Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(526 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(179 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
Mostrare 10 più sottocategorie
Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"
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12(S)-HpETE
CAS:12(S)-HpETE activates human blood leukocyte 5-LOE and mediates induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction.Formula:C20H32O4Colore e forma:SolidPeso molecolare:336.47AS2863619 free base
CAS:AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Formula:C16H12N8OColore e forma:SolidPeso molecolare:332.32BMVC2
CAS:BMVC2 (o-BMVC), a carbazole derivative of BMVC, is a G-quadruplex (G4) stabilizer.Formula:C28H25I2N3Colore e forma:SolidPeso molecolare:657.33CDK8-IN-10
CAS:CDK8-IN-10 is a selective and potent inhibitor of cell cycle protein-dependent kinase (CDK8) (IC50: 8.25 nM) that can be used to study cancer.Formula:C25H15ClF3N5O3Colore e forma:SolidPeso molecolare:525.87β-catenin-IN-3
CAS:β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFormula:C19H20Br2N2OSColore e forma:SolidPeso molecolare:484.25Dihydro-5-azacytidine acetate
CAS:Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Formula:C10H18N4O7Purezza:98%Colore e forma:SolidPeso molecolare:306.27IRE1α kinase-IN-8
CAS:IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α.Formula:C23H22N2O5Purezza:98%Colore e forma:SolidPeso molecolare:406.43Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formula:C27H27F2N7O5S2Purezza:98.71%Colore e forma:SolidPeso molecolare:631.67Thiarabine
CAS:Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Formula:C9H13N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:259.28IRE1α kinase-IN-9
CAS:IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM.Formula:C24H24N2O6Purezza:98%Colore e forma:SolidPeso molecolare:436.46GP29
CAS:GP29 is a Type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Formula:C33H28F3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:599.6Litronesib Racemate
CAS:Litronesib is a selective, allosteric inhibitor of kinesin Eg5.Litronesib (Racemate) is the racemate of litronesib.Formula:C23H37N5O4S2Colore e forma:SolidPeso molecolare:511.7M443
CAS:M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formula:C31H30F3N7O2Purezza:98.95%Colore e forma:SolidPeso molecolare:589.61KH-CB19
CAS:KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).Formula:C15H13Cl2N3O2Colore e forma:SolidPeso molecolare:338.19CDK8-IN-6
CAS:CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.Formula:C26H37ClN2Colore e forma:SolidPeso molecolare:413.04Ipivivint
CAS:<p>Ipivivint: orally active, potent CLK inhibitor; hinders CLK1, CLK2, & CLK3; curbs Wnt signaling & SRSF phosphorylation for cancer research.</p>Formula:C26H21FN8Colore e forma:SolidPeso molecolare:464.5LY 222306
CAS:LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.Formula:C19H23N5O7Purezza:98%Colore e forma:SolidPeso molecolare:433.42CCT245737(S)
CAS:CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.Formula:C16H16F3N7OColore e forma:SolidPeso molecolare:379.34Photoregulin3
CAS:Photoregulin3 is a inhibitor of rod photoreceptor gene expression, potentially though Nr2e3 modulation.Formula:C22H23N3O3Colore e forma:SolidPeso molecolare:377.44L 888607 Racemate
CAS:L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Formula:C19H15ClFNO2SColore e forma:SolidPeso molecolare:375.84Enocitabine
CAS:Enocitabine is a nucleoside analog.Formula:C31H55N3O6Purezza:97.22%Colore e forma:SolidPeso molecolare:565.78BI8622
CAS:BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.Formula:C25H26N6OPurezza:98.28% - 98.28%Colore e forma:SolidPeso molecolare:426.51DHODH-IN-4
CAS:DHODH-IN-4 inhibits human & Plasmodium DHODH; IC50: 4 μM (Pf), 0.18 μM (Hs). It has antimalarial properties.Formula:C17H12Cl2N2O2Purezza:99.34%Colore e forma:SolidPeso molecolare:347.2Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formula:C25H22ClFN6O2SPurezza:98.45%Colore e forma:SolidPeso molecolare:525CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Formula:C18H18N4O2Purezza:97.07%Colore e forma:SolidPeso molecolare:322.36SPC-839
