Angiogénese
Os inibidores da angiogênese são compostos que interferem na formação de novos vasos sanguíneos, um processo crítico no crescimento e metástase do câncer. Ao inibir a angiogênese, esses compostos podem restringir o suprimento de sangue para os tumores, retardando ou interrompendo seu crescimento. Os inibidores da angiogênese são essenciais na pesquisa do câncer e no desenvolvimento terapêutico, fornecendo insights sobre os mecanismos de progressão tumoral e oferecendo potenciais tratamentos para o câncer e outras doenças relacionadas à angiogênese. Na CymitQuimica, oferecemos uma ampla gama de inibidores da angiogênese de alta qualidade para apoiar sua pesquisa em oncologia e biologia vascular.
Subcategorias de "Angiogénese"
- BTK(146 produtos)
- Bcr-Abl(102 produtos)
- EGFR(572 produtos)
- FAK(72 produtos)
- FLT(92 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(169 produtos)
- JAK(245 produtos)
- PDGFR(126 produtos)
- RAAS(87 produtos)
- Src(79 produtos)
- Syk(37 produtos)
- Trombina(47 produtos)
- VDA(2 produtos)
- VEGFR(268 produtos)
Exibir 6 mais subcategorias
Foram encontrados 1431 produtos de "Angiogénese"
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Vatalanib succinate
CAS:<p>Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.</p>Fórmula:C24H21ClN4O4Cor e Forma:SolidPeso molecular:464.91Merestinib dihydrochloride
CAS:<p>Merestinib dihydrochloride (LY2801653 dihydrochloride) is a kinase inhibitor with antitumor activity that inhibits MET and MKNK1/2.</p>Fórmula:C30H24Cl2F2N6O3Cor e Forma:SolidPeso molecular:625.45RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Fórmula:C29H35N7O4Pureza:98% - 99.91%Cor e Forma:SolidPeso molecular:545.63Syk Inhibitor II dihydrochloride
CAS:<p>Syk inhibitor II selectively blocks Syk (IC50 = 41 nM), impacting platelet function and inflammation, with lower potency against other kinases.</p>Fórmula:C14H17Cl2F3N6OPureza:98.53%Cor e Forma:SolidPeso molecular:413.22GluR6 antagonist-1
CAS:<p>GluR6 antagonist-1 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.</p>Fórmula:C15H11ClN2OSPureza:99.89%Cor e Forma:SolidPeso molecular:302.78Adaphostin
CAS:<p>Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.</p>Fórmula:C24H27NO4Pureza:98.29%Cor e Forma:SolidPeso molecular:393.48Belzutifan
CAS:<p>"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."</p>Fórmula:C17H12F3NO4SPureza:99.34% - 99.88%Cor e Forma:SolidPeso molecular:383.34Vandetanib hydrochloride
CAS:<p>Vandetanib hydrochloride is an oral VEGFR2 inhibitor with an IC50 of 40 nM, also targeting VEGFR3 (110 nM) and EGFR (500 nM).</p>Fórmula:C22H25BrClFN4O2Cor e Forma:SolidPeso molecular:511.81(Z)-SU4312
CAS:<p>(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).</p>Fórmula:C17H16N2OPureza:99.17%Cor e Forma:SolidPeso molecular:264.321-Naphthyl PP1
CAS:<p>1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)</p>Fórmula:C19H19N5Pureza:99.85%Cor e Forma:White Cyrstalline SolidPeso molecular:317.39Gefitinib dihydrochloride
CAS:<p>Gefitinib dihydrochloride: orally active, selective EGFR inhibitor (IC50: 33-54 nM), hinders tumor growth, induces autophagy and apoptosis in cancer research.</p>Fórmula:C22H26Cl3FN4O3Cor e Forma:SolidPeso molecular:519.82Afatinib oxalate
CAS:<p>Afatinib oxalate (BIBW 2992) is an irreversible ErbB inhibitor, treating ESCC, NSCLC, and gastric cancer. Targets EGFRwt, EGFRL858R/T790M, HER2.</p>Fórmula:C28H29ClFN5O11Cor e Forma:SolidPeso molecular:666.01Cabozantinib hydrochloride
CAS:<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Fórmula:C28H25ClFN3O5Pureza:99.97%Cor e Forma:SolidPeso molecular:537.96E-4031 dihydrochloride
CAS:<p>E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)</p>Fórmula:C21H29Cl2N3O3SPureza:99.31% - 99.87%Cor e Forma:SolidPeso molecular:474.44WS6
