Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5592 produtos de "Apoptose"
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SP3N hydrochloride
<p>SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). Its alkylamine moiety is metabolized into an active aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for the degradation of FKBP12. SP3N hydrochloride is applicable in cancer research.</p>Cor e Forma:Odour SolidHellebrin
CAS:<p>Cytotoxic and antiproliferative effects of Hellebrin on breast and lung cancer cells.</p>Fórmula:C36H52O15Cor e Forma:SolidPeso molecular:724.79Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Fórmula:C38H44O12Pureza:98%Cor e Forma:SolidPeso molecular:692.75Psalmotoxin 1
CAS:<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Fórmula:C200H312N62O57S6Pureza:98%Cor e Forma:SolidPeso molecular:4689.41Epoprostenol sodium
CAS:<p>Epoprostenol sodium (Prostaglandin I2 sodium salt) is a vasodilator and a synthetic prostacyclin that can be used to study pulmonary hypertension.</p>Fórmula:C20H31NaO5Pureza:98%Cor e Forma:White Crystalline PowderPeso molecular:374.45DC-Y13-27
<p>Dc-y13-27, a derivative of DC-Y13, is a potent YTHDF2 inhibitor (KD: 37.9 μM).</p>Fórmula:C14H10N2O2SPureza:99.75%Cor e Forma:SoildPeso molecular:270.31Giloralimab
CAS:<p>Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.</p>Pureza:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Cor e Forma:LiquidTrxR-IN-7
<p>TrxR-IN-7 (14f) is a potent inhibitor of thioredoxin reductase (TrxR), with an IC50 value of 3.5 µM. It exhibits antiproliferative activity and can induce apoptosis and the production of reactive oxygen species (ROS).</p>Fórmula:C22H21NO3Cor e Forma:SolidPeso molecular:347.407Sotigalimab
CAS:<p>Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.</p>Pureza:98.50% - 98.50%Cor e Forma:LiquidTopoisomerase I/II inhibitor 6
<p>TopoisomeraseI/II inhibitor 6 (compound 3i) acts as an effective inhibitor of topoisomerase I and II, with IC50 values of 4.77 µM and 15 µM, respectively. Additionally, it exhibits antiproliferative activity against the human melanoma cell line LOX IMVI, demonstrating IC50 values of 26.7 µM and 25.4 µM.</p>Fórmula:C31H28F2N4O6SCor e Forma:SolidPeso molecular:622.64MG-277
<p>MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.</p>Fórmula:C41H42Cl2FN5O5Pureza:98%Cor e Forma:SolidPeso molecular:774.71RET-IN-28
CAS:<p>RET-IN-28 (Compound 16) is an inhibitor of RET (a transmembrane receptor tyrosine kinase). It specifically inhibits the activity of a mutant RET enzyme (RET-V804M) and is utilized in cancer research.</p>Fórmula:C26H29N9Cor e Forma:SolidPeso molecular:467.57H3B-8800
CAS:<p>H3B-8800 is an SF3B1 modulator that can be used to study transfusion-dependent anemia.</p>Fórmula:C31H45N3O6Pureza:98.31%Cor e Forma:SoildPeso molecular:555.71S-Adenosyl-L-methionine iodide
CAS:<p>S-(5'-Adenosyl)-L-methionine iodide, also known as S-Adenosyl-L-methionine iodide, is a vital methyl donor present in all living organisms [1].</p>Fórmula:C15H23IN6O5SCor e Forma:SolidPeso molecular:526.35Chloranil
CAS:<p>Chloranil (tetrachloro-p-benzoquinone) induces inflammation and neurological dysfunction and can be used to model inflammation in mice.</p>Fórmula:C6Cl4O2Pureza:99.38%Cor e Forma:SolidPeso molecular:245.88DefNEtTrp
<p>DefNEtTrp is an iron bis-chelating ligand composed of Def and Trp groups. It demonstrates potent broad-spectrum antiproliferative and cytotoxic effects in cancer cell lines. DefNEtTrp induces apoptosis and ferroptosis, exhibiting cytotoxicity with an IC50 value of 0.77 μM.</p>Fórmula:C30H27N9O3SCor e Forma:SolidPeso molecular:593.659Oxatomide
