Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5599 produtos de "Apoptose"
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Tibulizumab
CAS:<p>Tibulizumab (LY 3090106) is a bispecific antibody for BAFF & IL-17A; Kds: 60 & 14 pM; for autoimmune research.</p>Cor e Forma:LiquidFeTPPS
CAS:<p>FeTPPS, a decomposition catalyst for 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin iron(III) chloride peroxynitrite, neuroprotective.</p>Fórmula:C44H28ClFeN4O12S4Cor e Forma:SolidPeso molecular:1024.27dTAGV-1-NEG TFA
<p>dTAGV-1-NEG TFA, a diastereomer, serves as the heterobifunctional negative control for dTAGV-1. It acts specifically as an FKBP12 F36V-selective degrader [1].</p>Fórmula:C70H91F3N6O16SCor e Forma:SolidPeso molecular:1361.56Top1-IN-2
<p>Top1-IN-2 (Compound 1a) is an inhibitor of topoisomerase 1 (Top1). It suppresses the growth of P-gp drug-resistant tumor cells and induces apoptosis.</p>Cor e Forma:Odour Solidp53 (17-26)
CAS:<p>Peptide is p53's amino acids 17-26, contacts Mdm-2 binding domain, also called p53N.</p>Fórmula:C60H90N12O17Pureza:98%Cor e Forma:SolidPeso molecular:1251.43Peginterferon β-1a
CAS:<p>Peginterferon beta-1a: first pegylated interferon for cancer, RMS research; induces tumor cell apoptosis.</p>Cor e Forma:SolidNDI-Lyso
CAS:<p>NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).</p>Fórmula:C71H100N22O13Cor e Forma:SolidPeso molecular:1469.69Thalidomide-O-C8-Boc
CAS:<p>Thalidomide-O-C8-Boc: CRBN ligand for PROTAC creation, derived from Thalidomide.</p>Fórmula:C26H34N2O7Cor e Forma:SolidPeso molecular:486.565ATPase-IN-3
CAS:<p>ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.</p>Fórmula:C10H6N2O3S2Pureza:97.76%Cor e Forma:SoildPeso molecular:266.3NecroIr1
<p>NecroIr1, an iridium(III) complex, induces necroptosis in Cisplatin-resistant lung cells, targeting mitochondria and disrupting MMP.</p>Fórmula:C40H29ClIrN5OCor e Forma:SolidPeso molecular:823.36Holothurin A
CAS:<p>Holothurin A is a triterpene glycoside.</p>Fórmula:C54H86NaO27SCor e Forma:SolidPeso molecular:1222.3Besufetamig
CAS:<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Cor e Forma:LiquidThalidomide-O-C8-COOH
CAS:<p>Thalidomide-O-C8-COOH, also known as Cereblon ligand 3, is a Thalidomide-derived compound that serves as a Cereblon (CRBN) ligand for the targeted recruitment</p>Fórmula:C22H26N2O7Cor e Forma:SolidPeso molecular:430.45HTH-01-091 TFA
<p>HTH-01-091 TFA: Potent, selective MELK inhibitor (IC50=10.5 nM); also targets PIM1/2/3, RIPK2, DYRK3, smMLCK, CLK2; used in breast cancer research.</p>Fórmula:C28H29Cl2F3N4O4Cor e Forma:SolidPeso molecular:613.46LSD1-IN-26
<p>LSD1-IN-26 (12u) is a potent LSD1 inhibitor (IC50=25.3 nM), also inhibits MAO-A/B, induces apoptosis in MGC-803, for gastric cancer research.</p>Fórmula:C27H25Cl2F2N3OCor e Forma:SolidPeso molecular:516.41AP1867-2-(carboxymethoxy)
CAS:<p>AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG</p>Fórmula:C38H47NO11Cor e Forma:SolidPeso molecular:693.78Nemorosone
CAS:<p>Nemorosone, a PPAP from C. rosea, inhibits neuroblastoma and pancreatic cancer cell growth, induces apoptosis, and reduces mouse xenograft tumors.</p>Fórmula:C33H42O4Cor e Forma:SolidPeso molecular:502.695Humulone
<p>Humulone is a natural product and has a wide range of applications in life science related research.</p>Fórmula:C21H30O5Cor e Forma:SolidPeso molecular:362.47ChoKα inhibitor-3
