Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora(111 prodotti)
- CDK(525 prodotti)
- Arresto del ciclo cellulare(4 prodotti)
- Chk(46 prodotti)
- DYRK(49 prodotti)
- Dynamin(26 prodotti)
- Ferroptosi(224 prodotti)
- HSP(180 prodotti)
- Integrina(256 prodotti)
- Chinesina(86 prodotti)
- LIM chinasi(19 prodotti)
- Microtubulo associato(284 prodotti)
- PKC(111 prodotti)
- PLK(25 prodotti)
- ROCK(66 prodotti)
- Rho(2 prodotti)
- Wee1(14 prodotti)
- c-Myc(75 prodotti)
Mostrare 10 più sottocategorie
Trovati 3749 prodotti di "Ciclo cellulare/Checkpoint"
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Des-ethyl-carafiban
CAS:Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.Formula:C22H23N5O5Colore e forma:SolidPeso molecolare:437.448CYP2C19-IN-1
CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.Formula:C26H26N2O6SColore e forma:SolidPeso molecolare:494.56Fradafiban
CAS:Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.Formula:C20H21N3O4Purezza:98%Colore e forma:SolidPeso molecolare:367.40FR-β ligand 1
CAS:FR-β ligand 1 (III) is a ligand that specifically targets folate receptors, exhibiting antitumor activity, high selectivity, and strong affinity.Formula:C22H25N5O6Colore e forma:SolidPeso molecolare:455.46MY05
CAS:MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).Formula:C19H11ClN4OColore e forma:SolidPeso molecolare:346.77TA-316
CAS:Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.Formula:C28H25BrN4O5S2Purezza:98%Colore e forma:SolidPeso molecolare:641.56MTH1 activator-1
CAS:MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.Formula:C29H23F3N4O2Colore e forma:SolidPeso molecolare:516.514LNA-CTP
CAS:<p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Formula:C10H16N3O14P3Colore e forma:SolidPeso molecolare:495.17PAIR2
CAS:PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.Formula:C27H26F4N6O3SColore e forma:SolidPeso molecolare:590.59CTX-712
CAS:<p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>Formula:C19H17FN8O2Colore e forma:SolidPeso molecolare:408.39Anticancer agent 29
<p>Compound E/Z-6f, anticancer, IC50: CDK2 (0.054 μM), CDK1 (0.127 μM), CDK4 (0.129 μM), CDK6 (0.396 μM).</p>Formula:C22H15ClFNOColore e forma:SolidPeso molecolare:363.81ddCTP trisodium
ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.Formula:C9H13N3Na3O12P3Colore e forma:SolidPeso molecolare:517.1Dyrk1A/α-synuclein-IN-2
Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM).Formula:C21H16N4O4SColore e forma:SolidPeso molecolare:420.44ATIC-IN-2
CAS:<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Formula:C4H4N4O3SColore e forma:SolidPeso molecolare:188.165α5β1 integrin agonist-1
CAS:α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formula:C24H26FN5O9Colore e forma:SolidPeso molecolare:547.49TH9619
CAS:TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM). Anticancer.Formula:C17H18FN7O7Purezza:98.07%Peso molecolare:451.37CDK7-IN-18
CAS:CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.Formula:C22H24F3N7OSPurezza:99.28%Colore e forma:SolidPeso molecolare:491.53IXA62
CAS:IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.Formula:C24H23N3O3Colore e forma:SolidPeso molecolare:401.458Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Formula:C16H20Cl2N8O2SColore e forma:SolidPeso molecolare:459.35MtTMPK-IN-7
MtTMPK-IN-7 inhibits MtbTMPK (IC50: 47 μM), active against M. brevis (MIC: 2.3-4.7 μM), useful for tuberculosis research.Formula:C27H29ClN6O3Colore e forma:SolidPeso molecolare:521.01DHX9-IN-19
CAS:<p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>Formula:C20H21ClN4O4S2Colore e forma:SolidPeso molecolare:480.988Dyrk1A-IN-4
CAS:Dyrk1A-IN-4, compound 48, is an oral DYRK1A/DYRK2 inhibitor with IC50s: 2 nM (DYRK1A), 6 nM (DYRK2), anticancer properties.Formula:C14H13F3N6Colore e forma:SolidPeso molecolare:322.29EFdA-TP tetrasodium
CAS:EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.Formula:C12H11FN5Na4O12P3Purezza:98%Colore e forma:SolidPeso molecolare:621.12OPN expression inhibitor 1
CAS:OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Formula:C25H33N3O5Purezza:99.78%Colore e forma:SolidPeso molecolare:455.55MtTMPK-IN-5
MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.Formula:C21H23N5O2Colore e forma:SolidPeso molecolare:377.44PNR-3-80
CAS:PNR-3-80 is a selective inhibitor of apoptotic endonuclease G (EndoG), with an IC50 of 0.67 μM, showing greater inhibition than against DNase I. It exhibits no inhibitory activity against DNase II, RNase A, proteases, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-80 effectively protects human prostate cancer cells from cell death induced by Cisplatin and Docetaxel and inhibits DNA damage and autophagy (autophagy) prompted by Etoposide. This compound is applicable in studies of cellular damage.Formula:C24H14ClN3O3SColore e forma:SolidPeso molecolare:459.90Cdc7-IN-8
