Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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CVT-313
CAS:CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.Formula:C20H28N6O3Purezza:97.46% - 97.97%Colore e forma:SolidPeso molecolare:400.47GW779439X
CAS:GW779439X is an inhibitor of CDK.Formula:C22H21F3N8Purezza:97.87%Colore e forma:SolidPeso molecolare:454.45KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Formula:C16H27Cl2N5Purezza:99.79%Colore e forma:SolidPeso molecolare:360.33Raltitrexed
CAS:Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.Formula:C21H22N4O6SPurezza:98.99% - 99.29%Colore e forma:Yellow Crystalline PowderPeso molecolare:458.49AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Formula:C28H21N7OSPurezza:98.4% - 99.51%Colore e forma:SolidPeso molecolare:503.58Tirofiban hydrochloride monohydrate
CAS:<p>Tirofiban（MK383） hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist. Cost-effective and quality-assured.</p>Formula:C22H39ClN2O6SPurezza:98.81% - >99.99%Colore e forma:White SolidPeso molecolare:495.07Spermine tetrahydrochloride
CAS:Spermine tetrahydrochloride, a polyamine in all eukaryotic cells, protects DNA from free radicals.Formula:C10H26N4·4HClPurezza:99.75% - 99.82%Colore e forma:SolidPeso molecolare:348.18M2N12
CAS:M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.Formula:C20H16ClN5O2Purezza:98.01%Colore e forma:SolidPeso molecolare:393.83BMH-21
CAS:BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX.Formula:C21H20N4O2Purezza:99.47% - 99.84%Colore e forma:SolidPeso molecolare:360.41Ribociclib succinate hydrate
CAS:Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively).Formula:C27H38N8O6Purezza:98%Colore e forma:SolidPeso molecolare:570.651MKC3946
CAS:MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.Formula:C21H20N2O3SPurezza:99.65%Colore e forma:SolidPeso molecolare:380.46Silver sulfadiazine
CAS:Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.Formula:C10H9AgN4O2SPurezza:99.04% - 99.58%Colore e forma:SolidPeso molecolare:357.14Folinic acid calcium hydrate
CAS:Folinic acid (Leucovorin) calcium hydrate is a biofolic acid often used as a rescue agent with methotrexate (MTX) to reduce MTX-induced toxicity.Formula:C20H23CaN7O8Colore e forma:SolidPeso molecolare:529.523AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formula:C17H16ClN3OPurezza:98.04% - ≥95%Colore e forma:SolidPeso molecolare:313.78LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Formula:C26H39N7O3Purezza:99.66%Colore e forma:SolidPeso molecolare:497.632′-O-Methylcytidine
CAS:<p>2′-O-Methylcytidine inhibits NS5B-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.</p>Formula:C10H15N3O5Purezza:99.72%Colore e forma:SolidPeso molecolare:257.24Palbociclib Isethionate
CAS:<p>Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。</p>Formula:C24H29N7O2·C2H6O4SPurezza:99.01% - 99.27%Colore e forma:SolidPeso molecolare:573.66BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Formula:C22H32N6·HClPurezza:99.21%Colore e forma:SolidPeso molecolare:416.99Triazavirin
CAS:Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent.Formula:C5H7N6NaO5SPurezza:99.55%Colore e forma:SolidPeso molecolare:286.2Lurbinectedin
CAS:<p>Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.</p>Formula:C41H44N4O10SPurezza:98.11%Colore e forma:SolidPeso molecolare:784.87ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formula:C19H22O7SPurezza:98.27%Colore e forma:SolidPeso molecolare:394.44EG1
CAS:<p>EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.</p>Formula:C22H18N2O5Purezza:97.48%Colore e forma:SolidPeso molecolare:390.39ML264
CAS:ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.Formula:C17H21ClN2O4SPurezza:99.33% - 99.45%Colore e forma:SolidPeso molecolare:384.885-Chloro-2'-deoxyuridine
CAS:5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog.Formula:C9H11ClN2O5Purezza:99.54%Colore e forma:SolidPeso molecolare:262.65Mps1-IN-1 dihydrochloride
CAS:Mps1-IN-1 dihydrochloride, a potent ATP-competitive inhibitor of Mps1 kinase, exhibits an IC50 of 367 nM.Formula:C28H35Cl2N5O4SColore e forma:SolidPeso molecolare:608.58CHR-6494 TFA
