Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"
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CK0106023
CAS:CK0106023, a KSP inhibitor, shows strong antitumor effects in mice, outperforming paclitaxel, and induces monopolar spindles.Formula:C30H32BrClN4O2Colore e forma:SolidPeso molecolare:595.96(S)-CR8
CAS:(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.Formula:C24H29N7OColore e forma:SolidPeso molecolare:431.53DHODH-IN-13
CAS:<p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>Formula:C10H6F3N3O3Purezza:99.66%Colore e forma:SolidPeso molecolare:273.17OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formula:C13H14N4O3SColore e forma:SolidPeso molecolare:306.34Teloxantrone HCl
CAS:Teloxantrone, a DNA topoisomerase II inhibitor, is used potentially for the treatment of solid tumors.Formula:C21H28ClN5O5Colore e forma:SolidPeso molecolare:465.94Nexinhib20
CAS:Nexinhib20 is an inhibitor of exosome synthesis and transport with anti-inflammatory activity, inhibits RAB27A and neutral sphingomyelinase 2 (nSMase2) nsMase2.Formula:C15H16N4O3Purezza:99.89%Colore e forma:SolidPeso molecolare:300.31Aminopterin sodium
CAS:Aminopterin sodium is an immunosuppressive anticancer drug, blocking folate synthesis by inhibiting dihydrofolate reductase.Formula:C19H20N8NaO5Colore e forma:SolidPeso molecolare:463.41SMAPP1
CAS:SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.Formula:C27H25N5O5S2Purezza:98%Colore e forma:SolidPeso molecolare:563.6510-Deazaaminopterin
CAS:10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.Formula:C20H21N7O5Colore e forma:SolidPeso molecolare:439.42D-Xylofuranose, 1,2,3,5-tetraacetate
CAS:1,2,3,5-Tetra-O-acetyl-D-xylofuranose is a starting material for the synthesis of nucleosides.Formula:C13H18O9Colore e forma:SolidPeso molecolare:318.28CLK1/2-IN-3
CAS:CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.Formula:C21H21N5O2Purezza:99.04%Colore e forma:SolidPeso molecolare:375.42Yoshi-864
CAS:Yoshi-864, an alkyl sulfonate, alkylates DNA to hinder replication; potential anti-cancer agent.Formula:C8H20ClNO6S2Colore e forma:SolidPeso molecolare:325.83DDD100097
CAS:DDD100097 is a N-myristoyltransferase inhibitor with potential inhibitory effects on Trypanosoma brucei, which can be used to study neurological disorders.Formula:C22H30Cl2F2N4O2SPurezza:98.89%Colore e forma:SolidPeso molecolare:523.47IRE1α kinase-IN-3
CAS:IRE1α kinase-IN-3 is a potent, ATP-competitive inhibitor of IRE1α (Ki: 480 nM).Formula:C29H32N6O3SColore e forma:SolidPeso molecolare:544.67CDK7-IN-16
CAS:CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.Formula:C19H21F3N6O2SColore e forma:SolidPeso molecolare:454.47CDK12-IN-E9
CAS:CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Formula:C24H30N6O2Colore e forma:SolidPeso molecolare:434.53A 65281
CAS:A 65281: antibacterial isothiazoloquinolone, inhibits P4-unknotting, induces DNA breakage via topoisomerase II.Formula:C17H16F2N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:378.4PD-1/PD-L1-IN-NP19
CAS:PD-1/PD-L1-IN-NP19: a PD-1/PD-L1 inhibitor with 12.5 nM IC50, may boost antitumor immunity.Formula:C33H31ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:555.06AS2863619 free base
CAS:AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Formula:C16H12N8OColore e forma:SolidPeso molecolare:332.32Cdc7-IN-4
CAS:Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.Formula:C22H24F3N5O4Purezza:98%Colore e forma:SolidPeso molecolare:479.45SLK/STK10-IN-1
CAS:SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.Formula:C17H13ClN2O3Purezza:99.34%Colore e forma:SolidPeso molecolare:328.75Valategrast
CAS:Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.Formula:C30H32Cl3N3O4Purezza:98%Colore e forma:SolidPeso molecolare:604.95Capzimin
CAS:<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Formula:C30H24N6O2S4Purezza:98.31% - 99.32%Colore e forma:SolidPeso molecolare:628.81Eg5 Inhibitor V, trans-24
CAS:Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formula:C26H21N3O3Purezza:99.75%Colore e forma:SolidPeso molecolare:423.46(E/Z)-BIO-acetoxime
