Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(134 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(17 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6223 produtos de "Apoptose"
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TAT-BH4 (Bcl-xL) (TFA)
"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death.Fórmula:C159H268N58O45·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:3712.19 (free acid)GSPT1 degrader-1
GSPT1 Degrader-1 (Compound 9q) effectively facilitates the degradation of G1 to S phase transition 1 (GSPT1) through the ubiquitin-proteasome system and inducesFórmula:C28H33ClN4O5Pureza:98%Cor e Forma:SolidPeso molecular:541.04SACLAC
CAS:SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity used in the study of acute myeloid leukemia and cancer.Fórmula:C20H40ClNO3Pureza:97.03%Cor e Forma:SoildPeso molecular:377.99(E/Z)-Squalene
CAS:(E/Z)-Squalene modulates ROS, triggers apoptosis/necrosis, reduces liver cholesterol and triglycerides.Fórmula:C30H50Pureza:98.15%Cor e Forma:SolidPeso molecular:410.72Z-VDVA-(DL-Asp)-FMK
CAS:Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.Fórmula:C32H46FN5O11Cor e Forma:SolidPeso molecular:695.742MS41
CAS:MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). This compound effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest, and increases cellular apoptosis (Apoptosis). Additionally, MS41 reduces chromatin occupancy related to ENL-mediated transcription elongation mechanisms and suppresses the expression of oncogenes and the progression of leukemia.Fórmula:C56H70N8O9SCor e Forma:SolidPeso molecular:1031.27EJMC-1
CAS:EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.Fórmula:C17H11ClN2O4SPureza:98.38%Cor e Forma:SolidPeso molecular:374.8Trichostatin C
CAS:Trichostatin C, a natural glycosylated hydroxamate, is a histone deacetylase inhibitor with antifungal properties and can induce cell differentiation.Fórmula:C23H32N2O8Cor e Forma:SolidPeso molecular:464.515RSM3 TFA
RSM3 TFA is a stapled peptide and an inhibitor of METTL3-METTL14, exhibiting a dissociation constant (Kd) of 3.10 μM. It inhibits tumor growth and induces cell apoptosis. RSM3 TFA is utilized in cancer research.Cor e Forma:Odour SolidTRAP-1
TRAP-1 (XJZ-06-462) is a p53 transcription activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. In the p53Y220C pancreatic cell line, TRAP-1 rapidly upregulates p21 and other p53 target genes. TRAP-1 also inhibits cell proliferation, exhibiting IC50 values of 3.94 μM and 0.531 μM in BxPC-3 and A549 cell lines, respectively. Additionally, TRAP-1 modulates autophagy in lung cancer cells and provides protection against oxidative stress and apoptosis.Fórmula:C57H66ClF3N11O3PSCor e Forma:SolidPeso molecular:1108.69MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Fórmula:C41H42Cl2FN5O5Pureza:98%Cor e Forma:SolidPeso molecular:774.71JC2-11
CAS:JC2-11 is an anti-inflammatory agent blocking NLRC 4, AIM 2, ROS production, caspase-1 activity, and reducing GSDMD, IL-1β, and LDH in vesicles.
