Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(114 produtos)
- CDK(545 produtos)
- Ciclo celular/Parada(5 produtos)
- Chk(48 produtos)
- DYRK(47 produtos)
- Dinamina(27 produtos)
- Ferroptose(226 produtos)
- HSP(179 produtos)
- Integrinas(249 produtos)
- Cinesina(87 produtos)
- LIM Quinase(20 produtos)
- Microtúbulo associado(274 produtos)
- PKC(124 produtos)
- PLK(25 produtos)
- ROCK(62 produtos)
- Rho(6 produtos)
- Wee1(14 produtos)
- c-Myc(76 produtos)
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Foram encontrados 3860 produtos de "Ciclo celular/Ponto de verificação"
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N3-[(Pyrid-4-yl)methyl]uridine
N3-[(Pyrid-4-yl)methyl]uridine, a uridine analog, may have antiepileptic properties and aid in researching anticonvulsants and anxiolytics.Fórmula:C15H17N3O6Cor e Forma:SolidPeso molecular:335.31Guanosine triphosphate
CAS:Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].Fórmula:C10H16N5O14P3Cor e Forma:SolidPeso molecular:523.18RA-V
RA-V is a natural product that can be used as a reference standard.Fórmula:C160H202N24O41Cor e Forma:SolidPeso molecular:3117.5Chrysomycin A
CAS:Chrysomycin A is an antibiotic that can be derived from Streptomyces.Fórmula:C28H28O9Cor e Forma:SolidPeso molecular:508.52PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Fórmula:C17H12F3NO2Cor e Forma:SolidPeso molecular:319.2783'-Deoxy-GTP trisodium
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.
Cor e Forma:Odour SolidFuzapladib
CAS:Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.
Fórmula:C15H20F3N3O3SPureza:99.87%Cor e Forma:SoildPeso molecular:379.4dCeMM3
CAS:dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.
Fórmula:C14H11ClN4OSPureza:98.48% - 99.41%Cor e Forma:SolidPeso molecular:318.78Censavudine
CAS:Censavudine (OBP-601) is an HIV-1/2 treatment and prevention drug, a reverse transcriptase inhibitor with EC50 of 30-890 nM.Fórmula:C12H12N2O4Pureza:98%Cor e Forma:SolidPeso molecular:248.23Heliquinomycin
CAS:Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.Fórmula:C33H30O17Cor e Forma:SolidPeso molecular:698.586CDK4/6-IN-5
CAS:CDK4/6-IN-5 inhibits CDK4/6; Ki: 0.2 nM (CDK4/D1) & 4.4 nM (CDK6/D3). (WO2019207463A1, A93)Fórmula:C22H28ClFN6O4SCor e Forma:SolidPeso molecular:527.01DHFR-IN-11
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.Cor e Forma:Odour SolidCarboxy pyridostatin trifluoroacetate salt
Carboxy pyridostatin trifluoroacetate salt exhibits higher molecular specificity for RNA over DNA G4s.Fórmula:C37H35F3N10O9Pureza:98%Cor e Forma:SolidPeso molecular:820.73Filanesib TFA
CAS:Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.
Fórmula:C22H23F5N4O4SPureza:98%Cor e Forma:SolidPeso molecular:534.55'-O-DMT-rI
CAS:5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].Fórmula:C31H30N4O7Cor e Forma:SolidPeso molecular:570.59JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Fórmula:C43H45ClFN7O10SCor e Forma:SolidPeso molecular:906.375Sarecycline hydrochloride
CAS:Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.Fórmula:C24H30ClN3O8Pureza:99.23%Cor e Forma:SolidPeso molecular:523.965'-O-TBDMS-dA
CAS:5’-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
Fórmula:C16H27N5O3SiCor e Forma:SolidPeso molecular:365.509WAY-647802
CAS:WAY-647802 is a CDK inhibitor.Fórmula:C11H14N4O3Pureza:99.53%Cor e Forma:SolidPeso molecular:250.25Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Fórmula:C13H20N2O6Cor e Forma:SolidPeso molecular:300.308JH-XVI-178
CAS:JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Fórmula:C22H22ClN7OCor e Forma:SolidPeso molecular:435.92Bz-rC Phosphoramidite