CAS:(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.Formula:C18H12BrN3O3Colore e forma:SolidPeso molecolare:398.21Zaurategrast ethyl ester
CAS:Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.Formula:C28H29BrN4O3Purezza:98%Colore e forma:SolidPeso molecolare:549.46AS-136A
CAS:AS-136A is an orally active MV RdRp inhibitor with antiviral activity that inhibits measles virus and blocks viral RNA synthesis.Formula:C17H19F3N4O3SPurezza:98.52%Colore e forma:SolidPeso molecolare:416.42BRD9185
CAS:BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.Formula:C23H21F6N3O2Purezza:98%Colore e forma:SolidPeso molecolare:485.42hDHODH-IN-5
CAS:hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).Formula:C21H21F3N2O2Purezza:99.55%Colore e forma:SolidPeso molecolare:390.4R-82913
CAS:R-82913 blocks RNA-polymerase, lowers mouse DOI-head-shakes, halts 13 HIV-1 strains with 0.15µM IC50, beats AZT-TP by 20x; ineffective on HIV-2.Formula:C16H20ClN3SColore e forma:SolidPeso molecolare:321.87UCK2 Inhibitor-1
CAS:UCK2 Inhibitor-1 is a non-competitive UCK2 inhibitor with an IC 50 of 4.7 µM .Formula:C27H21N3O4SColore e forma:SolidPeso molecolare:483.54RTC14
CAS:RTC14 induces PTC readthrough, restoring dystrophin and aiding muscle function in Duchenne model mice.Formula:C17H18N2O3Colore e forma:SolidPeso molecolare:298.34Epiroprim
CAS:Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus and Streptococcus.Formula:C19H23N5O2Purezza:99.68% - >99.99%Colore e forma:SolidPeso molecolare:353.4212(S)-HpETE
CAS:12(S)-HpETE activates human blood leukocyte 5-LOE and mediates induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction.Formula:C20H32O4Colore e forma:SolidPeso molecolare:336.47CCT068127
CAS:CCT068127 is a potent CDK2 and CDK9 inhibitor.Formula:C19H27N7OColore e forma:SolidPeso molecolare:369.46Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formula:C27H27F2N7O5S2Purezza:98.71%Colore e forma:SolidPeso molecolare:631.67β-catenin-IN-3
CAS:β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFormula:C19H20Br2N2OSColore e forma:SolidPeso molecolare:484.25DHODH-IN-1
CAS:<p>DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.</p>Formula:C21H20F3N3O2Purezza:99.76%Colore e forma:SolidPeso molecolare:403.4Aurora A/PKC-IN-1
CAS:Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Formula:C16H14N6OSe2Colore e forma:SolidPeso molecolare:464.24CDK5 inhibitor 20-223
CAS:CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Formula:C19H19N3OColore e forma:SolidPeso molecolare:305.37NSC666715
CAS:NSC666715 is the strand-displacement activity of DNA polymerase inhibitor.Formula:C15H13Cl2N5O2S2Purezza:98%Colore e forma:SolidPeso molecolare:430.33L 888607 Racemate
CAS:L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Formula:C19H15ClFNO2SColore e forma:SolidPeso molecolare:375.84WNK1-IN-1
CAS:WNK1-IN-1, a WNK1 inhibitor (IC50: 1.6 μM), also inhibits OSR1 phosphorylation (IC50: 4.3 μM), used in blood pressure and cancer research.Formula:C13H15BrCl2N2O4SPurezza:98.09%Colore e forma:SolidPeso molecolare:446.14Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formula:C25H22ClFN6O2SPurezza:98.45%Colore e forma:SolidPeso molecolare:525CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Formula:C16H16F3N7OColore e forma:SolidPeso molecolare:379.34Photoregulin3
CAS:Photoregulin3 is a inhibitor of rod photoreceptor gene expression, potentially though Nr2e3 modulation.Formula:C22H23N3O3Colore e forma:SolidPeso molecolare:377.44Zaurategrast ethyl ester sulfate
CAS:Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.Formula:C56H60Br2N8O10SPurezza:98%Colore e forma:SolidPeso molecolare:1197.01NSC 693868
CAS:CDKs and GSK-3 inhibitorFormula:C9H7N5Purezza:98%Colore e forma:SolidPeso molecolare:185.19DHODH-IN-4
CAS:DHODH-IN-4 inhibits human & Plasmodium DHODH; IC50: 4 μM (Pf), 0.18 μM (Hs). It has antimalarial properties.Formula:C17H12Cl2N2O2Purezza:99.34%Colore e forma:SolidPeso molecolare:347.2