Fórmula:C17H15FO4Pureza:98.6%Cor e Forma:SoildPeso molecular:302.3Prodigiosin hydrochloride
CAS:Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.Fórmula:C20H26ClN3OCor e Forma:SolidPeso molecular:359.9CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Fórmula:C27H31N3O4Pureza:98%Cor e Forma:SolidPeso molecular:461.55Met-12
CAS:Met-12 is a peptide inhibitor of the Fas receptor. It suppresses Fas receptor-mediated apoptosis in photoreceptor cells and reduces Caspase activation, making it a potential candidate for research on photoreceptor protectants.Fórmula:C71H99N17O17Cor e Forma:SolidPeso molecular:1462.65Anticancer agent 272
Anticanceragent 272 (Compound 2) is an anticancer agent demonstrating significant activity against bladder cancer cells (T-24) with an IC50 of 2.81 μM. It depletes glutathione (GSH) through a Fenton-like reaction, generating reactive oxygen species (ROS) and hydroxyl radicals (•OH), thereby inducing apoptosis and ferroptosis. Anticanceragent 272 enhances chemodynamic therapy (CDT) and promotes tumor cell death through mitochondrial dysfunction and autophagy. It holds potential for further research in bladder cancer.Fórmula:C26H34Br2Cl4Cu2N8Cor e Forma:SolidPeso molecular:881.86192Arisostatin A
CAS:Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.Fórmula:C69H100N2O24Cor e Forma:SolidPeso molecular:1341.53SCR7
CAS:SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).Fórmula:C18H14N4OSPureza:98%Cor e Forma:SolidPeso molecular:334.4HSP90-IN-18
HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.Fórmula:C25H33FO3Cor e Forma:SolidPeso molecular:400.53GPX4-IN-6
CAS:GPX4-IN-6 is a GPX4 inhibitor with antitumor activity.GPX4-IN-6 induces iron death and is used for the treatment and prevention of triple-negative breast cancerFórmula:C18H17BrFNO5Pureza:99.54%Cor e Forma:SoildPeso molecular:426.23MDMX/MDM2-IN-2
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.Fórmula:C28H25Cl3FN3O3Cor e Forma:SolidPeso molecular:576.87D-CopA3
CAS:D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.Fórmula:C96H184N30O18S2Cor e Forma:SolidPeso molecular:2110.81Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.92% - 99.97%Cor e Forma:SolidPeso molecular:587.54Bcl-xL antagonist 2
CAS:Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM.Fórmula:C21H16N4O3S2Pureza:99.81%Cor e Forma:SolidPeso molecular:436.51Ref: TM-T38622
1mg77,00€5mg166,00€1mL*10mM (DMSO)182,00€10mg248,00€25mg447,00€50mg622,00€100mg800,00€200mg1.071,00€BCL-XL-IN-3
CAS:BCL-XL-IN-3 (Compound 11) is an inhibitor of BCL-XL, with a Ki of less than 0.01 nM. It suppresses cell viability in both normal Molt-4 cells and digitonin-permeabilized Molt-4 cells, with EC50 values of 77.8 nM and 0.07 nM, respectively. BCL-XL-IN-3 can be utilized as an ADC toxin for synthesizing Clezutoclax.Fórmula:C46H55N7O6SCor e Forma:SolidPeso molecular:834.04HNPMI
CAS:HNPMI is an epidermal growth factor receptor inhibitor that promotes apoptosis and is used in the study of colorectal cancer.Fórmula:C22H20N2O3Pureza:97.19%Cor e Forma:SoildPeso molecular:360.41CIGB-300 acetate
CIGB-300 acetate (P15-Tat acetate) is a peptide that acts as an inhibitor of casein kinase 2 (CK2). It exhibits anticancer properties by disrupting the phosphorylation activity of CK2. CIGB-300 acetate induces apoptosis in various tumor cell lines and is applicable for cancer research.Cor e Forma:Odour SolidMNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Fórmula:C15H12N2O2Pureza:99.74%Cor e Forma:SolidPeso molecular:252.27TG101209 analog 1
TG101209 analog 1 (Compound 8h) serves as an inhibitor of BUB1B, exhibiting an IC50 of 10.36 μM. It also possesses cytotoxic properties, demonstrated by an IC50 of 1.347 μM against Caki-1 cells, and can induce necrosis and apoptosis.Fórmula:C24H31N5O5SCor e Forma:SolidPeso molecular:501.598RIPK2-IN-2
CAS:RIPK2-IN-2, a RIP2 kinase PROTAC inhibitor, blocks proinflammatory signaling in autoinflammatory diseases.Fórmula:C53H65FN14O7S2Cor e Forma:SolidPeso molecular:1093.3CAY10726
CAS:CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.Fórmula:C24H36ClF3N2O3Cor e Forma:SolidPeso molecular:493P53/TLR2 modulator-1
P53/TLR2 modulator-1 (Compound Z9) is an agent that targets both the P53 pathway and TLR2, exhibiting radioprotective properties. It mitigates apoptosis by inhibiting radiation-induced expression of P53 and Bax. Concurrently, it enhances the TLR2 pathway by upregulating downstream proteins MyD88 and P65, which promotes secretion of cytokines like IL-6, providing radioprotective effects. P53/TLR2 modulator-1 shows significant radioprotective activity in AHH-1 and HUVECs cells, enhances survival rates in C57BL/6J mice exposed to lethal radiation doses, and alleviates radiation-induced damage to their hematopoietic system, intestinal villi, and spleen. It is applicable for research on radiation-related diseases.Cor e Forma:Odour SolidBMH-7 HCl
BMH-7 HCl is a p53 activator, showing anti-cancer activity by activating the p53 pathway.Fórmula:C20H22ClN5OPureza:99.62%Cor e Forma:SolidPeso molecular:383.88Pipernonaline
CAS:Pipernonaline is a useful organic compound for research related to life sciences. The catalog number is T124000 and the CAS number is 88660-10-0.Fórmula:C21H27NO3Cor e Forma:SolidPeso molecular:341.451eIF4E-IN-2
CAS:eIF4E-IN-2 effectively inhibits eIF4e, crucial for research on diseases like cancer.Fórmula:C37H33ClF2N8O4S2Cor e Forma:SolidPeso molecular:791.29DB2115 tertahydrochloride
CAS:DB2115 (tertahydrochloride) inhibits PU.1, key in leukemia; potential for cancer research.