CAS:Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)Formula:C19H21N5O2Colore e forma:SolidPeso molecolare:351.40FR-145715
CAS:FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.Formula:C16H21N5O2SColore e forma:SolidPeso molecolare:347.44RAD51-IN-5
CAS:RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)Formula:C26H38N4O5S2Colore e forma:SolidPeso molecolare:550.73Polθ-IN-7
CAS:<p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>Formula:C28H35F3N6O2Colore e forma:SolidPeso molecolare:544.612Antimalarial agent 44
Antimalarial agent 44 (Compound 3) is an antiparasitic agent effective against malaria. It exhibits good permeability in MDCK-MDR1 cell monolayers and has a high clearance rate in mouse liver microsomes.Formula:C37H37N5O7Colore e forma:SolidPeso molecolare:663.72Zorubicin
CAS:<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Formula:C34H35N3O10Colore e forma:SolidPeso molecolare:645.66CDK7-IN-26
CAS:CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.Formula:C22H22FN6OPSPeso molecolare:468.49Cdc7-IN-19
CAS:Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC 50 of 1.49 nM [1].Formula:C19H21N5O2Colore e forma:SolidPeso molecolare:351.403'-Deoxy-GTP
CAS:<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.</p>Formula:C10H16N5O13P3Colore e forma:SolidPeso molecolare:507.181Cdc7-IN-18
CAS:<p>Cdc7-IN-18 (1-2) inhibits CDC7 enzyme (IC50: 1.29 nM) and COLO205 cell proliferation (IC50: 53.62 nM).</p>Formula:C19H21N5OSColore e forma:SolidPeso molecolare:367.47N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
CAS:N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that resembles the natural nucleotide adenosine in structure. It acts as an activator of ribonucleotide reductase, facilitating the conversion of ribonucleotides into deoxyribonucleotides.Formula:C38H35N5O6Colore e forma:SolidPeso molecolare:657.714RNAP-σ interaction inhibitor-1
CAS:RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.Formula:C19H11Cl3N2O6S2Colore e forma:SolidPeso molecolare:533.79NVP-BQS481
CAS:NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).Formula:C27H33F3N4O2Colore e forma:SolidPeso molecolare:502.57PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.Colore e forma:SolidCDK8-IN-5
CAS:CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.Formula:C26H22N2O4Colore e forma:SolidPeso molecolare:426.46Adafosbuvir
CAS:Adafosbuvir has antiviral activity.Formula:C22H29FN3O10PColore e forma:SolidPeso molecolare:545.457Morpholino U subunit
CAS:Morpholino U subunit is one of the fundamental components of morpholino oligonucleotides, capable of pairing with adenine in target RNA.Formula:C30H32ClN4O5PColore e forma:SolidPeso molecolare:595.03Dyrk1A/α-synuclein-IN-1
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).Formula:C20H21N5O3SColore e forma:SolidPeso molecolare:411.48Deoxythymidine-5'-triphosphate-d15
CAS:Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is a deuterium-labeled form of deoxythymidine-5'-triphosphate. Deoxythymidine-5'-triphosphate (dTTP) is a triphosphate nucleotide utilized in DNA synthesis.Formula:C10H15Li2N2O14P3Colore e forma:SolidPeso molecolare:509.133'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite
CAS:3'-NH-Tr-2',3'-ddG(iBu)-5'-CE-Phosphoramidite is a nucleoside phosphoramidite monomer featuring protective group modifications, suitable for RNA oligonucleotide synthesis.Formula:C42H51N8O5PColore e forma:SolidPeso molecolare:778.88Antifolate agent 1
CAS:Antifolateagent 1 (Compound 1) is an antifolate agent featuring a single-carbon bridge. It lacks RFC transport, shows no affinity for FRα and FRβ, and exhibits no GARFTase inhibition activity. Antifolateagent 1 serves as a negative control in the development of folate receptor-targeted antifolate agents.Formula:C19H19N5O6Colore e forma:SolidPeso molecolare:413.386K465
CAS:6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Formula:C26H33ClFN9OPurezza:99.78%Colore e forma:SolidPeso molecolare:542.05DHICA
CAS:DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of eumelanin, as well as acting as a moderate potency agonist of GPR35. In the U2OS cell line, DHICA demonstrates the ability to induce β-arrestin translocation signaling with an EC50 value of 23.2 μM. Additionally, it plays a significant role in promoting and protecting against DNA damage.Formula:C9H7NO4Colore e forma:SolidPeso molecolare:193.16PKMYT1-IN-9
CAS:PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.Formula:C17H14FN5OColore e forma:SolidPeso molecolare:323.324
