Apoptose
Os inibidores da apoptose são compostos que previnem ou retardam o processo de morte celular programada, conhecido como apoptose. Esses inibidores são vitais no estudo dos mecanismos de sobrevivência celular e são usados para investigar doenças onde a apoptose é desregulada, como câncer, distúrbios neurodegenerativos e doenças autoimunes. Ao modular a apoptose, esses inibidores podem ajudar no desenvolvimento de terapias destinadas a controlar a morte celular. Na CymitQuimica, oferecemos uma ampla seleção de inibidores da apoptose de alta qualidade para apoiar sua pesquisa em biologia celular, oncologia e áreas relacionadas.
Subcategorias de "Apoptose"
- ASK(9 produtos)
- BCL(1 produtos)
- Caspase(154 produtos)
- FOXO1(2 produtos)
- IAP(67 produtos)
- Mdm2(12 produtos)
- PD-1/PD-L1(134 produtos)
- PDK(9 produtos)
- PERK(23 produtos)
- Serina/treonina quinase(17 produtos)
- Survivina(14 produtos)
- TNF(93 produtos)
- c-RET(61 produtos)
- p53(63 produtos)
Exibir 6 mais subcategorias
Foram encontrados 6190 produtos de "Apoptose"
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(-)-β-Bisabolene (>85%)
CAS:Produto ControladoApplications Bisabolene is a sesquiterpene and can be extracted from oregano and other aromatic plants. It may be a potential anticancer agent that can induce apoptosis in A549 cancer cell line.
References Grosso, N. R., et al.: Argent., Pat. Appl. AR 90961 A1 20141217 (2014); Yfanti, P., et al.: Am J Plant Sci. 6, 2092 (2015)Fórmula:C15H24Pureza:>85%Cor e Forma:Colourless To Light YellowPeso molecular:204.35β-Lapachone (>90%)
CAS:Produto ControladoApplications β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. Induces apoptosis in HL-60 and human prostate cancer cells.
References Renslo, A., et al.: Nat. Chem. Biol., 2, 701 (2006), Hopkins, A., et al.: Nat. Chem. Biol., 4, 682 (2008), Stuart, K., et al.: J. Clin. Invest., 118, 1301 (2008), Martin, R., et al.: Science, 25, 1680 (2009),Fórmula:C15H14O3Pureza:>90%Cor e Forma:Orange SolidPeso molecular:242.27Bisindolylmaleimide VIII Acetic Acid Salt
CAS:Produto ControladoApplications It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.
References Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998), Wiley, S., et al.: Immunity, 3, 673 (1995), MacFarlane, M., et al.: Biochem. J., 348, 93 (2000),Fórmula:C26H26N4O4Cor e Forma:NeatPeso molecular:458.51GDC 0152
CAS:Produto ControladoApplications GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.
References Yue, Q., et. al.: Drug Metab. Dispos., 41, 508 (2013)Fórmula:C25H34N6O3SCor e Forma:NeatPeso molecular:498.64Morusin
CAS:Produto ControladoStability Light Sensitive
Applications Morusin is an inhibitor of human cervical cancer stem cell growth, attenuating NF-kB activity, and initiating apoptosis.
