Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(6 produtos)
- BCL(11 produtos)
- Caspase(125 produtos)
- FOXO1(3 produtos)
- IAP(66 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(125 produtos)
- PDK(9 produtos)
- PERK(25 produtos)
- Serina/treonina quinase(15 produtos)
- Survivina(13 produtos)
- TNF(92 produtos)
- c-RET(51 produtos)
- p53(62 produtos)
Exibir 6 mais subcategorias
Foram encontrados 5600 produtos de "Apoptose"
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CCT018159
CAS:<p>CCT018159: ATP-competitive HSP90 inhibitor, IC50 3.2 μM (human), 6.6 μM (yeast), blocks invasion, angiogenesis, induces G1 arrest and apoptosis.</p>Fórmula:C20H20N2O4Pureza:98.78% - 99.79%Cor e Forma:SolidPeso molecular:352.38Tubulin inhibitor 11
CAS:<p>Potent, oral Tubulin inhibitor 11 hinders polymerization, targets Colchicine site, induces mitotic block, and apoptosis.</p>Fórmula:C22H23N3O3SPureza:98.32%Cor e Forma:SoildPeso molecular:409.5LDCA
CAS:<p>LDCA inhibits LDH-A, disrupts mitochondrial function, induces apoptosis in cancer cells, and is non-toxic.</p>Fórmula:C8H5Cl3FNOPureza:98.99%Cor e Forma:SolidPeso molecular:256.49N6-Cyclopentyladenosine
CAS:<p>N6-Cyclopentyladenosine (CPA) is a selective agonist of the adenosine A1 receptor and can be used to mimic the action of the adenosine A1 receptor, with Ki's of</p>Fórmula:C15H21N5O4Pureza:99.84%Cor e Forma:SolidPeso molecular:335.36DB1976
CAS:<p>DB1976: Selenophene DB270 analog, inhibits PU.1 (IC50=10 nM), disrupts PU.1/DNA (KD=12 nM), induces apoptosis, cell-permeable.</p>Fórmula:C20H16N8SePureza:98.74%Cor e Forma:SolidPeso molecular:447.35Tubulin inhibitor 32
CAS:<p>Tubulin inhibitor 32 is a microtubule inhibitor with antiproliferative and antitumor activity that induces apoptosis and cell cycle arrest in the G2/M phase.</p>Fórmula:C18H19N3O3Pureza:99.92%Cor e Forma:SolidPeso molecular:325.36PARP/PI3K-IN-1
CAS:PARP/PI3K-IN-1 is a PARP and PI3K dual inhibitor with anticancer and antiproliferative activities for the study of breast, pancreatic and lung cancers.Fórmula:C33H28F4N8O3Pureza:99.59%Cor e Forma:SolidPeso molecular:660.62HBDDE
CAS:<p>HBDDE inhibits PKCα/γ (IC50: 43/50 μM), favors them over PKCδ/βI/βII, and induces neuronal apoptosis. Derived from ellagic acid.</p>Fórmula:C16H18O8Pureza:97.94%Cor e Forma:SolidPeso molecular:338.31CBS9106
CAS:<p>CBS9106 (SL-801) is a CRM1 inhibitor with CRM1-degrading and anti-tumor activity that inhibits CRM1-dependent nuclear export.</p>Fórmula:C18H21ClF3N3O3Pureza:98.98%Cor e Forma:SolidPeso molecular:419.83Alethine
CAS:<p>Alethine is a small antitumor compound used to treat cancers and infections, boosting T-cell cytotoxicity by raising TNFα.</p>Fórmula:C10H22N4O2S2Pureza:98.83%Cor e Forma:SolidPeso molecular:294.44TL4-12
CAS:<p>TL4-12 is a MAP4K2 (GCK) inhibitor that inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro.</p>Fórmula:C25H27F3N6O2Pureza:98.38%Cor e Forma:SolidPeso molecular:500.52GSK-3β inhibitor 3
CAS:<p>GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3</p>Fórmula:C18H14FNO2SPureza:97.53%Cor e Forma:SolidPeso molecular:327.37KR-33493
CAS:<p>KR-33493 is a FAS-associated factor 1 (FAF1) inhibitor and can be used in studies about Parkinson's disease.</p>Fórmula:C20H18BrN3O3SPureza:99.96%Cor e Forma:SolidPeso molecular:460.34JY-2
CAS:<p>JY-2 is a forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity that inhibits FoxO1 transcription and can be used to study psoriasis.</p>Fórmula:C13H7Cl2N3OPureza:99.66%Cor e Forma:SolidPeso molecular:292.12FA16
