Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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Rg3039
CAS:Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy (SMA). RG3039 improves motor function in SMA mice.Formula:C21H23Cl2N5OPurezza:98.24% - 99.58%Colore e forma:SolidPeso molecolare:432.355-Fluorocytidine
CAS:5-Fluorocytidine with antiviral activityFormula:C9H12FN3O5Purezza:99.23%Colore e forma:White PowderPeso molecolare:261.217BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formula:C16H10BrN3O2Purezza:99.67%Colore e forma:SolidPeso molecolare:356.17Vidofludimus
CAS:Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).Formula:C20H18FNO4Purezza:98.33% - 99.58%Colore e forma:SolidPeso molecolare:355.36RAD51-IN-1
CAS:Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.Formula:C22H16ClN3OPurezza:99.95%Colore e forma:SolidPeso molecolare:373.83SP-146
<p>SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).</p>Formula:C25H20FN7OPurezza:97.82%Colore e forma:SolidPeso molecolare:453.47Hu7691
CAS:Hu7691 is an Akt inhibitor that inhibits Akt1, Akt2, and Akt3, suppresses neuroblastoma cell proliferation, and induces differentiation of neuroblastoma cells.Formula:C22H22ClF3N4OPurezza:99.81%Colore e forma:SolidPeso molecolare:450.88R-IMPP
CAS:<p>R-IMPP is an inhibitor of PCSK9 translation.</p>Formula:C24H27N3O2Purezza:99.47% - 99.85%Colore e forma:SolidPeso molecolare:389.49SBC-110736
CAS:SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitorFormula:C26H27N3O2Purezza:99.44%Colore e forma:SolidPeso molecolare:413.51BCH001
CAS:BCH001 is a specific small-molecule inhibitor of PAPD5.Formula:C20H15F3N2O5Purezza:99.06%Colore e forma:SolidPeso molecolare:420.34EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formula:C25H28Cl2N4O3Purezza:99.6%Colore e forma:SolidPeso molecolare:503.42Trifluridine/tipiracil hydrochloride mixture
CAS:Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in aFormula:C29H34Cl2F6N8O12Purezza:98% - 99.79%Colore e forma:SolidPeso molecolare:871.53FOY 251
CAS:FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.Formula:C17H19N3O7SPurezza:97.11% - 99.33%Colore e forma:SolidPeso molecolare:409.41CBFβ Inhibitor
CAS:<p>CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1.</p>Formula:C12H14N2OSPurezza:96.50%Colore e forma:SolidPeso molecolare:234.32Arg-Gly-Asp TFA (99896-85-2(free base))
Arg-Gly-Asp TFA (RGD, 99896-85-2) is a tripeptide that promotes cell adhesion and integrin binding.Formula:C14H23F3N6O8Purezza:99.2% - ≥98%Colore e forma:SolidPeso molecolare:460.36NITD-2
CAS:NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.Formula:C23H19N3O4SPurezza:98.03% - 99.46%Colore e forma:SolidPeso molecolare:433.48FEN1-IN-SC13
CAS:<p>FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1)</p>Formula:C24H23N3O3SPurezza:98.02%Colore e forma:SolidPeso molecolare:433.52Triciribine
CAS:Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.Formula:C13H16N6O4Purezza:99.01% - 99.87%Colore e forma:SolidPeso molecolare:320.3AZD-5597
CAS:<p>AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent</p>Formula:C23H28FN7OPurezza:98.01%Colore e forma:SolidPeso molecolare:437.51Tempo
CAS:Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as aFormula:C9H18NOPurezza:98.35%Colore e forma:Orange Crystals Or PowderPeso molecolare:156.25TAK-960 hydrochloride
CAS:TAK-960 hydrochloride is an oral, potent PLK1 inhibitor with IC50 of 0.8 nM, effective against various tumor cells and xenografts.Formula:C27H35ClF3N7O3Colore e forma:SolidPeso molecolare:598.06Carotegrast methyl
CAS:Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Formula:C28H26Cl2N4O5Purezza:99.26% - 99.72%Colore e forma:SolidPeso molecolare:569.44BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purezza:97.13% - 97.54%Colore e forma:SolidPeso molecolare:464.56Levomefolate calcium
CAS:<p>Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.</p>Formula:C20H23CaN7O6Purezza:97.35%Colore e forma:Off-White To Pale Yellow SolidPeso molecolare:497.52TH5427 hydrochloride
CAS:TH5427 HCl inhibits NUDT5 with 29 nM IC50; 690x more selective over MTH1; blocks ATP in breast cancer cells, hindering growth.Formula:C20H21Cl3N8O3Colore e forma:SolidPeso molecolare:527.79TAK-960 monohydrochloride