<p>ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability to</p>Fórmula:C50H54Br2Cl2N4S2Cor e Forma:SolidPeso molecular:1005.83Thalidomide-O-amido-PEG2-C2-NH2
CAS:<p>Thalidomide-O-amido-PEG2-C2-NH2, which combines an E3 ligase ligand with a linker, serves as an immunomodulator for cancer treatment.</p>Fórmula:C21H26N4O8Cor e Forma:SolidPeso molecular:462.459Mumefural
CAS:<p>Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.</p>Fórmula:C12H12O9Cor e Forma:SolidPeso molecular:300.22ZS3-046
<p>ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.</p>Fórmula:C49H57N9O7Cor e Forma:SolidPeso molecular:883.4381MEK/PI3K-IN-1
CAS:<p>MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.</p>Fórmula:C36H37F5IN9O6Cor e Forma:SolidPeso molecular:913.63Satratoxin G
CAS:<p>Satratoxin G, from Stachybotrys chartarum, triggers apoptosis in nasal and brain OSNs.</p>Fórmula:C29H36O10Cor e Forma:SolidPeso molecular:544.597Tubulysin B
CAS:<p>Tubulysin B: a potent, cytotoxic microtubule-disrupting peptide from Archangium geophyra and Angiococcus disciformis.</p>Fórmula:C42H63N5O10SPureza:98%Cor e Forma:SolidPeso molecular:830.04Targaprimir-96 TFA
<p>Targaprimir-96 TFA is a selective inhibitor of miR-96 in cancer, inducing apoptosis with high affinity for pri-miR-96 but not affecting healthy cells.</p>Fórmula:C79H103F3N18O9Cor e Forma:SolidPeso molecular:1505.77Thalidomide-O-C8-NH2 hydrochloride
CAS:<p>Thalidomide-derived cereblon ligand with PROTAC linker as an E3 ligase ligand-linker conjugate, in hydrochloride form.</p>Fórmula:C21H28ClN3O5Cor e Forma:SolidPeso molecular:437.92Thalidomide-PEG4-NH2 hydrochloride
CAS:<p>Thalidomide-PEG4-NH2 HCl, a cereblon ligand-linker for PROTAC.</p>Fórmula:C21H28ClN3O8Cor e Forma:SolidPeso molecular:485.92PARP-1/2-IN-2
<p>PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair</p>Fórmula:C25H23IN8O3Pureza:98%Cor e Forma:SolidPeso molecular:610.41Nargenicin
CAS:<p>Nargenicin: a macrolide antibiotic effective against S. aureus, MRSA, M. luteus; inhibits bacterial DnaE and reduces inflammation and leukemia cell growth.</p>Fórmula:C28H37NO8Cor e Forma:SolidPeso molecular:515.63-Hydroxykynurenine
CAS:<p>3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.</p>Fórmula:C10H12N2O4Pureza:98.83% - 99.69%Cor e Forma:SolidPeso molecular:224.21QN523
CAS:<p>QN523 has drug-like traits, kills cancer cells in vitro, effective in vivo against pancreatic cancer, works via autophagy.</p>Fórmula:C14H10N4OPureza:99.83%Cor e Forma:SolidPeso molecular:250.26Rosomidnar
CAS:<p>PNT100: 24-base DNA oligo targeting BCL-2 regulatory region; halts tumor cell growth, induces death.</p>Fórmula:C227H291O141P23Cor e Forma:SolidPeso molecular:7220.63LY3415244
<p>LY3415244 is a human bispecific antibody (bsAb) that targets B7-H1/PD-L1/CD274 and TIM-3/HAVCR2/CD366. This compound is applicable in the study of advanced solid tumors.</p>Cor e Forma:Odour LiquidAntitumor agent-61
CAS:<p>Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.</p>Fórmula:C54H63FN5O10PCor e Forma:SolidPeso molecular:992.08Ascochlorin
CAS:<p>Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.</p>Fórmula:C23H29ClO4Pureza:98%Cor e Forma:SolidPeso molecular:404.93Didocosahexaenoin
CAS:<p>Didocosahexaenoin, omega-3 diglyceride, disrupts mitochondria, induces ROS, apoptosis, and is cytotoxic to prostate cancer cells.</p>Fórmula:C25H40O5Cor e Forma:SolidPeso molecular:420.58PROTAC RIPK degrader-2
