Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(526 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(179 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
Mostrare 10 più sottocategorie
Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"
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CDK1-IN-1
CAS:CDK1-IN-7 inhibits CDK1 at 161.2 nM, triggers p53-dependent apoptosis, and selectively targets tumor growth.Formula:C27H23N5O3Colore e forma:SolidPeso molecolare:465.5FLDP-5
CAS:FLDP-5: BBB-penetrant curcuminoid, induces ROS, DNA damage, S phase arrest, suppresses tumors in LN-18 cells.Formula:C21H21NO5Colore e forma:SolidPeso molecolare:367.4Cdc7-IN-15
CAS:Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Formula:C12H14N4OSColore e forma:SolidPeso molecolare:262.33CDK7-IN-2
CAS:CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Formula:C26H39N7O3Colore e forma:SolidPeso molecolare:497.63MLAF50
CAS:MLAF50 is an inhibitor of the REV1 UBM2-Ubiquitin interaction.Formula:C15H12I2O4Colore e forma:SolidPeso molecolare:510.06BOP sodium
CAS:BOP sodium salt is an inhibitor of alpha9beta1 and alpha4beta1 integrin.Formula:C25H29N3NaO7SColore e forma:SolidPeso molecolare:538.57GSK317354A
CAS:GSK317354A is a GRK2 inhibitor.Formula:C25H18F4N6OColore e forma:SolidPeso molecolare:494.443,6-DMAD dihydrochloride
CAS:3,6-DMAD dihydrochloride: Potent IRE1α-XBP1s inhibitor, affects IL-6 secretion and RNase activity, used in cancer research.Formula:C22H33Cl2N5Colore e forma:SolidPeso molecolare:438.44CB10-277
CAS:CB10-277 is a synthetic anti-cancer drug related to dacarbazine that alkylates DNA, inhibits DNA replication and repair, and may block DNA synthesis.Formula:C9H11N3O2Colore e forma:SolidPeso molecolare:193.2SRPIN-803
CAS:SRPIN-803 is a selective dual SRPK1 and CK2 inhibitor.Formula:C14H9F3N4O3SPurezza:98%Colore e forma:SolidPeso molecolare:370.31Remdesivir maleate
CAS:Remdesivir (GS-5734) is a broad-spectrum antiviral prodrug effective against SARS-CoV-2 and Ebola, used for research, not human treatment.Formula:C31H39N6O12PColore e forma:SolidPeso molecolare:718.656JTK-101
CAS:JTK-101 is a potent and selective Tat-dependent HIV-1 replication inhibitor.Formula:C25H23N3O3Colore e forma:SolidPeso molecolare:413.47Olomoucine II
CAS:Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Formula:C19H26N6O2Purezza:99.94%Colore e forma:SolidPeso molecolare:370.45Pyrazofurin
CAS:Pyrazofurin, a pyrimidine analogue, blocks cell growth and DNA synthesis by targeting UMP synthase & orotate-phosphoribosyltransferase (IC50: 0.06-0.37 μM).Formula:C9H13N3O6Purezza:98%Colore e forma:SolidPeso molecolare:259.22IPR-803
CAS:IPR-803 is an effective inhibitor of the uPAR·uPA protein-protein interaction (PPI) with anti-tumor activity.Formula:C27H23N3O4Purezza:95%Colore e forma:SolidPeso molecolare:453.49LDN-209929 dihydrochloride
CAS:LDN-209929 dihydrochloride: potent haspin kinase inhibitor, 55 nM IC50, 180x more selective than DYRK2.Formula:C17H19Cl3N2OSColore e forma:SolidPeso molecolare:405.77MK-0668 Mesylate
CAS:MK-0668 Mesylate is the mesylate form of MK-0668 that is a very potent and orally active very late antigen-4 antagonist.Formula:C32H34Cl2N6O9S2Colore e forma:SolidPeso molecolare:781.68Edatrexate
CAS:Edatrexate (CGP 30694), a Methotrexate analog, combats MTX-resistant tumors and researches various cancers.Formula:C22H25N7O5Colore e forma:SolidPeso molecolare:467.48HBV-IN-21
CAS:HBV-IN-21 inhibits HBV DNA replication (IC50: 2.2 μM) and binds HBV capsid protein well (KD: 60.0 μM).Formula:C17H17FN4OS2Colore e forma:SolidPeso molecolare:376.47Laromustine
CAS:Laromustine (VNP40101M) is a sulfonyl hydrolysis alkylation prodrug for cancer treatment with significant anticancer activity, inhibiting thioredoxin reductase.Formula:C6H14ClN3O5S2Purezza:≥98%Colore e forma:SolidPeso molecolare:307.78SC-203885
CAS:<p>SC-203885 is a checkpoint kinase 2 inhibitor.</p>Formula:C15H13N5O2Purezza:98%Colore e forma:SolidPeso molecolare:295.3CFI-400437
CAS:CFI-400437 is an ATP-competitive PLK4 inhibitor (IC50: 0.6 nM) and is an indolequinone derivative.Formula:C29H28N6O2Colore e forma:SolidPeso molecolare:492.57CDK4/6-IN-7
CAS:CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.Formula:C18H18ClN5O3Colore e forma:SolidPeso molecolare:387.82Aurora Kinases-IN-3
