Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(224 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(86 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(284 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"
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IRE1α kinase-IN-3
CAS:IRE1α kinase-IN-3 is a potent, ATP-competitive inhibitor of IRE1α (Ki: 480 nM).Formula:C29H32N6O3SColore e forma:SolidPeso molecolare:544.67RECQL5-IN-1
CAS:RECQL5-IN-1, an oral RECQL5 inhibitor (IC50 46.3 nM), targets enzyme/non-enzyme domains, useful in breast cancer research.Formula:C25H18F6N4O2SColore e forma:SolidPeso molecolare:552.49MS0017509
CAS:MS0017509 is a DNA damage repair inhibitor.Formula:C11H10N4Purezza:98%Colore e forma:SolidPeso molecolare:198.22Nucleoside-Analog-2
CAS:Nucleoside-Analog-2 is a 4'-Azidocytidine analogue, used to against Hepatitis C virus (HCV) replication.Formula:C9H11N5O6Purezza:98%Colore e forma:SolidPeso molecolare:285.21CDK2-IN-13
CAS:CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.Formula:C13H12ClN5Colore e forma:SoildPeso molecolare:273.72DHFR-IN-5
CAS:<p>DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.</p>Formula:C18H24N4O4Colore e forma:SolidPeso molecolare:360.412'-Fluorothymidine
CAS:<p>2'-Fluorothymidine is a selective substrate for TK2, related to thymidine and methyluridine.</p>Formula:C10H13FN2O5Purezza:99.67%Colore e forma:SolidPeso molecolare:260.221-Methylcytosine
CAS:<p>1-Methylcytosine (4-amino-1-methylpyrimidin-2(1H)-one) is a methylated form of the cytosine and can be used as the nucleobase of hachimoji DNA paired with</p>Formula:C5H7N3OPurezza:99.88%Colore e forma:SolidPeso molecolare:125.13VE-465
CAS:VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formula:C22H28N8OSColore e forma:SolidPeso molecolare:452.58Antitumor agent-85
Antitumor agent-85 stabilizes G4-DNA with potent anti-tumor effects.Formula:C24H33N7Colore e forma:SolidPeso molecolare:419.57HBV-IN-4
CAS:HBV-IN-4, a phthalazinone, inhibits HBV DNA replication orally (IC50: 14 nM), encouraging genome-free capsids with strong anti-HBV effects.Formula:C24H19ClFN5O3Colore e forma:SolidPeso molecolare:479.89CDK7-IN-10
CAS:CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)Formula:C29H35N7O3Colore e forma:SolidPeso molecolare:529.63Antibacterial agent 89
CAS:Antibacterial agent 89 blocks bacterial transcription and clostridial cytotoxins, inhibiting β'CH-σ interactions.Formula:C21H10Cl2F3NO5SColore e forma:SolidPeso molecolare:516.27P1788
CAS:P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].Formula:C15H17NO3Colore e forma:SolidPeso molecolare:259.38-Azido-ADP disodium
CAS:8-Azido-ADP (disodium) is a covalent inhibitor of ADP/ATP exchange in mitochondria, causing irreversible inhibition in light.Formula:C10H13N8NaO10P2Colore e forma:SolidPeso molecolare:490.197DENV-IN-7
CAS:DENV-IN-7, a flavone analog, inhibits dengue virus at 70 nM EC50 with low toxicity to normal cells.Formula:C24H22O8Colore e forma:SolidPeso molecolare:438.43BSJ-01-175
CAS:BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.Formula:C30H33ClN6O2Colore e forma:SolidPeso molecolare:545.08Valategrast hydrochloride
CAS:Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Formula:C30H33Cl4N3O4Purezza:98%Colore e forma:SolidPeso molecolare:641.41BPKDi
CAS:BPKDi is a potent and selective inhibitor of PKD (protein kinase D).Formula:C21H28N6OPurezza:98%Colore e forma:SolidPeso molecolare:380.49ANI-7
CAS:ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).Formula:C13H8Cl2N2Purezza:99.07%Colore e forma:SolidPeso molecolare:263.125-Aminouridine
CAS:5-Aminouridine (4-Chloro-2-isopropyl-5-methylphenol(chlorothymol)) modifies nucleobases and is incorporated into the target DNA.Formula:C9H13N3O6Purezza:99.53%Colore e forma:SolidPeso molecolare:259.22CGP 53353
CAS:CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.Formula:C20H13F2N3O2Purezza:98.11%Colore e forma:SolidPeso molecolare:365.33DNA Gyrase-IN-5
CAS:DNA Gyrase-IN-5 is a potent inhibitor of DNA gyrase (IC50: 0.10 μM) and has an antibacterial effect on both wild-type and drug-resistant strains.Formula:C25H15BrClN5Colore e forma:SolidPeso molecolare:500.78Syntelin
CAS:Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.Formula:C21H20N6O2S3Colore e forma:SolidPeso molecolare:484.62Aloisine A