CAS:<p>Oxatomide: Dual H1/P2X7 antagonist, antihistamine, anti-allergic, treats immune diseases, IC50: 0.95 μM (P2X7), 0.43 μM (5-HT).</p>Fórmula:C27H30N4OPureza:98.82% - 99.72%Cor e Forma:White PowderPeso molecular:426.55XIAP BIR2/BIR2-3 inhibitor-1
CAS:<p>XIAP BIR2/BIR2-3 inhibitor-1 (compound 3) serves as a potent dual inhibitor targeting BIR2 and BIR2-3 domains, with IC50 values of 1.9 nM and 0.8 nM, respectively. This compound is utilized in cancer research studies [1].</p>Fórmula:C72H96N16O14Cor e Forma:SolidPeso molecular:1409.63Prodigiosin
CAS:<p>Prodigiosin is a secondary metabolite of Symbiotic bacteria. It also has anti-fungal and anti-cancer activity.</p>Fórmula:C20H25N3OPureza:98%Cor e Forma:SolidPeso molecular:323.44MDM2 ligand 4
<p>MDM2ligand 4 is a ligand of MDM2 and can be used in the synthesis of the PROTAC degrader [KT-253].</p>Fórmula:C31H33Cl2FN2O4Cor e Forma:SolidPeso molecular:587.509EGFR-IN-143
<p>EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. It induces apoptosis by arresting the cell cycle at the G2/M phase and exhibits antitumor activity.</p>Fórmula:C20H21ClN6O3Cor e Forma:SolidPeso molecular:428.872CYP51/PD-L1-IN-3
<p>CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM</p>Fórmula:C27H28N6O2Cor e Forma:SolidPeso molecular:468.55Human PD-L1 inhibitor II
CAS:<p>Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.</p>Fórmula:C103H151N25O30Cor e Forma:SolidPeso molecular:2219.486SM-164 Hydrochloride (957135-43-2 free base)
<p>SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.</p>Fórmula:C62H85ClN14O6Pureza:98%Cor e Forma:SolidPeso molecular:1157.88Thiocolchicine
CAS:<p>Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.</p>Fórmula:C22H25NO5SPureza:98.19%Cor e Forma:SolidPeso molecular:415.5INF 195
CAS:<p>INF 195 is an inflammasome NLRP3 inhibitor that can be used to study myocardial ischemia and myocardial infarction.</p>Fórmula:C17H22ClNO3Pureza:99.78%Cor e Forma:SoildPeso molecular:323.81Aloeresin G
CAS:<p>Aloeresin G, a chromone glycoside isolated from Aloe, exhibits a moderate inhibitory effect on TNFα-induced NF-κB transcriptional activity, evidenced by an IC50</p>Fórmula:C29H30O10Cor e Forma:SolidPeso molecular:538.54Bcl-xL antagonist 2
CAS:<p>Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM.</p>Fórmula:C21H16N4O3S2Pureza:99.81%Cor e Forma:SolidPeso molecular:436.51CDC20-IN-2
<p>CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.</p>Cor e Forma:Odour SolidBarakol
CAS:<p>Barakol, a primary compound found in Cassia siamea, inhibits MMP-3 activity and enhances the anti-metastatic effects of doxorubicin. Additionally, Barakol induces apoptosis (Apoptosis), generates reactive oxygen species, increases the Bax/Bcl-2 expression ratio, and activates caspase-9. This compound also exhibits laxative, anti-anxiety, central nervous system depressant, antioxidant, and anticancer properties.</p>Fórmula:C13H12O4Cor e Forma:SolidPeso molecular:232.23Pegsunercept
CAS:<p>Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].</p>Cor e Forma:LiquidSalinomycin sodium salt
CAS:<p>Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.</p>Fórmula:C42H69NaO11Pureza:98.76% - 99.11%Cor e Forma:White Or Light Yellow Crystalline Powder With Special SmelPeso molecular:772.98TOPOI/PARP-1-IN-2