CAS:<p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>Fórmula:C29H31F3N6O3Pureza:97.65% - 99.95%Cor e Forma:SolidPeso molecular:568.59Quizartinib HCl
CAS:<p>Quizartinib (AC220/AC010220) is an oral FLT3/STK1 inhibitor for treating AML, blocking kinase-driven cell proliferation and promoting apoptosis.</p>Fórmula:C29H34Cl2N6O4SCor e Forma:SolidPeso molecular:633.597BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Fórmula:C16H10BrN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:356.17NS309
CAS:<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Fórmula:C8H4Cl2N2O2Pureza:97.55%Cor e Forma:SolidPeso molecular:231.04Compound Lup-20(29)-en-3-yl acetate
<p>Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.</p>Fórmula:C32H52O2Pureza:98%Cor e Forma:SolidPeso molecular:468.75SB-431542
CAS:<p>SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.</p>Fórmula:C22H16N4O3Pureza:99.035% - >99.99%Cor e Forma:SolidPeso molecular:384.39GDC-0214
CAS:<p>GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).</p>Fórmula:C28H28ClF2N9O3Pureza:99.75%Cor e Forma:SolidPeso molecular:612.03Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.9%Cor e Forma:Off-White SolidPeso molecular:485.94Cetuximab
CAS:<p>Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).</p>Fórmula:C107H179N35O36S7Pureza:95 - 98.60%Cor e Forma:LiquidPeso molecular:152 kDaTranilast
CAS:<p>Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of</p>Fórmula:C18H17NO5Pureza:99.67% - >99.99%Cor e Forma:White With Light Yellow Crystalline PowderPeso molecular:327.33NVP-BSK805 trihydrochloride
CAS:<p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>Fórmula:C27H31Cl3F2N6OCor e Forma:SolidPeso molecular:599.93Zorifertinib
CAS:<p>Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.</p>Fórmula:C22H23ClFN5O3Pureza:98.20% - 99.36%Cor e Forma:White To Off-White SolidPeso molecular:459.9Treprostinil Sodium
CAS:<p>Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).</p>Fórmula:C23H33NaO5Pureza:99.67% - >99.99%Cor e Forma:SolidPeso molecular:412.5SKLB4771
CAS:<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Fórmula:C25H27N7O3S2Pureza:98% - >99.99%Cor e Forma:SolidPeso molecular:537.66AG1557
CAS:<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Fórmula:C16H14IN3O2Pureza:98.61% - 99.23%Cor e Forma:SolidPeso molecular:407.21Canertinib
CAS:<p>Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.</p>Fórmula:C24H25ClFN5O3Pureza:98% - >99.99%Cor e Forma:White Or Similar To White Crystalline PowderPeso molecular:485.94PF-06651600 malonate
CAS:<p>PF-06651600 is a potent and selective JAK3 inhibitor.</p>Fórmula:C18H23N5O5Cor e Forma:SolidPeso molecular:389.41SU 4313
CAS:SU 4313 is a bioactive chemical.Fórmula:C18H17NOPureza:99.51% - 99.89%Cor e Forma:SolidPeso molecular:263.33EBE-A22
CAS:<p>EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.</p>Fórmula:C17H16BrN3O2Pureza:99.087% - 99.88%Cor e Forma:SolidPeso molecular:374.23BAY 61-3606 HCl
CAS:<p>BAY 61-3606 HCl: a reversible Syk inhibitor, halts mast cell degranulation, cytokines, and sensitizes MCF-7 cells to TRAIL-induced apoptosis.</p>Fórmula:C20H19ClN6O3Cor e Forma:SolidPeso molecular:426.86ZM39923 hydrochloride
CAS:<p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>Fórmula:C23H25NO·HClPureza:98.05%Cor e Forma:SolidPeso molecular:367.91AMG 925 HCl
CAS:<p>AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM).</p>Fórmula:C26H30ClN7O2Cor e Forma:SolidPeso molecular:508.02Seralutinib
CAS:<p>Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.</p>Fórmula:C27H27N5O3Pureza:99.09%Cor e Forma:SolidPeso molecular:469.54Pacritinib hydrochloride