CAS:<p>PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.</p>Fórmula:C52H65N7O11S3Pureza:98%Cor e Forma:SolidPeso molecular:1060.31STM3006
CAS:<p>STM3006 is an orally active, selective and and potent METTL3 inhibitor with antitumor activity for the study of acute myeloid leukemia (AML).</p>Fórmula:C25H27BrN8Pureza:97.16%Cor e Forma:SoildPeso molecular:519.44Psalmotoxin 1
CAS:<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Fórmula:C200H312N62O57S6Pureza:98%Cor e Forma:SolidPeso molecular:4689.41SP3N hydrochloride
<p>SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.</p>Cor e Forma:Odour SolidSuramin
CAS:<p>Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.</p>Fórmula:C51H40N6O23S6Pureza:99.80%Cor e Forma:SolidPeso molecular:1297.28hMAO-B-IN-11
<p>hMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 value of 0.11 µM. It operates by competitively binding to the active site of hMAO-B, thereby preventing the oxidative deamination of monoamines and reducing hydrogen peroxide production. Additionally, hMAO-B-IN-11 inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia. This compound holds potential for research in neurodegenerative diseases such as Parkinson's and Alzheimer's.</p>Cor e Forma:Odour SolidSecalonic acid D
CAS:<p>Secalonic acid D, from Aspergillus aculeatus, is anti-tumor, activates GSK3-β, degrades β-catenin, inhibits c-Myc, and induces apoptosis.</p>Fórmula:C32H30O14Cor e Forma:SolidPeso molecular:638.57Thalidomide-NH-C8-NH2 hydrochloride
CAS:<p>Thalidomide-based E3 ligase ligand-linker for PROTAC, with cereblon ligand and C8-NH2 hydrochloride.</p>Fórmula:C21H29ClN4O4Cor e Forma:SolidPeso molecular:436.94Tomuzotuximab
CAS:<p>Tomuzotuximab: fully human, glycoengineered IgG1 anti-EGFR monoclonal antibody with anticancer properties.</p>Cor e Forma:LiquidPZ703b hydrochloride
<p>PZ703b hydrochloride, a Bcl-xl PROTAC, triggers apoptosis and halts cancer growth; used in bladder cancer studies.</p>Fórmula:C80H103Cl2F3N10O11S4Cor e Forma:SolidPeso molecular:1636.9Thalidomide-O-amido-C8-NH2 hydrochloride
<p>Thalidomide-O-amido-C8-NH2 hydrochloride, a synthetic cereblon ligand-linker for PROTAC synthesis.</p>Fórmula:C23H31ClN4O6Pureza:98%Cor e Forma:SolidPeso molecular:494.97Vallesiachotamine
CAS:<p>Vallesiachotamine, a recognized monoterpene indole alkaloid, exhibits anti-tumor activity [1].</p>Fórmula:C21H22N2O3Cor e Forma:SolidPeso molecular:350.41SDH-IN-26
<p>SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor with significant inhibitory activity against various plant pathogenic fungi, including solanrhizoctonia and Botrytis cinerea. It exhibits an EC50 value of 0.270 μg/mL against solanrhizoctonia. SDH-IN-26 compromises fungal cell membrane integrity, increases membrane permeability, disrupts cell structure, reduces mitochondrial count, and affects normal hyphal growth. It also decreases mitochondrial membrane potential, inducing apoptosis. SDH-IN-26 holds potential for studying plant diseases caused by fungi.</p>Cor e Forma:Odour SolidPROTAC EGFR degrader 5
CAS:<p>PROTAC EGFR degrader 5 effectively breaks down EGFR Del19 in HCC827 cells at 34.8 nM, inducing apoptosis and G1 arrest.</p>Fórmula:C57H72FN13O5SCor e Forma:SolidPeso molecular:1070.33HJC0416 hydrochloride