CAS:Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Formula:C20H16F3N3O4Colore e forma:SolidPeso molecolare:419.35CAY10760
CAS:CAY10760 inhibits RAD51-BRCA2 interaction (EC50=19 μM), reduces homologous recombination by 54%, and hinders BxPC-3/Capan-1 cancer cell proliferation.Formula:C28H24ClN3O3Colore e forma:SolidPeso molecolare:485.96SLM6
CAS:SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.Formula:C12H17N7O4Colore e forma:SolidPeso molecolare:323.31POLA1 inhibitor 1
CAS:POLA1 inhibitor 1: oral, antitumor, effective on various cancers and Adaroten-resistant cells.Formula:C26H27NO4Colore e forma:SolidPeso molecolare:417.5DHODH-IN-19
CAS:DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)Formula:C22H18ClF6N3O3Colore e forma:SolidPeso molecolare:521.84Akt1&PKA-IN-1
CAS:Akt1&PKA-IN-1 inhibits Akt/PKA: IC50 = 0.03μM (PKAa), 0.11μM (Akt), 9.8μM (CDK2); selective for CDK2.Formula:C20H17Cl2N3OColore e forma:SolidPeso molecolare:386.27Cdc7-IN-1
CAS:Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Formula:C21H16ClN3O4Colore e forma:SolidPeso molecolare:409.82TH470
CAS:TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Formula:C30H31N5O5S2Colore e forma:SolidPeso molecolare:605.73cp028
CAS:cp028 inhibits pre-mRNA splicing in vitro.Formula:C23H17FN2O4Colore e forma:SolidPeso molecolare:404.39SR7826
CAS:SR7826 is a selective LIMK inhibitor.Formula:C22H21N5O2Purezza:98%Colore e forma:SolidPeso molecolare:387.43CRT-0105446
CAS:CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formula:C20H18F3N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:421.4410-Formylfolic acid
CAS:10-Formylfolic acid is a novel and potent inhibitor of dihydrofolate reductase, which can be used in leukemia research.Formula:C20H19N7O7Purezza:99.97%Colore e forma:SolidPeso molecolare:469.41SMN-C2
CAS:SMN-C2, a SMN2 gene splicing regulator, is an RNA-binding ligand that regulates pre-mRNA splicing and has potential for studying spinal muscular atrophy.Formula:C24H27N5O2Purezza:99.14%Colore e forma:SolidPeso molecolare:417.5Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Formula:C16H15NO3Purezza:99.67%Colore e forma:SolidPeso molecolare:269.3TTP-8307
CAS:TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses and is used in the study of viral infections.Formula:C27H21FN4OPurezza:98.95%Colore e forma:SolidPeso molecolare:436.48Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFormula:C27H27F2NO6Purezza:99.67%Colore e forma:SolidPeso molecolare:499.5NR2F6 modulator-1
CAS:NR2F6 modulator-1, a potent agent for NR2F6, affects immune response and tumor stem cell activity.Formula:C23H17NO5SPurezza:98.31%Colore e forma:SolidPeso molecolare:419.45CHD1Li 6.11
CAS:CHD1Li 6.11 inhibits CHD1L protein (IC50: 3.3 µM), shrinks CRC tumors in vivo, and is orally active.Formula:C21H22BrN5OSPurezza:99.04%Colore e forma:SolidPeso molecolare:472.4Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Formula:C22H32N4O4Purezza:98.76%Colore e forma:SolidPeso molecolare:416.51Abemaciclib metabolite M20
CAS:Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。Formula:C27H32F2N8OPurezza:98.1% - 99.08%Colore e forma:SolidPeso molecolare:522.59CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Formula:C21H16ClN3OSPurezza:99.78% - 99.86%Colore e forma:SolidPeso molecolare:393.89CDK8-IN-1
CAS:CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Formula:C11H8F3N3OPurezza:98.48%Colore e forma:SolidPeso molecolare:255.2DS18561882
CAS:DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.Formula:C28H31F3N4O6SPurezza:98.19% - >99.99%Colore e forma:SolidPeso molecolare:608.63DIF-3
CAS:DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Formula:C13H17ClO4Purezza:99.57%Colore e forma:SolidPeso molecolare:272.72SB 328437
CAS:SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Formula:C21H18N2O5Purezza:99.54%Colore e forma:SolidPeso molecolare:378.38CDK9-IN-10
CAS:CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.Formula:C22H16O5Purezza:99.8%Colore e forma:SolidPeso molecolare:360.36SJ572403
CAS:SJ572403 inhibits p27 protein, Kd 2.2 mM at D2 subdomain of p27-KID; useful in disordered protein disease research.Formula:C13H17N5O2Purezza:99.93%Colore e forma:SolidPeso molecolare:275.31
