Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(137 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(18 produtos)
- Survivina(14 produtos)
- TNF(94 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6231 produtos de "Apoptose"
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C6 Ceramide
CAS:C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0/G1 phase by activating ERK.Fórmula:C24H47NO3Pureza:99.67% - 99.73%Cor e Forma:SolidPeso molecular:397.63Triciribine phosphate
CAS:Triciribine phosphate (VD 002) is an AKT inhibitor that inhibits neovascularization and can be used in the study of leukemia.Fórmula:C13H17N6O7PPureza:97.94%Cor e Forma:SolidPeso molecular:400.28SYM 2081
CAS:SYM 2081: Kainate receptor agonist, IC50 of 35 nM, depolarizes muscle, lowers EPSP amplitude.Fórmula:C6H11NO4Pureza:99.63%Cor e Forma:SolidPeso molecular:161.16cRIPGBM chloride
CAS:cRIPGBM chloride is a pro-apoptotic derivative found in GBM cancer stem cells with anti-tumor activity, inducing caspase-1-dependent apoptosis.Fórmula:C26H20ClFN2O2Pureza:99.75%Cor e Forma:SolidPeso molecular:446.9NLRP3/AIM2-IN-3
CAS:NLRP3/AIM2-IN-3 selectively blocks NLRP3/AIM2 inflammasomes; IC50 for cell lysis is 0.077 μM, disrupting ASC oligomerization.Fórmula:C16H14N2O2Pureza:97.04%Cor e Forma:SolidPeso molecular:266.29Ref: TM-T60442
5mg71,00€1mL*10mM (DMSO)78,00€10mg102,00€25mg205,00€50mg334,00€100mg537,00€500mg1.134,00€Stemazole
CAS:Stemazole activates human stem cell growth, boosts survival, reduces cell death, and aids myelin repair, with therapeutic potential in demyelinating diseases.Fórmula:C9H9N5OS2Pureza:98.59%Cor e Forma:SolidPeso molecular:267.33Ref: TM-T28866
1mg52,00€1mL*10mM (DMSO)95,00€5mg101,00€10mg164,00€25mg334,00€50mg532,00€100mg858,00€200mg1.149,00€ZDLD20
CAS:ZDLD20 is a CDK4 inhibitor with anti-HCT116 and anticancer activity that inhibits colony formation and blocks the G1 phase of the cell cycle.Fórmula:C22H22N6OPureza:98.59%Cor e Forma:SolidPeso molecular:386.45Erastin2
CAS:Erastin2 is an iron death inducer that induces cell death by binding to the lipophilic free radical trapping antioxidant ferrostatin-1 or the iron chelator DFO.
Fórmula:C36H35ClN4O4Pureza:99.63%Cor e Forma:SolidPeso molecular:623.14LDC7559
CAS:LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.Fórmula:C20H19N3O3Pureza:99.67% - 99.8%Cor e Forma:SoildPeso molecular:349.38Ref: TM-T11828
1mg66,00€1mL*10mM (DMSO)101,00€5mg130,00€10mg203,00€25mg409,00€50mg655,00€100mg964,00€Triparanol
CAS:Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1Fórmula:C27H32ClNO2Pureza:99.72%Cor e Forma:SolidPeso molecular:438Ref: TM-T26296
1mg284,00€5mg645,00€1mL*10mM (DMSO)690,00€10mg867,00€25mg1.283,00€50mg1.700,00€100mg2.347,00€Gallium maltolate
CAS:Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.Fórmula:C18H15GaO9Pureza:99.61% - 99.67%Cor e Forma:SolidPeso molecular:445.03Imipramine
