Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5593 produtos de "Apoptose"
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TRAP1-IN-1
CAS:<p>TRAP1-IN-1 is a selective TRAP1 inhibitor, induces degradation of TRAP1 downstream proteins, inhibits OXPHOS, and disrupts mitochondrial membrane potential.</p>Fórmula:C45H39F7N2O4P2Pureza:98%Cor e Forma:SolidPeso molecular:866.74L-threo-PPMP
CAS:<p>L-threo-PPMP blocks GlcT, curbs glycosphingolipid creation, and triggers cell death, showing anti-cancer effects.</p>Fórmula:C29H50N2O3Cor e Forma:SolidPeso molecular:474.73Antitumor agent-41
<p>Antitumor Agent-41 (Compound N-12) exhibits potent antitumor properties, demonstrating significant antimigration and anti-invasion activities.</p>Fórmula:C64H109IN2O21Cor e Forma:SolidPeso molecular:1369.46PARP1/BRD4-IN-3
<p>PARP1/BRD4-IN-3 (compound HF4) is an effective inhibitor of BRD4 and PARP1, with IC50 values of 1210 nM and 2019 nM respectively. The compound exhibits antiproliferative activity, induces apoptosis (apoptosis) and cell cycle arrest at the G0/G1 phase. Additionally, PARP1/BRD4-IN-3 causes DNA damage and reduces the expression of the Rad51 protein, demonstrating anti-tumor activity.</p>Cor e Forma:Odour SolidZigakibart
CAS:<p>Zigakibart (BION-1301) is a humanized monoclonal antibody targeting TNFSF13 with anti-inflammatory activity for the study of immunoglobulin A nephropathy (IgAN)</p>Pureza:95.8% (SDS-PAGE); 99.8% (SEC-HPLC) - 95.8% (SDS-PAGE); 99.8% (SEC-HPLC)Cor e Forma:LiquidNA-Ir
CAS:<p>NA-Ir is a ferroptosis (Ferroptosis) inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to stimulate ferritin autophagy (). It also induces the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depletes glutathione (GSH), and downregulates glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and ferroptosis. NA-Ir exhibits enhanced anticancer activity under light exposure and selectively inhibits cancer cells with high H2S content.</p>Fórmula:C49H36F6IrN8O4PCor e Forma:SolidPeso molecular:1138.04Dynorphin A
CAS:<p>Dynorphin A is a endogenous opioid peptide and a κ-opioid receptor (KOR) agonist,a neurotransmitter and regulator in the central and peripheral nervous systems</p>Fórmula:C99H155N31O23Pureza:95.93%Cor e Forma:SolidPeso molecular:2147.48HDAC-IN-79
<p>HDAC-IN-79 (compound 4) is an orally active dual inhibitor of xanthine oxidase and HDAC, exhibiting potent anti-hyperuricemia and antitumor activities in vivo (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM). Among leukemia cells, it is most effective in inhibiting the growth of HL60 cells (IC50=0.706 μM) and induces both apoptosis and autophagy. HDAC-IN-79 also modulates the expression levels of biomarkers associated with intracellular HDAC inhibition.</p>Cor e Forma:Odour SolidFlavopiridol
CAS:<p>Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.</p>Fórmula:C21H20ClNO5Pureza:97.74% - 99.86%Cor e Forma:SolidPeso molecular:401.84Photosensitizer-6
CAS:<p>Photosensitizer-6 (Compound 4) is a metal ion complex that inhibits TrxR. It induces apoptosis in 4T1 cells, targeting cancer cells and eliminating tumors through chemophototherapy and immunogenic cell death under illumination. Additionally, Photosensitizer-6 can be utilized for tumor imaging.</p>Fórmula:C47H35AuF6N4P2SCor e Forma:SolidPeso molecular:1060.78SM-164 Hydrochloride (957135-43-2 free base)
<p>SM-164 Hydrochloride: cell-permeable, binds to XIAP (BIR2/3 domains), IC50 of 1.39 nM, potent XIAP antagonist.</p>Fórmula:C62H85ClN14O6Pureza:98%Cor e Forma:SolidPeso molecular:1157.88Boc-AEVD-CHO
CAS:<p>Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].</p>Fórmula:C22H36N4O10Pureza:98%Cor e Forma:SolidPeso molecular:516.54VEGFR-2-IN-66
<p>VEGFR-2-IN-66 (Compound 6) is an orally active VEGFR-2 inhibitor with an IC50 of 0.509 µM and an IC50 value of 7.48 μM for inhibiting MCF-7 cell proliferation. Its anticancer activity is exerted through cell cycle arrest, induction of apoptosis (Apoptosis), and modulation of gene expression, making it suitable for breast cancer research.</p>Cor e Forma:Odour SolidTrichostatin C