CAS:Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Formula:C16H17N3OPurezza:98%Colore e forma:SolidPeso molecolare:267.33Synucleozid
CAS:Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.Formula:C22H20N6Purezza:98%Colore e forma:SolidPeso molecolare:368.43Werner syndrome RecQ helicase-IN-4
CAS:Werner syndrome RecQ helicase-IN-4 is a WRN inhibitor with anticancer and anti-proliferative activity, used in colorectal and gastric cancer research.Formula:C32H33F3N8O5Purezza:98.27%Colore e forma:SolidPeso molecolare:666.65Edatrexate
CAS:Edatrexate (CGP 30694), a Methotrexate analog, combats MTX-resistant tumors and researches various cancers.Formula:C22H25N7O5Colore e forma:SolidPeso molecolare:467.48DHODH-IN-12
CAS:DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.Formula:C10H9N3O2Purezza:99.53%Colore e forma:SolidPeso molecolare:203.2CM03
CAS:CM03 is a cell-selective G-quadruplex ligand with anti-cancer activity, stabilizing G4 genes, useful in pancreatic cancer research.Formula:C34H44N6O6Purezza:98.65%Colore e forma:SolidPeso molecolare:632.75XVA143
CAS:XVA143 is an integrin α/β I-like allosteric antagonist, inhibits LFA-1 (αLβ2 integrin)-dependent firm adhesion, induces extended conformations of integrins.Formula:C25H21Cl2N3O8Colore e forma:SolidPeso molecolare:562.36TP1287
CAS:TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib.Formula:C21H21ClNO8PColore e forma:SolidPeso molecolare:481.82(Rac)-Managlinat dialanetil
CAS:<p>Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.</p>Formula:C21H33N4O6PSPurezza:98.52%Colore e forma:SolidPeso molecolare:500.55Zalunfiban
CAS:RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.Formula:C16H18N8O2SColore e forma:SolidPeso molecolare:386.43MDK6204
CAS:MDK6204 is a selective inhibitor of CLK1 and CLK2.Formula:C20H20N6OPurezza:98%Colore e forma:SolidPeso molecolare:360.41Cylindrospermopsin
CAS:Cylindrospermopsin: a toxic cyanobacterial uracil derivative, disrupts protein/glutathione synthesis in hepatocytes, and is genotoxic.Formula:C15H21N5O7SColore e forma:SolidPeso molecolare:415.42CB10-277
CAS:CB10-277 is a synthetic anti-cancer drug related to dacarbazine that alkylates DNA, inhibits DNA replication and repair, and may block DNA synthesis.Formula:C9H11N3O2Colore e forma:SolidPeso molecolare:193.2CDK8-IN-7
CAS:CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Formula:C30H40N2Colore e forma:SolidPeso molecolare:428.65Digeranyl bisphosphonate
CAS:Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.DigeranylFormula:C21H34Na4O6P2Purezza:98.5%Colore e forma:SolidPeso molecolare:536.4Cdc7-IN-5
CAS:<p>Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.</p>Formula:C25H23N3O5Purezza:97.15%Colore e forma:SolidPeso molecolare:445.47Braco-19 trihydrochloride
CAS:BRACO19 3HCl inhibits telomerase, blocking its capping function, and prevents HAdV viral replication.Formula:C35H46Cl3N7O2Purezza:98.74%Colore e forma:SolidPeso molecolare:703.143'-Deoxyuridine-5'-triphosphate
CAS:3'-dUTP, a nucleotide analogue, competitively inhibits RNA polymerases I & II, with a Ki of 2.0 µM.Formula:C9H15N2O14P3Colore e forma:SolidPeso molecolare:468.14PF-2771
CAS:PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.Formula:C29H36ClN5O4Purezza:98%Colore e forma:SolidPeso molecolare:554.08CDK7-IN-2
CAS:CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Formula:C26H39N7O3Colore e forma:SolidPeso molecolare:497.63Triaziquone
CAS:Triaziquone is an alkylating agent that can react with DNA to form intrastrand crosslinks.Formula:C12H13N3O2Colore e forma:SolidPeso molecolare:231.25CDK5 inhibitor 20-223
CAS:CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Formula:C19H19N3OColore e forma:SolidPeso molecolare:305.37FLDP-5
CAS:FLDP-5: BBB-penetrant curcuminoid, induces ROS, DNA damage, S phase arrest, suppresses tumors in LN-18 cells.Formula:C21H21NO5Colore e forma:SolidPeso molecolare:367.4Binucleine 2
CAS:Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.Formula:C13H11ClFN5Colore e forma:SolidPeso molecolare:291.71DHODH-IN-4
CAS:DHODH-IN-4 inhibits human & Plasmodium DHODH; IC50: 4 μM (Pf), 0.18 μM (Hs). It has antimalarial properties.Formula:C17H12Cl2N2O2Purezza:99.34%Colore e forma:SolidPeso molecolare:347.2HIV-1 inhibitor-43
CAS:<p>HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.</p>Formula:C24H21ClN2O4SColore e forma:SolidPeso molecolare:468.95
