Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(224 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(86 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(284 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"
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Pipobroman
CAS:Pipobroman (Vercyte) is an alkylating anti-cancer drug effective in PV and ET with low toxicity and thrombosis risk.Formula:C10H16Br2N2O2Purezza:97.08%Colore e forma:SolidPeso molecolare:356.05BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Formula:C17H14Cl2F2N4OSPurezza:98.01% - 99.88%Colore e forma:SolidPeso molecolare:431.292′-Deoxy-2′-fluoroguanosine
CAS:2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Formula:C10H12FN5O4Purezza:99.89%Colore e forma:SolidPeso molecolare:285.232-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Formula:C6H6N4OPurezza:99.21% - 99.42%Colore e forma:SolidPeso molecolare:150.14Myoseverin
CAS:<p>Myoseverin triggers myotube fission into single cells, influencing genes for growth, immunity, matrix remodeling, and stress, aiding healing and regeneration.</p>Formula:C24H28N6O2Purezza:99.25%Colore e forma:SolidPeso molecolare:432.52LDC-4297 HCl (1453834-21-3(free base))
<p>LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.</p>Formula:C23H29ClN8OPurezza:100%Colore e forma:SolidPeso molecolare:469.027BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formula:C16H10BrN3O2Purezza:99.67%Colore e forma:SolidPeso molecolare:356.17Antitumor agent-152
CAS:<p>Organic compound, potential dCK inhibitor, with 2-ethyl-3-methoxyphenyl-1,3-thiazole and pyrimidine units.</p>Formula:C17H19N5O2S2Purezza:95.00%Colore e forma:SolidPeso molecolare:389.510074-G5
CAS:<p>10074-G5 is an inhibitor of c-Myc-Max dimerization.</p>Formula:C18H12N4O3Purezza:99.51% - 99.67%Colore e forma:SolidPeso molecolare:332.31TC-E 5003
CAS:TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.Formula:C16H14Cl2N2O4SPurezza:97.01%Colore e forma:SolidPeso molecolare:401.26MK-8745
CAS:<p>MK-8745 is a potent and selective Aurora A inhibitor.</p>Formula:C20H19ClFN5OSPurezza:99.09% - 99.79%Colore e forma:SolidPeso molecolare:431.91C/EBPα inducer 1
CAS:<p>C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) is a potential inducer of myeloid differentiation via</p>Formula:C20H12FN3O4Purezza:98.99%Colore e forma:SolidPeso molecolare:377.33VPC-80051 racemate
CAS:VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach.Formula:C16H13F2N3OPurezza:97.36%Colore e forma:SolidPeso molecolare:301.29CB-6644
CAS:<p>CB-6644 is a small molecule inhibitor of the ATPase activity of the RUVBL1/2 complex.Cost-effective and quality-assured.</p>Formula:C29H34ClFN4O5Purezza:96.33% - 99.85%Colore e forma:SolidPeso molecolare:573.062-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Formula:C4H3ClN2Purezza:98.98% - 99.89%Colore e forma:Clear Colorless To Yellowish LiquidPeso molecolare:114.53Eptifibatide acetate (148031-34-9 free base)
CAS:Eptifibatide acetate (148031-34-9), a cyclic heptapeptide GP IIb/IIIa inhibitor antiplatelet drug.Formula:C35H49N11O9S2·xC2H4O2Purezza:99.7% - 99.87%Colore e forma:SolidPeso molecolare:831.96 (free base)GNF2133 hydrochloride
CAS:GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.Formula:C24H31ClN6O2Colore e forma:SolidPeso molecolare:471.0roxifiban
CAS:<p>Roxifiban, a prodrug of XV459, is an antiplatelet agent with high affinity and specificity for platelet glycoprotein IIb/IIIa complex(GPIIb/IIIa) receptors.</p>Formula:C21H29N5O6Purezza:98%Colore e forma:SolidPeso molecolare:447.48Rabusertib
CAS:<p>Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.</p>Formula:C18H22BrN5O3Purezza:98.86% - 99.87%Colore e forma:SolidPeso molecolare:436.3Besifloxacin Hydrochloride
CAS:Besifloxacin Hydrochloride (BOL-303224-A) is a fourth-generation fluoroquinolone antibiotic.Formula:C19H21ClFN3O3·HClPurezza:99.20%Colore e forma:Pale Yellow SolidPeso molecolare:430.3FUBP1-IN-1
CAS:FUBP1-in-1: Potent FUBP1 inhibitor with 11.0 M IC50, disrupts FUBP1-DNA binding.Formula:C19H14F3N3O2SPurezza:99.7%Colore e forma:SolidPeso molecolare:405.39XMD8-92
CAS:XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).Formula:C26H30N6O3Purezza:98.21%Colore e forma:SolidPeso molecolare:474.55BTB-1
CAS:BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.Formula:C12H8ClNO4SPurezza:99.71%Colore e forma:SolidPeso molecolare:297.71Adefovir dipivoxil