CAS:<p>Pacritinib HCl: strong JAK2/Wild-type & JAK2V617F inhibitor (IC50: 23/19 nM), used in AML & MF research.</p>Fórmula:C28H32N4O3·xClHCor e Forma:SolidVerteporfin
CAS:<p>Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.</p>Fórmula:C41H42N4O8Pureza:95.37% - 99.82%Cor e Forma:Dark Green To Black SolidPeso molecular:718.79EHop-016
CAS:<p>EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.</p>Fórmula:C25H30N6OPureza:98.99% - >99.99%Cor e Forma:SolidPeso molecular:430.55Vactosertib Hydrochloride
CAS:<p>Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.</p>Fórmula:C22H19ClFN7Pureza:98.03%Cor e Forma:SolidPeso molecular:435.89Theliatinib tartrate
CAS:<p>Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.</p>Fórmula:C29H32N6O8Cor e Forma:SolidPeso molecular:592.6WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Fórmula:C28H30F3N7O3Pureza:97.93% - 99.94%Cor e Forma:SolidPeso molecular:569.58Endoxifen (Z-isomer)
CAS:<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Fórmula:C25H27NO2Pureza:99.19% - 99.81%Cor e Forma:SolidPeso molecular:373.49GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Fórmula:C18H15N3O2Pureza:99.52%Cor e Forma:SolidPeso molecular:305.33DGY-06-116
CAS:<p>DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.</p>Fórmula:C32H33ClN8O2Pureza:97.65%Cor e Forma:SolidPeso molecular:597.11(Z)-Semaxinib
CAS:<p>(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for</p>Fórmula:C15H14N2OPureza:98.82% - ≥95%Cor e Forma:SolidPeso molecular:238.28Avitinib maleate
CAS:Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.Fórmula:C30H30FN7O6Pureza:98% - 99.74%Cor e Forma:SolidPeso molecular:603.61AG-1557 hydrochloride (189290-58-2(free base))
AG-1557 hydrochloride is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).Fórmula:C16H15ClIN3O2Pureza:98.64%Cor e Forma:SolidPeso molecular:443.66Dapagliflozin
CAS:<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Fórmula:C21H25ClO6Pureza:99.5% - 99.93%Cor e Forma:SolidPeso molecular:408.87Radotinib
CAS:<p>Radotinib (IY-5511), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of Y, most notably</p>Fórmula:C27H21F3N8OPureza:99.13% - 99.97%Cor e Forma:SolidPeso molecular:530.5Naluzotan
CAS:<p>Naluzotan（PRX 00023） is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+</p>Fórmula:C23H38N4O3SPureza:>99.99%Cor e Forma:SolidPeso molecular:450.64ASP3026
CAS:<p>ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies,and Positive for Anaplastic Lymphoma Kinase.</p>Fórmula:C29H40N8O3SPureza:98.78% - 99.81%Cor e Forma:SolidPeso molecular:580.74Tropisetron
CAS:<p>Tropisetron (ICS 205-930) is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.</p>Fórmula:C17H20N2O2Pureza:99.68%Cor e Forma:White SolidPeso molecular:284.35Protein kinase inhibitor 6
CAS:<p>Protein kinase inhibitor 6 is a protein kinase inhibitor.</p>Fórmula:C13H9FN2SPureza:98.01%Cor e Forma:SolidPeso molecular:244.29AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Fórmula:C16H18N2OPureza:98.12%Cor e Forma:SolidPeso molecular:254.33Bafetinib
CAS:<p>Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.</p>Fórmula:C30H31F3N8OPureza:94.16% - 99.68%Cor e Forma:SolidPeso molecular:576.622,4-DPD
CAS:<p>2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)</p>Fórmula:C11H13NO4Pureza:99.74%Cor e Forma:Yellow Solid CrystallinePeso molecular:223.23PRT062607 hydrochloride
CAS:<p>PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk. PRT062607 displays at least 80-fold selectivity for Syk over other kinases.</p>Fórmula:C19H23N9O·HClPureza:97.7% - 99.81%Cor e Forma:SolidPeso molecular:429.912-(1,8-naphthyridin-2-yl)phenol
CAS:<p>2-NP is a STAT1 enhancer.</p>Fórmula:C14H10N2OPureza:99.33% - 99.82%Cor e Forma:SolidPeso molecular:222.24Nastorazepide