CAS:Imipramine (Dimipressin) is a Fascin1 inhibitor with antitumor activity and induces apoptosis.Fórmula:C19H24N2Pureza:99.4%Cor e Forma:White To Off-White /Hydrochloride/ SolidPeso molecular:280.41CDK9-IN-7
CAS:CDK9-IN-7: selective, oral CDK9/cyclin T inhibitor with 11 nM IC50, stronger than CDK4/6.Fórmula:C29H37N7O2SPureza:98.08%Cor e Forma:SolidPeso molecular:547.71Ref: TM-T10745
1mg90,00€5mg208,00€1mL*10mM (DMSO)229,00€10mg304,00€25mg457,00€50mg630,00€100mg845,00€200mg1.121,00€Sarmustine
CAS:SarCNU is an alkylating anticancer drug targeting prostate cancer through p53 pathways and selects P140K MGMT-transduced CD34(+) cells.Fórmula:C6H11ClN4O3Pureza:98.29% - 98.99%Cor e Forma:SolidPeso molecular:222.63Miclxin
CAS:Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potentFórmula:C26H27N5O2Pureza:99.17% - 99.99%Cor e Forma:SolidPeso molecular:441.52Ref: TM-T73415
1mg60,00€5mg133,00€1mL*10mM (DMSO)147,00€10mg182,00€25mg306,00€50mg427,00€100mg587,00€200mg792,00€KR-33493
CAS:KR-33493 is a FAS-associated factor 1 (FAF1) inhibitor and can be used in studies about Parkinson's disease.Fórmula:C20H18BrN3O3SPureza:99.96%Cor e Forma:SolidPeso molecular:460.34Mitazalimab
CAS:Mitazalimab (ADC-1013/JNJ-64457107) is a CD40 agonist that stimulates T cells to attack tumors and remodels the tumor microenvironment.Pureza:95.1% (SDS-PAGE); 98.7% (SEC-HPLC) - 95.1% (SDS-PAGE); 98.7% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:143.42 kDaAMG PERK 44
CAS:AMG PERK 44 is a PERK inhibitor that induces autophagy.AMG PERK 44 inhibits GCN2 and B-Raf and can be used in cancer research.Fórmula:C34H29ClN4O2Pureza:98.8% - 99.81%Cor e Forma:SolidPeso molecular:561.07Tiomolibdate diammonium
CAS:Tiomolibdate diammonium (NSC-286644) blocks SOD1 and COX, acting as an antiangiogenic and antitumor agent.Fórmula:H8MoN2S4Pureza:98%Cor e Forma:Brown To Black Iridescent Crystalline PowderPeso molecular:260.28TL4-12
CAS:TL4-12 is a MAP4K2 (GCK) inhibitor that inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro.Fórmula:C25H27F3N6O2Pureza:98.38%Cor e Forma:SolidPeso molecular:500.52EB1
CAS:EB1 is an MNK kinase inhibitor that inhibits cancer cell growth, promotes apoptosis, and inhibits eIF4E phosphorylation.Fórmula:C18H14N4Pureza:99.82%Cor e Forma:SolidPeso molecular:286.33Ref: TM-T73582
1mg71,00€5mg152,00€10mg215,00€25mg355,00€50mg533,00€100mg762,00€500mg2.115,00€1g3.142,00€iCRT-5
CAS:iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity and can be used in the study of multiple myeloma.Fórmula:C16H17NO5S2Pureza:99.68%Cor e Forma:SolidPeso molecular:367.44W146
CAS:W146 is an S1PR1 antagonist that induces a significant but transient decrease in blood lymphocytes in mice.Fórmula:C16H27N2O4PPureza:99.37%Cor e Forma:SolidPeso molecular:342.37CCT018159
CAS:CCT018159: ATP-competitive HSP90 inhibitor, IC50 3.2 μM (human), 6.6 μM (yeast), blocks invasion, angiogenesis, induces G1 arrest and apoptosis.