<p>TOPOI/PARP-1-IN-2 (compound 6c) serves as a dual inhibitor targeting both PARP-1 and topoisomerase 1 (TOPO-1), with IC50 values of 32.2 nM and 46.2 nM, respectively. This compound exhibits greater selectivity for PARP-1 over PARP-2. Additionally, TOPOI/PARP-1-IN-2 disrupts the S phase of the cell cycle and induces apoptosis in the NCI-60 cancer cell lines.</p>Fórmula:C16H11ClN4O2SCor e Forma:SolidPeso molecular:358.80CDK-TCIP1
CAS:<p>CDK-TCIP1 is a bivalent molecule that links the CDK9 inhibitor SNS-032 with the BCL6 ligand BI3812. It effectively and specifically kills cells overexpressing BCL6, with an EC50 of 7.7 nM for SUDHL5 cells.</p>Fórmula:C48H62ClN11O8S2Cor e Forma:SolidPeso molecular:1020.66Caerin 1.1 TFA
<p>Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cells</p>Pureza:98%Cor e Forma:Odour Solid2'-epi-2'-O-Acetylthevetin B
CAS:<p>2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L.</p>Fórmula:C44H68O19Pureza:98%Cor e Forma:SolidPeso molecular:901Taccalonolide E
CAS:<p>Taccalonolide E is a microtubule stabilizer and induces cancer cell apoptosis .</p>Fórmula:C34H44O12Cor e Forma:SolidPeso molecular:644.71HSP90-IN-33
<p>HSP90-IN-33 (compound 24e) is an effective Hsp90 inhibitor, demonstrating dissociation constants (Kd) of ≥200 µM for Hsp90α and 7.3 µM for Hsp90β. This compound induces cellular apoptosis (apoptosis) and arrests the cell cycle at the G0/G1 phase. Additionally, HSP90-IN-33 reduces the protein expression of ERα, CDK4, and Akt.</p>Fórmula:C21H25Cl2N5O2Cor e Forma:SolidPeso molecular:450.36MBC-11 triethylamine
<p>MBC-11 triethylamine, a first-in-class etidronate-araC conjugate, may treat TIBD.</p>Fórmula:C17H35N4O14P3Pureza:98%Cor e Forma:SolidPeso molecular:612.4Anticancer agent 52
CAS:<p>Anticancer agent 52 exhibits potent cytotoxicity, induces apoptosis, and has potential in bladder cancer research.</p>Fórmula:C50H43Br2N2PCor e Forma:SolidPeso molecular:862.67fac-[Re(CO)3(L6)(H2O)][NO3]
<p>Compound 6, fac-[Re(CO)3(L6)(H2O)][NO3], a rhenium(I) tricarbonyl aqua complex, serves as an anticancer agent by disrupting mitochondrial function.</p>Fórmula:C24H14N5O7ReSPureza:98%Cor e Forma:SolidPeso molecular:702.67Apoptosis inducer 11
<p>Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within</p>Fórmula:C27H28N2O5Pureza:98%Cor e Forma:SolidPeso molecular:460.52Thalidomide-Piperazine-PEG3-NH2
CAS:<p>Thalidomide-Piperazine-PEG3-NH2: a cereblon ligand-linker for PROTAC E3 ligase recruitment.</p>Fórmula:C25H35N5O7Cor e Forma:SolidPeso molecular:517.583Chetomin
CAS:<p>Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar</p>Fórmula:C31H30N6O6S4Pureza:98%Cor e Forma:Off-White To Fawn SolidPeso molecular:710.87Antitumor agent-61
CAS:<p>Antitumor agent-61, a potent Irinotecan derivative, exhibits IC50s of 0.92-3.23 μM in 6 cancer cells, inducing apoptosis via mitochondrial pathways.</p>Fórmula:C54H63FN5O10PCor e Forma:SolidPeso molecular:992.08HDAC3-IN-2
<p>HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells.</p>Fórmula:C16H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:315.37HPOB
CAS:<p>HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.</p>Fórmula:C17H18N2O4Pureza:99.91%Cor e Forma:SolidPeso molecular:314.34Ecdysone
CAS:<p>Ecdysone is a major steroid hormone in insects and herbs.</p>Fórmula:C27H44O6Pureza:99.22%Cor e Forma:PowderPeso molecular:464.63Asparanin A
CAS:<p>Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways.</p>Fórmula:C39H64O13Pureza:98%Cor e Forma:SolidPeso molecular:740.92BDK-IN-1