CAS:<p>Nastorazepide is a selective, orally available antagonist of gastrin/cholecystokinin 2 (CCK-2) receptor with potential antineoplastic activity.</p>Fórmula:C29H36N4O5Pureza:99.83%Cor e Forma:SolidPeso molecular:520.62Filgotinib maleate
CAS:<p>Filgotinib maleate, a selective oral JAK1 inhibitor, treats RA and Crohn's. IC50s: JAK1-10nM, JAK2-28nM, JAK3-810nM, TYK2-116nM.</p>Fórmula:C25H27N5O7SCor e Forma:SolidPeso molecular:541.58Fostamatinib
CAS:<p>Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.</p>Fórmula:C23H26FN6O9PPureza:93.08% - 99.38%Cor e Forma:SolidPeso molecular:580.46Isoliquiritin apioside
CAS:<p>Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and fights oxidative DNA damage.</p>Fórmula:C26H30O13Pureza:98.84% - 99.27%Cor e Forma:SolidPeso molecular:550.51FGFR2-IN-3 hydrochloride
CAS:<p>FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.</p>Fórmula:C28H25ClFN7O2Cor e Forma:SolidPeso molecular:546.0Regorafenib
CAS:<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Fórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:482.82KRCA-0008
CAS:<p>KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.</p>Fórmula:C30H37ClN8O4Pureza:96.19%Cor e Forma:SolidPeso molecular:609.12WHI-P180
CAS:<p>WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.</p>Fórmula:C16H15N3O3Pureza:99.21%Cor e Forma:SolidPeso molecular:297.31N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS:<p>Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.</p>Fórmula:C22H18BrN7Pureza:99.935%Cor e Forma:SolidPeso molecular:460.33Epitinib
CAS:<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Fórmula:C24H26N6O2Cor e Forma:SolidPeso molecular:430.5(E/Z)-Zotiraciclib citrate
<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.</p>Fórmula:C29H32N4O8Cor e Forma:SolidPeso molecular:564.59PKI-166 hydrochloride
CAS:<p>EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.</p>Fórmula:C20H19ClN4OCor e Forma:SolidPeso molecular:366.85NRC-2694 hydrochloride
CAS:<p>NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.</p>Fórmula:C24H27ClN4O3Cor e Forma:SolidPeso molecular:454.95R1530
CAS:<p>R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.</p>Fórmula:C18H14ClFN4OPureza:98.422%Cor e Forma:SolidPeso molecular:356.78ALK kinase inhibitor-1
CAS:<p>SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.</p>Fórmula:C28H32FN5O3SPureza:99.84%Cor e Forma:SolidPeso molecular:537.65Ritlecitinib tosylate
CAS:<p>Ritlecitinib (PF-06651600) is a potent, selective JAK3 inhibitor with proven in vivo efficacy, low clearance, and has undergone clinical trials.</p>Fórmula:C22H27N5O4SCor e Forma:SolidPeso molecular:457.549Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Fórmula:C32H33ClFN5O11Pureza:98.11% - 99.87%Cor e Forma:SolidPeso molecular:718.08Atopaxar hydrochloride
CAS:<p>Atopaxar hydrochloride is used in the Treatment of Cardiovascular Disorders.</p>Fórmula:C29H39ClFN3O5Cor e Forma:SolidPeso molecular:564.1Ensartinib
CAS:<p>Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).</p>Fórmula:C26H27Cl2FN6O3Pureza:99.92%Cor e Forma:SolidPeso molecular:561.44Vandetanib trifluoroacetate
CAS:<p>Vandetanib trifluoroacetate: oral VEGFR2/KDR inhibitor, IC50=40nM, also blocks VEGFR3/FLT4 (110nM) and EGFR/HER1 (500nM).</p>Fórmula:C24H25BrF4N4O4Cor e Forma:SolidPeso molecular:589.386HA 155
CAS:<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>Fórmula:C24H19BFNO5SPureza:99.88%Cor e Forma:SolidPeso molecular:463.29Cevidoplenib dimesylate hydrochloride
CAS:<p>Cevidoplenib dimesylate hydrochloride is a spleen tyrosine kinase (Syk) inhibitor showing potential immunomodulating and anti-inflammatory properties.</p>Fórmula:C90H132Cl5N27O12Pureza:97.52%Cor e Forma:SolidPeso molecular:1957.9Derazantinib dihydrochloride