CAS:Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Fórmula:C52H66N5O9PSiCor e Forma:SolidPeso molecular:964.185XT17
XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.Cor e Forma:Odour Solid16,16-dimethyl Prostaglandin A1
CAS:16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Fórmula:C22H36O4Cor e Forma:SolidPeso molecular:364.526GSK270822A
CAS:GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.Fórmula:C24H20N4O2Pureza:98.64% - 99.78%Cor e Forma:SolidPeso molecular:396.44Ref: TM-T27467
1mg133,00€5mg314,00€10mg416,00€25mg632,00€50mg847,00€100mg1.134,00€200mg1.513,00€1mL*10mM (DMSO)323,00€CDK12-IN-6
CAS:CDK12-IN-6, a pyrazolotriazine, strongly inhibits CDK12 (IC50 1.19 μM at 2 mM ATP), but not CDK2/Cyclin E or CDK9/Cyclin T1 (both IC50 >20 μM).Fórmula:C20H21F2N9Cor e Forma:SolidPeso molecular:425.448αVβ8-IN-1
CAS:αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Fórmula:C25H32ClN5O4Cor e Forma:SolidPeso molecular:502.01EC0488
CAS:EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity.Fórmula:C65H98N16O34SPureza:98%Cor e Forma:SolidPeso molecular:1679.63(1S,3R,5R)-PIM447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).Fórmula:C24H25Cl2F3N4OPureza:98%Cor e Forma:SolidPeso molecular:513.385-O-TBDMS-N4-Benzoyl-2-deoxycytidine
CAS:5-O-TBDMS-N4-Benzoyl-2-deoxycytidine is a modified nucleoside utilized in the synthesis of deoxyribonucleic acid (DNA) or nucleic acid.Fórmula:C22H31N3O5SiCor e Forma:SolidPeso molecular:445.58Nitrosofolic acid
CAS:Nitrosofolic acid is a folic acid derivaive.Fórmula:C19H18N8O7Cor e Forma:SolidPeso molecular:470.40Gly-Arg-Gly-Asp-Ser
CAS:Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.Fórmula:C17H30N8O9Pureza:98%Cor e Forma:SolidPeso molecular:490.47TTK/PLK1-IN-1
CAS:TTK/PLK1-IN-1 (Formula I) is a dual inhibitor of TTK (threonine tyrosine kinase) and PLK1 (polo-like kinase 1), with IC₅₀ values of 7 nM and 72 nM respectively.Fórmula:C30H33N7O2Pureza:97.39%Cor e Forma:SolidPeso molecular:523.63SP27
CAS:SP27, a selective PROTAC, degrades PLK4 with a DC50 of 19.5 nM and may be utilized in breast cancer research [1].Fórmula:C40H40F2N12O5Pureza:98%Cor e Forma:SolidPeso molecular:806.82Adenosine Dialdehyde (ADOX)
CAS:Adenosine Dialdehyde, a purine analogue, inhibits SAHH (Ki=3.3 nM), and shows strong anti-tumor effects in vivo.Fórmula:C10H11N5O4Pureza:95%Cor e Forma:SolidPeso molecular:265.23Ref: TM-T22231
5mg52,00€10mg66,00€25mg88,00€50mg155,00€100mg225,00€200mg335,00€500mg565,00€1mL*10mM (DMSO)57,00€5'-O-DMT-N2-DMF-dG
CAS:5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, finds application in deoxyribonucleic acid (DNA) or nucleic acid synthesis.Fórmula:C34H36N6O6Cor e Forma:SolidPeso molecular:624.698GK13S
G13KS: UCHL1 ligand, deubiquitinase inhibitor; reduces monoubiquitin in glioblastoma cells.Fórmula:C21H22N6O2Cor e Forma:SolidPeso molecular:390.44Cdk2/Cyclin Inhibitory Peptide I
CDK2, a Ser/Thr kinase, is akin to yeast cdc28 and human Cdk1, crucial for cell division.Fórmula:C111H196N48O23Pureza:98%Cor e Forma:SolidPeso molecular:2571.05Mumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.
Fórmula:C12H12O9Cor e Forma:SolidPeso molecular:300.22DHODH-IN-16
CAS:DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).Fórmula:C24H25FN4O3Pureza:99.64%Cor e Forma:SolidPeso molecular:436.48Ref: TM-T40168
1mg72,00€5mg160,00€10mgA consultar25mgA consultar50mgA consultar1mL*10mM (DMSO)170,00€3'-Deoxyuridine-5'-triphosphate trisodium
3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).Fórmula:C9H12N2Na3O14P3Cor e Forma:SoildPeso molecular:534.08Cy5-dATP
Cy5-dATP is a Cy5 -labeled dATP . Cy5-dATP can be incorporated into a DNA primer [1] [2] .
