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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

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Trovati 3730 prodotti di "Ciclo cellulare/Checkpoint"

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  • Logo CymitQuimica
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    Chrexanthomycin C

    <p>Chrexanthomycin C, orally active, binds DNA (G4C2)4 G4, Kd 2.8 mM, potential in ALS research.</p>
    Formula:C31H24O15
    Colore e forma:Solid
    Peso molecolare:636.51

    Ref: TM-T75527

  • Adenosine Dialdehyde (ADOX)
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    Adenosine Dialdehyde (ADOX)

    CAS:
    <p>Adenosine Dialdehyde, a purine analogue, inhibits SAHH (Ki=3.3 nM), and shows strong anti-tumor effects in vivo.</p>
    Formula:C10H11N5O4
    Purezza:95%
    Colore e forma:Solid
    Peso molecolare:265.23

    Ref: TM-T22231

  • Uridine triphosphate 13C9,15N2 sodium
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    Uridine triphosphate 13C9,15N2 sodium

    CAS:
    Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.
    Formula:C9H1415N2NaO15P3
    Colore e forma:Solid
    Peso molecolare:517.04

    Ref: TM-T36299

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    Anti-EMMPRIN/CD147 Antibody

    Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.
    Colore e forma:Odour Liquid

    Ref: TM-T9901A-803

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    wrwyar-NH2 TFA

    <p>wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.</p>
    Colore e forma:Odour Solid

    Ref: TM-TP3210

  • 5'-O-DMT-rU
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    5'-O-DMT-rU

    CAS:
    5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.
    Formula:C30H30N2O8
    Colore e forma:Solid
    Peso molecolare:546.57

    Ref: TM-T37141

  • (1S,3R,5R)-PIM447 dihydrochloride
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    (1S,3R,5R)-PIM447 dihydrochloride

    <p>(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).</p>
    Formula:C24H25Cl2F3N4O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:513.38

    Ref: TM-T13425

  • HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt
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    HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt

    CAS:
    HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt inhibits pre-miR-21 RNA, potential for cancer research.
    Formula:C57H62N8O10S
    Colore e forma:Solid
    Peso molecolare:1051.21

    Ref: TM-T74244

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    N4-Benzoyl-3'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine

    <p>N4-Benzoyl-3'-O-DMT cytidine analog inhibits DNA methyltransferases like Zebularine.</p>
    Formula:C41H43N3O9
    Colore e forma:Solid
    Peso molecolare:721.79

    Ref: TM-T75224

  • Erythromycin thiocyanate
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    Erythromycin thiocyanate

    CAS:
    Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.
    Formula:C38H68N2O13S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:793.02

    Ref: TM-T11233

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    Etrolizumab

    CAS:
    MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.
    Purezza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)
    Colore e forma:Liquid

    Ref: TM-T77154

  • Guanosine triphosphate
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    Guanosine triphosphate

    CAS:
    Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].
    Formula:C10H16N5O14P3
    Colore e forma:Solid
    Peso molecolare:523.18

    Ref: TM-T73596

  • CCT241533 dihydrochloride
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    CCT241533 dihydrochloride

    CAS:
    Potent Chk2 inhibitor with 3 nM IC50, 63-fold more selective over Chk1, affects 84 kinases, reduces DNA damage response and apoptosis in cells.
    Formula:C23H29Cl2FN4O4
    Colore e forma:Solid
    Peso molecolare:515.41

    Ref: TM-T36704

  • CDK4/6-IN-23
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    CDK4/6-IN-23

    CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.
    Formula:C32H34FN7O4
    Colore e forma:Solid
    Peso molecolare:599.655

    Ref: TM-T204550

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    DSPE-PEG2000-cRGD

    DSPE-PEG2000-cRGD is a PEG compound composed of DSPE and an αvβ3-targeting peptide (cRGD). The cRGD peptide specifically binds to αvβ3 on the surface of various cancer cells and neovascular cells. This compound can be utilized for drug delivery.
    Colore e forma:Odour Solid

    Ref: TM-TCL-01138

  • Nusinersen
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    Nusinersen

    CAS:
    <p>Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.</p>
    Purezza:98.62%
    Colore e forma:Solid

    Ref: TM-T38656

  • Chrysomycin A
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    Chrysomycin A

    CAS:
    Chrysomycin A is an antibiotic that can be derived from Streptomyces.
    Formula:C28H28O9
    Colore e forma:Solid
    Peso molecolare:508.52

    Ref: TM-T36467

  • JH-XVI-178
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    JH-XVI-178

    CAS:
    JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.
    Formula:C22H22ClN7O
    Colore e forma:Solid
    Peso molecolare:435.92

    Ref: TM-T40280

  • JB300
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    JB300

    CAS:
    JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.
    Formula:C43H45ClFN7O10S
    Colore e forma:Solid
    Peso molecolare:906.375

    Ref: TM-T204223

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    HDAC-IN-85

    HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.
    Formula:C24H27FN4O5
    Colore e forma:Solid
    Peso molecolare:470.49

    Ref: TM-T205411