Angiogénese
Os inibidores da angiogênese são compostos que interferem na formação de novos vasos sanguíneos, um processo crítico no crescimento e metástase do câncer. Ao inibir a angiogênese, esses compostos podem restringir o suprimento de sangue para os tumores, retardando ou interrompendo seu crescimento. Os inibidores da angiogênese são essenciais na pesquisa do câncer e no desenvolvimento terapêutico, fornecendo insights sobre os mecanismos de progressão tumoral e oferecendo potenciais tratamentos para o câncer e outras doenças relacionadas à angiogênese. Na CymitQuimica, oferecemos uma ampla gama de inibidores da angiogênese de alta qualidade para apoiar sua pesquisa em oncologia e biologia vascular.
Subcategorias de "Angiogénese"
- BTK(147 produtos)
- Bcr-Abl(103 produtos)
- EGFR(572 produtos)
- FAK(71 produtos)
- FLT(91 produtos)
- Receptor do Factor de Crescimento Fibroblasto (FGFR)(169 produtos)
- JAK(246 produtos)
- PDGFR(126 produtos)
- RAAS(88 produtos)
- Src(80 produtos)
- Syk(37 produtos)
- Trombina(47 produtos)
- VDA(2 produtos)
- VEGFR(267 produtos)
Exibir 6 mais subcategorias
Foram encontrados 1483 produtos de "Angiogénese"
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BPR1K871
CAS:BPR1K871, a preclinical development candidate for anti-cancer therapy [1], is a potent, selective dual inhibitor targeting FLT3 and AURKA, with IC50 values ofFórmula:C25H28ClN7O2SCor e Forma:SolidPeso molecular:526.05FLT3-IN-16
CAS:<p>FLT3-IN-16 is a potent FLT3 inhibitor (IC50 = 1.1 μM) for acute myeloid leukemia research.</p>Fórmula:C15H15N3O2SPureza:99.21%Cor e Forma:SolidPeso molecular:301.36Asciminib hydrochloride
CAS:<p>Asciminib (ABL001) hydrochloride is a selective and potent mutant BCR-ABL1 inhibitor that inhibits Ba/F3 cell growth (IC50: 0.25 nM).</p>Fórmula:C20H19Cl2F2N5O3Cor e Forma:SolidPeso molecular:486.3Cediranib maleate
CAS:<p>Cediranib maleate (AZD2171 maleate) is a VEGFR2 inhibitor that inhibits Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit.</p>Fórmula:C29H31FN4O7Cor e Forma:SolidPeso molecular:566.58(Z)-Orantinib
CAS:<p>(Z)-Orantinib, oral ATP-competitive blocker for Flk-1/KDR, PDGFRβ, FGFR1 (IC50: 2.1, 0.008, 1.2 μM), is a strong antiangiogenic, antitumor drug.</p>Fórmula:C18H18N2O3Cor e Forma:SolidPeso molecular:310.35Mavelertinib
CAS:Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Fórmula:C18H22FN9O2Pureza:99.89%Cor e Forma:SolidPeso molecular:415.42N-piperidine Ibrutinib hydrochloride
CAS:<p>N-piperidine Ibrutinib hydrochloride is a BTK inhibitor that inhibits WT BTK and C481S BTK , which inhibits the growth and proliferation of cancer cells.</p>Fórmula:C22H23ClN6OPureza:98.83%Cor e Forma:SolidPeso molecular:422.91Telatinib mesylate
CAS:<p>Telatinib mesylate is a potent, orally active inhibitor of VEGFR2 (IC50: 6 nM), VEGFR3 (IC50: 4 nM), PDGFα (IC50: 15 nM) and c-Kit (IC50: 1 nM).</p>Fórmula:C21H20ClN5O6SCor e Forma:SolidPeso molecular:505.93Lanraplenib succinate
CAS:Lanraplenib succinate is an oral SYK inhibitor (IC50=9.5 nM) that doesn't extend BT, targeting GPVI in platelets for inflammation treatment.Fórmula:C58H68N18O14Cor e Forma:SolidPeso molecular:1241.294Neratinib maleate
CAS:Neratinib maleate is a selective HER2/EGFR inhibitor (IC50: 59/92 nM) used in breast and prostate cancer studies.Fórmula:C34H33ClN6O7Pureza:99.99%Cor e Forma:SolidPeso molecular:673.11Surfen dihydrochloride
CAS:<p>Surfen dihydrochloride (Aminoquinuride dihydrochloride) is a heparin sulfate antagonist with antimicrobial properties and inhibits blockade of signaling.</p>Fórmula:C21H22Cl2N6OPureza:97.08%Cor e Forma:SolidPeso molecular:445.35Gefitinib-d8
