Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5599 produtos de "Apoptose"
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IRF1-IN-2
CAS:<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Fórmula:C18H20N2O4SPureza:99.85%Cor e Forma:SolidPeso molecular:360.43A947
CAS:<p>A947 is a potent and selective SMARCA2 PROTAC that induces the degradation of SMARCA2, with significant antitumor activity in SMARCA4-mutant NSCLC cells.</p>Fórmula:C61H76N12O7SPureza:98.84%Cor e Forma:SolidPeso molecular:1121.4VEGFR/PARP-IN-1
<p>VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively.</p>Fórmula:C29H27N9OPureza:98%Cor e Forma:SolidPeso molecular:517.58Cannflavin A
CAS:<p>Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation and</p>Fórmula:C26H28O6Cor e Forma:SolidPeso molecular:436.5PD-L1 inhibitory peptide
CAS:<p>PD-L1inhibitory peptide is an inhibitor peptide that targets the programmed cell death ligand 1 (PD-L1). By binding to PD-L1, it lifts immune suppression and restores the anti-tumor activity of T cells. PD-L1inhibitory peptide holds promise for use in tumor research.</p>Fórmula:C96H135N21O23SCor e Forma:SolidPeso molecular:1983.29KTX-582
CAS:<p>KTX-582: potent IRAK4/Ikaros degrader (DC50=4/5nM), induces MYD88 MT DLBCL apoptosis & tumor regression in lymphoma.</p>Fórmula:C45H51F3N8O7Cor e Forma:SolidPeso molecular:872.93YX0798
<p>YX0798 is a selective, orally active CDK9 inhibitor (Kd: 0.28 nM). It downregulates the oncogenic protein c-MYC and the pro-survival protein MCL-1. YX0798 disrupts the cell cycle and causes transcriptome reprogramming, ultimately leading to apoptosis. The compound exhibits antitumor activity.</p>Fórmula:C21H19ClF3N5O2Cor e Forma:SolidPeso molecular:465.86OPBP-1
<p>OPBP-1 is a D-peptide developed through phage display screening, molecular docking, and molecular dynamics simulations. It exhibits high stability, strong antitumor activity, and oral bioavailability. OPBP-1 selectively binds to the PD-L1 protein, significantly blocking the interaction between PD-1 and PD-L1, which helps restore and enhance T lymphocyte function while reducing the proportion of myeloid-derived suppressor cells (MDSCs), counteracting tumor-induced immune evasion. OPBP-1 is applicable for research in cancer immunotherapy.</p>Fórmula:C64H92N20O19SPeso molecular:1476.65683Thalidomide-5,6-Cl
CAS:<p>Thalidomide-5,6-Cl is a cereblon ligand derivative that recruits CRBN protein and forms PROTACs with a linker.</p>Fórmula:C13H8Cl2N2O4Cor e Forma:SolidPeso molecular:327.12TNF-α Antagonist
CAS:<p>TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with</p>Fórmula:C58H71N11O15S2Cor e Forma:SolidPeso molecular:1226.39PBE-AMF
<p>PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells.</p>Cor e Forma:Odour SolidS2/IAPinh
<p>S2/IAPinh is a conjugate composed of an inhibitor of apoptosis proteins inhibitor (IAPinh) and a ligand of sigma 2 SW43. It demonstrates anti-proliferative and apoptosis-inducing activity by degrading inhibitor of apoptosis proteins (clAP-1).</p>Fórmula:C52H75Cl2FN6O6SPeso molecular:1000.48299NAE-IN-1
<p>NAE-IN-1 (compound X-10) is a potent inhibitor of NAE1. It induces apoptosis and causes cell cycle arrest in the G2/M phase. Furthermore, NAE-IN-1 increases ROS levels and inhibits cell migration, demonstrating antiproliferative activity.</p>Fórmula:C29H30N4O2SPeso molecular:498.20895Sandalore
CAS:<p>Sandalore boosts hair growth, reduces cell death, and raises IGF-1, acting on olfactory receptor OR2AT4.</p>Fórmula:C14H26OPureza:97.96%Cor e Forma:Light Yellow Viscous LiquidPeso molecular:210.36IDH1/2-IN-1
