Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
Mostrare 10 più sottocategorie
Trovati 3752 prodotti di "Ciclo cellulare/Checkpoint"
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NSC 625987
CAS:Cyclin-dependent kinase (cdk) 4 inhibitorFormula:C15H13NO2SPurezza:98%Colore e forma:SolidPeso molecolare:271.33Dihydro-5-azacytidine acetate
CAS:Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Formula:C10H18N4O7Purezza:98%Colore e forma:SolidPeso molecolare:306.27TDRL-551
CAS:TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 µM) with potential anticancer activity.TDRL-551 inhibits RPA-DNA interaction andFormula:C25H23ClIN3O4Purezza:98.09%Colore e forma:SolidPeso molecolare:591.83BI8622
CAS:BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.Formula:C25H26N6OPurezza:98.28% - 98.28%Colore e forma:SolidPeso molecolare:426.51FAK/aurora kinase-IN-1
CAS:FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].Formula:C23H24ClN7O3Colore e forma:SolidPeso molecolare:481.93TIBI
CAS:TIBI is an ATP-competitive Rio1 inhibitor that acts in a similar manner to fungamycin and enhances the thermal stability of the enzyme.Formula:C7H2I4N2Purezza:>99.99%Colore e forma:SolidPeso molecolare:621.72CDK12-IN-3
CAS:CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Formula:C23H28F2N8OPurezza:99.85%Colore e forma:SolidPeso molecolare:470.52ANI-7
CAS:ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).Formula:C13H8Cl2N2Purezza:99.07%Colore e forma:SolidPeso molecolare:263.12CBL 0100 free base
CAS:CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.Formula:C24H26N2O2Purezza:98.18% - 98.86%Colore e forma:SolidPeso molecolare:374.48CDK9-IN-14
CAS:CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.Formula:C21H23F2N3O4Colore e forma:SolidPeso molecolare:419.42BAY-707 acetate
CAS:BAY-707: potent, selective MTH1 inhibitor with excellent engagement and pharmacokinetics but no anticancer efficacy alone or combined.Formula:C17H24N4O4Colore e forma:SolidPeso molecolare:348.18Piposulfan
CAS:Piposulfan, a water-insoluble alkylating agent, is used as an antineoplastic and anti-tumor agent.Formula:C12H22N2O8S2Colore e forma:SolidPeso molecolare:386.44AZD7762 HCl
CAS:AZD7762 HCl is a checkpoint kinase inhibitor, driving checkpoint abrogation and enhancing DNA-targeted treatment.Formula:C17H20ClFN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:398.88VPC-70619
CAS:VPC-70619: Oral, selective N-Myc inhibitor; blocks cancer growth by hindering N-Myc-Max/DNA binding; well-absorbed.Formula:C16H8ClF3N4OColore e forma:SolidPeso molecolare:364.71KIF18A-IN-3
CAS:KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Formula:C28H38N4O5S2Purezza:98.45%Colore e forma:SolidPeso molecolare:574.76360A iodide
CAS:360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay).Formula:C27H23I2N5O2Purezza:98%Colore e forma:SolidPeso molecolare:703.31Valomaciclovir
CAS:Valomaciclovir is a DNA polymerase inhibitor potentially for treatment of acute herpes zoster and EB virus infection.Formula:C15H24N6O4Colore e forma:SolidPeso molecolare:352.39ROCK2-IN-5
ROCK2-IN-5, a compound blending fasudil, caffeic, and ferulic acids, shows promise for ALS research involving SOD1 mutations.Formula:C23H25N3O5SColore e forma:SolidPeso molecolare:455.53CID 5951923
CAS:CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.Formula:C16H18N2O7SPurezza:99.95%Colore e forma:SolidPeso molecolare:382.39Fozivudine tidoxil
CAS:Fozivudine tidoxil, a reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.Formula:C35H64N5O8PSColore e forma:SolidPeso molecolare:745.95BAP1-IN-1
CAS:BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Formula:C18H16N2O2Purezza:98.11%Colore e forma:SolidPeso molecolare:292.33BAY-958
CAS:BAY-958 is a potent and selective inhibitor of PTEFb/CDK9.Formula:C17H16FN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:389.4AnnH31
CAS:AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm theFormula:C15H13N3OPurezza:99.99%Colore e forma:SolidPeso molecolare:251.28Bis-Pro-5FU
CAS:Bis-Pro-5FU enhances oral uptake and safety of 5-FU, an anti-cancer drug for colorectal and pancreatic tumors.Formula:C10H7FN2O2Colore e forma:SolidPeso molecolare:206.17ATB107
