Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(526 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(225 prodotti)
- HSP(179 prodotti)
- Integrina(256 prodotti)
- Chinesina(87 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(283 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(76 prodotti)
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Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"
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WRN inhibitor 5
CAS:WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).Formula:C23H20N2O6SColore e forma:SolidPeso molecolare:452.48LDC3140
CAS:LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).Formula:C23H33N7OPurezza:98%Colore e forma:SolidPeso molecolare:423.55CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFormula:C25H29N5O2SColore e forma:SolidPeso molecolare:463.6KIF18A-IN-7
CAS:KIF18A-IN-7 is an orally active inhibitor targeting KIF18A, demonstrating potent inhibition with an IC50 value of 9.4 nM against the microtubule-dependentFormula:C27H35N3O5S2Colore e forma:SoildPeso molecolare:545.71Zaurategrast
CAS:Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.Formula:C26H25BrN4O3Purezza:98%Colore e forma:SolidPeso molecolare:521.41Cytidine 3'-monophosphate
CAS:Cytidine 3'-monophosphate, a ribonucleotide, results from the hydrolysis of cytidine 2',3'-cyclic monophosphate via RNase—a process that cytidine 3'-monophosphate itself inhibits. Additionally, it can be dephosphorylated to cytidine by 3'-nucleotidase.Formula:C9H14N3O8PColore e forma:SolidPeso molecolare:323.2CCT239065
CAS:CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor.Formula:C29H29N7O3SColore e forma:SolidPeso molecolare:555.65NVS-SM2
CAS:NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.Formula:C23H30N6OColore e forma:SolidPeso molecolare:406.52PLK1/p38γ-IN-1
CAS:<p>PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular</p>Formula:C21H26ClN3O2Purezza:98%Colore e forma:SolidPeso molecolare:387.9SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Formula:C22H24F3N3O4Purezza:98%Colore e forma:SolidPeso molecolare:451.445'-ODMT cEt m5U Phosphoramidite (Amidite)
CAS:<p>5'-ODMT cEt m5U Phosphoramidite Amidite, a locked nucleic acid (LNA) analog, demonstrates exceptional safety and antisense activity [1] [2].</p>Formula:C42H51N4O9PColore e forma:SolidPeso molecolare:786.853-Cyanovinylcarbazole phosphoramidite
CAS:3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.Formula:C50H53N4O6PColore e forma:SolidPeso molecolare:836.955'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
CAS:5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits hybridization and mismatch discrimination capabilities similar to LNA, and shows resistance to exonuclease digestion [1].Formula:C49H54N7O8PColore e forma:SolidPeso molecolare:899.97JNJ-26076713
CAS:JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Formula:C29H38N4O3Purezza:98%Colore e forma:SolidPeso molecolare:490.64Voruciclib hydrochloride
CAS:Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).Formula:C22H20Cl2F3NO5Purezza:98%Colore e forma:SolidPeso molecolare:506.3MOMA-341
CAS:MOMA-341 is a highly selective inhibitor targeting the Werner RecQ-like helicase (WRN). It exerts a dual mechanism of allosteric regulation and ATP competitive inhibition by binding to the cysteine 727 site of the WRN protein. In mouse models with mismatch repair deficiency (dMMR) or high microsatellite instability (MSI-H), MOMA-341 can induce DNA damage, cell apoptosis, and promote tumor shrinkage. This compound exhibits significant anti-tumor activity and has potential application prospects in the study of advanced and metastatic solid tumors.Formula:C28H26F4N6O3Peso molecolare:570.54Cytarabine 5′-monophosphate
CAS:Cytarabine 5′-monophosphate (ara-CMP), an active metabolite of the nucleoside analog cytarabine formed by deoxycytidine kinase, is incorporated into DNA by DNA polymerase α, significantly slowing DNA synthesis. It inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM and improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg.Formula:C9H14N3O8PColore e forma:SolidPeso molecolare:323.1985′-Guanylyl methylenediphosphonate sodium
CAS:5′-Guanylyl methylenediphosphonate (sodium) serves as a GTP analogue and acts as a specific, competitive inhibitor of the GTP reaction in protein synthesis [1].Formula:C11H15N5Na3O13P3Colore e forma:SolidPeso molecolare:587.15Amotosalen free base
CAS:Amotosalen is a Dermatologic Agent.Formula:C17H19NO4Colore e forma:SolidPeso molecolare:301.34GRK2 Inhibitor 2
CAS:GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formula:C19H16N4O2Colore e forma:SolidPeso molecolare:332.36PDD00031705
CAS:PDD00031705 is a benzimidazolone core cell-inactive Poly (ADP-ribose) glycohydrolase (PARG) inhibitor.Formula:C20H22N6O3S3Purezza:98%Colore e forma:SolidPeso molecolare:490.62Pelitrexol
