Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"
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OXA-06 Dihydrochloride
CAS:OXA-06 Dihydrochloride is a PANC-1 cell migration and MYPT1 phosphorylation inhibitor.Formula:C21H18FN3Purezza:98%Colore e forma:SolidPeso molecolare:331.39Edatrexate
CAS:Edatrexate (CGP 30694), a Methotrexate analog, combats MTX-resistant tumors and researches various cancers.Formula:C22H25N7O5Colore e forma:SolidPeso molecolare:467.48CB10-277
CAS:CB10-277 is a synthetic anti-cancer drug related to dacarbazine that alkylates DNA, inhibits DNA replication and repair, and may block DNA synthesis.Formula:C9H11N3O2Colore e forma:SolidPeso molecolare:193.2SRPIN-803
CAS:SRPIN-803 is a selective dual SRPK1 and CK2 inhibitor.Formula:C14H9F3N4O3SPurezza:98%Colore e forma:SolidPeso molecolare:370.31GSK317354A
CAS:GSK317354A is a GRK2 inhibitor.Formula:C25H18F4N6OColore e forma:SolidPeso molecolare:494.44BOP sodium
CAS:BOP sodium salt is an inhibitor of alpha9beta1 and alpha4beta1 integrin.Formula:C25H29N3NaO7SColore e forma:SolidPeso molecolare:538.57CDK7-IN-2
CAS:CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Formula:C26H39N7O3Colore e forma:SolidPeso molecolare:497.63FLDP-5
CAS:FLDP-5: BBB-penetrant curcuminoid, induces ROS, DNA damage, S phase arrest, suppresses tumors in LN-18 cells.Formula:C21H21NO5Colore e forma:SolidPeso molecolare:367.4CDK1-IN-1
CAS:CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.Formula:C27H23N5O3Colore e forma:SolidPeso molecolare:465.5Akt1&PKA-IN-2
CAS:Akt1&PKA-IN-2 ((R)-29) inhibits AKT1, PKAα, CDK2 with IC50s: 0.007, 0.01, 0.69 µM respectively.Formula:C20H17Cl2N3OColore e forma:SolidPeso molecolare:386.27JH-XIV-68-3
CAS:JH-XIV-68-3: Selective DYRK1A/B inhibitor; effective in HNSCC cell lines.Formula:C21H17F3N8OColore e forma:SolidPeso molecolare:454.41BPKDi
CAS:BPKDi is a potent and selective inhibitor of PKD (protein kinase D).Formula:C21H28N6OPurezza:98%Colore e forma:SolidPeso molecolare:380.49FINDY
CAS:FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.Formula:C16H17NO2S2SiColore e forma:SolidPeso molecolare:347.53Braco-19 trihydrochloride
CAS:BRACO19 3HCl inhibits telomerase, blocking its capping function, and prevents HAdV viral replication.Formula:C35H46Cl3N7O2Purezza:98.74%Colore e forma:SolidPeso molecolare:703.14IACS-4759
CAS:IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.Formula:C10H17N3O2Colore e forma:SolidPeso molecolare:211.26Dyrk1A-IN-3
CAS:Dyrk1A-IN-3 is a selective DYRK1A inhibitor with an IC50 of 76 nM, useful for neurodegenerative disease research.Formula:C18H16N6Colore e forma:SolidPeso molecolare:316.36Sibrafiban
CAS:Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Formula:C20H28N4O6Colore e forma:SolidPeso molecolare:420.46CB 3717
CAS:CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.Formula:C24H23N5O6Colore e forma:SolidPeso molecolare:477.47LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Formula:C23H23N7O2SColore e forma:SolidPeso molecolare:461.54HBV-IN-15
CAS:HBV-IN-15, a flavone derivative, is a potent cccDNA inhibitor, potentially aiding HBV research.Formula:C24H23ClO6Colore e forma:SolidPeso molecolare:442.89Antitumor agent-85
Antitumor agent-85 stabilizes G4-DNA with potent anti-tumor effects.Formula:C24H33N7Colore e forma:SolidPeso molecolare:419.57VE-465
CAS:VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formula:C22H28N8OSColore e forma:SolidPeso molecolare:452.582'-Deoxy-L-guanosine
CAS:2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death.Formula:C10H13N5O4Colore e forma:SolidPeso molecolare:267.24CDK7-IN-8
CAS:CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.Formula:C25H38N8O3Colore e forma:SolidPeso molecolare:498.62SP-471P
CAS:SP-471P inhibits DENV protease; EC50: DENV1-5.9 μM, DENV2-1.4 μM, DENV3-5.1 μM, DENV4-1.7 μM; CC50 >100 μM; lowers viral RNA synthesis.Formula:C33H26BrN5O2Colore e forma:SolidPeso molecolare:604.5Mps1-IN-4
