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Proteina G/GPCR

Proteina G/GPCR

Gli inibitori dei GPCR/proteine G sono composti che bersagliano i recettori accoppiati alle proteine G (GPCR) e le proteine G associate, che svolgono ruoli critici nella trasmissione dei segnali dall'esterno all'interno delle cellule. Questi inibitori sono essenziali per studiare le vie di segnalazione mediate dai GPCR, coinvolte in numerosi processi fisiologici, tra cui la percezione sensoriale, la risposta immunitaria e la neurotrasmissione. Gli inibitori dei GPCR sono anche importanti nello sviluppo di farmaci, poiché molti agenti terapeutici prendono di mira questi recettori. Presso CymitQuimica, offriamo una vasta gamma di inibitori dei GPCR/proteine G di alta qualità per supportare le tue ricerche in farmacologia, biologia cellulare e campi correlati.

Sottocategorie di "Proteina G/GPCR"

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Trovati 5352 prodotti di "Proteina G/GPCR"

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  • GLP-1R agonist 8
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    GLP-1R agonist 8

    CAS:
    <p>GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 &lt; 2 nM).</p>
    Formula:C33H32N4O5
    Colore e forma:Solid
    Peso molecolare:564.63

    Ref: TM-T63999

  • L-657926
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    L-657926

    CAS:
    <p>L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid. The IC50 values for the (-) and (+) configurations against TxA2 are 0.27 nM and 124 nM, respectively.</p>
    Formula:C21H19ClFNO2
    Colore e forma:Solid
    Peso molecolare:371.832

    Ref: TM-T204805

  • BD-1047
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    BD-1047

    CAS:
    <p>BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.</p>
    Formula:C13H20Cl2N2
    Colore e forma:Solid
    Peso molecolare:275.217

    Ref: TM-T205677

  • KMN-80
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    KMN-80

    CAS:
    <p>KMN-80 is a potent, selective EP4 agonist with IC50 3 nM, spurring osteoblast differentiation, and showing in vivo bone repair efficacy.</p>
    Formula:C21H33NO4
    Colore e forma:Solid
    Peso molecolare:363.49

    Ref: TM-T37441

  • RBM10-8
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    RBM10-8

    CAS:
    <p>RBM10-8 irreversibly inhibits human sphingosine-1- phosphate lyase (hS1PL) while behaving also as an enzyme substrate.</p>
    Formula:C17H36NO5P
    Colore e forma:Solid
    Peso molecolare:365.45

    Ref: TM-T61406

  • 8-iso Prostaglandin F3α
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    8-iso Prostaglandin F3α

    CAS:
    <p>8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA.</p>
    Formula:C20H32O5
    Colore e forma:Solid
    Peso molecolare:352.47

    Ref: TM-T36164

  • Tipelukast
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    Tipelukast

    CAS:
    <p>Tipelukast (KCA 757), an oral drug for asthma research, blocks leukotrienes and fights inflammation and fibrosis.</p>
    Formula:C29H38O7S
    Purezza:>99.99%
    Colore e forma:Solid
    Peso molecolare:530.67

    Ref: TM-T15647

  • SGL5213
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    SGL5213

    CAS:
    <p>SGL5213 is a potent oral SGLT1 inhibitor (IC50: 29 nM) with potential for treating type 2 diabetes.</p>
    Formula:C37H55N3O8
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:669.85

    Ref: TM-T12892

  • BI-44370
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    BI-44370

    CAS:
    <p>BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.</p>
    Formula:C35H47N5O6
    Colore e forma:Solid
    Peso molecolare:633.78

    Ref: TM-T26796

  • Pexacerfont
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    Pexacerfont

    CAS:
    <p>Pexacerfont (BMS-562086) is a selective antagonist of the corticotropin-releasing factor receptor (IC50: 6.1±0.6 nM for the human CRF1 receptor).</p>
    Formula:C18H24N6O
    Purezza:99.77%
    Colore e forma:Solid
    Peso molecolare:340.42

    Ref: TM-T16475

  • CB2 receptor antagonist 1
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    CB2 receptor antagonist 1

    CAS:
    <p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 &amp; 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>
    Formula:C28H47NO3
    Colore e forma:Solid
    Peso molecolare:445.68

    Ref: TM-T62631

  • MK-3207
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    MK-3207

    CAS:
    <p>MK-3207 is a potent, oral CGRP receptor antagonist with high selectivity for human and monkey receptors, inhibiting blood flow in vivo.</p>
    Formula:C31H29F2N5O3
    Colore e forma:Solid
    Peso molecolare:557.59

    Ref: TM-T21558

  • Delmadinone acetate
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    Delmadinone acetate

    CAS:
    <p>Delmadinone acetate is an orally active compound used to control estrus and ovulation in both female and male pets. It induces adrenal suppression by inhibiting the pituitary release of ACTH.</p>
    Formula:C23H27ClO4
    Colore e forma:Solid
    Peso molecolare:402.911

    Ref: TM-T206595

  • NBI 35965 hydrochloride
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    NBI 35965 hydrochloride

    CAS:
    <p>NBI 35965 hydrochloride is a selective CRF1 (corticotropin-releasing factor receptor 1) antagonist that is both orally active and capable of penetrating the brain. It possesses a K i value of 4 nM and a pK i of 8.5, and does not affect CRF2. This compound effectively diminishes CRF or stress-triggered ACTH (adrenocorticotropic hormone) production in vivo, demonstrating pIC 50 values of 7.1 and 6.9. Additionally, NBI 35965 hydrochloride exhibits anxiolytic properties [1] [2].</p>
    Formula:C21H23Cl3N4
    Colore e forma:Solid
    Peso molecolare:437.79

    Ref: TM-T86978

  • PF-06372222
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    PF-06372222

    CAS:
    <p>PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.</p>
    Formula:C26H28F3N5O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:515.53

    Ref: TM-T24620

  • (S)-Praziquantel
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    (S)-Praziquantel

    CAS:
    <p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>
    Formula:C19H24N2O2
    Colore e forma:Solid
    Peso molecolare:312.406

    Ref: TM-T206068

  • Logo CymitQuimica
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    hA3AR agonist 1

    <p>hA3AR agonist 1 is a potent human A 3 adenosine receptor (hA 3 AR) agonist (Ki = 2.40 nM) .</p>
    Formula:C10H14N6OS
    Colore e forma:Solid
    Peso molecolare:266.32

    Ref: TM-T60444

  • BAY-3153
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    BAY-3153

    CAS:
    <p>BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .</p>
    Formula:C25H29Cl2N3O4
    Colore e forma:Solid
    Peso molecolare:506.42

    Ref: TM-T73371

  • Elsovaptan
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    Elsovaptan

    CAS:
    <p>Elsovaptan is an antagonist of the vasopressin receptor and is applicable for research in Alzheimer's disease.</p>
    Formula:C19H20ClN5O2
    Colore e forma:Solid
    Peso molecolare:385.847

    Ref: TM-T206306

  • VGD071
    Targetmol
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    VGD071

    CAS:
    <p>VGD071, a compound that targets sortilin, presents a promising avenue for forthcoming research utilizing mouse models of breast cancer.</p>
    Formula:C32H41N3O4S2
    Colore e forma:Solid
    Peso molecolare:595.82

    Ref: TM-T64206