CAS:<p>Trichostatin C, a natural glycosylated hydroxamate, is a histone deacetylase inhibitor with antifungal properties and can induce cell differentiation.</p>Fórmula:C23H32N2O8Cor e Forma:SolidPeso molecular:464.515Golimumab
CAS:<p>Golimumab (CNTO-148), an anti-TNFα IgG1κ monoclonal antibody with anti-inflammatory and anti-cancer activity, can be used to prevent inflammation and cartilage.</p>Cor e Forma:LiquidPeso molecular:146.93 kDaZS3-046
<p>ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.</p>Fórmula:C49H57N9O7Cor e Forma:SolidPeso molecular:883.4381ZYH-23
<p>ZYH-23 is a potent inhibitor of necroptosis. It targets HSP90 to inhibit the phosphorylation of RIPK1, RIPK3, and MLKL, effectively blocking programmed cell necrosis.</p>Fórmula:C41H50N4O3Cor e Forma:SolidPeso molecular:646.38829DD0-2363
<p>DD0-2363 (Compound 32d) is a dual-target inhibitor of WDR5-MLL1/HDAC. It can suppress the proliferation of acute myeloid leukemia cells and induce apoptosis. With its antitumor properties, DD0-2363 is applicable for research on acute myeloid leukemia.</p>Fórmula:C36H36ClFN6O4Cor e Forma:SolidPeso molecular:671.16UBX1325
CAS:<p>UBX1325, a potent Bcl-xL inhibitor, induces cell death in aging cells, useful for age-related eye disease research.</p>Fórmula:C53H59ClF3N6O10PS3Cor e Forma:SolidPeso molecular:1159.69Dimethachlor
CAS:<p>Dimethachlor is a pesticide and herbicide used in wetland areas.</p>Fórmula:C13H18ClNO2Cor e Forma:SolidPeso molecular:255.74Anticancer agent 204
<p>Anticanceragent 204 (Compound 6) is a fluorinated derivative of cinnamamides with anticancer activity. It can arrest the cell cycle of HepG2 cells in the G1 phase and induces apoptosis by reducing mitochondrial membrane polarization (MMP) levels.</p>Fórmula:C26H18FN5O3SPeso molecular:499.11144SB 699551
CAS:<p>SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.</p>Fórmula:C34H45N3OPureza:99.83%Peso molecular:511.74CDK9-IN-24
<p>CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.</p>Fórmula:C27H31N3O4Pureza:98%Cor e Forma:SolidPeso molecular:461.55Met-12
CAS:<p>Met-12 is a peptide inhibitor of the Fas receptor. It suppresses Fas receptor-mediated apoptosis in photoreceptor cells and reduces Caspase activation, making it a potential candidate for research on photoreceptor protectants.</p>Fórmula:C71H99N17O17Cor e Forma:SolidPeso molecular:1462.65FF2039
<p>FF2039 (compound 1j) is a PROTAC degrader specifically targeting HDAC1, HDAC6, and various subtypes of class I, IIa, and IIb HDACs. It induces cell cycle arrest and apoptosis, showing significant antiproliferative activity against both hematological and solid tumor cell lines. The IC50 values for FF2039 against HDAC1, HDAC2, HDAC4, and HDAC6 are 1.03, 2.15, 12.4, and 0.053 μM, respectively. FF2039 exhibits antiproliferative effects on solid tumors such as MM.1S, MDA-MB-231, and U-87MG, with EC50 values of 2.8, 28, and 30 μM, respectively.</p>Fórmula:C43H56Cl3N5O6Cor e Forma:SolidPeso molecular:845.29Arisostatin A
CAS:<p>Arisostatin A is a secondary metabolite produced by microorganisms, recognized as an antibiotic (antibiotic) with activity against Gram-positive bacteria. This compound also exhibits potent antitumor properties. It induces apoptosis (apoptosis) by activating caspase-3 and generating reactive oxygen species (ROS) in AMC-HN-4 cells.</p>Fórmula:C69H100N2O24Cor e Forma:SolidPeso molecular:1341.53Antimycobacterial agent-5
<p>Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide compound that targets the Mycobacterium electron transport chain (ETC) respiratory CIII2CIV2 supercomplex. It acts on Mycobacterium smegmatis CIII2CIV2 with an IC50 of 441 nM.</p>Fórmula:C25H34ClN3OPeso molecular:427.23904HSP90-IN-18
<p>HSP90-IN-18 inhibits Hsp90 with 0.39 μM IC50, useful for viral, neurodegenerative, and inflammatory research.</p>Fórmula:C25H33FO3Cor e Forma:SolidPeso molecular:400.53BRD-810
CAS:<p>BRD-810 is a highly selective MCL1 inhibitor (Kd=0.3 nM) capable of inducing tumour cell apoptosis, for haematological malignancies and solid tumours.</p>Fórmula:C39H44ClFN4O5Pureza:97.88%Cor e Forma:SolidPeso molecular:703.24(±)-Indoxacarb
