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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

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Trovati 3756 prodotti di "Ciclo cellulare/Checkpoint"

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  • Logo CymitQuimica
    Targetmol
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    IRE1α kinase-IN-5

    IRE1α kinase-IN-5 (compound 7) is a potent inhibitor of IRE1α (Ki: 98 nM) and is an ATP-competitive ligand for IRE1α.
    Formula:C28H30N6O3S
    Colore e forma:Solid
    Peso molecolare:530.64

    Ref: TM-T63734

  • RNAP-σ interaction inhibitor-1
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    RNAP-σ interaction inhibitor-1

    CAS:
    RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.
    Formula:C19H11Cl3N2O6S2
    Colore e forma:Solid
    Peso molecolare:533.79

    Ref: TM-T207529

  • 6-N-Hydroxylaminopurine
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    6-N-Hydroxylaminopurine

    CAS:
    6-N-Hydroxylaminopurine is a base analog with mutagenic activity.
    Formula:C5H5N5O
    Peso molecolare:151.13

    Ref: TM-T210412

  • HNC-1664
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    HNC-1664

    CAS:
    HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.
    Formula:C12H13FIN3O3
    Colore e forma:Solid
    Peso molecolare:393.153

    Ref: TM-T205157

  • LIMK1 inhibitor 1
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    LIMK1 inhibitor 1

    CAS:
    LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.
    Formula:C12H15N3S2
    Colore e forma:Solid
    Peso molecolare:265.398

    Ref: TM-T204784

  • PolQi1
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    PolQi1

    CAS:
    PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.
    Formula:C18H14ClF5N4O2
    Purezza:98.97%
    Colore e forma:Solid
    Peso molecolare:448.77

    Ref: TM-T89335

  • LNA-GTP
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    LNA-GTP

    CAS:
    LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.
    Formula:C11H16N5O14P3
    Colore e forma:Solid
    Peso molecolare:535.19

    Ref: TM-TSW-00969

  • DHX9-IN-9
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    DHX9-IN-9

    CAS:
    DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].
    Formula:C21H21ClFN5O3S2
    Colore e forma:Solid
    Peso molecolare:510

    Ref: TM-T86205

  • RNase L ligand 3
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    RNase L ligand 3

    CAS:
    RNase L ligand 3 is an RNase L ligand employed in the synthesis of F3-PEG8-RiboTAC.
    Formula:C27H27N3OS
    Colore e forma:Solid
    Peso molecolare:441.59

    Ref: TM-T210787

  • Uridine 3',5'-diphosphate
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    Uridine 3',5'-diphosphate

    CAS:
    Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].
    Formula:C9H14N2O12P2
    Colore e forma:Solid
    Peso molecolare:404.16

    Ref: TM-T87599

  • BET/Aurora kinase-IN-1
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    BET/Aurora kinase-IN-1

    CAS:
    BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.
    Formula:C25H30FN7O
    Colore e forma:Solid
    Peso molecolare:463.55

    Ref: TM-T205073

  • BRD4 Inhibitor-40
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    BRD4 Inhibitor-40

    CAS:
    BRD4 Inhibitor-40 (Compound 23) functions as an inhibitor of BRD, effectively targeting BRD4-BD1, BRD4-BD2, BRD2-BD1, and BRD2-BD2, with IC50 values of 16.1, 142.18, 29.35, and 302.35 nM, respectively. It modulates the expression of c-Myc and p21, induces cell cycle arrest in the G1 phase, and inhibits Pkd1-deficient (PN) renal cystic epithelial cells. Additionally, it prevents renal cyst formation in both Madin-Darby canine kidney and embryonic kidney cyst models, and demonstrates renal cyst inhibition activity in mouse models.
    Formula:C27H32N8O
    Colore e forma:Solid
    Peso molecolare:484.596

    Ref: TM-T205510

  • DNA Gyrase-IN-16
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    DNA Gyrase-IN-16

    CAS:
    <p>DNA Gyrase-IN-16 (Compound 9) is an inhibitor of DNA gyrase, with an IC50 of 1.609 μM. It exhibits antibacterial properties, effectively inhibiting S. aureus and MRSA, with a MIC of 3.125 μM for both.</p>
    Formula:C17H15N3O3
    Colore e forma:Solid
    Peso molecolare:309.319

    Ref: TM-T205315

  • Logo CymitQuimica
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    CDK1-IN-3

    CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.
    Formula:C28H25ClF3N5O2
    Colore e forma:Solid
    Peso molecolare:555.98