CAS:Pelitrexol (AG2037) is a GARFT inhibitor, which can inhibit the activity of mTORC1, block the cell cycle in the s-phase, with antiproliferative activity,NSCLC .Formula:C20H25N5O6SPurezza:98.03%Colore e forma:SolidPeso molecolare:463.51LX7101 hydrochloride
CAS:LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Formula:C23H29N7O3HClColore e forma:SolidPeso molecolare:488ROCK2-IN-7
CAS:<p>ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis.</p>Formula:C26H28FN5OPurezza:98%Colore e forma:SolidPeso molecolare:445.53DHODH-IN-14
CAS:DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Formula:C15H7F4N3O3Purezza:99.81%Colore e forma:SolidPeso molecolare:353.23GSK2850163
CAS:GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit RNase activity and IRE1α kinase activity (IC50s: 200 and 20 nM).Formula:C24H29Cl2N3OPurezza:99.04%Colore e forma:SolidPeso molecolare:446.41CASK-IN-1
CAS:CASK-IN-1 is a highly potent and selective CASK inhibitor with a K d value of 0.022 μM.Formula:C24H30Br2N6O3Colore e forma:SolidPeso molecolare:610.34TAK 029
CAS:TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Formula:C19H23N5O7Colore e forma:SolidPeso molecolare:433.42DHX9-IN-6
CAS:DHX9-IN-6 is a highly effective ATP-dependent RNA helicase A (DHX9) inhibitor, used in cancer research.Formula:C23H18ClFN4O4S2Purezza:99.71%Colore e forma:SolidPeso molecolare:533AR-13503
CAS:AR-13503, a Netarsudil metabolite, is a ROCK inhibitor, potentially treating glaucoma and lowering eye pressure.Formula:C19H19N3O2Colore e forma:SolidPeso molecolare:321.37Senexin C
CAS:Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formula:C28H27N5OPurezza:98.06%Colore e forma:SolidPeso molecolare:449.55EHT 5372
CAS:EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.Formula:C17H11Cl2N5OSColore e forma:SolidPeso molecolare:404.27GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formula:C19H16N6OPeso molecolare:344.37Anti-hepatic fibrosis agent 2
CAS:Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting theFormula:C26H41N3OColore e forma:SolidPeso molecolare:411.62DHX9-IN-4
CAS:DHX9-IN-4 is an ATP-dependent RNA helicase DHX9 inhibitor used in cancer research.Formula:C21H22ClN5O4S2Purezza:98.12%Colore e forma:SolidPeso molecolare:508.01Mps1-IN-10
CAS:Mps1-IN-6 (Compound 9) is a highly effective Mps1 inhibitor with an IC50 value of 6.4 nM and exhibits significant anti-proliferation and anti-tumor effects onFormula:C24H27N7O2Colore e forma:SolidPeso molecolare:445.52HQ005
CAS:HQ005, a potent CCNK degrader, exhibits an impressive DC50 value of 0.041 µM and functions as a molecular-glue degrader.Formula:C15H15N5O2S2Colore e forma:SolidPeso molecolare:361.44TNH
CAS:TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].Formula:C39H57ClN6O13Colore e forma:SolidPeso molecolare:853.36PD-321852
CAS:PD-321852, a Chk1 inhibitor, boosts gemcitabine's effect in pancreatic cancer cells, varying from minimal in Panc1 to >30-fold in MiaPaCa2.Formula:C24H19Cl2N3O3Colore e forma:SolidPeso molecolare:468.33CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purezza:99%Colore e forma:SolidPeso molecolare:425.93ATN-161
CAS:ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Formula:C23H35N9O8SPurezza:98%Colore e forma:SolidPeso molecolare:597.64Netropsin dihydrochloride
CAS:Netropsin dihydrochloride, a small MGB, blocks topoisomerase I/II, hindering cleavable complex stabilization.Formula:C18H28Cl2N10O3Purezza:98%Colore e forma:SolidPeso molecolare:503.39PTC258
CAS:PTC258 is a specific, orally active modulator of the splicing of the Elongator complex protein 1 gene (ELP1), enhancing its expression both in vitro and in vivoFormula:C16H18ClN3S2Colore e forma:SolidPeso molecolare:351.92Lerociclib
CAS:<p>Lerociclib (G1T38) is a CDK4/6 inhibitor with anticancer and antitumor activities, inhibiting CDK4/CyclinD1 and CDK6/CyclinD3.</p>Formula:C26H34N8OPurezza:99%Colore e forma:SolidPeso molecolare:474.6AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formula:C21H13Cl2N3O2SPurezza:97.05%Colore e forma:SolidPeso molecolare:442.32Bisindolylmaleimide X hydrochloride
CAS:Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).Formula:C26H25ClN4O2Purezza:99.23%Colore e forma:SolidPeso molecolare:460.96Senexin A hydrochloride
CAS:Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].Formula:C17H15ClN4Colore e forma:SolidPeso molecolare:310.78CCG-232964
CAS:CCG-232964 is an orally active Rho/MRTF/SRF inhibitor that suppresses LPA-induced CTGF gene expression [1].Formula:C15H15ClN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:338.81CCT-251921
CAS:CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).Formula:C21H23ClN6OPurezza:99.07%Colore e forma:SolidPeso molecolare:410.9Mefenidil
CAS:Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.Formula:C12H11N3Purezza:98.27%Colore e forma:SolidPeso molecolare:197.24