CAS:<p>Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.</p>Fórmula:C29H31Cl2FN4OCor e Forma:SolidPeso molecular:541.49(S)-Sunvozertinib
CAS:<p>(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.</p>Fórmula:C29H35ClFN7O3Pureza:99.64%Cor e Forma:SolidPeso molecular:584.08Tandutinib hydrochloride
CAS:<p>Tandutinib hydrochloride: FLT3 inhibitor (IC50 0.22 μM), targets c-Kit, PDGFR, treats AML, crosses blood-brain barrier.</p>Fórmula:C31H43ClN6O4Cor e Forma:SolidPeso molecular:599.16ZM323881
CAS:<p>ZM323881 is a potent and selective inhibitor of VEGFR2 with an IC 50 of less than 2 nM.</p>Fórmula:C22H18FN3O2Cor e Forma:SolidPeso molecular:375.4Saracatinib difumarate
CAS:<p>Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.</p>Fórmula:C35H40ClN5O13Cor e Forma:SolidPeso molecular:774.18ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Fórmula:C20H21N5O2Pureza:99.8%Cor e Forma:SolidPeso molecular:363.41Cabozantinib
CAS:<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Fórmula:C28H24FN3O5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:501.51Arnebin 1
CAS:<p>(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver.</p>Fórmula:C21H22O6Pureza:98.76% - 99.81%Cor e Forma:SolidPeso molecular:370.396TG 100801
CAS:<p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>Fórmula:C33H30ClN5O3Pureza:99.28% - 99.61%Cor e Forma:SolidPeso molecular:580.08N-Acryloyl Osimertinib (>85%)
CAS:<p>Applications N-Acryloyl Osimertinib is used in the preparation of pyrimidinyl indole derivative as EGFR inhibitor for targeted therapy of cancer<br>References Rao, Y., et al.: Faming Zhuanli Shenqing (2016), CN 105777716 A 20160720<br></p>Fórmula:C31H35N7O3Pureza:>85%Cor e Forma:Off White SolidPeso molecular:553.65SB 203580 hydrochloride
CAS:<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>Fórmula:C21H17ClFN3OSPureza:97.79%Cor e Forma:SolidPeso molecular:413.9AZ 12799734
CAS:<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Fórmula:C18H18N4O3SPureza:98.23%Cor e Forma:SolidPeso molecular:370.43CCT241161
CAS:<p>CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF (30); fights BRAF/NRAS melanomas, anti-proliferative.</p>Fórmula:C28H27N7O3SPureza:99.76% - 99.77%Cor e Forma:SolidPeso molecular:541.62Behenamide
CAS:Produto Controlado<p>Applications Behenamide is a fatty acid amide as an angiogenic. The mechanism of angiogenic activity is unknown and this lipid does not promote proliferation of endothelial cells or induce inflammatory effects.<br>References Wakamatsu, K., et al.: Biochem. Biophysical Res. Comm., 168, 423 (1990),<br></p>Fórmula:C22H45NOCor e Forma:White To Off-WhitePeso molecular:339.6rac-Clopidogrel Hydrochloride
CAS:<p>Impurity Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B<br>Applications Clopidogrel Related Compound B (Clopidogrel Impurity B; Clopidogrel USP B; Clopidogrel USP Related Compound B) is a tetrahydrothienopyridine as inhibitor of angiogenesis.<br>References Maffrand, J. P., et al.: Eur. J. Med. Chem., 9, 483 (1974), Thebault, J.J., et al.: Clin. Pharmacol. Ther., 18, 485 (1975),<br></p>Fórmula:C16H16ClNO2S·ClHCor e Forma:NeatPeso molecular:358.28Dapolsertib
CAS:<p>Dapolsertib (SEL24-B489) is an orally active and efficient PIM and FLT3-ITD inhibitor, reducing PIM-specific substrate phosphorylation.</p>Fórmula:C15H18Br2N4O2Pureza:99.61%Cor e Forma:SolidPeso molecular:446.14Itacnosertib
CAS:<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Fórmula:C26H28N8OPureza:99.38%Cor e Forma:SolidPeso molecular:468.55Seribantumab
CAS:<p>Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting cancer cell proliferation.</p>Pureza:>95%Cor e Forma:LiquidPeso molecular:143.2 (kDa)
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