<p>BDK-IN-1 (compound (-)-43) is a BDK inhibitor with an IC50 of 0.23 μM and a maximum inhibition rate of 90%. It reduces phosphorylated-E1 levels and is useful in the study of cardiac metabolic diseases.</p>Fórmula:C18H14F2N2O3SCor e Forma:SolidPeso molecular:376.38Apoptosis inducer 29
<p>Apoptosis Inducer 29 (compound Y9) demonstrates anticancer efficacy in non-small cell lung cancer by inducing lysosomal dysfunction and apoptosis, and exhibits superior performance to Gboixn both in vitro and in vivo.</p>Fórmula:C33H46ClN3O3Cor e Forma:SolidPeso molecular:568.19TS-IN-5
<p>TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.</p>Fórmula:C16H17N5OSCor e Forma:SolidPeso molecular:327.404PERK-IN-6
CAS:<p>PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).</p>Fórmula:C23H22N6OPureza:99.62% - 99.92%Cor e Forma:SolidPeso molecular:398.46Balstilimab
CAS:<p>Balstilimab (AGEN2034) is a fully human monoclonal IgG4 antibody against PD-1 [1] .</p>Cor e Forma:LiquidXM-U-14
<p>XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.</p>Cor e Forma:Odour SolidFludarabine triphosphate trisodium
<p>Fludarabine triphosphate (F-ara-ATP) trisodium inhibits DNA synthesis; IC50 2.3 μM, Ki 6.1 μM, blocks DNA primase, prompts apoptosis.</p>Fórmula:C10H12FN5Na3O13P3Cor e Forma:SolidPeso molecular:591.12Pim-1 kinase inhibitor 4
<p>Pim-1 kinase inhibitor 4 is a potent Pim-1 kinase inhibitor with an IC50 value of 17.01 nM.Pim-1 kinase inhibitor 4 also possesses antioxidant activity and</p>Fórmula:C19H12ClN3OPureza:97.72%Cor e Forma:SolidPeso molecular:333.77CPT2
CAS:<p>Carnitine palmitoyltransferase 2 (CPT2), an enzyme involved in fatty acid oxidation, serves as a prognostic biomarker for colorectal cancer (CRC).</p>Pureza:98%Cor e Forma:SolidALK/ROS1 inhibitor 2e HCL
<p>(R)-1-(2-((2-MeO-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(CF3O)benzyl)piperidine-3-carboxamide HCl is anti-apoptotic and anti-cancer.</p>Fórmula:C30H36ClF3N6O3Pureza:98.30%Cor e Forma:SoildPeso molecular:621.09HEMTAC CDK4/6 degrader 1
CAS:<p>HEMTAC CDK4/6 degrader 1, a PROTAC targeting HSP90/CDK4/6, Kd of 35.7 μM, disrupts B16F10 melanoma cell cycle, and induces apoptosis.</p>Fórmula:C48H53ClN16O4Cor e Forma:SolidPeso molecular:953.49Opucolimab
CAS:<p>Opucolimab is a human antibody targeting PD-L1, used in advanced solid tumor research and antibody-drug conjugate synthesis.</p>Cor e Forma:LiquidSB 699551
CAS:<p>SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.</p>Fórmula:C34H45N3OPureza:99.83%Peso molecular:511.74Kurzipene D
CAS:<p>Kurzipene D: anticancer, induces apoptosis, halts HepG2 at S phase, anti-tumor in zebrafish, inhibits tumor growth and spread.</p>Fórmula:C26H36O8Cor e Forma:SolidPeso molecular:476.56Tomuzotuximab
CAS:<p>Tomuzotuximab: fully human, glycoengineered IgG1 anti-EGFR monoclonal antibody with anticancer properties.</p>Cor e Forma:LiquidGGTI298 Trifluoroacetate
CAS:<p>GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.</p>Fórmula:C27H33N3O3S·C2HF3O2Pureza:98.07% - >99.99%Cor e Forma:SolidPeso molecular:593.66Ferroptosis-IN-14
<p>Ferroptosis-IN-14 (compund 36) exhibits the most potent anti-ferroptotic activity with an EC50 value of 0.58 ± 0.02 μM, demonstrating excellent anti-ferroptotic efficacy, as well as stability in microsomes and plasma.</p>Cor e Forma:Odour SolidEtanercept
CAS:<p>Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.</p>Pureza:98%Cor e Forma:Liquid(+)-Mcl-1 inhibitor 21