Fórmula:C32H34Cl4N8O2Cor e Forma:SolidPeso molecular:704.48Violacein
CAS:Violacein, a purple antibacterial and antiprotozoal compound from C. violaceum, effective against Gram-positive bacteria and P. falciparum.
Fórmula:C20H13N3O3Cor e Forma:SolidPeso molecular:343.3484-B10
CAS:84-B10 provides protection in cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors.Fórmula:C25H22F3NO5Pureza:99.76%Cor e Forma:SolidPeso molecular:473.44Ref: TM-T75268
1mg47,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg152,00€25mg289,00€50mg447,00€100mg670,00€200mg888,00€Photosensitizer-3
CAS:Photosensitizer-3, generates single-linear oxygen upon near-infrared light excitation in combination with FAP,potent and selective killing cancer cells.Fórmula:C29H33ClI2N2O3Pureza:99.61%Cor e Forma:SolidPeso molecular:746.85PPA-904 FA
PPA-904 FA is a cationic photosensitizer with antimicrobial activity that can be used to study chronic leg ulcers and diabetic foot ulcers.Fórmula:C29H43N3O2SPureza:98%Cor e Forma:SolidPeso molecular:497.74PARP-1/2-IN-2
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repairFórmula:C25H23IN8O3Pureza:98%Cor e Forma:SolidPeso molecular:610.41XZ338
XZ338 is a highly selective degrader targeting BCL-XL without degrading BCL-2. It exhibits an IC50 value of 3.7 nM against MOLT-4 cells and possesses antiproliferative properties, making it useful for cancer research.Cor e Forma:Odour SolidUCM-1336
CAS:UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved inFórmula:C26H37N3O2Pureza:98.86%Cor e Forma:SolidPeso molecular:423.59RO7567132
RO7567132 is a bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, inducing the formation of local TLS.Cor e Forma:Odour LiquidPRLX-93936 HCL
CAS:PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.Fórmula:C21H26Cl2N4O2Pureza:98.4% - 99.94%Cor e Forma:SolidPeso molecular:437.37Mcl-1 antagonist 1
CAS:Mcl-1 antagonist 1 is a Mcl-1 protein antagonist.Fórmula:C41H54ClF2N5O8SPureza:98%Cor e Forma:SolidPeso molecular:850.42VEGFR-2-IN-64
VEGFR-2-IN-64 (Compound 28) is an inhibitor of VEGFR2 with an IC50 of 27.8 nM. It suppresses the proliferation of cancer cells A549, T-47D, and Caco-2, exhibits anti-migration and anti-colony formation activities in T-47D cells, and induces apoptosis in T-47D cells.Fórmula:C72H123N9O6Cor e Forma:SolidPeso molecular:1210.8NTR 368
CAS:cytoplasmic peptide of the neurotrophin receptor p75NTRFórmula:C69H124N22O19Pureza:98%Cor e Forma:SolidPeso molecular:1565.86SM-164 Hydrochloride (957135-43-2 free base)
SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.Fórmula:C62H85ClN14O6Pureza:98%Cor e Forma:SolidPeso molecular:1157.88anti-TNBC agent-1
CAS:anti-TNBC agent-1 targets TNBC effectively, with IC50 of 0.20-0.27 μM, inducing apoptosis and G1 arrest in SUM-159 cells.Fórmula:C26H30O7Cor e Forma:SolidPeso molecular:454.51Phenamet
CAS:Phenamet is a bioactive chemical.Fórmula:C19H28Cl2N2O3SCor e Forma:SolidPeso molecular:435.41Etanercept
CAS:Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.
