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Ciclo cellulare/Checkpoint

Ciclo cellulare/Checkpoint

Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.

Sottocategorie di "Ciclo cellulare/Checkpoint"

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Trovati 3764 prodotti di "Ciclo cellulare/Checkpoint"

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  • DDD85646
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    DDD85646

    CAS:
    DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.
    Formula:C21H24Cl2N6O2S
    Purezza:97.8% - 99.76%
    Colore e forma:Solid
    Peso molecolare:495.43

    Ref: TM-T27135

  • Synstatin (92-119)
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    Synstatin (92-119)

    CAS:
    Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and
    Formula:C133H207N35O46
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:3032.27

    Ref: TM-T78064

  • GSK2163632A
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    GSK2163632A

    CAS:
    GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.
    Formula:C27H32N8O3S
    Colore e forma:Solid
    Peso molecolare:548.66

    Ref: TM-T24106

  • Nε-(1-Carboxyethyl)-L-lysine
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    Nε-(1-Carboxyethyl)-L-lysine

    CAS:
    Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE). Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus.
    Formula:C9H18N2O4
    Colore e forma:Solid
    Peso molecolare:218.25

    Ref: TM-T85157

  • CCT251455
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    CCT251455

    CAS:
    <p>CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.</p>
    Formula:C26H26ClN7O2
    Purezza:99.1% - 99.1%
    Colore e forma:Solid
    Peso molecolare:503.98

    Ref: TM-T14906

  • Logo CymitQuimica
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    Palbociclib orotate

    CAS:
    <p>Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.</p>
    Formula:C29H33N9O6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:603.63

    Ref: TM-T72507

  • DCB-3503
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    DCB-3503

    CAS:
    DCB-3503, a tylophorine analog, may fight cancer and aid immunosuppression by hindering protein synthesis and modulating HSC70 ATPase function.
    Formula:C24H27NO5
    Colore e forma:Solid
    Peso molecolare:409.47

    Ref: TM-T27128

  • USP1-IN-6
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    USP1-IN-6

    CAS:
    USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.
    Formula:C29H27F3N8O
    Colore e forma:Solid
    Peso molecolare:560.57

    Ref: TM-T79796

  • Logo CymitQuimica
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    MOMA-341

    CAS:
    MOMA-341 is a highly selective inhibitor targeting the Werner RecQ-like helicase (WRN). It exerts a dual mechanism of allosteric regulation and ATP competitive inhibition by binding to the cysteine 727 site of the WRN protein. In mouse models with mismatch repair deficiency (dMMR) or high microsatellite instability (MSI-H), MOMA-341 can induce DNA damage, cell apoptosis, and promote tumor shrinkage. This compound exhibits significant anti-tumor activity and has potential application prospects in the study of advanced and metastatic solid tumors.
    Formula:C28H26F4N6O3
    Peso molecolare:570.54

    Ref: TM-T210496

  • CDK7-IN-14
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    CDK7-IN-14

    CAS:
    CDK7-IN-14, a potent CDK7 inhibitor from pyrimidines, may treat transcriptionally dysregulated cancers (CN114249712A).
    Formula:C22H24F3N6OP
    Purezza:99.48%
    Colore e forma:Solid
    Peso molecolare:476.43

    Ref: TM-T63108

  • Xylocydine
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    Xylocydine

    CAS:
    Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.
    Formula:C12H14BrN5O5
    Colore e forma:Solid
    Peso molecolare:388.17

    Ref: TM-T68875

  • PVZB1194
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    PVZB1194

    CAS:
    PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through
    Formula:C13H9F4NO2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:319.28

    Ref: TM-T78125

  • L 738167
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    L 738167

    CAS:
    L 738167 is a potent antagonist of the long-acting fibrinogen receptor.
    Formula:C25H34N6O6S
    Colore e forma:Solid
    Peso molecolare:546.64

    Ref: TM-T24353

  • Voruciclib hydrochloride
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    Voruciclib hydrochloride

    CAS:
    Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
    Formula:C22H20Cl2F3NO5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:506.3

    Ref: TM-T13309

  • ICAM-1-IN-1
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    ICAM-1-IN-1

    CAS:
    <p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>
    Formula:C15H11BrN2O2S
    Purezza:99.67%
    Colore e forma:Solid
    Peso molecolare:363.23

    Ref: TM-T13147

  • CT1113
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    CT1113

    CAS:
    CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDX
    Formula:C25H29N5O2S
    Colore e forma:Solid
    Peso molecolare:463.6

    Ref: TM-T79187

  • EHT 5372
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    EHT 5372

    CAS:
    EHT 5372 inhibits DYRK kinases; IC50: 0.22-221 nM for DYRK1A/B, DYRK2/3, CLK1/2/4, GSK-3α/β.
    Formula:C17H11Cl2N5OS
    Colore e forma:Solid
    Peso molecolare:404.27

    Ref: TM-T61985

  • Amotosalen free base
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    Amotosalen free base

    CAS:
    Amotosalen is a Dermatologic Agent.
    Formula:C17H19NO4
    Colore e forma:Solid
    Peso molecolare:301.34

    Ref: TM-T30030

  • KSP-IA
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    KSP-IA

    CAS:
    KSP-IA is a potent, specific, allosteric, and cell-active KSP inhibitor.
    Formula:C21H22F2N2O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:356.41

    Ref: TM-T24271

  • UNC2170 maleate
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    UNC2170 maleate

    CAS:
    53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.
    Formula:C14H21BrN2OC4H4O4
    Colore e forma:Solid
    Peso molecolare:429.31

    Ref: TM-T84416