Fórmula:C47H58N7O19P3S2Cor e Forma:SolidPeso molecular:1182.05Brr2-IN-2
Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.Fórmula:C21H25FN4O2Cor e Forma:SolidPeso molecular:384.45UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Fórmula:C39H35NO10C6H15NCor e Forma:SolidPeso molecular:778.346555'-O-DMTr-2',2'-difluoro-dC(Bz)-methyl phosphonamidite
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies.Fórmula:C44H49F2N4O7PCor e Forma:SolidPeso molecular:814.855-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Fórmula:C27H30N2O9Cor e Forma:SolidPeso molecular:526.54CDK4/6-IN-23
CDK4/6-IN-23 (Compound 42) is a potent and selective inhibitor of CDK4/6, displaying an IC50 of 11 nM for CDK6. This compound significantly activates immune cells and enhances IL-3 production. In mice undergoing 5-FU chemotherapy, CDK4/6-IN-23 demonstrates dual bone marrow protection and immunomodulatory effects.Fórmula:C32H34FN7O4Cor e Forma:SolidPeso molecular:599.6555'(R)-C-Methyl-5-fluorouridine
5’(R)-C-Methyl-5-fluorouridine, a uridine analogue, possesses potential antiepileptic properties.Fórmula:C10H13FN2O6Cor e Forma:SolidPeso molecular:276.22Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SCor e Forma:SolidPeso molecular:655.727PROTAC CDK9 degrader-7
CAS:PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (Fórmula:C43H50Cl2N8O9Cor e Forma:SoildPeso molecular:893.81Rifalazil
CAS:Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Fórmula:C51H64N4O13Pureza:98%Cor e Forma:SolidPeso molecular:941.075'-O-DMT-Bz-rC
CAS:5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.Fórmula:C37H35N3O8Cor e Forma:SolidPeso molecular:649.69Cytarabine triphosphate
CAS:Ara-CTP, active Cytarabine metabolite, inhibits DNA synthesis, predicts leukemic chemosensitivity.Fórmula:C9H16N3O14P3Cor e Forma:SolidPeso molecular:483.16STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Cor e Forma:Odour LiquidChk1-IN-6
CAS:Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
Fórmula:C16H18F3N7Cor e Forma:SolidPeso molecular:365.364Aclacinomycin A
CAS:Aclacinomycin A has a wide range of applications in life science related research.Fórmula:C42H53NO15Pureza:99.43%Cor e Forma:SolidPeso molecular:811.87Flurocitabine HCl
CAS:Fluorocitabine HCl, a cytarabine analog, hydrolyzes into ara-FC and ara-FU, showing antitumor effects in leukemia and solid cancers.Fórmula:C9H11ClFN3O4Pureza:99.23% - 99.76%Cor e Forma:SoildPeso molecular:279.655'-O-TBDMS-Bz-dA
CAS:5’-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.Fórmula:C23H31N5O4SiCor e Forma:SolidPeso molecular:469.617PROTAC CDK9 degrader-8
PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].Fórmula:C44H52Cl2N10O7Pureza:98%Cor e Forma:SolidPeso molecular:903.85Ac-dA Phosphoramidite
CAS:Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.Fórmula:C42H50N7O7PCor e Forma:SolidPeso molecular:795.878Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.92% - 99.97%Cor e Forma:SolidPeso molecular:587.543'-β-C-Methyl-2-thiouridine
3’-β-C-Methyl-2-thiouridine, a purine nucleoside analog, exhibits extensive antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C10H14N2O5SCor e Forma:SolidPeso molecular:274.29N7-Methyl-2'-O-(2-methoxyethyl) guanosine
N7-Methyl-2’-O-(2-methoxyethyl) guanosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C14H21N5O6Cor e Forma:SolidPeso molecular:355.35ONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Fórmula:C32H30N5Na3O10Cor e Forma:SolidPeso molecular:713.58AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.61α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFórmula:C14H22N4O9Pureza:98%Cor e Forma:SolidPeso molecular:390.35Erythromycin lactobionate
CAS:Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.Fórmula:C49H89NO25Cor e Forma:SolidPeso molecular:1092.233N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].
Fórmula:C21H35N12O17P3Cor e Forma:SolidPeso molecular:820.498-NH2-ATP
CAS:8-NH2-ATP is an inactive derivative of adenosine triphosphate (ATP), synthesized from 8-NH2-Ado.Fórmula:C10H17N6O13P3Cor e Forma:SolidPeso molecular:522.205-Caroxy uracil-1-yl acetic acid benzyl ester
5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine analog, inhibits DNA synthesis and induces apoptosis to combat lymphoid cancers.Fórmula:C14H12N2O6Cor e Forma:SolidPeso molecular:304.256-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-hydrozino-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue with broad antitumor activity, particularly againstFórmula:C10H15N7O4Cor e Forma:SolidPeso molecular:297.27Rev 2'-O-MOE-C(Bz)-5'-amidite
'Rev 2’-O-MOE-C(Bz)-5’-amidite, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Fórmula:C49H58N5O10PCor e Forma:SolidPeso molecular:907.99XY028-133
CAS:XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.