Fórmula:C20H20N2O4Pureza:98.78% - 99.79%Cor e Forma:SolidPeso molecular:352.38GSK2593074A
CAS:GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.Fórmula:C27H23N5OSPureza:99.99%Cor e Forma:SolidPeso molecular:465.57Ref: TM-T11484
1mg108,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg409,00€25mg687,00€50mg964,00€100mg1.288,00€1G244
CAS:1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties.Fórmula:C29H30F2N4O2Pureza:99.14%Cor e Forma:SolidPeso molecular:504.57AQ4
CAS:AQ4 is a topoisomerase II inhibitor and DNA-inserting agent that inhibits proliferation and induces apoptosis in two cell lines.Fórmula:C22H28N4O4Pureza:96.28% - 97.15%Cor e Forma:SolidPeso molecular:412.48Pyrazoloacridine
CAS:Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.Fórmula:C19H21N5O3Pureza:99.72%Cor e Forma:SolidPeso molecular:367.4Nedometinib
CAS:Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.Fórmula:C17H16FIN4O3Pureza:99.18%Cor e Forma:SolidPeso molecular:470.24Ref: TM-T78209
1mg66,00€5mg145,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg708,00€Biguanidinium-porphyrin
CAS:Imidodicarbonimidic diamide hydrochloride, a phototoxic compound with anti-proliferative properties.Fórmula:C46H36ClN9Pureza:92.48% - 93.91%Cor e Forma:SoildPeso molecular:750.29TC ASK 10
CAS:TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.Fórmula:C21H23Cl2N5OPureza:99.86%Cor e Forma:SolidPeso molecular:432.35Ref: TM-T13099
1mg33,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg124,00€25mg236,00€50mg371,00€100mg532,00€200mg705,00€HDAC-IN-60
CAS:HDAC-IN-60 (compound 21a), a potent histone deacetylase (HDAC) inhibitor, promotes intracellular reactive oxygen species (ROS) production, induces DNA damage,Fórmula:C20H26N2O6Pureza:98%Cor e Forma:SolidPeso molecular:390.43eIF4A3-IN-9
CAS:eIF4A3-IN-9, a silvestrol analogue, disrupts eIF4F complex assembly; EC50s: 29/450/80 nM (myc/tub-LUC, MB-231 cells); for cancer research.Fórmula:C28H27NO8Cor e Forma:SolidPeso molecular:505.52Sirt1/2-IN-3
CAS:Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively.Fórmula:C17H14ClNO4SPureza:98%Cor e Forma:SolidPeso molecular:363.82GCN2-IN-6
CAS:GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Fórmula:C19H12Cl2F2N4O3SPureza:95.04% - 98%Cor e Forma:SolidPeso molecular:485.29RUNX-IN-1
CAS:RUNX-IN-1, also known as Compound Conjugate 1, covalently attaches to RUNX-binding sequences, thereby preventing RUNX proteins from associating with theirFórmula:C71H88Cl2N24O11Pureza:98%Cor e Forma:SolidPeso molecular:1524.52LSD1-IN-25
CAS:LSD1-IN-25: potent, selective oral LSD1 inhibitor; IC50=46 nM, Ki=30.3 nM; induces cancer cell apoptosis.Fórmula:C32H33ClN6O3SPureza:98%Cor e Forma:SolidPeso molecular:617.16BAX-IN-1
CAS:BAX-IN-1 is a potential selective inhibitor of Bcl-2-associated X protein (BAX).Fórmula:C16H14N6OCor e Forma:SolidPeso molecular:306.32WNY1613
CAS:WNY1613: Potent PI3Kδ inhibitor with anti-NHL properties, induces apoptosis in cells, affects phosphorylation in vitro/in vivo.Fórmula:C29H35N9O3Cor e Forma:SolidPeso molecular:557.65HDAC-IN-50
CAS:HDAC-IN-50, a potent FGFR/HDAC inhibitor (IC50: 0.18-13 nM), induces apoptosis, cell cycle arrest, and shows anti-tumor activity.Fórmula:C31H41N7O4Cor e Forma:SolidPeso molecular:575.7Estrogen receptor modulator 10
CAS:Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM).Fórmula:C32H37F9N4O3SPureza:98%Cor e Forma:SolidPeso molecular:728.71BET-IN-20
