Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(224 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(86 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(284 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"
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GW406108X(Z/E)
CAS:GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Formula:C20H11Cl2NO4Purezza:98.23%Colore e forma:SolidPeso molecolare:400.21AZD-5597
CAS:<p>AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent</p>Formula:C23H28FN7OPurezza:98.01%Colore e forma:SolidPeso molecolare:437.51Saccharin 1-methylimidazole
CAS:Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.Formula:C7H5NO3S·C4H6N2Purezza:98.21%Colore e forma:SolidPeso molecolare:265.29A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Formula:C15H12N2OS2Purezza:98.07% - 98.52%Colore e forma:SolidPeso molecolare:300.4Ispinesib
CAS:<p>Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic</p>Formula:C30H33ClN4O2Purezza:98% - 99.09%Colore e forma:SolidPeso molecolare:517.06LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Formula:C18H22Cl2N2O2SPurezza:98%Colore e forma:SolidPeso molecolare:401.35Y16 acetate(429653-73-6 free base)
<p>Y16 acetate(429653-73-6 free base) is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA</p>Formula:C51H74N14O13Purezza:98%Colore e forma:SolidPeso molecolare:1091.246-O-Methyl Guanosine
CAS:6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.Formula:C11H15N5O5Purezza:97.5%Colore e forma:SolidPeso molecolare:297.27ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formula:C19H22O7SPurezza:98.27%Colore e forma:SolidPeso molecolare:394.44BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formula:C17H12Cl2F2N4OSPurezza:99.31% - 99.81%Colore e forma:SolidPeso molecolare:429.27AZ5576
CAS:<p>AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].</p>Formula:C21H24FN3O3Purezza:99.88%Colore e forma:SoildPeso molecolare:385.432'-O-(2-Methoxyethyl)adenosine
CAS:2'-O-(2-Methoxyethyl)adenosine is a nucleoside analog used to improve RNA target affinity and nuclease resistance of therapeutic oligonucleotides in preclin.Formula:C13H19N5O5Purezza:99.35%Colore e forma:SolidPeso molecolare:325.32O6-Methyldeoxy guanosine
CAS:O6-Methyldeoxy guanosine, a deoxypurine nucleoside, is a weak inhibitor of the removal of O6-methylguanine from methylated DNA by rat liver enzymes in vitro.Formula:C11H15N5O4Purezza:99.57%Colore e forma:SolidPeso molecolare:281.27Braco-19
CAS:<p>Braco-19 is a telomerase/telomere inhibitor and an inhibitor of HAdV viral replication with antiviral activity that reduces lipid vacuolization in adipocytes, inhibits proliferation and decreases telomerase activity in human glioblastoma cells.</p>Formula:C35H43N7O2Purezza:97.01%Colore e forma:SolidPeso molecolare:593.76RO0270608
CAS:RO0270608 is an α4β1/α4β7 integrin antagonist with anti-inflammatory activity for the study of allergic inflammatory responses.Formula:C24H19Cl3N2O4Purezza:98.26%Colore e forma:SolidPeso molecolare:505.782'-C-β-Methylguanosine
CAS:<p>2'-C-beta-Methylguanosine (2'-C-Methylguanosine), with antiviral activity, inhibits dengue virus 2.</p>Formula:C11H15N5O5Purezza:99.37%Colore e forma:SolidPeso molecolare:297.27DS44960156
CAS:DS44960156 is an inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) that inhibits both MTHFD2 and MTHFD1 and can be used in cancer research.Formula:C20H15NO5Purezza:99.13%Colore e forma:SolidPeso molecolare:349.349-(β-D-Xylofuranosyl)adenine