CAS:Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity againstFormula:C20H32N5O8PPurezza:98% - 99.80%Colore e forma:It Has Broad-Spectrum Antiviral ActivityPeso molecolare:501.475-Fluorocytidine
CAS:5-Fluorocytidine with antiviral activityFormula:C9H12FN3O5Purezza:99.23%Colore e forma:White PowderPeso molecolare:261.21Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formula:C16H16F3N5Purezza:99.97%Colore e forma:SolidPeso molecolare:335.33SBC-115337
CAS:SBC-115337 is a PCSK9 inhibitor.Formula:C29H19N3O4Purezza:99.41%Colore e forma:SolidPeso molecolare:473.48BAY-1816032
CAS:<p>BAY-1816032 is a benzimidazole budding inhibition relieved homolog protein 1 kinase (BUB1) inhibitor.Cost-effective and quality-assured.</p>Formula:C27H24F2N6O4Purezza:98.02% - 99.81%Colore e forma:SolidPeso molecolare:534.51Simeprevir
CAS:Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.Formula:C38H47N5O7S2Purezza:99.45% - 99.92%Colore e forma:SolidPeso molecolare:749.94TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Formula:C24H21Cl2NO5Purezza:98.98%Colore e forma:SolidPeso molecolare:474.33EG1
CAS:<p>EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.</p>Formula:C22H18N2O5Purezza:97.48%Colore e forma:SolidPeso molecolare:390.395-Chloro-2'-deoxyuridine
CAS:5-Chloro-2'-deoxyuridine (5-Chlorodeoxyuridine) is a thymine analog.Formula:C9H11ClN2O5Purezza:99.54%Colore e forma:SolidPeso molecolare:262.65WR99210 hydrochloride(47326-86-3 free base)
CAS:WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.Formula:C14H19Cl4N5O2Purezza:97.77% - 99.8%Colore e forma:SolidPeso molecolare:431.14WNK-IN-11
CAS:WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)Formula:C21H21Cl2N5OSPurezza:98.32%Colore e forma:SolidPeso molecolare:462.4AT-9283 HCl
CAS:AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.Formula:C19H24ClN7O2Colore e forma:SolidPeso molecolare:417.893'-Deoxyguanosine
CAS:3'-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors.Formula:C10H13N5O4Purezza:98.85% - 98.96%Colore e forma:SolidPeso molecolare:267.24TH-263
CAS:TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Formula:C21H20N2O3SPurezza:99.54%Colore e forma:SolidPeso molecolare:380.46Phosphonoformic acid trisodium salt hexa
CAS:Phosphonoformic acid trisodium salt hexa (Sodium phosphonatoformate hexahydrate) is an antiviral drug for the treatment of CMV retinitis.Formula:CH12Na3O11PPurezza:98%Colore e forma:SolidPeso molecolare:300.03Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formula:C21H22ClNO4Purezza:97.9% - 99.47%Colore e forma:SolidPeso molecolare:387.86RCM-1
CAS:RCM-1 is an inhibitor of FOXM1.Formula:C20H12N2OS4Purezza:98.08%Colore e forma:SolidPeso molecolare:424.58UNC10217938A
CAS:UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.Formula:C26H28N6O2Purezza:98%Colore e forma:SolidPeso molecolare:456.54Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formula:C31H43F6N9O12Purezza:95.28% - ≥95%Colore e forma:SolidPeso molecolare:847.72PfDHODH-IN-1
CAS:PfDHODH-IN-1 is an inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase(PfDHODH) which catalyzes the rate-limiting step for DNA and RNA biosynthesis.Formula:C14H11F3N2O2Purezza:99.87%Colore e forma:SolidPeso molecolare:296.24GAK inhibitor 49 hydrochloride
Potent GAK inhibitor 49 hydrochloride: ATP-competitive, highly selective, Ki=0.54 nM, IC50=56 nM, binds to RIPK2.Formula:C20H23ClN2O5Colore e forma:SolidPeso molecolare:406.86GSK461364
CAS:GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.Formula:C27H28F3N5O2SPurezza:99% - 99.73%Colore e forma:SolidPeso molecolare:543.6Tirapazamine
CAS:Tirapazamine (Win59075) triggers apoptosis in hypoxic cells by damaging DNA and enhances effects of radiation and cisplatin.Formula:C7H6N4O2Purezza:96.65% - 99.87%Colore e forma:Orange-Red Crystalline PowderPeso molecolare:178.15ILK-IN-2
CAS:<p>ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.</p>Formula:C30H30F3N5OPurezza:99.30%Colore e forma:SolidPeso molecolare:533.593-AP
CAS:3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).Formula:C7H9N5SPurezza:97.33% - 99.87%Colore e forma:SolidPeso molecolare:195.24SP-146
<p>SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).</p>Formula:C25H20FN7OPurezza:97.82%Colore e forma:SolidPeso molecolare:453.47Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formula:C21H18F3N5OPurezza:98.91%Colore e forma:SolidPeso molecolare:413.4
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