Pureza:98%Cor e Forma:LiquidAcetyl coenzyme A
CAS:Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesisFórmula:C23H38N7O17P3SPureza:91.68%Cor e Forma:SolidPeso molecular:809.57Dynorphin A
CAS:Dynorphin A is a endogenous opioid peptide and a κ-opioid receptor (KOR) agonist,a neurotransmitter and regulator in the central and peripheral nervous systemsFórmula:C99H155N31O23Pureza:95.93%Cor e Forma:SolidPeso molecular:2147.48Macrophage-activating lipopeptide 2 TFA
Macrophage-activating lipopeptide 2 TFA (MALP-2 TFA) is a diacylglycerol lipopeptide and TLR-2/TLR-6 agonist activates immune cell responses macrophages,Fórmula:C99H167N19O30S·xC2HF3O2Pureza:97.56%Cor e Forma:SolidPeso molecular:2135.56 (free base)MPT0B014
CAS:MPT0B014 is a potent tubulin polymerization inhibitor. MPT0B014 can induce cancer cell apoptosis.
Fórmula:C19H17NO4Pureza:99.52%Cor e Forma:SolidPeso molecular:323.34Baceridin
CAS:Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus.Fórmula:C37H57N7O6Pureza:98%Cor e Forma:SolidPeso molecular:695.89Calphostin C
CAS:Calphostin C is a protein kinase C inhibitor.Fórmula:C44H38O14Pureza:98%Cor e Forma:Red To Brown PowderPeso molecular:790.76Ac-LEHD-AMC
CAS:Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.Fórmula:C33H41N7O11Cor e Forma:SolidPeso molecular:711.729Anti-Mouse PD-1 (LALA-PG) Antibody (RMP1-14)
Anti-MousePD-1(LALA-PG) Antibody (RMP1-14) is an IgG2a, κ antibody inhibitor derived from mice that targets and inhibits mouse PD-1.Cor e Forma:Odour LiquidPROTAC Bcl2 degrader-1
CAS:PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Fórmula:C45H45BrN6O10SPureza:98%Cor e Forma:SolidPeso molecular:941.84Dapirolizumab
Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.Pureza:>95%Cor e Forma:LiquidPeso molecular:150 kDaCyanoacetamide
CAS:Cyanoacetamide has inhibitory activity against the myeloid leukaemia cell differentiation protein Mcl-1Fórmula:C3H4N2OPureza:97.04%Cor e Forma:Needles From Alcohol White To Light Cream Crystalline PowderPeso molecular:84.08PKM2-IN-8
PKM2-IN-8 (Compound 9b) is an inhibitor of pyruvate kinase M2 (PKM2) with an IC50 of 0.31 μM. It exhibits potent antiproliferative activity against U87MG glioma cells. PKM2-IN-8 induces early apoptosis and reduces lactate levels. This compound is useful for research in glioblastoma.Fórmula:C19H13N7OCor e Forma:SolidPeso molecular:355.353TQB-2858
TQB-2858 is a bifunctional fusion protein composed of an anti-PD-L1 monoclonal antibody fused with the extracellular domain of the TGF-β receptor. It exhibits high affinity for PD-L1, TGF-β1, and TGF-β3, and demonstrates a high target occupancy rate for PD-L1. TQB-2858 can be used in research on osteosarcoma and alveolar soft part sarcoma (ASPS).Cor e Forma:Odour LiquidAjoene
CAS:Ajoene from garlic has antibacterial, anticancer, antiplatelet, and antioxidant effects; it combats various bacteria, yeasts, and cancer cells.