    Ref: TM-T63933

  • CDK2-IN-18
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    CDK2-IN-18

    CAS:
    <p>CDK2-IN-18 (compound 8q) serves as a powerful inhibitor of CDK 2/E and CDK 4/D1, showing IC50 values of 8 nM and 46 nM, respectively. It effectively inhibits tumor cell proliferation [1].</p>
    Formula:C21H23N7O2S
    Colore e forma:Solid
    Peso molecolare:437.52

    Ref: TM-T86027

  • AGH-107
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    AGH-107

    CAS:
    AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.
    Formula:C13H12IN3
    Colore e forma:Solid
    Peso molecolare:337.16

    Ref: TM-T201735

  • KWR095
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    KWR095

    CAS:
    <p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>
    Formula:C33H31ClF3N9O4
    Colore e forma:Solid
    Peso molecolare:710.105

    Ref: TM-T205595

  • PKMYT1-IN-2
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    PKMYT1-IN-2

    CAS:
    PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].
    Formula:C22H19N5O2
    Colore e forma:Solid
    Peso molecolare:385.42

    Ref: TM-T87219

  • DB18
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    DB18

    CAS:
    DB18 serves as a potent, selective inhibitor of CDC2-like kinases (CLKs), exhibiting IC50 values between 10-30 nM for CLK1, CLK2, and CLK4. Additionally, it possesses anti-tumor activity [1].
    Formula:C24H18ClN7O3
    Colore e forma:Solid
    Peso molecolare:487.9

    Ref: TM-T86165

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS:
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Formula:C27H23N3O6
    Colore e forma:Solid
    Peso molecolare:485.49

    Ref: TM-T87635

  • 6K465
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    6K465

    CAS:
    6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.
    Formula:C26H33ClFN9O
    Purezza:99.78%
    Colore e forma:Solid
    Peso molecolare:542.05

    Ref: TM-T85508

  • LY309887
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    LY309887

    CAS:
    LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
    Formula:C19H23N5O6S
    Colore e forma:Solid
    Peso molecolare:449.48

    Ref: TM-T15813

  • L-2'-Fd4C
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    L-2'-Fd4C

    CAS:
    L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].
    Formula:C9H10FN3O3
    Colore e forma:Solid
    Peso molecolare:227.19

    Ref: TM-T60285

  • CDK4/6-IN-24
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    CDK4/6-IN-24

    CAS:
    CDK4/6-IN-24 (Compound A) is an inhibitor of CDK4/6 with broad-spectrum antitumor activity. It can effectively inhibit various cancer cells, exhibiting an IC50 in the submicromolar range.
    Formula:C32H41N7O3
    Colore e forma:Solid
    Peso molecolare:571.713

    Ref: TM-T205628

  • Cdc7-IN-18
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    Cdc7-IN-18

    CAS:
    <p>Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).</p>
    Formula:C19H21N5OS
    Colore e forma:Solid
    Peso molecolare:367.47

    Ref: TM-T61436

  • Logo CymitQuimica
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    Pol I-IN-1

    Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition
    Formula:C23H22N4O2
    Colore e forma:Solid
    Peso molecolare:386.45

    Ref: TM-T61720

  • PKMYT1-IN-9
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    PKMYT1-IN-9

    CAS:
    PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.
    Formula:C17H14FN5O
    Colore e forma:Solid
    Peso molecolare:323.324

    Ref: TM-T206301

  • MU1409
    Targetmol
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    MU1409

    CAS:
    <p>MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.</p>
    Formula:C20H14BrN3O3S
    Colore e forma:Solid
    Peso molecolare:456.312

    Ref: TM-T205338

  • CDK2 degrader 6
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    CDK2 degrader 6

    CAS:
    CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.
    Formula:C23H22F5N5O3
    Colore e forma:Solid
    Peso molecolare:511.44

    Ref: TM-T207287

  • (R)-Atuveciclib
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    (R)-Atuveciclib

    CAS:
    Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].
    Formula:C18H18FN5O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:387.43

    Ref: TM-T10464

  • TREX1-IN-4
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    TREX1-IN-4

    CAS:
    <p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Colore e forma:Solid
    Peso molecolare:490.898

    Ref: TM-T205208

  • DL-Alanosine
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    DL-Alanosine

    CAS:
    <p>DL-Alanosine is an amino acid analog with antitumor activity.</p>
    Formula:C3H7N3O4
    Colore e forma:Solid
    Peso molecolare:149.105

    Ref: TM-T205451

  • 3′-Amino-2′,3′-dideoxy-CTP
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    3′-Amino-2′,3′-dideoxy-CTP