CAS:<p>HJC0416 hydrochloride: potent oral STAT3 inhibitor, better anticancer effects than Stattic, promising for breast cancer research.</p>Fórmula:C18H18Cl2N2O4SCor e Forma:SolidPeso molecular:429.31AM-8553
CAS:<p>AM-8553 is potent and selective piperidine the MDM2-p53 interaction inhibitor.</p>Fórmula:C25H29Cl2NO4Cor e Forma:SolidPeso molecular:478.41EAD1
CAS:<p>EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.</p>Fórmula:C24H27Cl2N7Pureza:98%Cor e Forma:SolidPeso molecular:484.42Ac-VDVAD-CHO TFA
<p>Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.</p>Cor e Forma:Odour SolidPRLX-93936 HCL
CAS:<p>PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.</p>Fórmula:C21H26Cl2N4O2Pureza:98.4% - 99.94%Cor e Forma:SolidPeso molecular:437.37eIF4A3-IN-5
CAS:<p>eIF4A3-IN-5 potently inhibits eIF4AI/II, promising for cancer research.</p>Fórmula:C26H22N2O7Cor e Forma:SolidPeso molecular:474.469PL120131
<p>PL120131 is a PD-1/PD-L1 inhibitory peptide that disrupts the interaction between PD-1 and PD-L1 by binding to PD-1. This compound can inhibit the apoptosis signaling pathway mediated by PD-1, thereby preventing apoptosis (apoptosis) in Jurkat cells and primary lymphocytes. Additionally, PL120131 supports cytotoxic T lymphocytes (CTL) in exhibiting antitumor activity.</p>Fórmula:C62H105N19O18Cor e Forma:SolidPeso molecular:1404.61RIPK3-IN-3
<p>RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM.</p>Fórmula:C16H11N5SCor e Forma:SolidPeso molecular:305.36MDM2/4-p53-IN-2
<p>MDM2/4-p53-IN-2 (2q) is a dual MDM2/MDM4 inhibitor, p53 activator; IC50: 70.7 nM(MDM2), 81.4 nM(MDM4); tumor suppressor.</p>Fórmula:C25H17Cl3FN3O3Cor e Forma:SolidPeso molecular:532.78SZUH280
CAS:<p>SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells.</p>Fórmula:C36H34N8O8Cor e Forma:SolidPeso molecular:706.7Z-VEID-FMK
CAS:<p>Z-VEID-FMK is a selective caspase-6 peptide inhibitor that irreversibly covalently binds to the enzyme, thereby inhibiting apoptosis and DNA breakage.</p>Fórmula:C31H45FN4O10Pureza:98%Cor e Forma:SolidPeso molecular:652.71RET ligand-3
<p>RETligand-3 is the ligand for PROTAC QZ2135, which targets RET.</p>Fórmula:C38H42N10O3Cor e Forma:SolidPeso molecular:686.81Apoptosis inducer 12
CAS:<p>Apoptosis Inducer 12 (Compound 3z) is a compound that promotes cell death via the mitochondrial pathway and is utilized in cancer research [1].</p>Fórmula:C26H27N3O5Cor e Forma:SolidPeso molecular:461.51Fluorescein-diisobutyrate-6-amide
CAS:<p>Fluorescein-diisobutyrate-6-amide, a powerful inducer of ferroptosis, shows promise for cancer research applications [1].</p>Fórmula:C62H61ClN6O16Cor e Forma:SolidPeso molecular:1181.63PTD-p65-P1 Peptide
<p>PTD-p65-P1: a NF-kappaB inhibitor blocking activation from multiple inflammatory stimuli.</p>Fórmula:C168H275N57O44SPureza:98%Cor e Forma:SolidPeso molecular:3829.5Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS:<p>Thalidomide-based E3 ligase ligand with PEG2-C2 linker; used as an immunomodulatory cancer treatment.</p>Fórmula:C21H27ClN4O8Pureza:98.09%Cor e Forma:SolidPeso molecular:498.914Thalidomide-O-amido-C3-COOH
CAS:<p>Thalidomide-O-amido-C3-COOH is a cereblon ligand-linker for PROTACs, melding Thalidomide with a standard linker.</p>Fórmula:C19H19N3O8Pureza:98%Cor e Forma:SolidPeso molecular:417.37XZ739
CAS:<p>XZ739: Cereblon-based PROTAC, degrades BCL-XL (DC50 2.5 nM in MOLT-4, 16hr), induces caspase apoptosis.</p>Fórmula:C65H76ClF3N8O12S3Cor e Forma:SolidPeso molecular:1349.99TD52 dihydrochloride
