS:5-Fluoroorotic acid is an inhibitor of thymidylate synthase.Formula:C5H3FN2O4Purezza:99.7% - >99.99%Colore e forma:White To Pale Yellow PowderPeso molecolare:174.09Favipiravir
CAS:<p>Favipiravir is a potent and selective RNA-dependent RNA polymerase inhibitor for the treatment of influenza virus infections.Cost-effective and quality-assured.</p>Formula:C5H4FN3O2Purezza:97.32% - 99.90%Colore e forma:SolidPeso molecolare:157.1Simeprevir
CAS:Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.Formula:C38H47N5O7S2Purezza:99.45% - 99.92%Colore e forma:SolidPeso molecolare:749.94MNS
CAS:MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.Formula:C9H7NO4Purezza:98.53%Colore e forma:Yellow PowderPeso molecolare:193.16CID-797718
CAS:CID-797718 is a protein kinase D1 (PKD1) inhibitor.Formula:C12H11NO3Purezza:98.91% - 99.21%Colore e forma:SolidPeso molecolare:217.22NSAH
CAS:NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Formula:C18H14N2O3Purezza:99.27%Colore e forma:SolidPeso molecolare:306.32RI-2
CAS:RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR repair.Formula:C21H18Cl2N2O4Purezza:99.63% - 99.86%Colore e forma:SolidPeso molecolare:433.28SBC-115337
CAS:SBC-115337 is a PCSK9 inhibitor.Formula:C29H19N3O4Purezza:99.41%Colore e forma:SolidPeso molecolare:473.48CID755673
CAS:CID755673 inhibits PKD (IC50: 182 nM), with selectivity over PLK1, AKT, CAMKIIα, CAK, PKC.Formula:C12H11NO3Purezza:97.68% - 99.84%Colore e forma:SolidPeso molecolare:217.226-Thio-2'-Deoxyguanosine
CAS:6-Thio-2'-Deoxyguanosine (β-TGdR) is a nucleoside analog and telomerase substrate.Formula:C10H13N5O3SPurezza:97.52%Colore e forma:SolidPeso molecolare:283.31
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