Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5599 produtos de "Apoptose"
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Cambinol
CAS:<p>Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.</p>Fórmula:C21H16N2O2SPureza:98.02% - 99.83%Cor e Forma:SolidPeso molecular:360.43Lumichrome
CAS:<p>Lumichrome, a riboflavin metabolite, influences plant growth, ascidian metamorphosis, bacterial communication, and blocks riboflavin uptake.</p>Fórmula:C12H10N4O2Pureza:99.69% - 99.93%Cor e Forma:SolidPeso molecular:242.23GSK2801
CAS:<p>GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.</p>Fórmula:C20H21NO4SPureza:97.78% - 99.45%Cor e Forma:SolidPeso molecular:371.45Ruxolitinib
CAS:<p>Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.</p>Fórmula:C17H18N6Pureza:99.4% - >99.99%Cor e Forma:SolidPeso molecular:306.36Eribulin mesylate
CAS:<p>Eribulin mesylate (E7389), a microtubule inhibitor, treats metastatic breast cancer by halting cell division.</p>Fórmula:C41H63NO14SPureza:97.02% - >99.99%Cor e Forma:SolidPeso molecular:826XI-006
CAS:<p>NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.</p>Fórmula:C11H13N5O4Pureza:99.51%Cor e Forma:SolidPeso molecular:279.25Cabozantinib
CAS:<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Fórmula:C28H24FN3O5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:501.513,4-Dicaffeoylquinic acid
CAS:<p>3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) has antioxidant activity.</p>Fórmula:C25H24O12Pureza:96.33% - 98.82%Cor e Forma:SolidPeso molecular:516.45PRIMA-1
CAS:<p>PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.</p>Fórmula:C9H15NO3Pureza:99.22%Cor e Forma:SolidPeso molecular:185.22GSK2656157
CAS:<p>GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.</p>Fórmula:C23H21FN6OPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:416.45ICCB-19 hydrochloride
CAS:<p>ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.</p>Fórmula:C12H22ClN3OSPureza:99.3%Cor e Forma:SolidPeso molecular:291.84ON1231320
CAS:<p>ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor.</p>Fórmula:C22H15F2N5O3SPureza:97.31%Cor e Forma:SolidPeso molecular:467.45Pictilisib
CAS:<p>Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).</p>Fórmula:C23H27N7O3S2Pureza:98.69% - 99.97%Cor e Forma:SolidPeso molecular:513.64LQZ-7I
CAS:<p>LQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors</p>Fórmula:C20H14F2N4Pureza:99.81% - 99.87%Cor e Forma:SolidPeso molecular:348.356-Thioguanine
CAS:<p>6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.</p>Fórmula:C5H5N5SPureza:98.34% - >99.99%Cor e Forma:Odorless Or Almost Odorless Pale Yellow Crystalline PowderPeso molecular:167.19Mollugin
CAS:Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.Fórmula:C17H16O4Pureza:99.87% - ≥95%Cor e Forma:SolidPeso molecular:284.31Atorvastatin hemicalcium salt
CAS:<p>Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.</p>Fórmula:C33H34FN2O5CaPureza:99.27% - >99.99%Cor e Forma:White Crystalline PowderPeso molecular:577.67Bafilomycin A1
CAS:<p>Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible.</p>Fórmula:C35H58O9Pureza:95.87% - 99.36%Cor e Forma:SolidPeso molecular:622.83Picropodophyllin
CAS:<p>Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.</p>Fórmula:C22H22O8Pureza:98.88% - 99.62%Cor e Forma:SolidPeso molecular:414.41Zinc Protoporphyrin
CAS:<p>Zinc Protoporphyrin is an oral HO-1 inhibitor that reduces PG's protection against H2O2 and has anti-cancer properties.</p>Fórmula:C34H32N4O4ZnPureza:95.43% - 99.27%Cor e Forma:SolidPeso molecular:626.02LY-294002 hydrochloride
CAS:<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Fórmula:C19H17NO3·HClPureza:99.95%Cor e Forma:SolidPeso molecular:343.81Larotrectinib sulfate
CAS:<p>Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).</p>Fórmula:C21H22F2N6O2·H2O4SPureza:98.62% - 99.76%Cor e Forma:SolidPeso molecular:526.51VER-50589
CAS:<p>VER-50589 is a potent HSP90 inhibitor.</p>Fórmula:C19H17ClN2O5Pureza:99.96% - >99.99%Cor e Forma:SolidPeso molecular:388.8MG 149
CAS:<p>MG 149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF(IC50= 47 uM).</p>Fórmula:C22H28O3Pureza:98.69% - 99.86%Cor e Forma:SolidPeso molecular:340.46MSC 2032964A
