Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
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Trovati 3752 prodotti di "Ciclo cellulare/Checkpoint"
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ML372
CAS:ML372 is a potent and selective SMN Modulator (EC50 = 12 nM, 325% increase inSMN2) with good potency, pharmacokinetics, tolerance, and CNS penetration.Formula:C18H20N2O4SColore e forma:SolidPeso molecolare:360.43RSK-IN-1
CAS:RSK-IN-1 (compound 7d) shows anti-tumor activity. RSK-IN-1 is an inhibitor of RSK that inhibits the phosphorylation of YB-1 [1].Formula:C22H17NO2Colore e forma:SolidPeso molecolare:327.38CDK4/6-IN-8
CAS:CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).Formula:C18H18N6O5Colore e forma:SolidPeso molecolare:398.37ERCC1-XPF-IN-1
CAS:ERCC1-XPF-IN-1: potent ERCC1-XPF inhibitor (IC50: 0.49 μM), hampers CPD removal, boosts UV toxicity, hinders DNA repair.Formula:C28H32ClN5O2Colore e forma:SolidPeso molecolare:506.04Aditoprime
CAS:Aditoprime inhibits bacterial growth by blocking DHFR, effective against L.casei and E.coli with IC50 of 520/47 nM.Formula:C15H21N5O2Colore e forma:SolidPeso molecolare:303.36Teloxantrone
CAS:Teloxantrone: an anthrapyrazole antibiotic inhibiting DNA replication, RNA/protein synthesis by interacting with DNA and topoisomerase II.Formula:C21H25N5O4Colore e forma:SolidPeso molecolare:411.45MtTMPK-IN-6
CAS:MtTMPK-IN-6 inhibits M. tuberculosis thymidylate kinase with IC50 of 29 μM, promising for TB research.Formula:C23H25N3O3Colore e forma:SolidPeso molecolare:391.46FINDY
CAS:FINDY selectively inhibits DYRK1A at 35 μM IC50, blocking Ser97 autophosphorylation, useful for neurological disorder research.Formula:C16H17NO2S2SiColore e forma:SolidPeso molecolare:347.53M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formula:C31H30F3N7O2Purezza:98.95%Colore e forma:SolidPeso molecolare:589.61IS-741 potassium
CAS:IS-741 potassium is a phospholipase A2 inhibitor.Formula:C15H19F3KN3O3SColore e forma:SolidPeso molecolare:417.49IACS-4759
CAS:IACS-4759 is a novel potent and selective MTH1 inhibitor with excellent cell permeability and good metabolic stability in microsomes.Formula:C10H17N3O2Colore e forma:SolidPeso molecolare:211.2610-Formyl-5,8-dideazafolic acid
CAS:10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.Formula:C22H21N5O7Purezza:96.04%Colore e forma:SolidPeso molecolare:467.43Braco-19 trihydrochloride
CAS:BRACO19 3HCl inhibits telomerase, blocking its capping function, and prevents HAdV viral replication.Formula:C35H46Cl3N7O2Purezza:98.74%Colore e forma:SolidPeso molecolare:703.14Sibrafiban
CAS:Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Formula:C20H28N4O6Colore e forma:SolidPeso molecolare:420.46MMV688844
CAS:MMV688844 inhibits M. abscessus DNA cyclooxygenase (IC50: 2μM) and has MIC50 of 12μM on strain bamboo; useful in antimicrobial studies.Formula:C23H25ClN4O2Colore e forma:SolidPeso molecolare:424.92CFI-400936
CAS:CFI-400936: potent TTK inhibitor (IC50=3.6nM), potential anticancer, active in cell assays, selective vs. human kinases.Formula:C25H27N5O3SColore e forma:SolidPeso molecolare:477.58CB 3717
CAS:CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.Formula:C24H23N5O6Colore e forma:SolidPeso molecolare:477.47LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Formula:C23H23N7O2SColore e forma:SolidPeso molecolare:461.54ST7612AA1
CAS:<p>ST7612AA1: potent, oral HDAC inhibitor; reactivates HIV-1 latency; shows antitumor effects; may study malaria.</p>Formula:C20H27N3O4SPurezza:99.71%Colore e forma:SolidPeso molecolare:405.51HBV-IN-15
CAS:HBV-IN-15, a flavone derivative, is a potent cccDNA inhibitor, potentially aiding HBV research.Formula:C24H23ClO6Colore e forma:SolidPeso molecolare:442.89BMH-23
CAS:BMH-23 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types.Formula:C15H15N3Purezza:98%Colore e forma:SolidPeso molecolare:237.3Antitumor agent-85
Antitumor agent-85 stabilizes G4-DNA with potent anti-tumor effects.Formula:C24H33N7Colore e forma:SolidPeso molecolare:419.57VE-465
CAS:VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formula:C22H28N8OSColore e forma:SolidPeso molecolare:452.58IS-741 calcium
CAS:IS-741 calcium is a phospholipase A2 inhibitor.Formula:C30H38CaF6N6O6S2Colore e forma:SolidPeso molecolare:796.86PD-1-IN-22