CAS:CHR-6494 TFA: potent haspin inhibitor (IC50=2 nM), blocks H3T3 phosphorylation, triggers apoptosis in cancer cells. Used for cancer research.Formula:C18H17F3N6O2Purezza:99.50%Colore e forma:SolidPeso molecolare:406.36Mitonafide
CAS:<p>Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.</p>Formula:C16H15N3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:313.31SNS-314
CAS:<p>SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.</p>Formula:C18H15ClN6OS2Purezza:98%Colore e forma:SolidPeso molecolare:430.939-Ethylguanine
CAS:<p>9-Ethylguanine is a model nucleobase commonly used in the studies of DNA interactions with organometallic complexes.</p>Formula:C7H9N5OPurezza:98.6%Colore e forma:SolidPeso molecolare:179.18IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purezza:97.73%Colore e forma:SolidPeso molecolare:485.45NU2058
CAS:NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Formula:C12H17N5OPurezza:99.34% - 99.92%Colore e forma:SolidPeso molecolare:247.3Calcium N5-methyltetrahydrofolate
CAS:<p>Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and</p>Formula:C20H23CaN7O6Purezza:99.41%Colore e forma:SolidPeso molecolare:497.51Pyridostatin hydrochloride
CAS:Pyridostatin hydrochloride stabilizes G-quadruplex DNA (Kd=490nM), inhibits cancer cell growth, and reduces SRC in breast cancer.Formula:C31H37Cl5N8O5Colore e forma:SolidPeso molecolare:778.94Ispinesib
CAS:<p>Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic</p>Formula:C30H33ClN4O2Purezza:98% - 99.09%Colore e forma:SolidPeso molecolare:517.06Levofloxacin hydrochloride
CAS:<p>Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Formula:C18H21ClFN3O4Purezza:99.78% - 99.98%Colore e forma:SolidPeso molecolare:397.8Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formula:C29H42F3N9O9Purezza:98.99% - 99.54%Colore e forma:SolidPeso molecolare:717.69BMS-265246
CAS:<p>BMS-265246 is a potent and selective CDK1/2 inhibitor.</p>Formula:C18H17F2N3O2Purezza:99.25% - 99.57%Colore e forma:SolidPeso molecolare:345.34NSC 617145
CAS:NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependentFormula:C13H10Cl4N2O4Purezza:99.78%Colore e forma:SolidPeso molecolare:400.04KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formula:C20H20N4OPurezza:98.43% - 99.69%Colore e forma:SolidPeso molecolare:332.4LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Formula:C16H12FN5OColore e forma:SolidPeso molecolare:309.3LDC-4297 HCl (1453834-21-3(free base))
<p>LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.</p>Formula:C23H29ClN8OPurezza:100%Colore e forma:SolidPeso molecolare:469.026-O-Methyl Guanosine
CAS:6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.Formula:C11H15N5O5Purezza:97.5%Colore e forma:SolidPeso molecolare:297.27PNU112455A hydrochloride
CAS:PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.Formula:C10H12ClN5O2SPurezza:98.58% - 99.22%Colore e forma:SolidPeso molecolare:301.75HAMNO
CAS:<p>HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).</p>Formula:C17H13NO2Purezza:99.96%Colore e forma:SolidPeso molecolare:263.29BS194
CAS:BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.Formula:C20H27N5O3Purezza:99.85%Colore e forma:SolidPeso molecolare:385.46Pipobroman
CAS:Pipobroman (Vercyte) is an alkylating anti-cancer drug effective in PV and ET with low toxicity and thrombosis risk.Formula:C10H16Br2N2O2Purezza:97.08%Colore e forma:SolidPeso molecolare:356.05TH287
CAS:<p>TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.</p>Formula:C11H10Cl2N4Purezza:97.73% - 99%Colore e forma:SolidPeso molecolare:269.13AT-9283 HCl
CAS:AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.Formula:C19H24ClN7O2Colore e forma:SolidPeso molecolare:417.89Barasertib-HQPA
CAS:<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Formula:C26H30FN7O3Purezza:98.43% - 99.29%Colore e forma:SolidPeso molecolare:507.56Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Formula:C18H22BrN5O3Purezza:98.86% - 99.87%Colore e forma:SolidPeso molecolare:436.3