CAS:<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.</p>Fórmula:C22H24ClFN4O3Pureza:98%Cor e Forma:SolidPeso molecular:454.95Ribociclib-d6
CAS:<p>Ribociclib-d6 is a deuterated compound of Ribociclib (LEE011) for isotope tracing.Ribociclib is an orally available CDK4/6 inhibitor with antitumor activity.</p>Fórmula:C23H30N8OCor e Forma:SolidPeso molecular:440.57Pazopanib-d6
CAS:Pazopanib-d6 is a deuterated compound of Pazopanib.Fórmula:C21H17D6N7O2SPeso molecular:443.56Bleximenib oxalate
CAS:<p>Bleximenib oxalate (Menin-MLL inhibitor 24 oxalate) is a menin-MLL inhibitor that blocks the binding of the menin-KMT2A complex to chromatin at gene promoters.</p>Fórmula:C34H52FN7O7Pureza:98%Cor e Forma:SolidPeso molecular:689.82Tirbanibulin dihydrochloride
CAS:<p>Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).</p>Fórmula:C26H31Cl2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:504.45Elsubrutinib
CAS:<p>Elsubrutinib (ABBV-105) is a highly active, potent, and selective orally-administered inhibitor of Bruton's tyrosine kinase (BTK). It irreversibly inhibits the catalytic domain of BTK with an IC50 value of 0.18 μM. Elsubrutinib holds potential for the advancement of research on inflammatory diseases.</p>Fórmula:C17H19N3O2Cor e Forma:SolidPeso molecular:297.358Erlotinib-d6
CAS:<p>Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. Erlotinib D6 is a deuterium labeled Erlotinib .</p>Fórmula:C22H23N3O4Pureza:98%Cor e Forma:SolidPeso molecular:399.47SB1317
CAS:SB1317 (TG02) is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).Fórmula:C23H24N4OPureza:99.86%Cor e Forma:SolidPeso molecular:372.46Osimertinib dimesylate
CAS:Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Fórmula:C30H41N7O8S2Pureza:98%Cor e Forma:SolidPeso molecular:691.82Iruplinalkib
CAS:<p>Iruplinalkib (WX-0593) is an orally active, selective and potent ALK and ROS1 tyrosine kinase inhibitor with anticancer activity for use in the study of non-small cell lung cancer.</p>Fórmula:C29H38ClN6O2PPureza:97.38%Cor e Forma:SolidPeso molecular:569.08Conteltinib tetrahydrochloride
<p>Conteltinibtetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of Conteltinib. It acts as an inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. When used in combination with Cabozantinib, Conteltinib tetrahydrochloride exhibits a synergistic antitumor effect.</p>Fórmula:C32H49Cl4N9O3SCor e Forma:SolidPeso molecular:781.667Afatinib D6
CAS:<p>Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.</p>Fórmula:C24H25ClFN5O3Cor e Forma:SolidPeso molecular:491.98Poseltinib
CAS:<p>Poseltinib is an oral, irreversible BTK inhibitor (IC50 1.95 nM) with higher selectivity over BMX, TEC, and TXK, blocking BCR, FcR, and TLR signaling.</p>Fórmula:C26H26N6O3Cor e Forma:SolidPeso molecular:470.52Pentagamavunon-1
CAS:<p>PGV-1, an oral Curcumin analog, induces apoptosis by inhibiting COX-2, VEGF, and NF-κB activation.</p>Fórmula:C23H24O3Cor e Forma:SolidPeso molecular:348.43Disitamab
CAS:<p>Disitamab (RC48-0) is a humanized anti-HER2 monoclonal antibody used in ADC synthesis.</p>Pureza:95.00%Cor e Forma:LiquidAflibercept
CAS:<p>Aflibercept has a wide range of applications in life science related research.</p>Cor e Forma:LiquidImatinib D4
CAS:<p>Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.</p>Fórmula:C29H31N7OPureza:98%Cor e Forma:SolidPeso molecular:497.63KG-548
CAS:<p>KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.</p>Fórmula:C9H4F6N4Pureza:99.62%Cor e Forma:SolidPeso molecular:282.15SM1-71