CAS:<p>(±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.</p>Fórmula:C22H17ClF3N3O7Cor e Forma:SolidPeso molecular:527.83Dapirolizumab
<p>Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.</p>Pureza:>95%Cor e Forma:LiquidPeso molecular:145.5 kDa(-)-Mcl-1 inhibitor 21
CAS:<p>(-)-Mcl-1 inhibitor 21 (Example 1-38) is an Mcl-1 inhibitor with an IC50 of 7.51 μM. It exhibits pro-apoptotic and anti-proliferative activity against SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.</p>Fórmula:C32H33N3O4Cor e Forma:SolidPeso molecular:523.622MDMX/MDM2-IN-2
<p>MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, demonstrating dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX.</p>Fórmula:C28H25Cl3FN3O3Cor e Forma:SolidPeso molecular:576.87W1131 TFA
<p>W1131 TFA is a STAT3 inhibitor and ferroptosis inducer that regulates the IL6-JAK-STAT3 and ferroptosis pathways,gastric cancer.</p>Fórmula:C25H20F3N5O6Pureza:98.1%Cor e Forma:SolidPeso molecular:543.45MD-222
CAS:<p>MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.</p>Fórmula:C48H47Cl2FN6O6Cor e Forma:SolidPeso molecular:893.84PROTAC Bcl-xL degrader-3
CAS:<p>PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.</p>Fórmula:C82H105ClF3N11O11S4Cor e Forma:SolidPeso molecular:1641.49Hematein
CAS:<p>Hematein blocks Akt/PKB, Wnt signaling, promotes apoptosis in lung cancer, is a dye from hematoxylin, and inhibits casein kinase II (IC50: 0.74 μM).</p>Fórmula:C16H12O6Pureza:98%Cor e Forma:Dark Brown Crystalline PowderPeso molecular:300.26Satratoxin G
CAS:<p>Satratoxin G, from Stachybotrys chartarum, triggers apoptosis in nasal and brain OSNs.</p>Fórmula:C29H36O10Cor e Forma:SolidPeso molecular:544.597KH16
<p>KH16 is an HDAC inhibitor.KH16 stimulates apoptosis and is able to inhibit gene expression patterns in a variety of tumor cells.</p>Fórmula:C18H20N6O2Pureza:98.15%Cor e Forma:SolidPeso molecular:352.39PROTAC RIPK degrader-6
CAS:<p>PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker</p>Fórmula:C43H48N6O11S2Cor e Forma:SolidPeso molecular:889.01(-)-Rasfonin
CAS:<p>Rasfonin, a fungal metabolite from T. terrophilus, halts mouse splenocyte growth; IC50: 0.7 μg/ml (ConA), 0.5 μg/ml (LPS).</p>Fórmula:C25H38O6Cor e Forma:SolidPeso molecular:434.57Liensinine Perchlorate
CAS:<p>Liensinine is the active constituent of plumula nelambinis with anti-hypertension.</p>Fórmula:C37H43ClN2O10Pureza:99.80%Cor e Forma:SolidPeso molecular:711.2Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
CAS:<p>Cereblon ligand for PROTAC R&D; has E3 ligase, alkylC1-PEG3-alkylC3 linker, terminal amine. Part of Arvinas-licensed tool molecules.</p>Fórmula:C25H35ClN4O9Cor e Forma:SolidPeso molecular:571.02Sodium propionate
CAS:<p>Sodium propionate (Propionic acid sodium salt) has potential anti-inflammatory and anti-apoptotic activities, inhibiting certain signaling pathways.</p>Fórmula:C3H5NaO2Cor e Forma:SoildPeso molecular:96.06CAY10678
CAS:<p>CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS</p>Fórmula:C23H34N4OPureza:99.66%Cor e Forma:SolidPeso molecular:382.54SLF TFA
CAS:<p>SLF TFA, a synthetic FKBP ligand, binds FKBP51 (3.1 μM) and inhibits FKBP12 (IC50 2.6 μM); used in PROTAC synthesis.</p>Fórmula:C32H41F3N2O8Cor e Forma:SolidPeso molecular:638.67YW-N-7 TFA
<p>YW-N-7 (TFA) is a PROTAC designed to target, inhibit, and degrade RET kinase, demonstrating a DC50 of 88 nM. It exhibits antitumor activity in xenograft mouse models driven by KIF5B-RET, making it a valuable compound for cancer research.</p>Fórmula:C58H63F3N12O9Cor e Forma:SolidPeso molecular:1129.19Diethanolamine hydrochloride
CAS:<p>Diethanolamine hydrochloride is HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), p53 Estrogen receptor.</p>Fórmula:C4H12ClNO2Pureza:99.69%Cor e Forma:SolidPeso molecular:141.6RIPK2-IN-2
CAS:<p>RIPK2-IN-2, a RIP2 kinase PROTAC inhibitor, blocks proinflammatory signaling in autoinflammatory diseases.</p>Fórmula:C53H65FN14O7S2Cor e Forma:SolidPeso molecular:1093.3CAY10726
CAS:<p>CAY10726, an arylurea fatty acid, cuts ATP by 28% and promotes apoptosis in breast cancer cells by depleting mitochondrial lipids.</p>Fórmula:C24H36ClF3N2O3Cor e Forma:SolidPeso molecular:493