<p>IDH1/2-IN-1 (Compound 6b) is a dual inhibitor of IDH1(R132H)/IDH2(R140Q) with IC50 values of 0.22 μM and 1.6 μM, respectively. This compound effectively inhibits tumor growth by suppressing tumor cell proliferation and activating antioxidative enzymes to enhance host defense. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating significant anti-tumor activity. It is also utilized in leukemia research.</p>Cor e Forma:Odour Solidd-(KLAKLAK)2, Proapoptotic Peptide
CAS:<p>d-(KLAKLAK)2 is an antimicrobial and antitumor peptide, notable within the group of antimicrobial peptides, and exhibits strong anticancer properties. It kills bacteria by disrupting their cell membranes, causing leakage of cell contents. Additionally, d-(KLAKLAK)2 inhibits tumor cell proliferation by inducing apoptosis through mitochondrial swelling and membrane damage.</p>Fórmula:C72H139N21O14Cor e Forma:SolidPeso molecular:1523.01C-Peptide 1 (rat)
CAS:<p>C-Peptide 1 (rat) is a polypeptide isolated from proinsulin. C-Peptide acts as a β-catenin/GSK-3β activator, influences Na/K-ATPase, regulates apoptosis.</p>Fórmula:C140H228N38O51Pureza:99.788%Cor e Forma:SolidPeso molecular:3259.58MS105
CAS:<p>MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.</p>Fórmula:C56H70FN13O6SCor e Forma:SolidPeso molecular:1072.30Halenaquinone
CAS:<p>Halenaquinone: PI3K inhibitor, stops RAD51 DNA binding & osteoclastogenesis, induces PC12 cell apoptosis.</p>Fórmula:C20H12O5Pureza:98%Cor e Forma:SolidPeso molecular:332.31JGB1741
CAS:<p>JGB1741, a SIRT1 inhibitor (IC50=15µM), modulates apoptosis markers and p53 acetylation in breast cancer research.</p>Fórmula:C27H24N2O2SPureza:99.86%Cor e Forma:SolidPeso molecular:440.56Ferroptosis-IN-17
<p>Ferroptosis-IN-17 (Compound 18) is an inhibitor of ferroptosis with an EC50 value of 0.57 μM. It effectively reduces the accumulation of intracellular ferrous ions and lipid peroxidation while restoring levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4). In rat plasma, Ferroptosis-IN-17 demonstrates good solubility and notable metabolic stability. This compound holds potential for research in tumor suppression, neurodegenerative diseases, and cardiovascular disorders.</p>Fórmula:C21H26N4O5SCor e Forma:SolidPeso molecular:446.52Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
CAS:<p>Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.</p>Fórmula:C28H39F3N8O9Pureza:98%Cor e Forma:SolidPeso molecular:688.662Moflerafusp alfa
CAS:<p>Moflerafusp alfa is a fusion protein that targets the human signal-regulatory protein alpha (SIRPα) variant V2 D1 domain and human programmed death-ligand 1 (PD-L1). It shows potential for research in various cancer treatments.</p>Cor e Forma:LiquidThalidomide-O-amido-C3-PEG3-C1-NH2
CAS:<p>Thalidomide-based E3 ligase linker for PROTACs with a 3-unit PEG chain.</p>Fórmula:C27H35F3N4O11Cor e Forma:SolidPeso molecular:648.589CSF1R-IN-26
<p>CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.</p>Cor e Forma:Odour SolidPamrevlumab
CAS:<p>FG-3019 (Pamrevlumab), a human antibody, targets CTGF, potentially treating idiopathic pulmonary fibrosis.</p>Pureza:100% (SEC-HPLC) - 95%Cor e Forma:LiquidDL-Sulforaphane N-acetyl-L-cysteine
CAS:<p>DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC), induces apoptosis through α-microtubulin and phosphorylation of ERK1/2-mediated Stathmin-1, and Hsp70 (NSCLC).</p>Fórmula:C11H20N2O4S3Cor e Forma:SolidPeso molecular:340.48DCZ3301
CAS:<p>DCZ3301 is a novel aryl-guanidino inhibitor.</p>Fórmula:C20H16ClF3N6O2Pureza:99.89%Cor e Forma:SolidPeso molecular:464.83RD-23
CAS:<p>RD-23 is an orally active and selective RET PROTAC degrader. It facilitates the ubiquitination and degradation of the RETG810C mutant with a DC50 value of 11.7 nM. Additionally, RD-23 inhibits the activation of downstream Shc signaling and induces apoptosis (Apoptosis). It is useful for studying RET-related cancers.</p>Fórmula:C52H56N12O4Cor e Forma:SolidPeso molecular:913.079cpm-1285