Fórmula:C9H14OS3Cor e Forma:SolidPeso molecular:234.39FTO-IN-14
FTO-IN-14 (Compound F97) is an inhibitor of the RNA demethylase Fat mass and obesity-associated protein (FTO), with an IC50 of 0.45 μM. It modulates the expression of the ASB2, RARA, and MYC proteins. FTO-IN-14 demonstrates antiproliferative activity in AML cancer cells, with IC50 values of 0.7-5.5 μM against MOLM13, NB4, HEL, OCI-AML3, MV4-11, and MONOMAC6, and induces apoptosis in NB4 cells. Additionally, FTO-IN-14 exhibits antitumor activity in a mouse NB4 xenograft model.Fórmula:C22H23N3O2SCor e Forma:SolidPeso molecular:393.502Thalidomide-O-C7-acid
CAS:Thalidomide-O-C7-acid: A cereblon ligand from Thalidomide linked via a PROTAC-used linker.Fórmula:C21H24N2O7Cor e Forma:SolidPeso molecular:416.43EGCG-4″-sulfate
CAS:EGCG-4″-sulfate, a predominant polyphenol in green tea, demonstrates notable anticancer, antioxidant, and anti-inflammatory effects, particularly againstFórmula:C22H18O14SCor e Forma:SolidPeso molecular:538.43DAPK Substrate Peptide
CAS:DAPK Substrate Peptide is a synthetic peptide substrate for death-associated protein kinase (DAPK) (Km = 9 μM).Fórmula:C70H115N25O17Pureza:98%Cor e Forma:SolidPeso molecular:1578.82PROTAC AR Degrader-8
CAS:PROTAC AR Degrader-8 (Compound NP18) functions as a PROTAC degrader targeting the androgen receptor (AR) and effectively degrades AR-FL in both 22Rv1 and LNCaP cells with DC50 values of 0.018 μM and 0.14 μM, respectively. It also degrades AR-V7 in 22Rv1 cells with a DC50 of 0.026 μM. Additionally, PROTAC AR Degrader-8 inhibits the proliferation of 22Rv1 and LNCaP cancer cells, exhibiting IC50 values of 0.038 μM and 1.11 μM. It induces cell cycle arrest at the G2/M phase and triggers apoptosis in 22Rv1 cells (apoptosis). Demonstrating anticancer efficacy, PROTAC AR Degrader-8 shows activity in both mouse and zebrafish models. [Pink: ligand for target protein AR ligand-33; Black: linker; Blue: ligand for E3 ligase Cereblon]Fórmula:C40H41N5O7Cor e Forma:SolidPeso molecular:703.783Sodium fluoride
CAS:Sodium fluoride is a fluorinated inorganic salt. With wide range of applications. Sodium fluoride is used in trace amounts in the fluoridation of drinking water to prevent tooth decay, and in toothpastes and topical pharmaceuticals for the same purpose, it can also act as an insectcide, herbicide and fungicide.Fórmula:FnaCor e Forma:SolidPeso molecular:41.99RIPK1 ligand-Linker Conjugate-1
RIPK1ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that consists of a RIPK1 ligand and a PROTAC linker, designed to recruit E3 ligase. It is utilized in the synthesis of PROTACRIPK1Degrader-1.Cor e Forma:Odour SolidThalidomide-O-amido-PEG3-C2-NH2
CAS:Thalidomide-O-amido-PEG3-C2-NH2 is a cereblon ligand-linker for PROTACs with a 3-unit PEG.Fórmula:C23H30N4O9Pureza:98%Cor e Forma:SolidPeso molecular:506.51β-Amyloid (1-40) (rat)
CAS:Rat form of the beta-Amyloid (1-40) peptideFórmula:C190H291N51O57SPureza:98%Cor e Forma:SolidPeso molecular:4233.76STAT3-IN-40
CAS:STAT3-IN-40 (Compound 8b) is an anticancer agent. It initiates immune responses in CD4+ and CD8+ T lymphocytes by inhibiting the expression and phosphorylation of STAT3, and induces ferroptosis and apoptosis in tumor cells. STAT3-IN-40 is valuable for research into cancer chemoimmunotherapy drugs.Fórmula:C34H40ClN3O10PtCor e Forma:SolidPeso molecular:881.232ZZM-1220
ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP.Fórmula:C25H29N5O3Pureza:98%Cor e Forma:SolidPeso molecular:447.53Fuscin
CAS:Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).Fórmula:C15H16O5Cor e Forma:SolidPeso molecular:276.288WR-S-462