References Wang, L. et al.: Mol. Cell. Biochem., 379, 7 (2013);Fórmula:C25H24O6Cor e Forma:NeatPeso molecular:420.45Tributyrin
CAS:Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid.Fórmula:C15H26O6Pureza:96.35% - 97.01%Cor e Forma:Colorless LiquidPeso molecular:302.36RAPTA-C
CAS:RAPTA-C 可通过线粒体和 p53-JNK 途径诱导 EAC 细胞周期停滞和凋亡，可用于研究乳腺癌和卵巢癌。Fórmula:C16H26Cl2N3PRuPureza:99.15%Cor e Forma:SolidPeso molecular:463.35EasyStep Human GDF15(Growth Differentiation Factor 15) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human GDF15, and the Human GDF15 standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human GDF15. After TMB substrate solution is added, only those wells that contain Human GDF15 and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human GDF15 in the samples is then determined by comparing the OD of the samples to the standard curve.Cor e Forma:Colourless TransparentliquidVamifeport
CAS:Vamifeport (VIT-2763), an inhibitor targeting iron transport proteins, improves anemia and erythropoiesis and can be studied β-thalassemiaFórmula:C21H21FN6O2Pureza:99.91%Cor e Forma:SolidPeso molecular:408.43Ac-YVAD-CHO
CAS:Ac-YVAD-CHO (L 709049) is an ICE and caspase-1-like protease inhibitor with anti-inflammatory activity that inhibits the production of mature IL-lβ.Fórmula:C23H32N4O8Pureza:96.49%Cor e Forma:SolidPeso molecular:492.52Lovastatin-d3
CAS:Lovastatin-d3 is a deuterated compound of Lovastatin. Lovastatin has a CAS number of 75330-75-5. Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.Fórmula:C24H33D3O5Cor e Forma:SolidPeso molecular:407.56Glyphosate-13C2-15N
CAS:Glyphosate-13C2-15N is the 13C and 15N labeled compound of Glyphosate. Glyphosate has a CAS number of 1071-83-6. Glyphosate is an herbicide. It also is a possible carcinogen to humans.Fórmula:C2C1D0H8NO5PCor e Forma:SolidPeso molecular:172.05Sulfasalazine-d4
CAS:Sulfasalazine-d4 is a deuterated compound of Sulfasalazine. Sulfasalazine has a CAS number of 599-79-1. Sulfasalazine is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrugFórmula:C18H10D4N4O5SCor e Forma:SolidPeso molecular:402.42Docetaxel-d9
CAS:Docetaxel-d9 is a deuterated compound of Docetaxel. Docetaxel has a CAS number of 114977-28-5. Docetaxel is a microtubule inhibitor that inhibits microtubule disassembly (IC50: 0.2 μM).Fórmula:C43H44D9NO14Cor e Forma:SolidPeso molecular:816.93Verapamil-d7 Hydrochloride
CAS:Verapamil-d7 Hydrochloride is a deuterated compound of Verapamil Hydrochloride. Verapamil Hydrochloride has a CAS number of 152-11-4. Verapamil hydrochloride is a calcium channel blocker that is a class IV anti-arrhythmia agent.Fórmula:C27H32D7ClN2O4Cor e Forma:SolidPeso molecular:498.11Flubendazole-d3 (methyl-d3)
CAS:Flubendazole-d3 (methyl-d3) is a deuterated compound of Flubendazole. Flubendazole has a CAS number of 31430-15-6. Flubendazole is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.Fórmula:C16H9D3FN3O3Cor e Forma:SolidPeso molecular:316.30Tauroursodeoxycholic-2,2,3,4,4-d5 Acid
CAS:Tauroursodeoxycholic-2,2,3,4,4-d5 Acid is a deuterated compound of Tauroursodeoxycholic Acid. Tauroursodeoxycholic Acid has a CAS number of 14605-22-2. Tauroursodeoxycholate, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.Fórmula:C26H40D5NO6SCor e Forma:SolidPeso molecular:504.73Mebendazole-d3
CAS:Mebendazole-d3 is a deuterated compound of Mebendazole. Mebendazole has a CAS number of 31431-39-7. Mebendazole is a hedgehog inhibitor, used as an antihelminthic.Fórmula:C16H10D3N3O3Cor e Forma:SolidPeso molecular:298.31Vildagliptin-d7
CAS:Vildagliptin-d7 is a deuterated compound of Vildagliptin. Vildagliptin has a CAS number of 274901-16-5. Vildagliptin is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolite is excreted mainly via the urine.Fórmula:C17H18D7N3O2Cor e Forma:SolidPeso molecular:310.44