CAS:<p>9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) is an adenine nucleoside analog that is a potential smooth muscle vasodilator.9-(β-D-Xylofuranosyl)adenine has</p>Formula:C10H13N5O4Purezza:99.97%Colore e forma:SolidPeso molecolare:267.242'-Deoxy-N2-methylguanosine
CAS:2'-Deoxy-N2-methylguanosine is a purine nucleoside analog that can be used as a chemical probe to study DNA-protein interactions.Formula:C11H15N5O4Purezza:99.79%Colore e forma:SolidPeso molecolare:281.275-Bromouridine
CAS:5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.Formula:C9H11BrN2O6Purezza:99.89%Colore e forma:White PowderPeso molecolare:323.1PDD00017273
CAS:<p>PDD00017273 is a radiosensitizing PARG) inhibitor with antitumor or activity for the study of epithelial ovaries.</p>Formula:C23H26N6O4S2Purezza:99.14% - 99.21%Colore e forma:SolidPeso molecolare:514.625-Bromo-2',3',5'-tri-O-acetyluridine
CAS:5-Bromo-2',3',5'-tri-O-acetyluridine is a purine nucleoside analog that can be used to explore explore improve Parkinson's disease.Formula:C15H17BrN2O9Purezza:99%Colore e forma:SolidPeso molecolare:449.21Bexotegrast
CAS:Bexotegrast (PLN-74809) is an αvβ6 and αvβ1 integrin inhibitor with antifibrotic properties for the study of idiopathic pulmonary fibrosis (IPF).Formula:C27H36N6O3Purezza:99.53%Colore e forma:SolidPeso molecolare:492.61Rabacfosadine
CAS:Rabacfosadine (GS-9219) is a novel prodrug of PMEG, an acyclic nucleotide phosphonate, with antitumor activity for the study of lymphoma.Formula:C21H35N8O6PPurezza:99.06% - 99.37%Colore e forma:SolidPeso molecolare:526.53PolQi2
CAS:PolQi2 is a Polθ inhibitor that suppresses the helicase activity of Polθ, and when combined with AZD7648.Formula:C21H16ClN5O3SPurezza:99.19%Colore e forma:SolidPeso molecolare:453.93'-Deoxy-3'-fluoroadenosine
CAS:3'-Deoxy-3'-fluoroadenosine is a purine nucleoside analogue with a wide range of anti-tumor and anti-viral activity, and has inhibitory effects on tick-borneFormula:C10H12FN5O3Purezza:99.84%Colore e forma:SolidPeso molecolare:269.23N6-(p-Methoxybenzyl)adenosine
CAS:Nucleoside Derivatives - 6-Modified purine nucleosides; Drugs and Inhibitors; plant growth regulator, plant hormoneFormula:C18H21N5O5Purezza:99.79%Colore e forma:SolidPeso molecolare:387.392',3'-Bis-(O-t-butyldimethylsilyl)uridine
CAS:2',3'-Bis-(O-t-butyldimethylsilyl)uridine is a nucleoside derivative protect the NH2/OH groups of nucleosides.inhibitory on viral replication，AIDS and herpes.Formula:C21H40N2O6Si2Purezza:99.88%Colore e forma:SolidPeso molecolare:472.725-Hydroxyuridine
CAS:5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue with potential antitumour activity, showing cytotoxicity against human colon adenocarcinoma cell lines.Formula:C9H12N2O7Purezza:98.76%Colore e forma:SolidPeso molecolare:260.2Z62954982
CAS:Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteriesFormula:C20H21N3O5SPurezza:98.28%Colore e forma:SolidPeso molecolare:415.462'-Deoxy-N4-methylcytidine
CAS:2’-Deoxy-N4-methylcytidine (N(3)-Methyl-2'-deoxycytidine) is a purine nucleoside analog with potential antitumor activity for the study of apoptosis.Formula:C10H15N3O4Purezza:99.61%Colore e forma:SolidPeso molecolare:241.24P-2'-deoxyribose
CAS:P-2'-deoxyribose (P-Nucleoside) is a deoxyribose that is widely found in organisms.Formula:C11H15N3O5Purezza:99.71%Colore e forma:SolidPeso molecolare:269.252'-Deoxy-2-iodoadenosine