WR-S-462 is a STAT3 inhibitor. It effectively blocks the phosphorylation and biological functions of STAT3 in vitro. The IC50 of WR-S-462 for inhibiting MDA-MB-231 cells is 0.03 μM, and it exhibits a strong binding affinity for STAT3 protein with a Kd of 58 nM. WR-S-462 prevents the nuclear translocation of p-STAT3 and selectively inhibits the expression of p-STAT3Tyr705 in MDA-MB-231 cells, as well as the expression of downstream target genes regulated by STAT3, such as Cyclin D1, Bcl-2, and Bcl-xl. This compound inhibits the growth and metastasis of triple-negative breast cancer (TNBC).Fórmula:C24H22N4O4SCor e Forma:SolidPeso molecular:462.52VEGFR-2-IN-68
VEGFR-2-IN-68 (13b) is an inhibitor of VEGFR-2 with an IC50 value of 41.51 nM. It can induce apoptosis and cause G2/M cell cycle arrest, as well as exhibit anti-cancer metastasis properties.Fórmula:C27H25N5O2SCor e Forma:SolidPeso molecular:483.1729Thalidomide-O-PEG4-NHS ester
CAS:Thalidomide-O-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker, commonly employed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].Fórmula:C28H33N3O13Pureza:98%Cor e Forma:SolidPeso molecular:619.57PROTAC c-Met degrader-6
PROTACc-Met degrader-6 is a potent and orally active c-Met PROTAC degrader. It effectively promotes the degradation of c-Met protein, with DC50 values of 0.52 nM in EBC-1 cells and 0.45 nM in Hs746T cells. This compound almost completely abolishes the migration and invasion capabilities of tumor cells, significantly induces apoptosis (apoptosis), and arrests the cell cycle at the G0/G1 phase. PROTACc-Met degrader-6 is useful for studying various cancers, including non-small cell lung cancer and gastric cancer.Cor e Forma:Odour SolidTopoII/tubulin-IN-1
TopoII/tubulin-IN-1 (Compound 1B8) is an inhibitor of TopoII/tubulin. It effectively suppresses the proliferation of tumor cells and reduces ROS levels, while inducing apoptosis and cell cycle arrest, without showing significant cytotoxicity to normal cells. TopoII/tubulin-IN-1 exhibits antitumor activity.Fórmula:C21H18ClN5O3Cor e Forma:SolidPeso molecular:423.85Anticancer agent 153
Anticancer Agent 153 (Compound 3) promotes apoptosis through the generation of Reactive Oxygen Species (ROS) and elevates the loss of Mitochondrial MembraneFórmula:C16H11Cl2N3O3Pureza:98%Cor e Forma:SolidPeso molecular:364.18BIO8898
BIO8898: potent CD40-CD154 inhibitor, IC50 of 25 µM, prevents CD40L-induced apoptosis.Fórmula:C53H64N8O6Cor e Forma:SolidPeso molecular:909.13Gamgertamig
CAS:Gamgertamig is a humanized bispecific antibody of the IgG4 type that targets TNFRSF17 and CD3E.Cor e Forma:LiquidSTAT3/NF-κB-IN-1
STAT3/NF-κB-IN-1 is a potent inhibitor of STAT3 and NF-κB, exhibiting IC50 values of 5.86 μM for STAT3 and 4.22 μM for NF-κB in 4 T1 cells. It induces apoptosis by upregulating key apoptotic regulators (caspases-3, 9, Bax) and downregulating Bcl-2 expression. STAT3/NF-κB-IN-1 shows significant anticancer activity against breast cancer cell lines and can reduce tumor volume in vivo. It is applicable for research in breast cancer.Cor e Forma:Odour SolidEGFR-IN-169
EGFR-IN-169 is an epidermal growth factor receptor (EGFR) inhibitor derived from ginsenoside, with an IC50 of 5.19 μM. It disrupts colorectal cancer cell migration and growth by inhibiting the EGFR-mediated RalA/EMT pathway. With an IC50 of 4.46 μM against HCT-116 cells and a selectivity index (SI) of 16.92, EGFR-IN-169 also inhibits CDKs, induces G0/G1 cell cycle arrest, and suppresses cell migration and invasion. Additionally, EGFR-IN-169 reduces mitochondrial membrane potential, induces apoptosis and reactive oxygen species (ROS) production. It is applicable in cancer research, particularly for colorectal cancer.Cor e Forma:Odour SolidAnticancer agent 267