CAS:<p>(+)-Mcl-1 inhibitor 21 (Example 1-37) is a chemical compound that acts as an Mcl-1 inhibitor with an IC50 value of 172 nM. It demonstrates pro-apoptotic and antiproliferative activities in SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.</p>Fórmula:C32H33N3O4Cor e Forma:SolidPeso molecular:523.622Spexin
CAS:<p>Potent GAL2/GAL3 agonist (EC50 = 45.7, 112.2 nM), inactive at GAL1. Reduces appetite, fatty acid uptake in adipocytes, and LH in goldfish; anxiolytic in vivo.</p>Fórmula:C74H114N20O19SPureza:98%Cor e Forma:SolidPeso molecular:1619.9Z-LEHD-fmk
CAS:<p>Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and</p>Fórmula:C32H43FN6O10Pureza:96.13%Cor e Forma:SolidPeso molecular:690.72WKYMVM
CAS:<p>WKYMVM is a N-formyl peptide receptor (FPR1) agonist.</p>Fórmula:C41H61N9O7S2Pureza:98%Cor e Forma:SolidPeso molecular:856.11Z-DQMD-FMK
CAS:<p>Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.</p>Fórmula:C29H40FN5O11SPureza:98%Cor e Forma:SolidPeso molecular:685.72NLRP3-IN-60
<p>NLRP3-IN-60 (Compound 39) is an orally bioavailable inhibitor of NLRP3. It effectively suppresses pyroptosis in THP-1 cells with an IC50 of 13 nM and inhibits IL-1β release in human whole blood, exhibiting an IC50 of 225 nM.</p>Fórmula:C23H24F2N4O4SCor e Forma:SolidPeso molecular:490.523ChoKα inhibitor-5
<p>ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis.</p>Fórmula:C54H68Br2N4S4Cor e Forma:SolidPeso molecular:1061.21Ac-IEPD-AFC
CAS:<p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>Fórmula:C32H38F3N5O11Pureza:99.16%Cor e Forma:SolidPeso molecular:725.67MK-0731
CAS:<p>MK-0731 inhibits kinesin spindle protein, disrupting mitosis and triggering apoptosis in KSP-overexpressing tumor cells.</p>Fórmula:C25H28F3N3O2Cor e Forma:SolidPeso molecular:459.5Thalidomide-NH-C6-NH-Boc
CAS:<p>Thalidomide-based E3 ligase ligand for PROTAC degrader MI-389 synthesis, linked to cereblon and Boc.</p>Fórmula:C24H32N4O6Cor e Forma:SolidPeso molecular:472.542Tubulin polymerization-IN-45
<p>Tubulin polymerization-IN-45, a tubulin-targeting agent, acts as a tubulin polymerization inhibitor by binding to the tubulin's colchicine site.</p>Fórmula:C20H18N4O3Cor e Forma:SolidPeso molecular:362.38PROTAC LZK-IN-1
CAS:<p>PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.</p>Fórmula:C51H64F2N10O5SCor e Forma:SolidPeso molecular:967.18Thalidomide-NH-PEG8-Ts
CAS:<p>Thalidomide-NH-PEG8-Ts: a synthesized Thalidomide-PEG8 E3 ligase linker for PROTAC-mediated IDO1 degradation.</p>Fórmula:C36H49N3O14SCor e Forma:SolidPeso molecular:779.86RBN013209
CAS:<p>RBN013209 is a potent CD38 inhibitor. RBN013209 is useful in the treatment of cancer.</p>Fórmula:C19H24N6O3Pureza:99.84%Cor e Forma:SoildPeso molecular:384.43VEGFR-2-IN-61
<p>VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with an IC50 of 2.83 µM. It effectively inhibits the proliferation of various cancer cells, including MCF-7 cells, with an IC50 of 2.12 µM. Additionally, VEGFR-2-IN-61 suppresses cell migration and induces oxidative stress and apoptosis in MCF-7 cells.</p>Fórmula:C27H25N5OCor e Forma:SolidPeso molecular:435.52LC-1-40
<p>LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC50=0.97 nM). In mouse models, LC-1-40 selectively inhibits tumor growth induced by MYCN and induces nucleotide damage and apoptosis (cell death) in MYCN-associated tumors. It is applicable for cancer research.</p>Fórmula:C49H48N8O6Peso molecular:844.36968Leucettamol A