CAS:Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.Formula:C26H31F3N6O2Colore e forma:SolidPeso molecolare:516.56Crisnatol
CAS:Crisnatol (BWA770U) is an oral anticancer DNA intercalator, toxic to breast cancer cells, not skin fibroblasts.Formula:C23H23NO2Colore e forma:SolidPeso molecolare:345.43BDM44768
CAS:BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.Formula:C24H22FN5O3Colore e forma:SolidPeso molecolare:447.4614α-Demethylase/DNA Gyrase-IN-2
CAS:14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formula:C24H22N4O4Colore e forma:SolidPeso molecolare:430.46NSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFormula:C26H32N10O4SPurezza:98%Colore e forma:SolidPeso molecolare:580.66Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Formula:C9H16N2O6Purezza:98%Colore e forma:SolidPeso molecolare:248.23Indirubin-5-sulfonate
CAS:Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.Formula:C16H10N2O5SPurezza:98%Colore e forma:SolidPeso molecolare:342.33Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Formula:C13H15N5OSColore e forma:SolidPeso molecolare:289.36Mps-BAY2b
CAS:Mps-BAY2b is a novel MPS1 inhibitor.Formula:C20H23N5OColore e forma:SolidPeso molecolare:349.43Werner syndrome RecQ helicase-IN-3
CAS:Potent WRN inhibitor, Werner syndrome RecQ helicase-IN-3, is orally active with 0.06 µM IC50; exhibits antiproliferative and anticancer effects.Formula:C31H30ClF3N8O5Colore e forma:SolidPeso molecolare:687.07Crisnatol mesylate
CAS:Crisnatol, a potent and selective DNA intercalator, has potential anticancer activity.Formula:C24H27NO5SColore e forma:SolidPeso molecolare:441.54CDK7-IN-12
CAS:CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.Formula:C20H19F3N6Colore e forma:SolidPeso molecolare:400.4UIAA-II-232
CAS:UIAA-II-232 (compound 19b) is a potent inhibitor of DNA gyrase catalytic (IC 50= 3.5 μM).Formula:C20H24FN5O3Colore e forma:SolidPeso molecolare:401.43HBV-IN-16
CAS:HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).Formula:C22H20ClNO4Colore e forma:SolidPeso molecolare:397.85CDK4/6-IN-9
CAS:CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.Formula:C22H23FN8Colore e forma:SolidPeso molecolare:418.47DAP-81
CAS:DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.Formula:C25H20N6O4Colore e forma:SolidPeso molecolare:468.46Cdc7-IN-13
CAS:Cdc7-IN-13 (compound 84) is a highly potent CDC7 inhibitor, exhibiting an IC50 value of <1 nM. This compound holds promise for cancer research [1].Formula:C18H20N4O2SColore e forma:SolidPeso molecolare:356.443'-Deoxyuridine-5'-triphosphate
CAS:3'-dUTP, a nucleotide analogue, competitively inhibits RNA polymerases I & II, with a Ki of 2.0 µM.Formula:C9H15N2O14P3Colore e forma:SolidPeso molecolare:468.14Ulecaciclib
CAS:Ulecaciclib: oral, BBB-permeable CDK inhibitor; favorable pharmacokinetics; ki: 0.62 μM (CDK2/A), 3 nM (CDK6/D3), 0.2 nM (CDK4/D1), 0.63 μM (CDK7/H).Formula:C25H33FN8SColore e forma:SolidPeso molecolare:496.65CDK8-IN-7
CAS:CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Formula:C30H40N2Colore e forma:SolidPeso molecolare:428.65XVA143
CAS:XVA143 is an integrin α/β I-like allosteric antagonist, inhibits LFA-1 (αLβ2 integrin)-dependent firm adhesion, induces extended conformations of integrins.Formula:C25H21Cl2N3O8Colore e forma:SolidPeso molecolare:562.36Type II topoisomerase inhibitor 1
CAS:Potent E. coli DNA gyrase inhibitor (IC50: 1.7 nM), targets Asp73; weak topoisomerase IV inhibitor (IC50: 0.98 μM).Formula:C18H15N3O4Colore e forma:SolidPeso molecolare:337.33CDK7-IN-15
CAS:CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.Formula:C21H24F4N6OSPurezza:99.27%Colore e forma:SolidPeso molecolare:484.51DHODH-IN-3
CAS:DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.Formula:C17H13ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:312.75LDN-209929 dihydrochloride
CAS:LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.Formula:C17H19Cl3N2OSColore e forma:SolidPeso molecolare:405.77