CAS:BET-IN-20 (compound 10), a BRD4 BD1 inhibitor (IC 50 =1.9 nM), exhibits significant anticancer properties. It promotes apoptosis in acute myeloid leukemia (AML) cells and arrests the cell cycle in the G0/G1 phase. Additionally, BET-IN-20 inhibits both c-Myc and CDK6, and enhances PARP cleavage [1].Fórmula:C25H24N4O2Cor e Forma:SolidPeso molecular:412.48USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Fórmula:C29H31F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:568.59MOTS-c
CAS:MOTS-c is a mitochondria-derived polypeptide (MDP) that has anti-damage and anti-inflammatory effects by activating the AMPK pathway and inhibiting the MAPFórmula:C101H152N28O22S2Cor e Forma:SolidPeso molecular:2174.6FLT3-IN-14
CAS:FLT3-IN-14: FLT3 inhibitor; FLT3-WT IC50=5.6nM, FLT3-ITD IC50=1.4nM; blocks Y591 phosphorylation; G1 arrest; pro-apoptotic.Fórmula:C25H24N6O2SCor e Forma:SolidPeso molecular:472.56Antitumor agent-97
CAS:Antitumor agent-97 (compound 42), an anticancer agent, effectively inhibits proliferation and autophagy in MGC 803 cells, induces apoptosis, and enhances ROSFórmula:C24H34O3Pureza:98%Cor e Forma:SolidPeso molecular:370.52YM458
CAS:YM458 inhibits EZH2 (490 nM) and BRD4 (34 nM), curbing tumor cell growth and inducing apoptosis.Fórmula:C53H61ClN8O5SPureza:98%Cor e Forma:SolidPeso molecular:957.62Antitumor agent-60
CAS:Antitumor agent-60 inhibits growth by targeting RAS-RAF, binding CRAF (Kd: 721.3 nM), boosting p53/ROS, causing apoptosis, and arresting G2/M phase.Fórmula:C24H28O10SCor e Forma:SolidPeso molecular:508.54RIP2 kinase inhibitor 2
CAS:RIP2 kinase inhibitor 2 is a receptor-interacting protein-2 kinase inhibitor.Fórmula:C21H28N4O4SPureza:98%Cor e Forma:SolidPeso molecular:432.54rac-CCT-250863
CAS:Rac-CCT-250863, a potent Nek2 inhibitor, exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.Fórmula:C24H25F3N4O2SCor e Forma:SolidPeso molecular:490.54Lepadin E
CAS:Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway.Fórmula:C26H47NO3Pureza:98%Cor e Forma:SolidPeso molecular:421.66PRMT6-IN-3
CAS:PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.Fórmula:C19H26N4O2SPureza:98.12%Cor e Forma:SolidPeso molecular:374.54E2RCat
CAS:4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expressionFórmula:C22H14ClNO4S2Pureza:98.44%Cor e Forma:SolidPeso molecular:455.93SF5
CAS:SF5 is an inhibitor of the apoptosis pathway through JNK-p53-caspase apoptotic cascade.Fórmula:C15H13NSPureza:99.59%Cor e Forma:SolidPeso molecular:239.34Ac-YVAD-pNA
CAS:Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].Fórmula:C29H36N6O10Cor e Forma:SolidPeso molecular:628.639Zn(BQTC)
CAS:Zn(BQTC) inhibits mtDNA and nDNA, damages mitochondria/nuclei, triggers apoptosis, and targets A549R cancer cells.Fórmula:C30H36Cl2N5O3ZnPureza:98%Cor e Forma:SolidPeso molecular:650.92PD-1/PD-L1-IN-27
CAS:PD-1/PD-L1-IN-27: potent anti-cancer, IC50 134nM, minimal T cell harm, boosts CD8+ T cells, reduces fatigue.Fórmula:C44H35NO6Pureza:98%Cor e Forma:SolidPeso molecular:673.75(S)-Verapamil hydrochloride
CAS:(S)-Verapamil hydrochloride is an inhibitor of leukotriene C4 (LTC4) and calcein transport by MRP1,and leads to the death of potentially resistant tumor cells.Fórmula:C27H39ClN2O4Cor e Forma:SolidPeso molecular:491.06cis-3,4',5-Trimethoxy-3'-hydroxystilbene