Anticanceragent 267 (Compound 5q) serves as an activator of RIPK3 and MLKL. It effectively inhibits the proliferation of several cancer cell lines, with IC50 values of 9.79, 10.77, and 5.94 μM for MDA-MB-231, MDA-MB-486, and MCF-7, respectively. The compound induces cell cycle arrest at the subG1 phase and triggers necroptosis in MDA-MB-231 cells. Additionally, Anticanceragent 267 demonstrates antitumor activity in mouse xenograft models.Fórmula:C13H11N5O4SCor e Forma:SolidPeso molecular:333.32Anticancer agent 273
Anticanceragent 273 (Compound 9q) is an effective anticancer compound identified from matrine. It inhibits cancer cell proliferation, with an IC50 of 4.48 μM against HeLa cells. Anticanceragent 273 exerts its anticancer effects by modulating PI3K/AKT expression and activating activating transcription factor 4 (ATF4), which induces endoplasmic reticulum stress and triggers apoptosis. It holds potential for cancer research, including cervical cancer.Cor e Forma:Odour SolidGSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-Fórmula:C17H16N6OSCor e Forma:SolidPeso molecular:352.419(E),11(E),13(E)-Octadecatrienoic Acid
CAS:β-ESA, a polyunsaturated fatty acid in seed oils, inhibits Caco-2 cell growth dose- and time-dependently.Fórmula:C18H30O2Cor e Forma:SolidPeso molecular:278.436PK095
CAS:PK095 is a proprietary compound in the guanidine - based F1F0-ATPase inhibitor family.
Fórmula:C20H18N4O2SPureza:96.84%Cor e Forma:SoildPeso molecular:378.45YTHDF2-IN-1
YTHDF2-IN-1 (Compound CK-75) is an inhibitor of YT521-B homology domain family 2 (YTHDF2) with a dissociation constant (Kd) of 26.2 μM, and it effectively blocks the interaction between YTHDF2 and m6A RNA. It suppresses colony formation in JAR cells and exhibits antiproliferative activity in various cancer cell lines, with an IC50 in the micromolar range. Additionally, YTHDF2-IN-1 induces apoptosis in K562 cells and causes cell cycle arrest at the G0/G1 phase.Fórmula:C21H14N2O4Cor e Forma:SolidPeso molecular:358.35Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride: anti-cancer, inhibits tumour metabolism, targets ANT, promotes apoptosis, marks cell proteins.Fórmula:C18H26AsClN4O9SPureza:99.74%Cor e Forma:SoildPeso molecular:584.86Cardanol (C15:1)
CAS:Cardanol (C15:1), found in cashew nut shell liquid, induces mitochondria-associated apoptosis in human melanoma cells.Fórmula:C21H34OPureza:98.48% - 99.77%Cor e Forma:SolidPeso molecular:302.49Ref: TM-TN3594
100mgA consultar1mg92,00€2mg135,00€5mg259,00€1mL*10mM (DMSO)268,00€10mg371,00€25mg583,00€50mg800,00€AZD5153
CAS:AZD5153 is an orally active and selective BET/BRD4 bromodomain inhibitor with an IC50 value of 1.7nM for BRD4.Fórmula:C25H33N7O3Pureza:99.25%Cor e Forma:SolidPeso molecular:479.57GPI-1485
CAS:GPI-1485 (GM1485) (GM1485) is a nonimmunosuppressive immunophilin ligand, promoting neurofunctional improvement and neural regeneration following stroke.Fórmula:C12H19NO4Pureza:99.80%Cor e Forma:SolidPeso molecular:241.28Ref: TM-T9820
1mg58,00€5mg126,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg340,00€50mg505,00€100mg715,00€200mg1.054,00€Nrf2 activator-9
Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-densityFórmula:C26H27N5O4Cor e Forma:SolidPeso molecular:473.52H-20
CAS:H-20 is a PD-1 agonist that reduces the required dosage of morphine for analgesia. It can be used in studies related to chronic pain.Fórmula:C44H64N10O15Cor e Forma:SolidPeso molecular:973.037