CAS:ATB107 is a potent and novel inhibitor of indole-3-glycerol phosphate synthase (IGPS, KD: 3 μM).Formula:C21H28N8Purezza:98%Colore e forma:SolidPeso molecolare:392.5Kif15-IN-1
CAS:Kif15-IN-1 is a Kif15 inhibitor with antiproliferative and potential anticancer activity, which can be used to study gastric cancer.Formula:C20H22N4O5SPurezza:99.39% - 99.39%Colore e forma:SolidPeso molecolare:430.48MSC-1186
CAS:MSC-1186 selectively inhibits SRPKs—IC50: 2.7nM (SRPK1), 81nM (SRPK2), 0.6nM (SRPK3)—for cancer research.Formula:C19H17ClFN7O2SColore e forma:SolidPeso molecolare:461.9Integrin-IN-2
CAS:Integrin-IN-2, an oral αv integrin blocker, enhances αvβ6/3/5/8 affinities with pIC50s: 7.8/8.4/8.4/7.4.Formula:C27H30N4O3Purezza:98%Colore e forma:SolidPeso molecolare:458.55HBV-IN-22
CAS:HBV-IN-22 (Compound LC5f) is an HBV DNA replication inhibitor that acts on both wild-type HBV (IC50: 0.71 μM) and drug-resistant HBV (IC50: 0.84 μM).Formula:C26H29N3O2S2Colore e forma:SolidPeso molecolare:479.66Laflunimus
CAS:Laflunimus (HR325) is a DHODH inhibitor that inhibits immunoglobulin secretion in vitro and in vivo,by interfering with pyrimidine metabolism,neuralgia.Formula:C15H13F3N2O2Purezza:99.86%Colore e forma:SolidPeso molecolare:310.27Trimetrexate
CAS:Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.Formula:C19H23N5O3Purezza:98%Colore e forma:SolidPeso molecolare:369.42Mycro2
CAS:Mycro2 is an inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max.Formula:C17H11F3N4OS2Colore e forma:SolidPeso molecolare:408.42Nitracrine dihydrochloride
CAS:Nitracrine dihydrochloride is an acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.Formula:C18H22Cl2N4O2Colore e forma:SolidPeso molecolare:397.3TCS 2312
CAS:checkpoint kinase 1 (chk1) inhibitorFormula:C25H24N4O2Purezza:98%Colore e forma:SolidPeso molecolare:412.48Antitumor agent-84
Antitumor agent-84 stabilizes G-quadruplex DNA, exhibits potent anti-tumor effects.Formula:C24H31N7Colore e forma:SolidPeso molecolare:417.55Atuveciclib S-Enantiomer
CAS:<p>Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.</p>Formula:C18H18FN5O2SPurezza:98%Colore e forma:SolidPeso molecolare:387.43CDK8-IN-10
CAS:CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.Formula:C25H15ClF3N5O3Colore e forma:SolidPeso molecolare:525.87BMVC
CAS:BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities.Formula:C28H25I2N3Colore e forma:SolidPeso molecolare:657.33Metralindole
CAS:Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).Formula:C15H17N3OColore e forma:SolidPeso molecolare:255.32DHFR-IN-5
CAS:<p>DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.</p>Formula:C18H24N4O4Colore e forma:SolidPeso molecolare:360.41αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Formula:C28H35F3N6O8SPurezza:98%Colore e forma:SolidPeso molecolare:672.67Nucleoside-Analog-2
CAS:Nucleoside-Analog-2 is a 4'-Azidocytidine analogue, used to against Hepatitis C virus (HCV) replication.Formula:C9H11N5O6Purezza:98%Colore e forma:SolidPeso molecolare:285.21Phen-DC3
CAS:Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases (IC50s of 65±6 and 50±10 nM, respectively).Formula:C34H26N6O2Purezza:98%Colore e forma:SolidPeso molecolare:550.61A 65282
CAS:A 65282: antibacterial isothiazoloquinolone, inhibits P4-unknotting, causes DNA breaks via topoisomerase II.Formula:C17H16F2N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:378.4hDHODH-IN-3
CAS:hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.Formula:C18H19BrN4O2Purezza:99.871%Colore e forma:SolidPeso molecolare:403.27RP-106
CAS:RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.Formula:C17H19N3OPurezza:98%Colore e forma:SolidPeso molecolare:281.35OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formula:C13H14N4O3SColore e forma:SolidPeso molecolare:306.34THZ1-R
CAS:THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.Formula:C31H30ClN7O2Purezza:98%Colore e forma:SolidPeso molecolare:568.07DHODH-IN-24
CAS:DHODH-IN-24 (compound 16) serves as a powerful inhibitor of human dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value of 91 nM [1].Formula:C26H26N4Colore e forma:SolidPeso molecolare:394.51Pyrazofurin
CAS:Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).Formula:C9H13N3O6Purezza:98%Colore e forma:SolidPeso molecolare:259.22