<p>FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16</p>Fórmula:C22H27F3N4O2SPureza:99.44%Cor e Forma:SolidPeso molecular:468.54Trk-IN-9
CAS:<p>Trk-IN-9 is a TRK inhibitor with anticancer and antiproliferative activity and can be used in cancer research.</p>Fórmula:C23H24ClFN6OPureza:98.15%Cor e Forma:SolidPeso molecular:454.93Necrostatin-5
CAS:<p>Necrostatin-5 (Nec-5) inhibits RIP1 kinase, prevents cell necrosis, and protects Fadd-deficient Jurkat cells with an EC50 of 240 nM.</p>Fórmula:C19H17N3O2S2Pureza:98.03%Cor e Forma:SolidPeso molecular:383.49NecroX-7
CAS:<p>NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor.</p>Fórmula:C24H29N3O3SPureza:98.22%Cor e Forma:SolidPeso molecular:439.57MJN68390
CAS:<p>MJN68390 has an apparent IC50 value of 15 μM against CASP8 and shows no activity against CASP10.</p>Fórmula:C24H28ClN3O3Pureza:98.86%Cor e Forma:SolidPeso molecular:441.95HS38
CAS:<p>HS38: DAPK-specific ATP-competitive inhibitor; Kds: DAPK1 (300 nM), PIM3 (200 nM), ZIPK (280 nM); useful in smooth muscle disorder research.</p>Fórmula:C14H12ClN5O2SPureza:98.19%Cor e Forma:SolidPeso molecular:349.8CSN5i-3
CAS:<p>CSN5i-3 is a potent, selective, and orally available inhibitor of the proteolytic subunit of the CSN complex, CSN5, as an anticancer agent.Cost-effective and quality-assured.</p>Fórmula:C28H29F2N5O2Pureza:99.56% - >99.99%Cor e Forma:SolidPeso molecular:505.56CTA 056
CAS:<p>CTA 056 is an ITK inhibitor that inhibits the growth of MOLT-4 xenograft tumors in mice and can be used to study autoimmune disorders.</p>Fórmula:C35H34N6OPureza:97.22% - 97.76%Cor e Forma:SolidPeso molecular:554.68Minodronic acid
CAS:Minodronic acid (YM-529) is a P2X2/3 antagonist with anticancer properties, inhibiting cell growth and metastasis, and used in osteoporosis research.Fórmula:C9H12N2O7P2Pureza:98.02%Cor e Forma:SolidPeso molecular:322.15SCFSkp2-IN-2
CAS:<p>SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM.</p>Fórmula:C17H20N4O2Pureza:99.86%Cor e Forma:SolidPeso molecular:312.37UC-112
CAS:<p>UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).</p>Fórmula:C22H24N2O2Pureza:99.54%Cor e Forma:SolidPeso molecular:348.44HS-276
CAS:<p>HS-276, a selective oral TAK1 inhibitor (Ki: 2.5 nM), also targets CLK2, GCK, ULK2, MAP4K5; potential for RA research.</p>Fórmula:C24H29N5O2Pureza:97.852% - 98.81%Cor e Forma:SolidPeso molecular:419.52DCG066
CAS:<p>DCG066 is an inhibitor of lysine methyltransferase G9a with anticancer activity and may be used in the study of leukemia.</p>Fórmula:C30H31F6N3O2Pureza:98.26% - 98.38%Cor e Forma:SolidPeso molecular:579.58CMLD-2
CAS:<p>CMLD-2 is a HuR-ARE inhibitor (Ki: 350 nM) that promotes apoptosis, has antitumor properties, and reduces thyroid cancer cell viability.</p>Fórmula:C31H31NO6Pureza:99.99%Cor e Forma:SolidPeso molecular:513.58NM-3
CAS:<p>NM-3, an oral anti-angiogenic and anti-tumor agent, modulates radiation and blocks VEGF to curb endothelial growth and induce apoptosis.</p>Fórmula:C13H12O6Pureza:99.89%Cor e Forma:SolidPeso molecular:264.23DX3-213B
CAS:<p>DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM.</p>Fórmula:C20H28F2N2O5S2Pureza:99.85%Cor e Forma:SolidPeso molecular:478.57XX-650-23
CAS:<p>XX-650-23 is a CREB inhibitor that induces apoptosis and cell cycle arrest in AML cells and can be used to study acute myeloid leukemia (AML).</p>Fórmula:C18H12N2O2Pureza:97.01%Cor e Forma:SolidPeso molecular:288.3Perphenazine dihydrochloride