    CAS:
    3′-Amino-2′,3′-dideoxy-CTP is an analog of nucleoside triphosphates. It selectively inhibits DNA polymerase β.
    Formula:C9H17N4O12P3
    Colore e forma:Solid
    Peso molecolare:466.17

    Ref: TM-TSW-01126

  • CDK9/PARP-IN-1
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    CDK9/PARP-IN-1

    CAS:
    CDK9/PARP-IN-1 (compound 37) is an inhibitor of CDK9 and PARP. It demonstrates IC50 values of 118 nM for CDK9 and 107 nM for PARP1. This compound exhibits a broad-spectrum anti-proliferative effect across various cancer cell lines.
    Formula:C38H34F2N8O3
    Colore e forma:Solid
    Peso molecolare:688.725

    Ref: TM-T205731

  • Zeltociclib
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    Zeltociclib

    CAS:
    Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.
    Formula:C18H20F3N4O2P
    Colore e forma:Solid
    Peso molecolare:412.346

    Ref: TM-T205641

  • HPH-15
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    HPH-15

    CAS:
    <p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>
    Formula:C19H31N3S4
    Colore e forma:Solid
    Peso molecolare:429.73

    Ref: TM-T205327

  • CHK1-IN-4
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    CHK1-IN-4

    CAS:
    <p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>
    Formula:C18H18BrN7O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:444.29

    Ref: TM-T10792

  • TREX1-IN-3
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    TREX1-IN-3

    CAS:
    <p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Colore e forma:Solid
    Peso molecolare:490.898

    Ref: TM-T205254

  • MU147
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    MU147

    CAS:
    MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.
    Formula:C19H13N3O3S
    Colore e forma:Solid
    Peso molecolare:363.39

    Ref: TM-T205293

  • Cdc7-IN-19
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    Cdc7-IN-19

    CAS:
    Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].
    Formula:C19H21N5O2
    Colore e forma:Solid
    Peso molecolare:351.40

    Ref: TM-T61223

  • Dencatistat
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    Dencatistat

    CAS:
    <p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>
    Formula:C24H27N7O5S
    Purezza:98.85%
    Colore e forma:Solid
    Peso molecolare:525.58

    Ref: TM-T86106

  • CDK2-IN-40
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    CDK2-IN-40

    CAS:
    CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.
    Formula:C16H21N7O2
    Colore e forma:Solid
    Peso molecolare:343.384

    Ref: TM-T205452

  • CDK2-IN-39
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    CDK2-IN-39

    CAS:
    <p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>
    Formula:C14H15N3O4S
    Colore e forma:Solid
    Peso molecolare:321.352

    Ref: TM-T204890

  • INX-315
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    INX-315

    CAS:
    INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.
    Formula:C19H21N7O3S
    Purezza:99.88%
    Colore e forma:Solid
    Peso molecolare:427.48

    Ref: TM-T86723

  • MKLP2-IN-1
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    MKLP2-IN-1

    CAS:
    <p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>
    Formula:C23H19BrFN3O2
    Colore e forma:Solid
    Peso molecolare:468.318

    Ref: TM-T205538

  • CBP/p300-IN-2
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    CBP/p300-IN-2

    CAS:
    CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).
    Formula:C27H29F2N7O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:521.56

    Ref: TM-T10702

  • 2′-OMe-ADP
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    2′-OMe-ADP

    CAS:
    <p>2′-OMe-ADP is a nucleotide analogue used in oligonucleotide synthesis.</p>
    Formula:C11H17N5O10P2
    Colore e forma:Solid
    Peso molecolare:441.23

    Ref: TM-TSW-00949

  • 2'-F-CDP
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    2'-F-CDP

    CAS:
    2'-F-CDP is a nucleotide analog that can be utilized in the synthesis of oligonucleotides.
    Formula:C9H14FN3O10P2
    Colore e forma:Solid
    Peso molecolare:405.17

    Ref: TM-TSW-00957

  • CDK4/9-IN-1
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    CDK4/9-IN-1

    CAS:
    CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.
    Formula:C22H34N6O2
    Colore e forma:Solid
    Peso molecolare:414.544

    Ref: TM-T205312

  • Werner syndrome RecQ helicase-IN-2
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    Werner syndrome RecQ helicase-IN-2

    CAS:
    Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.
    Formula:C32H34F3N9O5
    Purezza:99.02%
    Colore e forma:Solid
    Peso molecolare:681.67

    Ref: TM-T72108