CAS:2'-Deoxy-2-iodoadenosine is a purine nucleoside analog with potential antimicrobial, antioxidant and anti-leukemic activities.Formula:C10H12IN5O3Purezza:99.37%Colore e forma:SolidPeso molecolare:377.145'-O-DMT-N4-Bz-5-Me-dC
CAS:5'-O-DMT-N4-Bz-5-Me-dC (DMT-NBZ-5-METHYL DC) is a modified nucleoside used in the synthesis of nucleoside phosphoramidites.Formula:C38H37N3O7Purezza:98.88%Colore e forma:SolidPeso molecolare:647.72LSN2839567
CAS:<p>LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.</p>Formula:C25H28F2N8Purezza:99.14%Colore e forma:SolidPeso molecolare:478.54N6-Methyl-2'-O-methyladenosine
CAS:N6-Methyl-2'-O-methyladenosine (N6,2′-O-Dimethyladenosine), a substrate for adiposity and obesity-related genes (FTO), is a reversible modifier compound foundFormula:C12H17N5O4Purezza:99.97%Colore e forma:SolidPeso molecolare:295.29CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Formula:C18H15F5N8OPurezza:99.37%Colore e forma:SolidPeso molecolare:454.36N6-(2-Hydroxyethyl)adenosine
CAS:<p>N6-(2-Hydroxyethyl)adenosine is a sedative, Ca2+ antagonist, and anti-inflammatory, affecting brain and heart blood flow.</p>Formula:C12H17N5O5Purezza:99.4%Colore e forma:SolidPeso molecolare:311.29ARB-272572
CAS:ARB-272572 is a PD-L1 signaling inhibitor that produces immunostimulatory activity in human primary cells.Formula:C32H36N6O4Purezza:97.36% - 98.07%Colore e forma:SolidPeso molecolare:568.672'-O-Methyl-2-thiouridine
CAS:2'-O-Methyl-2-thiouridine, a purine nucleoside analog present in synthetic thermophilic bacterial tRNAs, is more selective for A than unmodified U.Formula:C10H14N2O5SPurezza:99.89%Colore e forma:SolidPeso molecolare:274.29Levomefolate sodium
CAS:Levomefolate sodium (L-5-MTHF sodium) is a dietary supplement that can be used to study megaloblastic anemia and neurological disorders.Formula:C20H23N7Na2O6Purezza:98.7%Colore e forma:SolidPeso molecolare:503.42Mps1-IN-2
CAS:Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.Formula:C26H36N6O3Purezza:96.24% - 99.75%Colore e forma:SolidPeso molecolare:480.6MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formula:C22H21ClFN3O3SPurezza:99.22%Colore e forma:SolidPeso molecolare:461.94SCH-1473759 hydrochloride
CAS:SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Formula:C20H27ClN8OSPurezza:98.29%Colore e forma:SolidPeso molecolare:463Anti-Mouse IL-1a Antibody (ALF-161)
Anti-Mouse IL-1a Antibody is an IgG1 subtype inhibitor specific to mouse IL-1a, derived from the Armenian Hamster.Purezza:98%Colore e forma:Odour LiquidN6-Etheno 2'-deoxyadenosine
CAS:<p>N6-Etheno 2'-deoxyadenosine is used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.</p>Formula:C12H13N5O3Purezza:98%Colore e forma:SolidPeso molecolare:275.26Rinatabart
CAS:Rinatabart is a humanised monoclonal antibody targeting FRα/FOLR1, suitable for investigating ovarian and endometrial cancers expressing FRα.Purezza:95% - 95.7% (SDS-PAGE); 96.0% (SEC-HPLC)Colore e forma:Odour LiquidVoxalatamab
CAS:Voxalatamab (JNJ-63898081), an IgG4 bispecific antibody targeting PSMA and CD3, demonstrates anti-cancer efficacy in prostate cancer research [1].Colore e forma:LiquidRovelizumab
CAS:Rovelizumab: humanized anti-CD11/CD18 antibody for MS, hemorrhagic shock, MI, and stroke research.Purezza:95% - 95%Colore e forma:LiquidVatelizumab
CAS:Vatelizumab is a humanised monoclonal antibody targeting Integrin α2β1 ( VLA-2, CD49b), which enhances the frequency of regulatory T cells multiple sclerosis.Purezza:95%Colore e forma:Liquid