CAS:<p>Perphenazine dihydrochloride: Oral dopamine, histamine-1 antagonist; targets D2, D3, 5-HT2A, Alpha-1A; may treat psychiatric disorders, cancer.</p>Fórmula:C21H28Cl3N3OSPureza:99.67%Cor e Forma:SolidPeso molecular:476.89Cipepofol
CAS:<p>HSK3486 is similar to propofol and is a general anesthetic, which may have therapeutic potential in insomnia, migraine, anxiety, analgesia, and other aspects.</p>Fórmula:C14H20OPureza:99.77%Cor e Forma:SolidPeso molecular:204.31Lanperisone HCl
CAS:<p>Lanperisone (NK433) is a potent, long-lasting muscle relaxant that inhibits spinal reflexes via noradrenergic system suppression.</p>Fórmula:C15H19ClF3NOPureza:98.67% - >99.99%Cor e Forma:SolidPeso molecular:321.77AOH1160
CAS:<p>AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA).</p>Fórmula:C25H20N2O3Pureza:98.46% - 99.52%Cor e Forma:SolidPeso molecular:396.44SPD304 dihydrochloride
CAS:<p>SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.</p>Fórmula:C32H34Cl2F3N3O2Pureza:99.25%Cor e Forma:SolidPeso molecular:620.53Epristeride
CAS:<p>Epristeride (ONO-9302) is a steroidal 5-alpha-reductase isoform 2 inhibitor that inhibits SR isoform 2. Epristeride reduces prostate size.</p>Fórmula:C25H37NO3Pureza:98.12% - >99.99%Cor e Forma:SolidPeso molecular:399.57UCB-5307
CAS:<p>UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.</p>Fórmula:C22H21N3OPureza:98.76%Cor e Forma:SolidPeso molecular:343.42Antifolate C2
CAS:<p>Antifolate C2 (AGF 154) inhibits tumor growth with 0.14 nM IC, useful in cancer/autoimmune research.</p>Fórmula:C19H21N5O6SPureza:99.57%Cor e Forma:SolidPeso molecular:447.46Mepazine
CAS:<p>Mepazine, a MALT1 inhibitor, blocks GSTMALT1 (IC50: 0.83μM) and GSTMALT1 325-760 (IC50: 0.42μM), promoting apoptosis and reducing cell viability.</p>Fórmula:C19H22N2SPureza:99.88% - 99.92%Cor e Forma:SolidPeso molecular:310.46LCS3
CAS:<p>LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3</p>Fórmula:C11H7ClN2O4Pureza:99.68%Cor e Forma:SolidPeso molecular:266.64LQZ-7F
CAS:<p>LQZ-7F is a survivin dimerization inhibitor with anticancer activity.LQZ-7F induces proteasome-dependent survivin degradation and inhibits human tumor growth.</p>Fórmula:C14H7N9O3Pureza:98.64%Cor e Forma:SolidPeso molecular:349.26SYM 2081
CAS:<p>SYM 2081: Kainate receptor agonist, IC50 of 35 nM, depolarizes muscle, lowers EPSP amplitude.</p>Fórmula:C6H11NO4Pureza:99.59%Cor e Forma:SolidPeso molecular:161.16Triciribine phosphate
CAS:<p>Triciribine phosphate (VD 002) is an AKT inhibitor that inhibits neovascularization and can be used in the study of leukemia.</p>Fórmula:C13H17N6O7PPureza:97.94%Cor e Forma:SolidPeso molecular:400.28Triparanol
CAS:<p>Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1</p>Fórmula:C27H32ClNO2Pureza:99.72%Cor e Forma:SolidPeso molecular:438Ciglitazone
CAS:<p>Ciglitazone: potent PPARγ agonist, EC50 3 μM, oral hypoglycemic; reduces insulin, blood pressure, Th17 cells, VEGF; halts gastric cancer growth.</p>Fórmula:C18H23NO3SPureza:98.23% - 99.59%Cor e Forma:White Cyrstalline SolidPeso molecular:333.45RO-5963
CAS:<p>RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).</p>Fórmula:C24H21ClF2N4O5Pureza:99.28%Cor e Forma:SolidPeso molecular:518.9p53-MDM2-IN-1
CAS:<p>p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM.</p>Fórmula:C23H20ClN3O3Pureza:99.98%Cor e Forma:SoildPeso molecular:421.88HBED
CAS:<p>HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.</p>Fórmula:C20H24N2O6Pureza:97.35% - 98.58%Cor e Forma:SolidPeso molecular:388.41HTH-01-091
CAS:<p>HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,</p>Fórmula:C26H28Cl2N4O2Pureza:98.4%Cor e Forma:SolidPeso molecular:499.43