<p>TD52 dihydrochloride, an Erlotinib derivative, inhibits protein phosphatase 2A and induces apoptosis in TNBC by disrupting CIP2A/PP2A/p-Akt signaling.</p>Fórmula:C24H18Cl2N4Pureza:97.23%Cor e Forma:SoildPeso molecular:433.33MSU-42011
CAS:<p>MSU-42011: oral RXR-like agonist, inhibits iNOS & p-ERK, antitumor in lung cancer model, effective preclinical treatment.</p>Fórmula:C24H34N2O2Pureza:99.52%Cor e Forma:SoildPeso molecular:382.54MAO-B-IN-30
CAS:<p>MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.</p>Fórmula:C15H10BrN3O2Pureza:98.31%Cor e Forma:SoildPeso molecular:344.16GPLGIAGQ acetate
<p>GPLGIAGQ acetate: MMP2-cleavable peptide; stimulus-sensitive linker for MMP2-targeted liposomal/micellar carriers in photodynamic therapy.</p>Fórmula:C33H57N9O12Pureza:97.85%Cor e Forma:SolidPeso molecular:771.86Linearol
CAS:<p>Linearol: diterpene from Sideritis L. with antioxidant, anti-inflammatory, anti-apoptotic effects.</p>Fórmula:C22H34O4Pureza:98%Cor e Forma:SolidPeso molecular:362.50Aspochalasin D
CAS:<p>Aspochalasin D, isolated from A. microcysticus, shows antibacterial properties and cytotoxicity affecting Ba/F3-V12 cells, with IC50s of 0.49 and 1.9 μg/ml.</p>Fórmula:C24H35NO4Cor e Forma:SolidPeso molecular:401.54Fludioxonil
CAS:<p>Fludioxonil (CGA 173506), a phenylpyrrole fungicide, inhibits the growth of B. cinerea from strawberry and blackberry crops.</p>Fórmula:C12H6F2N2O2Pureza:99.971%Cor e Forma:SolidPeso molecular:248.18Eldecalcitol
CAS:<p>Eldecalcitol, orally active vitamin D analog, boosts bone density and treats osteoporosis.</p>Fórmula:C30H50O5Pureza:98%Cor e Forma:SolidPeso molecular:490.72Lambertianic acid
CAS:<p>Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.</p>Fórmula:C20H28O3Pureza:98%Cor e Forma:SolidPeso molecular:316.441LIB3S0280
<p>LIB3S0280 is a potent inhibitor of TBK1, with an IC50 of 493.9 nM. It suppresses TBK1 downstream signaling by reducing the phosphorylation of IκBα and AKT. LIB3S0280 causes G2/M phase arrest and induces apoptosis in pancreatic cancer cells. Notably, it exhibits significant inhibitory effects on pancreatic cancer cell lines with high TBK1 expression, with a 96-hour IC50 value ranging from 6.64-10.98 μM. LIB3S0280 shows potential for research in pancreatic ductal adenocarcinoma (PDAC).</p>Cor e Forma:Odour SolidThalidomide 4'-oxyacetamide-alkyl-C2-amine HCl
CAS:<p>Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl is an E3 ligase ligand-linker conjugate containing the E3 ubiquitin ligase cereblon (CRBN) and linker.</p>Fórmula:C17H19ClN4O6Pureza:99.78%Cor e Forma:SolidPeso molecular:410.81Apoptosis inducer 33
<p>Apoptosisinducer 33 (compound H2) is a hydrazone derivative. It exhibits antioxidant and antimicrobial properties, capable of inhibiting the growth of Staphylococcus aureus, Escherichia coli, and Candida albicans. Additionally, Apoptosisinducer 33 can suppress tumor cell proliferation and induce apoptosis (apoptosis), making it useful for tumor research.</p>Fórmula:C16H13N3O2Cor e Forma:SolidPeso molecular:279.293JAK/HDAC-IN-2
<p>JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.</p>Fórmula:C28H38N6O5SPureza:98%Cor e Forma:SolidPeso molecular:570.7Apoptosis inducer 29
Apoptosis Inducer 29 (compound Y9) demonstrates anticancer efficacy in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis, and exhibits superior performance to Gboixn both in vitro and in vivo.Fórmula:C33H46ClN3O3Cor e Forma:SolidPeso molecular:568.19Methyl-4-oxoretinoate