CAS:Cis-3,4',5-Trimethoxy-3'-hydroxystilbene, a stilbene derivative, induces apoptosis through the mitochondrial release of cytochrome c and suppresses tubulin polymerization. It is also noted for its application in leukemic research [1].Fórmula:C17H18O4Cor e Forma:SolidPeso molecular:286.327BAI1 hydrochloride
CAS:BAI1 hydrochloride is a selective inhibitor of the apoptosis factor BAX, functioning through an allosteric mechanism. By binding to BAX, it allosterically inhibits its activation, showcasing potential applications in the research of diseases mediated by BAX-dependent cell death [1].Fórmula:C19H23Br2Cl2N3OCor e Forma:SolidPeso molecular:540.12c-Met/MEK1/Flt-3-IN-1
Antiproliferative Against-3 (comp 33) demonstrates significant activity against Hela (IC 50 = 0.21 µM), A549 (IC 50 = 0.39 µM), and MCF-7 (IC 50 = 0.33 µM) cellFórmula:C39H37FN6O5Cor e Forma:SolidPeso molecular:688.75RIPK3-IN-4
CAS:RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage.Fórmula:C24H18BrFN4O3SPureza:98%Cor e Forma:SolidPeso molecular:541.39NSC 689534
CAS:NSC 689534 forms a chelate with copper (Cu 2+), resulting in the NSC 689534/Cu 2+ complex, which is a potent inducer of oxidative stress and exhibits antitumor activity [1].Fórmula:C19H18N6SCor e Forma:SolidPeso molecular:362.45Prostaglandin A1
CAS:Prostaglandin A1, a dehydration derivative of Prostaglandin E1, demonstrates inhibitory effects on tumor growth, inflammation, virus replication, platelet aggregation, and excitotoxin-induced neuron apoptosis [1].Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.472HSP90/mTOR-IN-1
"HSP90/mTOR-IN-1 is a dual Hsp90/mTOR inhibitor (IC50: 69/29 nM), halting SW780 cell growth and inducing apoptosis/autophagy in cancer research."Fórmula:C36H34ClFN6O5SCor e Forma:SolidPeso molecular:717.21BQZ-485
CAS:BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction.Fórmula:C32H39NO3Pureza:98%Cor e Forma:SolidPeso molecular:485.66FOXO1-IN-3
CAS:FOXO1-IN-3 is a highly-selective, orally active inhibitor of FOXO1 that diminishes hepatic glucose production and enhances insulin sensitivity and glucoseFórmula:C22H23N7OPureza:98%Cor e Forma:SolidPeso molecular:401.46Pelcitoclax
CAS:Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].Fórmula:C57H66ClF4N6O11PS4Cor e Forma:SolidPeso molecular:1281.84TBTDC
CAS:TBTDC serves as a multifunctional organic photosensitizer exhibiting aggregation-induced emission characteristics, optimal for in vivo bioimaging andFórmula:C36H22N6S3Cor e Forma:SolidPeso molecular:634.8Necrocide 1
CAS:Necrocide 1 is a inducer of cancer cell necrosis that is not inhibited by caspase, BCL2 , or TNFα, and acts through the mitochondrial regulatory pathway.Fórmula:C23H27NO3Pureza:98%Cor e Forma:SolidPeso molecular:365.47SD 1008
CAS:SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. SD 1008 inhibits activation of STAT3, JAK2, and Src.Fórmula:C18H19NO5Pureza:98%Cor e Forma:SolidPeso molecular:329.35AR420626
CAS:AR420626: selective FA3R agonist, guards against SALS, effects blocked by BHB, a FA3R antagonist.Fórmula:C21H18Cl2N2O3Pureza:98.62%Cor e Forma:SolidPeso molecular:417.29PDK4-IN-1 hydrochloride
CAS:PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).Fórmula:C22H20ClN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:393.87Ref: TM-T12412L
1mg70,00€5mg150,00€1mL*10mM (DMSO)165,00€10mg215,00€25mg358,00€50mg515,00€100mg707,00€200mg1.009,00€ERα antagonist 1
