Product Information
Name:
Arimoclomol
Synonyms:
- (R)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide
- Arimoclomol [INN]
- Arimoclomolum
- Arimoclomolum [INN-Latin]
- Brx 345
- N-((2R)-2-Hydroxy-3-(1-piperidyl)propoxy)pyridine-3-carboximidoyl chloride, 1-oxide
- Unii-Eut3557Rt5
- 3-Pyridinecarboximidoyl chloride, N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-, 1-oxide
- N-{[(2R)-2-hydroxy-3-(piperidin-1-yl)propyl]oxy}pyridine-3-carboximidoyl chloride 1-oxide
- BRX 345 free base
- See more synonyms
Description:
Stability Hygroscopic
Applications Arimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.
References Kieran, Dairin., et al.: Nature Medicine., 10, 402 (2004); Brown, Ian R., et al.: Ann N Y Acad Sci., 1113, 147 (2007); Traynor, B. J., et al.: Neurology., 67, 20 (2006),
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
313.78
Formula:
C14H20ClN3O3
Color/Form:
White to Off-White Solid
InChI:
InChI=1S/C14H20ClN3O3/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17/h4-5,8-9,13,19H,1-3,6-7,10-11H2/b16-14-/t13-/m1/s1
InChI key:
InChIKey=SGEIEGAXKLMUIZ-XUVDNFPMSA-N
SMILES:
[O-][n+]1cccc(/C(Cl)=N/OC[C@H](O)CN2CCCCC2)c1
MDL:
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