CAS:TAK-960 monohydrochloride, an oral compound, inhibits PLK1 (IC50=0.8 nM), PLK2, PLK3, stunts cancer cell growth, and is effective in tumor models.Formula:C27H35ClF3N7O3Colore e forma:SolidPeso molecolare:598.07GDC0575 monohydrochloride
CAS:<p>GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.</p>Formula:C16H21BrClN5OPurezza:97.85%Colore e forma:SolidPeso molecolare:414.73TH5487
CAS:<p>TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)</p>Formula:C19H18BrIN4O2Purezza:98.38% - 98.73%Colore e forma:SolidPeso molecolare:541.182'-Fluoro-2'-Deoxyadenosine
CAS:2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP).Formula:C10H12FN5O3Purezza:99.95%Colore e forma:SolidPeso molecolare:269.23N2-Methylguanosine
CAS:<p>N2-methylguanosine is a modified nucleoside of tRNA that occurs at several specific locations in many tRNA's</p>Formula:C11H15N5O5Purezza:97.77%Colore e forma:SolidPeso molecolare:297.27Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formula:C23H20N4O3Purezza:98.66%Colore e forma:SolidPeso molecolare:400.43SR18662
SR18662, improved ML264 derivative, inhibits KLF5 at 4.4 nM IC50; curbs colorectal cancer cell growth and triggers apoptosis.Formula:C16H19Cl2N3O4SPurezza:98.97% - 99.2%Colore e forma:SolidPeso molecolare:420.31RNase L-IN-2
CAS:RNase L-IN-2 activates RNase L at 22 uM, has antiviral effects on various RNA viruses, non-toxic at effective levels.Formula:C16H14N2O2SPurezza:98.81%Colore e forma:SolidPeso molecolare:298.36BIO-1211
CAS:BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Formula:C36H48N6O9Purezza:99.33%Colore e forma:SolidPeso molecolare:708.8STAMBP-IN-1
CAS:STAMBP-IN-1 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release afterFormula:C27H28N4O4SPurezza:99.64%Colore e forma:SolidPeso molecolare:504.6H-Gly-Arg-Gly-Asp-Asn-Pro-OH
CAS:RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) is a integrin-ligand interactions inhibitor.Formula:C23H38N10O10Purezza:>99.99%Colore e forma:SolidPeso molecolare:614.61Garenoxacin mesylate hydrate
CAS:Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strainsFormula:C23H20F2N2O4·CH4O3S·H2OPurezza:99.56%Colore e forma:SolidPeso molecolare:540.53LP-935509
CAS:LP-935509 is a selective, brain-permeable, small molecule competitive inhibitor of articulin-2-associated kinase 1 (AAK1).Cost-effective and quality-assured.Formula:C20H24N6O3Purezza:98.34% - 99.64%Colore e forma:SolidPeso molecolare:396.44P18IN011
CAS:<p>P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).</p>Formula:C15H12N2O5SPurezza:97.63%Colore e forma:SolidPeso molecolare:332.33Nemorubicin
CAS:<p>Nemorubicin (PNU 152243) is a unique doxorubicin variant with varied antitumor action, metabolism, and toxicity, effective against resistant tumors.</p>Formula:C32H37NO13Purezza:97.4%Colore e forma:SolidPeso molecolare:643.64AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Formula:C17H19FN4O2SPurezza:98.96% - 99.19%Colore e forma:SolidPeso molecolare:362.42Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Formula:C24H29N7O2Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:447.532-Aminofluorene
CAS:2-Aminofluorene (2-Fluorenamine) is a biochemical.Formula:C13H11NPurezza:99.9%Colore e forma:Light Yellow CrystallinePeso molecolare:181.23Methotrexate metabolite
CAS:DAMPA, active metabolite of Methotrexate, is a chemotherapeutic and immunosuppressive folic acid antagonist.Formula:C15H15N7O2Purezza:95.60% - 97.59%Colore e forma:SolidPeso molecolare:325.33Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formula:C16H16F3N5Purezza:99.97%Colore e forma:SolidPeso molecolare:335.33iRGD peptide
CAS:iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Formula:C35H57N13O14S2Purezza:98.77%Colore e forma:SolidPeso molecolare:948.04Roniciclib
CAS:<p>Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.</p>Formula:C18H21F3N4O3SPurezza:98% - 98.63%Colore e forma:SolidPeso molecolare:430.44Monastrol
CAS:Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formula:C14H16N2O3SPurezza:98.02% - 98.59%Colore e forma:SolidPeso molecolare:292.35dGTP
CAS:dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFormula:C10H16N5O13P3Purezza:99.64%Colore e forma:SolidPeso molecolare:507.18AUZ 454
CAS:<p>AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.</p>Formula:C24H26F3N7O2Purezza:99.59%Colore e forma:SolidPeso molecolare:501.5