CAS:PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).Formula:C25H25N5O4Purezza:99.51%Colore e forma:SolidPeso molecolare:459.52'-Deoxy-L-guanosine
CAS:2'-Deoxy-L-guanosine is a nucleoside that shows antibiotic properties by inhibiting protein synthesis, leading to cell death.Formula:C10H13N5O4Colore e forma:SolidPeso molecolare:267.24CDK7-IN-8
CAS:CDK7-IN-8 is a potent inhibitor of CDK7 (IC50: 54.29 nM) and exhibits inhibitory activity against several cancer cells and in vivo tumor models.Formula:C25H38N8O3Colore e forma:SolidPeso molecolare:498.62Chlorozotocin
CAS:Chlorozotocin is a nitrosourea. It is used for cancer therapy.Formula:C9H16ClN3O7Colore e forma:SolidPeso molecolare:313.69HR22C16
CAS:HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.Formula:C23H23N3O3Colore e forma:SolidPeso molecolare:389.45SP-471P
CAS:SP-471P inhibits DENV protease; EC50: DENV1-5.9 μM, DENV2-1.4 μM, DENV3-5.1 μM, DENV4-1.7 μM; CC50 >100 μM; lowers viral RNA synthesis.Formula:C33H26BrN5O2Colore e forma:SolidPeso molecolare:604.5Mps1-IN-4
CAS:Mps1-IN-4 is a compound that selectively inhibits Monopolar spindle 1 (Mps1), exhibiting antiproliferative properties useful in cancer research.Formula:C26H31F3N6O2Colore e forma:SolidPeso molecolare:516.56Metralindole HCl
CAS:Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.Formula:C15H18ClN3OPurezza:98%Colore e forma:SolidPeso molecolare:291.78XL-188
CAS:XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Formula:C32H42N6O4Colore e forma:SolidPeso molecolare:574.71IDD388
CAS:IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.Formula:C16H12BrClFNO4Purezza:99.56%Colore e forma:SolidPeso molecolare:416.63Crisnatol
CAS:Crisnatol (BWA770U) is an oral anticancer DNA intercalator, toxic to breast cancer cells, not skin fibroblasts.Formula:C23H23NO2Colore e forma:SolidPeso molecolare:345.43BDM44768
CAS:BDM44768 is an insulin-degrading enzyme (IDE) inhibitor that acts by inducing glucose intolerance.Formula:C24H22FN5O3Colore e forma:SolidPeso molecolare:447.4614α-Demethylase/DNA Gyrase-IN-2
CAS:14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.Formula:C24H22N4O4Colore e forma:SolidPeso molecolare:430.46NSC 109555 ditosylate
CAS:Chk2 inhibitor,ATP-competitiveFormula:C26H32N10O4SPurezza:98%Colore e forma:SolidPeso molecolare:580.66HHL-6
CAS:HHL-6 is a c-Fos and BDNF protein expression modulator.Formula:C19H26N2O3Colore e forma:SolidPeso molecolare:330.42Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Formula:C9H16N2O6Purezza:98%Colore e forma:SolidPeso molecolare:248.23Indirubin-5-sulfonate
CAS:Indirubin-5-sulfonate inhibits GSK-3β & CDKs with IC50: 55/35/150/300/65 nM for CDK1/B, 2/A&E, 4/D1, 5/p35.Formula:C16H10N2O5SPurezza:98%Colore e forma:SolidPeso molecolare:342.33Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Formula:C13H15N5OSColore e forma:SolidPeso molecolare:289.36Mps-BAY2b
CAS:Mps-BAY2b is a novel MPS1 inhibitor.Formula:C20H23N5OColore e forma:SolidPeso molecolare:349.43Werner syndrome RecQ helicase-IN-3
CAS:Potent WRN inhibitor, Werner syndrome RecQ helicase-IN-3, is orally active with 0.06 µM IC50; exhibits antiproliferative and anticancer effects.Formula:C31H30ClF3N8O5Colore e forma:SolidPeso molecolare:687.07Crisnatol mesylate
CAS:Crisnatol, a potent and selective DNA intercalator, has potential anticancer activity.Formula:C24H27NO5SColore e forma:SolidPeso molecolare:441.54CDK7-IN-12
CAS:CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.Formula:C20H19F3N6Colore e forma:SolidPeso molecolare:400.4Picoplatin
CAS:Picoplatin, an anti-cancer agent overcoming platinum resistance, alkylates DNA to block replication, transcription, and induce apoptosis.Formula:C6H10Cl2N2PtPurezza:98%Colore e forma:SolidPeso molecolare:376.14HBV-IN-16
CAS:HBV-IN-16, a quinoline derivative, inhibits HBV cccDNA, key for viral replication (from patent WO2019121357A1).Formula:C22H20ClNO4Colore e forma:SolidPeso molecolare:397.85CDK4/6-IN-9
CAS:CDK4/6-IN-9 selectively inhibits CDK4/6 (IC50: 905 nM); potential for MM research.Formula:C22H23FN8Colore e forma:SolidPeso molecolare:418.47DAP-81
CAS:DAP-81, a diaminopyrimidine, inhibits Plk1 (IC50: 0.9 nM), disrupts microtubules, causes monopolar spindles; in preclinical studies.Formula:C25H20N6O4Colore e forma:SolidPeso molecolare:468.46