CAS:ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and inducesFórmula:C33H32N2O5SCor e Forma:SolidPeso molecular:568.68MI-219
CAS:MI-219 is a human double minute 2 (HDM2) inhibitor.Fórmula:C27H32Cl2FN3O4Cor e Forma:SolidPeso molecular:552.47HAPSBC
CAS:HAPSBC, an S-benzyl iron chelator, modulates the intracellular distribution of ^59Fe [1].Fórmula:C15H15N3S2Cor e Forma:SolidPeso molecular:301.43Vepafestinib
CAS:Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].Fórmula:C26H30N6O3Pureza:98.56%Cor e Forma:SolidPeso molecular:474.55Ogremorphin
CAS:Ogremorphin (GPR68-IN-1) is a potent inhibitor of GPR68, exhibiting an EC50 of 170 nM.it is utilized in the study of autoimmune chronic inflammatory diseases [1Fórmula:C21H17N3OSPureza:99.65% - 99.65%Cor e Forma:SolidPeso molecular:359.44PIM447
CAS:PIM447 (LGH447) is a pan-PIM kinase inhibitor with anti-tumor and bone protective effects. PIM447 reduces the viability, and motility of HuH6 cell.Fórmula:C24H23F3N4OPureza:98.97%Cor e Forma:SolidPeso molecular:440.46AMRI-59
CAS:AMRI-59 is a potent inhibitor of PrxI with anti-tumor activity.Fórmula:C25H27N3O2Pureza:99.79%Cor e Forma:SolidPeso molecular:401.5Ref: TM-T26623
1mg109,00€5mg235,00€1mL*10mM (DMSO)260,00€10mg349,00€25mg532,00€50mg745,00€100mg999,00€500mg2.008,00€CUR61414
CAS:CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).Fórmula:C31H42N4O5Pureza:97.34% - 98%Cor e Forma:SolidPeso molecular:550.69Ref: TM-T15019
1mg50,00€2mg71,00€5mg104,00€1mL*10mM (DMSO)116,00€10mg168,00€25mg326,00€50mg492,00€100mg738,00€200mg973,00€Calicheamicin
CAS:Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.Fórmula:C55H74IN3O21S4Pureza:98.22% - 98.78%Cor e Forma:SolidPeso molecular:1368.35TMX-2164
CAS:TMX-2164: strong, irreversible BCL6 inhibitor, IC50=152 nM, long-lasting action, inhibits cell proliferation.Fórmula:C25H24ClFN6O6SCor e Forma:SolidPeso molecular:591.01viFSP1
CAS:viFSP1, a species-independent FSP1 inhibitor, effectively induces ferroptosis in FSP1-dependent cells by targeting the highly conserved NAD(P)H binding pocket of FSP1, directly inhibiting its activity. This action results in lipid peroxidation and exhibits anticancer activity [1].Fórmula:C16H17N3O3SCor e Forma:SolidPeso molecular:331.39AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Fórmula:C21H13Cl2N3O2SPureza:97.05%Cor e Forma:SolidPeso molecular:442.32Ref: TM-T10215
1mg54,00€5mg118,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€Ataquimast
CAS:Ataquimast is used in curing advanced receptor-positive breast cancer.Fórmula:C11H14ClN3OPureza:99.92%Cor e Forma:SolidPeso molecular:239.7Ref: TM-T30190
1mg64,00€1mL*10mM (DMSO)116,00€5mg129,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€Nirogacestat dihydrobromide
CAS:Potent γ-secretase inhibitor; IC50: 1.2 nM (cell), 6.2 nM (cell-free); lowers Aβ in mice/guinea pigs' brain, CSF, plasma.Fórmula:C27H43Br2F2N5OCor e Forma:SolidPeso molecular:651.4810-OAHSA
CAS:10-OAHSA is a newly discovered endogenous lipid categorized within the group of branched fatty acid esters of hydroxy fatty acids (FAHFAs). This specific FAHFA comprises oleic acid esterified to 10-hydroxy stearic acid. It stands out among its FAHFA counterparts for its potential bioactive properties, similar to other members of its family such as PAHSAs, which are notably prevalent in the adipose tissue of AG4OX mice exhibiting glucose tolerance due to overexpression of the Glut4 glucose transporter specifically in adipose tissue. Like other FAHFAs, 10-OAHSA may play significant roles in enhancing glucose tolerance, stimulating insulin secretion, and exerting anti-inflammatory effects, which suggests its importance in managing metabolic syndrome and inflammation.Fórmula:C36H68O4Cor e Forma:SolidPeso molecular:564.9C6 Urea Ceramide