CAS:<p>SPC-839 is an IKK-2 Inhibitor with oral activity.</p>Formula:C18H14N4O3SColore e forma:SolidPeso molecolare:366.39Levofloxacin sodium
CAS:Levofloxacin sodium: synthetic antibacterial, stops DNA replication by inhibiting bacterial DNA gyrase.Formula:C18H20FN3NaO4Purezza:98%Colore e forma:SolidPeso molecolare:384.363HIV-1 inhibitor-43
CAS:<p>HIV-1 Inhibitor-43 suppresses HIV-1, with EC50: 21.3 nM (Y188L), 6.2 nM (K103N-Y181C), <0.7 nM (K103N/Y181C), and lowers HIV RNA/p24 protein.</p>Formula:C24H21ClN2O4SColore e forma:SolidPeso molecolare:468.95Antibacterial agent 89
CAS:Antibacterial agent 89 blocks bacterial transcription and clostridial cytotoxins, inhibiting β'CH-σ interactions.Formula:C21H10Cl2F3NO5SColore e forma:SolidPeso molecolare:516.27HBV-IN-14
CAS:HBV-IN-14: a pyridinopyrimidinone, potent cccDNA inhibitor for HBV study (patent WO2021190502A1, comp 5).Formula:C22H21ClN2O5Colore e forma:SolidPeso molecolare:428.87Tripolin A
CAS:<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Formula:C15H11NO3Purezza:98%Colore e forma:SolidPeso molecolare:253.25P1788
CAS:P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].Formula:C15H17NO3Colore e forma:SolidPeso molecolare:259.3(Rac)-Managlinat dialanetil
CAS:<p>Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.</p>Formula:C21H33N4O6PSPurezza:98.52%Colore e forma:SolidPeso molecolare:500.55DHODH-IN-12
CAS:DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.Formula:C10H9N3O2Purezza:99.53%Colore e forma:SolidPeso molecolare:203.25-OHdU
CAS:<p>5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.</p>Formula:C9H12N2O6Purezza:99.5%Colore e forma:SolidPeso molecolare:244.2CGP 53353
CAS:CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.Formula:C20H13F2N3O2Purezza:98.11%Colore e forma:SolidPeso molecolare:365.335-Ethynyluridine
CAS:5-Ethynyluridine marks new RNA for RICK, capturing proteins on various RNAs, even nonpolyadenylated types.Formula:C11H12N2O6Purezza:99.78%Colore e forma:SolidPeso molecolare:268.22DENV-IN-7
CAS:DENV-IN-7, a flavone analog, inhibits dengue virus at 70 nM EC50 with low toxicity to normal cells.Formula:C24H22O8Colore e forma:SolidPeso molecolare:438.43JFN05510
CAS:Compound: 3'-O-tert-BDMS-5'-O-DMT-N2-IBG 2'-CE phosphoramidite; has anticancer properties and activates enzymes.Formula:C50H68N7O9PSiColore e forma:SolidPeso molecolare:970.185,10-Dideazaaminopterin
CAS:5,10-Dideazaaminopterin is an antileukemic drug.Formula:C21H22N6O5Purezza:98%Colore e forma:SolidPeso molecolare:438.44BSJ-01-175
CAS:BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.Formula:C30H33ClN6O2Colore e forma:SolidPeso molecolare:545.082-Fluoroadenine
CAS:<p>2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.</p>Formula:C5H4FN5Purezza:98.84% - 99.62%Colore e forma:White To Light Yellow Crystal PowderPeso molecolare:153.12DNA Gyrase-IN-5
CAS:DNA Gyrase-IN-5 is a potent inhibitor of DNA gyrase (IC50: 0.10 μM) and has an antibacterial effect on both wild-type and drug-resistant strains.Formula:C25H15BrClN5Colore e forma:SolidPeso molecolare:500.78BMS-688521
CAS:BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Formula:C26H19Cl2N5O4Purezza:98.87%Colore e forma:SolidPeso molecolare:536.37Fosteabine
CAS:Fosteabine is an oral and prodrug analog of cytarabine. It is resistant to deoxycytidine deaminase.Formula:C27H50N3O8PPurezza:98%Colore e forma:SolidPeso molecolare:575.67Syntelin
CAS:Syntelin: a selective CENP-E inhibitor with an IC50 of 160 nM; distinct from GSK923295, effective on resistant mutants.Formula:C21H20N6O2S3Colore e forma:SolidPeso molecolare:484.62OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formula:C13H14N4O3SColore e forma:SolidPeso molecolare:306.34MK-0668
CAS:MK-0668 is a very potent and orally active very late antigen-4 antagonist.Formula:C31H30Cl2N6O6SColore e forma:SolidPeso molecolare:685.58Zalunfiban
CAS:RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.Formula:C16H18N8O2SColore e forma:SolidPeso molecolare:386.43