CAS:<p>CPM-1285 induces apoptosis by effectively inhibiting the function of intracellular Bcl-2 and associated death antagonists.</p>Fórmula:C153H240N44O42SPureza:98%Cor e Forma:SolidPeso molecular:3399.88FeTPPS
CAS:<p>FeTPPS, a decomposition catalyst for 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin iron(III) chloride peroxynitrite, neuroprotective.</p>Fórmula:C44H28ClFeN4O12S4Cor e Forma:SolidPeso molecular:1024.27FD2157
<p>FD2157, a photosensitive PI3K inhibitor, exhibits inhibitory IC50 values of 43 nM for PI3Kα, 83 nM for PI3Kβ, 84 nM for PI3Kγ, and 14 nM for PI3Kδ.</p>Fórmula:C27H21ClN6O8SPureza:98%Cor e Forma:SolidPeso molecular:625.01AB-3PRGD2
CAS:<p>AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.</p>Fórmula:C137H215IN30O45SCor e Forma:SolidPeso molecular:3161.32Anticancer agent 106
<p>Compound 106 (compound 10ic) induces apoptosis in B16-F10 melanoma cells and potently inhibits metastatic nodules in mouse models of lung metastatic melanoma,</p>Fórmula:C26H25N3O4SPureza:98%Cor e Forma:SolidPeso molecular:475.56Antitumor agent-112
<p>Antitumor agent-112 (compound 3a) is a potent antitumor agent that induces apoptosis and exhibits cytotoxic activity on A549 cells, with an IC50 value of 91.35</p>Fórmula:C18H17ClN4O2SPureza:98%Cor e Forma:SolidPeso molecular:388.87Lacto-N-fucopentaose I
CAS:<p>Lacto-N-fucopentaose I is a milk oligosaccharide.</p>Fórmula:C32H55NO25Cor e Forma:SolidPeso molecular:853.774Platycoside G3
CAS:<p>Platycoside G3 is a useful organic compound for research related to life sciences. The catalog number is T124100 and the CAS number is 849758-44-7.</p>Fórmula:C63H102O32Cor e Forma:SolidPeso molecular:1371.48IRAK4-IN-27
<p>IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM.</p>Fórmula:C23H22N6O3Pureza:98%Cor e Forma:SolidPeso molecular:430.46Pyridinium bisretinoid A2E TFA
CAS:<p>Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediates</p>Fórmula:C44H58F3NO3Pureza:98%Cor e Forma:SolidPeso molecular:705.93ChoKα inhibitor-3
<p>ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability to</p>Fórmula:C50H54Br2Cl2N4S2Cor e Forma:SolidPeso molecular:1005.83Apoptosis inducer 11
<p>Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within</p>Fórmula:C27H28N2O5Pureza:98%Cor e Forma:SolidPeso molecular:460.52PTD-p65-P1 Peptide TFA
<p>Ptd-p65-p1 Peptide TFA inhibits NF-kappaB, has a cell-penetrating antennapedia sequence, and selectively blocks NF-kappaB activation.</p>Fórmula:C170H276F3N57O46SPureza:98%Cor e Forma:SolidPeso molecular:3943.522'-epi-2'-O-Acetylthevetin B
CAS:<p>2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L.</p>Fórmula:C44H68O19Pureza:98%Cor e Forma:SolidPeso molecular:901Ara-SH
<p>Ara-SH, a derivative of Cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded Cytarabine</p>Fórmula:C12H17N3O6SPureza:98%Cor e Forma:SolidPeso molecular:331.34Anti-inflammatory agent 45
<p>Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies,</p>Fórmula:C25H22BrNO6Pureza:98%Cor e Forma:SolidPeso molecular:512.35Tubulin inhibitor 34
<p>Tubulin Inhibitor 34 (compound b5), a potent anticancer agent, inhibits tubulin polymerization and induces G2/M arrest and apoptosis.</p>Fórmula:C21H22N4O3SCor e Forma:SolidPeso molecular:410.49BAY 1892005
CAS:<p>BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein</p>Fórmula:C11H8ClFN2OSPureza:99.62%Cor e Forma:SoildPeso molecular:270.71Mcl1-IN-26
CAS:<p>Mcl1-IN-26 is an effective and selective myeloid cell leukemia 1 inhibitor.</p>Fórmula:C45H52ClN5O6SCor e Forma:SolidPeso molecular:826.44CWI1-2 HCL
CAS:<p>CWI1-2 HCL: Potent IGF2BP2 inhibitor, induces apoptosis/differentiation, targets leukemia therapy.</p>Fórmula:C22H18Cl4N6O3Pureza:98.09%Cor e Forma:SolidPeso molecular:556.23Psalmotoxin 1
CAS:<p>Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.</p>Fórmula:C200H312N62O57S6Pureza:98%Cor e Forma:SolidPeso molecular:4689.41