CAS:<p>Leucettamol A, from Leucetta microraphis, blocks LTB4 receptor and prevents Ubc13-Uev1A complex formation.</p>Fórmula:C30H52N2O2Pureza:98%Cor e Forma:SolidPeso molecular:472.758Antitumor agent-64
CAS:<p>Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cells</p>Fórmula:C35H47N3O3SCor e Forma:SolidPeso molecular:589.83Annonacin
CAS:<p>Annonacin is a cytotoxic acetogenin in Graviola leaf extract; it blocks mitochondrial complex and inhibits NKA/SERCA ATPase pumps.</p>Fórmula:C35H64O7Pureza:98%Cor e Forma:SolidPeso molecular:596.88BC13
<p>BC13 is a CDK6/BRD4 inhibitor with IC50 values of 234 nM for CDK6 and 36 nM for BRD4. It exhibits antiproliferative properties, induces apoptosis (cell death) and DNA damage, and elevates ROS levels.</p>Fórmula:C37H39N7O5Cor e Forma:SolidPeso molecular:661.75KC01
CAS:<p>KC01 selectively inhibits ABHD16A (IC50: 0.2-0.5 μM), much more potent than KC02 (>10 μM); human ABHD16A IC50: 90±20 nM.</p>Fórmula:C22H39NO3Pureza:98%Cor e Forma:SolidPeso molecular:365.558Flavopiridol
CAS:<p>Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.</p>Fórmula:C21H20ClNO5Pureza:97.74% - 99.86%Cor e Forma:SolidPeso molecular:401.84ECDD-S18
<p>ECDD-S18 (compound ECDD-S18) induces apoptosis in a dose-dependent manner, effectively targeting the vacuolar ATPase (V-ATPase) and impairing lysosomal acidification.</p>Fórmula:C35H31BrO12Cor e Forma:SolidPeso molecular:723.52Bleomycin A5
CAS:<p>Bleomycin A5, or Pingyangmycin, is an oral glycopeptide antibiotic and acts as an antineoplastic and apoptosis inducer.</p>Fórmula:C57H89N19O21S2Cor e Forma:SolidPeso molecular:1440.56PRDX1-IN-2
<p>PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) with an IC50 of 0.35 μM. It reduces mitochondrial membrane potential in SW620 cells, potentially due to increased ROS resulting from PRDX1 inhibition, leading to apoptosis. PRDX1-IN-2 is applicable in colorectal cancer research.</p>DP-15
CAS:<p>DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]</p>Fórmula:C42H44ClN9O5SCor e Forma:SolidPeso molecular:822.374FOXO4-DRI
CAS:<p>FOXO4-DRI: a peptide blocking FOXO4/p53 interaction; induces senescent cells' apoptosis.</p>Fórmula:C228H388N86O64Cor e Forma:SolidPeso molecular:5358.06Ianalumab
CAS:<p>Ianalumab (VAY-736) is a decarboxylated humanized antibody against BAFF-R.</p>Pureza:100% (SEC-HPLC) - > 95%Cor e Forma:LiquidPeso molecular:146.44 kDaAntitumor photosensitizer-4
<p>Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2.</p>Fórmula:C65H77ClN12O11SPureza:98%Cor e Forma:SolidPeso molecular:1269.9CDK2-IN-32
<p>CDK2-IN-32 (Compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.21 μM. It exhibits cytotoxicity towards Vero cells with an IC50 of 28.52 μM.</p>Fórmula:C18H13Cl2N5O2Cor e Forma:SolidPeso molecular:402.23TP4 (Nile tilapia piscidin)
CAS:<p>TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial</p>Fórmula:C135H226N50O27Pureza:98%Cor e Forma:SolidPeso molecular:2981.56ROS inducer 5
<p>ROS inducer 5 (compound 6e) induces intracellular ROS accumulation and subsequent nuclear fragmentation. It can provoke apoptosis in MCF-7 cells with an IC50 of 3.85 μM. ROS inducer 5 is useful for cancer research applications.</p>Fórmula:C20H15ClN4O2S3Cor e Forma:SolidPeso molecular:475.01RIPK1-IN-22
<p>RIPK1-IN-13 (compound 28) is a selective inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), showing a pKi of 7.66 as measured by the ADP-Glo kinase assay. It exhibits inhibitory effects in human leukemia U937 cells with a pIC50 of 7.2.</p>Fórmula:C22H22N4O3SPeso molecular:422.14126