CAS:C6 urea ceramide blocks neutral ceramidase, boosts ceramide levels, halts HT-29 cancer cell growth, and shrinks HT-29 tumors in mice when dosed.Fórmula:C25H50N2O3Cor e Forma:SolidPeso molecular:426.68RMC-4998
CAS:RMC-4998 is an orally available KRASG12C mutant inhibitor that targets the active or GTP-bound state of the KRASG12C mutant,inhibit ERK and apoptosis.Fórmula:C57H74N8O7Pureza:99.11%Cor e Forma:SolidPeso molecular:983.25Ref: TM-T79870
1mg85,00€5mg177,00€10mg259,00€1mL*10mM (DMSO)281,00€25mg439,00€50mg762,00€100mg1.314,00€200mg1.773,00€CPT-Se4
CAS:CPT-Se4, a seleno-derivative of CPT, effectively kills cancer cells, triggers apoptosis, and is cytotoxic against various cell lines.Fórmula:C25H24N2O7Se2Pureza:98%Cor e Forma:SolidPeso molecular:622.39iMAC2 hydrochloride
CAS:iMAC2 hydrochloride, a potent inhibitor of the mitochondrial apoptosis-induced channel (MAC), demonstrates an IC50 of 28 nM and an LD50 of 15000 nM. It exhibits an anti-apoptotic effect by blocking the release of cytochrome c [1].Fórmula:C19H22Br2Cl2FN3Cor e Forma:SolidPeso molecular:542.11HDAC-IN-53
CAS:HDAC-IN-53 inhibits HDAC1-3 with IC50s: 47, 125, 450 nM. Inactive on class II HDACs; triggers apoptosis; reduces tumor growth in mice.Fórmula:C23H20ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:461.9CR-6086
CAS:CR6086: potent EP4 antagonist with DMARD effects, low Ki (16.6 nM), and specific anti-inflammatory action.Fórmula:C26H27F3N2O3Cor e Forma:SolidPeso molecular:472.5LY303511 hydrochloride
CAS:LY303511, a structural analog of LY294002, selectively inhibits mTOR-dependent phosphorylation of S6K, unlike its counterpart, which acts as a phosphatidylinositol 3-kinase (PI3K) inhibitor. It effectively reduces cell proliferation in human lung epithelial adenocarcinoma cells by hindering G2/M phase progression and suppressing casein kinase 2 activity. Additionally, LY303511 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitivity in HeLa cells resistant to TRAIL-induced apoptosis and blocks voltage-gated potassium (Kv) channels.Fórmula:C19H20Cl2N2O2Cor e Forma:SolidPeso molecular:379.28GDC-2394
CAS:GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.Fórmula:C20H25N5O4SCor e Forma:SolidPeso molecular:431.51Atiprimod (free base)
CAS:Atiprimod: an oral azaspirane inhibiting STAT3, blocking IL-6/VEGF pathways, and promoting apoptosis by downregulating Bcl-2 and Mcl-1.Fórmula:C22H44N2Cor e Forma:SolidPeso molecular:336.6MK-2206 free base
CAS:MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1,Fórmula:C25H21N5OPureza:98%Cor e Forma:SolidPeso molecular:407.47ER proteostasis regulator-1
CAS:ER Proteostasis Regulator-1 (Compound 481) is a potent modulator of endoplasmic reticulum proteostasis with research applications in Alzheimer's disease andFórmula:C18H22N2O3Cor e Forma:SolidPeso molecular:314.38BRD4 Inhibitor-18
CAS:BRD4 Inhibitor-18: potent (IC50: 110 nM), impairs MV-4-11 cell growth, disrupts G0/G1 phase, and induces apoptosis.Fórmula:C26H26ClN3O3SCor e Forma:SolidPeso molecular:496.02