CAS:<p>MSC 2032964A: Potent, selective ASK1 inhibitor, IC50=93 nM, oral, brain-permeable, curbs neuroinflammation, blocks LPS-induced ASK1/p38 activation.</p>Fórmula:C16H13F3N6OPureza:99.76%Cor e Forma:SolidPeso molecular:362.31CHS-828
CAS:<p>CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).</p>Fórmula:C19H22ClN5OPureza:98% - 99.9%Cor e Forma:SolidPeso molecular:371.86LW6
CAS:<p>LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.</p>Fórmula:C26H29NO5Pureza:98.1% - 98.22%Cor e Forma:SolidPeso molecular:435.51Stattic
CAS:<p>Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.</p>Fórmula:C8H5NO4SPureza:98.32% - 99.76%Cor e Forma:SolidPeso molecular:211.19Pifithrin-α hydrobromide
CAS:<p>Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes.</p>Fórmula:C16H18N2OS·HBrPureza:97.71% - >99.99%Cor e Forma:SolidPeso molecular:367.3SGI-1027
CAS:<p>SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).</p>Fórmula:C27H23N7OPureza:99.45% - 99.78%Cor e Forma:SolidPeso molecular:461.52Tasisulam
CAS:<p>Tasisulam (LY573636) is an apoptosis inducer and an antitumor agent via the intrinsic pathway.</p>Fórmula:C11H6BrCl2NO3S2Pureza:99% - >99.99%Cor e Forma:SolidPeso molecular:415.11Pifithrin-β hydrobromide
CAS:<p>Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis.</p>Fórmula:C16H17BrN2SPureza:99.24% - 99.74%Cor e Forma:SolidPeso molecular:349.29Sal003
CAS:<p>Sal003, an effective cell-permeable analog, inhibitis the eIF2α phosphatase.</p>Fórmula:C18H15Cl4N3OSPureza:99.17% - 99.77%Cor e Forma:SolidPeso molecular:463.21Hypericin
CAS:<p>Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.</p>Fórmula:C30H16O8Pureza:99.05% - ≥98%Cor e Forma:Red-Coloured Anthraquinone-DerivativePeso molecular:504.44Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.9%Cor e Forma:Off-White SolidPeso molecular:485.94Glycochenodeoxycholic Acid
CAS:<p>Glycochenodeoxycholic Acid (Lithocholylglycine) is a glycine conjugate of lithocholic acid, a bile acid.</p>Fórmula:C26H43NO5Pureza:97% - 99.97%Cor e Forma:SolidPeso molecular:449.62IC261
CAS:<p>IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.</p>Fórmula:C18H17NO4Pureza:99.45% - 99.91%Cor e Forma:SolidPeso molecular:311.33Vesatolimod
CAS:<p>Vesatolimod (GS-9620) is an effective and specific orally active agonist of Toll-like receptor 7.</p>Fórmula:C22H30N6O2Pureza:97.46% - 99.03%Cor e Forma:SolidPeso molecular:410.51Salubrinal
CAS:<p>Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).</p>Fórmula:C21H17Cl3N4OSPureza:97.25% - >99.99%Cor e Forma:SolidPeso molecular:479.81BI-3802
CAS:<p>BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM.</p>Fórmula:C24H29ClN6O3Pureza:97.93% - 98.58%Cor e Forma:SolidPeso molecular:484.98JG-98
CAS:<p>JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).</p>Fórmula:C24H21Cl2N3OS3Pureza:99.13%Cor e Forma:SolidPeso molecular:534.53OTS514
CAS:OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor.Fórmula:C21H20N2O2SPureza:99.62%Cor e Forma:SolidPeso molecular:364.46Enzastaurin
CAS:<p>Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.</p>Fórmula:C32H29N5O2Pureza:98% - >99.99%Cor e Forma:SolidPeso molecular:515.6MK-2206 dihydrochloride
CAS:<p>MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and</p>Fórmula:C25H23Cl2N5OPureza:99.228% - 99.94%Cor e Forma:SolidPeso molecular:480.39WT-161
CAS:<p>WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).</p>Fórmula:C27H30N4O3Pureza:95.98% - 98.34%Cor e Forma:SolidPeso molecular:458.55JX06
CAS:<p>JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.</p>Fórmula:C10H16N2O2S4Pureza:99.4%Cor e Forma:SolidPeso molecular:324.51Siramesine hydrochloride
CAS:<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>Fórmula:C30H32ClFN2OPureza:99.72% - >99.99%Cor e Forma:SolidPeso molecular:491.04PF-4989216
CAS:<p>PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.</p>Fórmula:C18H13FN6OSPureza:99.85%Cor e Forma:SolidPeso molecular:380.4ABT-737
CAS:<p>ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits antitumor activity and anti-aging activity. Cost-effective and quality-assured.</p>Fórmula:C42H45ClN6O5S2Pureza:98.15% - >99.99%Cor e Forma:SolidPeso molecular:813.43GSK778 hydrochloride
CAS:<p>GSK778 hydrochloride is a selective BET BD1 bromodomain inhibitor, with IC50s ranging from 41 to 143 nM, effective in cancer models.</p>Fórmula:C30H34ClN5O3Pureza:97.26% - 98.35%Cor e Forma:SolidPeso molecular:548.08