CAS:<p>SM1-71 is a TAK1 inhibitor that inhibits MKNK2 and RSK2.SM1-71 acts as a kinase probe with anticancer activity.</p>Fórmula:C24H26ClN7OPureza:96%Cor e Forma:SolidPeso molecular:463.96Itacitinib adipate
CAS:Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Fórmula:C32H33F4N9O5Cor e Forma:SolidPeso molecular:699.66BI-3663
CAS:<p>BI-3663 is a selective PTK2/FAK PROTAC with cereblon ligands, degrading PTK2 (IC50: 18 nM), and shows anti-cancer properties.</p>Fórmula:C44H42F3N7O12Pureza:98%Cor e Forma:SolidPeso molecular:917.84EW-7195
CAS:<p>EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.</p>Fórmula:C23H18N8Pureza:98.76%Cor e Forma:SolidPeso molecular:406.44Lestaurtinib
CAS:<p>Lestaurtinib (CEP 701) is a FLT3 inhibitor that inhibits the phosphorylation of RPTKs and can be used to study leukemia.</p>Fórmula:C26H21N3O4Pureza:99.17%Cor e Forma:Off-White SolidPeso molecular:439.46GMB-475
CAS:<p>GMB-475, a PROTAC-based BCR-ABL1 inhibitor, tackles drug resistance by promoting VHL-mediated degradation.</p>Fórmula:C43H46F3N7O7SPureza:98.78% - >99.99%Cor e Forma:SolidPeso molecular:861.93Gefitinib-based PROTAC 3
CAS:<p>Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).</p>Fórmula:C47H57ClFN7O8SPureza:97.29% - 98.25%Cor e Forma:SolidPeso molecular:934.51N-piperidine Ibrutinib
CAS:<p>N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.</p>Fórmula:C22H22N6OPureza:96.65%Cor e Forma:SolidPeso molecular:386.45DGY-06-116
CAS:<p>DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.</p>Fórmula:C32H33ClN8O2Pureza:97.65%Cor e Forma:SolidPeso molecular:597.11SKLB4771
CAS:<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Fórmula:C25H27N7O3S2Pureza:98% - >99.99%Cor e Forma:SolidPeso molecular:537.66Dasatinib N-oxide
CAS:<p>Dasatinib N-oxide is a key metabolite and potential impurity of the kinase inhibitor dasatinib.</p>Fórmula:C22H26ClN7O3SPureza:98.54% - 99.94%Cor e Forma:SolidPeso molecular:504UF010
CAS:<p>UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.</p>Fórmula:C11H15BrN2OPureza:98.03% - 99.68%Cor e Forma:SolidPeso molecular:271.15AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Fórmula:C29H28F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:535.56Arnebin 1
CAS:<p>(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) has anti-tumor, anti-inflammatory, anti-immune deficiency and protecting liver.</p>Fórmula:C21H22O6Pureza:98.76% - 99.81%Cor e Forma:SolidPeso molecular:370.396NVP-BAW2881
CAS:NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and acute skin inflammation.Fórmula:C22H15F3N4O2Pureza:98.19% - 99.97%Cor e Forma:SolidPeso molecular:424.38Protein kinase inhibitor 6
CAS:<p>Protein kinase inhibitor 6 is a protein kinase inhibitor.</p>Fórmula:C13H9FN2SPureza:98.01%Cor e Forma:SolidPeso molecular:244.29OICR-9429
CAS:<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Fórmula:C29H32F3N5O3Pureza:97.07% - 99.93%Cor e Forma:SolidPeso molecular:555.59Nastorazepide
CAS:<p>Nastorazepide is a selective, orally available antagonist of gastrin/cholecystokinin 2 (CCK-2) receptor with potential antineoplastic activity.</p>Fórmula:C29H36N4O5Pureza:99.83%Cor e Forma:SolidPeso molecular:520.62Zorifertinib
CAS:<p>Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.</p>Fórmula:C22H23ClFN5O3Pureza:98.20% - 99.36%Cor e Forma:White To Off-White SolidPeso molecular:459.9A 83-01
CAS:<p>A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.</p>Fórmula:C25H19N5SPureza:97% - 98.2%Cor e Forma:SolidPeso molecular:421.52PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Fórmula:C13H20Cl4N2O3Pureza:97% - 99.79%Cor e Forma:SolidPeso molecular:394.12