CAS:<p>Methyl-4-oxoretinoate is a synthetic retinoid with anticancer properties, used for skin conditions and potential ocular treatments.</p>Fórmula:C21H28O3Pureza:98.07%Cor e Forma:SolidPeso molecular:328.45Thalidomide-Piperazine-Piperidine
CAS:<p>Thalidomide-based E3 ligase ligand linked to a PROTAC piperazine-piperidine chain.</p>Fórmula:C22H27N5O4Cor e Forma:SolidPeso molecular:425.489BDK-IN-1
<p>BDK-IN-1 (compound (-)-43) is a BDK inhibitor with an IC50 of 0.23 μM and a maximum inhibition rate of 90%. It reduces phosphorylated-E1 levels and is useful in the study of cardiac metabolic diseases.</p>Fórmula:C18H14F2N2O3SCor e Forma:SolidPeso molecular:376.38β-Glucuronide-dPBD-PEG5-NH2 TFA
CAS:<p>β-Glucuronide-dPBD-PEG5-NH2 TFA is a β-glucuronide-linked pyrrolobenzodiazepine dimer employed in the synthesis of the antibody-drug conjugate (ADC) cIRCR201-</p>Fórmula:C80H102F3N7O37Cor e Forma:SolidPeso molecular:1810.69Isomahanine
<p>Isomahanine is a useful organic compound for research related to life sciences and the catalog number is T125848.</p>Fórmula:C23H25NO2Cor e Forma:SolidPeso molecular:347.458PERK-IN-4
CAS:<p>PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.</p>Fórmula:C24H19F4N5OPureza:98.07% - 98.95%Cor e Forma:SolidPeso molecular:469.43Linsidomine hydrochloride
CAS:<p>SIN-1 chloride is a moxidomine metabolite with vasodilatory, anti-platelet, and antianginal effects, reducing myocardial ischemia-related damage.</p>Fórmula:C6H11ClN4O2Pureza:99.27% - 99.67%Cor e Forma:White Solid CrystallinePeso molecular:206.632,2'-Dihydroxy chalcone
CAS:<p>2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.</p>Fórmula:C15H12O3Pureza:99.7%Cor e Forma:SolidPeso molecular:240.25PROTAC GPX4 degrader-1
CAS:<p>PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080</p>Fórmula:C50H57ClN10O10Cor e Forma:SolidPeso molecular:993.5Antitumor photosensitizer-7
<p>Antitumor photosensitizer-7 (compound 15), a photosensitizer possessing anti-cancer properties, demonstrates substantial cytotoxic effects on the G361 melanoma cell line when exposed to 414 nm blue light irradiation.</p>Fórmula:C23H20N2O3Cor e Forma:SolidPeso molecular:372.42Amorfrutin A
CAS:<p>Amorfrutin A is a useful organic compound for research related to life sciences. The catalog number is T124190 and the CAS number is 80489-90-3.</p>Fórmula:C21H24O4Cor e Forma:SolidPeso molecular:340.419RMC-6291
CAS:<p>RMC-6291: Oral, covalent KRAS G12C inhibitor, blocks signaling, forms tri-complex with CypA, suppresses RAS activity in tumors.</p>Fórmula:C55H78FN9O8Pureza:98.73%Cor e Forma:SolidPeso molecular:1012.26PRMT5-IN-31
<p>PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and</p>Fórmula:C21H24N2O2Pureza:98%Cor e Forma:SolidPeso molecular:336.43S65487 hydrochloride
CAS:<p>S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is effective against BCL-2 mutations, including G101V and D103Y.</p>Fórmula:C41H42Cl2N6O4Cor e Forma:SolidPeso molecular:753.73Enterodiol
<p>Enterodiol is a natural product that can be used as a reference standard.</p>Fórmula:C18H22O4Cor e Forma:SolidPeso molecular:302.37Thalidomide-NH-C6-NH2 TFA
CAS:<p>Thalidomide-based cereblon ligand linked to PROTAC technology as E3 ligase ligand-linker.</p>Fórmula:C21H25F3N4O6Pureza:98%Cor e Forma:SolidPeso molecular:486.44
