Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(522 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(85 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(285 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(67 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3739 prodotti di "Ciclo cellulare/Checkpoint"
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IV-361
CAS:IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1Formula:C23H32FN5O2SiColore e forma:SolidPeso molecolare:457.625Catumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Purezza:95%Colore e forma:LiquidObtustatin
<p>Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.</p>Formula:C184H284N52O57S8Purezza:98%Colore e forma:SolidPeso molecolare:4393.07JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Formula:C21H26N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:338.44Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Purezza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Colore e forma:LiquidWAY-647802
CAS:<p>WAY-647802 is a CDK inhibitor.</p>Formula:C11H14N4O3Purezza:99.53%Colore e forma:SolidPeso molecolare:250.25XY028-133
CAS:<p>XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.</p>Formula:C53H67N11O7SPurezza:97.11%Colore e forma:SolidPeso molecolare:1002.23Lorutengitide
CAS:<p>Lorutengitide is a transcription-regulating peptide with antiproliferative activity.</p>Formula:C30H50N8O12Colore e forma:SolidPeso molecolare:714.764SMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Formula:C20H21NO5Purezza:98.29%Colore e forma:SoildPeso molecolare:355.38TFMU-ADPr triethylamine
<p>TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.</p>Formula:C25H26F3N5O16P2·5C6H15NColore e forma:SolidPeso molecolare:1024.42Farletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.36 kDaCTP Synthetase-IN-1 Ammonium salt
<p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>Formula:C20H22F3N7O3S2Purezza:99.97%Colore e forma:SolidPeso molecolare:529.56TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purezza:99.65%Colore e forma:SolidPeso molecolare:506.36Nogalamycin
CAS:Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater.Formula:C39H49NO16Purezza:98%Colore e forma:SolidPeso molecolare:787.812(E/Z)-THZ1 2HCl
CAS:<p>THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.</p>Formula:C31H30Cl3N7O2Purezza:99.51%Colore e forma:SolidPeso molecolare:638.98Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Formula:C217H341N71O74S9Purezza:98%Colore e forma:SolidPeso molecolare:5417.1Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formula:C10H13ClFN5O9P2Colore e forma:SolidPeso molecolare:463.64Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidDSPE-PEG2000-cRGD
DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.Colore e forma:Odour SolidPD-1/PD-L1-IN-51
<p>PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.</p>Colore e forma:Odour SolidPAT-LM1
PAT-LM1 is a human monoclonal antibody that targets NRB54/NONO. It is applicable in the study of hematological malignancies.Colore e forma:Odour Liquid16,16-dimethyl Prostaglandin A1
CAS:16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Formula:C22H36O4Colore e forma:SolidPeso molecolare:364.526(1S,3R,5R)-PIM447 dihydrochloride
<p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>Formula:C24H25Cl2F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:513.385'-O-TBDMS-dA
CAS:<p>5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formula:C16H27N5O3SiColore e forma:SolidPeso molecolare:365.509DNA Gyrase-IN-12
<p>DNA Gyrase-IN-12 (Compound 6d) is an inhibitor of DNA gyrase. It exhibits antibacterial activity with MIC values ranging from 0.031 to 0.0625 μg/mL against Vancomycin-Intermediate Staphylococcus aureus (VISA) and Enterococcus faecium.</p>Colore e forma:Odour SolidAnticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Formula:C13H20N2O6Colore e forma:SolidPeso molecolare:300.308IRE1-IN-2
IRE1-IN-2 (compound G15) functions as a potent inhibitor of IRE1. It effectively suppresses lipid accumulation induced by FFA, exhibiting an IC50 value of 2.06 μM.Formula:C16H20O6Colore e forma:SolidPeso molecolare:308.125995'-O-DMT-Bz-rC
CAS:<p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Formula:C37H35N3O8Colore e forma:SolidPeso molecolare:649.69N3-(2S)-[2-(tert-Butoxycarbonyl)amino-3-(tert-butoxy carbonyl)]propyluridine
N3-(2S)-propyluridine is a uridine analog with potential as an antiepileptic and for antihypertensive agent research.Formula:C22H35N3O10Colore e forma:SolidPeso molecolare:501.53LXY3
CAS:LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.Formula:C32H43N11O15S2Colore e forma:SolidPeso molecolare:885.88Anti-c-myc Antibody (9E10)
Anti-c-myc Antibody (9E10) is a chimeric mouse IgG1 antibody targeting human c-myc.Colore e forma:Odour LiquidClofarabine-5'-diphosphate trisodium
<p>Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>Formula:C10H10ClFN5Na3O9P2Colore e forma:SolidPeso molecolare:529.58DSPE-PEG3000-iRGD
DSPE-PEG3000-iRGD is a PEG compound comprising DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrin and undergoes proteolytic cleavage within tumors to produce CRGDK/R, interacting with neuropilin-1. This results in tumor targeting and penetration capabilities. DSPE-PEG3000-iRGD is applicable in drug delivery.Colore e forma:Odour SolidViquidacin
CAS:NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.Formula:C25H29FN2O4S2Colore e forma:SolidPeso molecolare:504.64α-Methyl-DL-aspartic acid
CAS:α-Methyl-DL-aspartic acid specifically inhibits argininosuccinate synthase (ASS), the rate-limiting enzyme in 1-citrulline-to-1-arginine recycling.Formula:C5H9NO4Purezza:99.91%Colore e forma:SolidPeso molecolare:147.13Chk1-IN-6
CAS:<p>Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.</p>Formula:C16H18F3N7Colore e forma:SolidPeso molecolare:365.364WAY-230563
CAS:<p>WAY-230563 is a serine/threonine kinase inhibitor that blocks CHK1/CHK2-mediated cell cycle checkpoints, leading to G2/M phase arrest in tumour cells</p>Formula:C17H12N2O2SPurezza:98.40%Colore e forma:SolidPeso molecolare:308.35TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Formula:C37H50F2N12O13Colore e forma:SolidPeso molecolare:908.86Erythromycin lactobionate
CAS:Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.Formula:C49H89NO25Colore e forma:SolidPeso molecolare:1092.233Nusinersen
CAS:<p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>Purezza:98.62%Colore e forma:SolidSTX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Purezza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:Odour LiquidNitrosofolic acid
CAS:<p>Nitrosofolic acid is a folic acid derivaive.</p>Formula:C19H18N8O7Colore e forma:SolidPeso molecolare:470.40WRN inhibitor 17
CAS:<p>WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.</p>Formula:C33H34F4N4O6SColore e forma:SolidPeso molecolare:690.71Carboxy-pyridostatin
CAS:<p>Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.</p>Formula:C35H34N10O7Colore e forma:SolidPeso molecolare:706.715'-DMTr-3'dA(Bz)-methylphosphonami dite
5’-DMTr-3’dA(Bz)-methylphosphonamidite, a purine nucleoside analog, exhibits wide-ranging antitumor activity, specifically targeting indolent lymphoidFormula:C45H51N6O6PColore e forma:SolidPeso molecolare:802.95'-O-DMT-rU
CAS:5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.Formula:C30H30N2O8Colore e forma:SolidPeso molecolare:546.57PROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Formula:C44H38N6O8Colore e forma:SolidPeso molecolare:778.27511Dihydro-5-azacytidine
CAS:Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.Formula:C8H14N4O5Purezza:>99.99%Colore e forma:SolidPeso molecolare:246.22N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine
<p>N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.</p>Formula:C41H43N3O9Colore e forma:SolidPeso molecolare:721.79NUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Formula:C25H30N6OColore e forma:SolidPeso molecolare:430.545