Fórmula:C53H67N11O7SPureza:97.11%Cor e Forma:SolidPeso molecular:1002.237-TFA-ap-7-Deaza-ddA
CAS:Compound 19c is a nucleotide derivative for DNA sequencing dye terminators.Fórmula:C16H16F3N5O3Cor e Forma:SolidPeso molecular:383.3311-(β-D-Xylofuranosyl)-N6-Isopentenyladenine
1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog.Fórmula:C15H21N5O4Cor e Forma:SolidPeso molecular:335.365'-O-DMT-ibu-dC
CAS:5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.Fórmula:C34H37N3O7Cor e Forma:SolidPeso molecular:599.67N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Fórmula:C10H13Li4N2O15P3Cor e Forma:SolidPeso molecular:521.9N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-deoxycytidine
N4-Acetyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-deoxycytidine, a purine nucleoside analog, exhibits broad antitumor activity particularly against indolentFórmula:C33H35N3O7Cor e Forma:SolidPeso molecular:585.65DSPE-PEG2000-iRGD
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and the αv-integrin targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and subsequently undergoes proteolytic cleavage within tumors, producing CRGDK/R, which interacts with neuropilin-1. This compound is characterized by its tumor-targeting and tumor-penetrating properties, making DSPE-PEG2000-iRGD suitable for drug delivery applications.Cor e Forma:Odour SolidIRE1α kinase-IN-6
CAS:IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.Fórmula:C25H23Cl2FN6O3S2Cor e Forma:SolidPeso molecular:609.52Adenosine-2-carboxy methyl amide
Adenosine-2-carboxy methyl amide: a purine analog with antitumor effects, inhibits DNA synthesis and induces apoptosis.Fórmula:C12H16N6O5Cor e Forma:SolidPeso molecular:324.29LDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Fórmula:C48H70N10O12Pureza:98%Cor e Forma:SolidPeso molecular:979.13Psammaplin A
CAS:Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.Fórmula:C22H24Br2N4O6S2Cor e Forma:SolidPeso molecular:664.38KWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Fórmula:C33H31ClF3N9O4Cor e Forma:SolidPeso molecular:710.105NUAK1-IN-1
NUAK1-IN-1 (Compound 9) is an inhibitor of NUAK1 with an IC50 of 5.012 nM, as well as a CDK4 inhibitor. It is suitable for research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Fórmula:C25H30N6OCor e Forma:SolidPeso molecular:430.545Nusinersen
CAS:Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Pureza:98.62%Cor e Forma:SolidSNX7
CAS:SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Fórmula:C15H14N2OPureza:99.96%Cor e Forma:SolidPeso molecular:238.282'-Deoxy-2'-fluoro-l-uridine
CAS:2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Fórmula:C9H11FN2O5Cor e Forma:SolidPeso molecular:246.198-Chloro-2'-O-methyl inosine
8-Chloro-2’-O-methyl inosine, a purine nucleoside analog, exhibits broad antitumor activity against indolent lymphoid malignancies.Fórmula:C11H13ClN4O5Cor e Forma:SolidPeso molecular:316.72'-Deoxy-2'-fluoro-N3-[3-(tert-butoxycarbonyl) amino]propyluridine
2’-Deoxy-2’-fluoro-N3-[3-(tert-butoxycarbonyl)amino]propyluridine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolentFórmula:C17H26FN3O7Cor e Forma:SolidPeso molecular:403.4PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Fórmula:C24H26FN5O2Cor e Forma:SolidPeso molecular:435.49Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Cor e Forma:Odour Solidm7GpppCmpG
CAS:m7GpppCmpG, a trinucleotide cap analogue, enables RNA manufacturing with cap 0 or cap 1 structures.Fórmula:C31H43N13O25P4Cor e Forma:SolidPeso molecular:1121.642'-O-Acetyl-5'-O-benzoyl-3'-O-(2-methoxyethyl) uridine
2’-O-Acetyl-5’-O-benzoyl-3’-O-(2-methoxyethyl) uridine, an analog of uridine known for its potential antiepileptic properties, is utilized in researchingFórmula:C21H24N2O9Cor e Forma:SolidPeso molecular:448.42Guanosine 5'-triphosphate trisodium salt hydrate
CAS:5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.Fórmula:C10H18N5NaO15P3Pureza:98%Cor e Forma:SolidPeso molecular:564.1853'Ome-m7GpppAmpG
CAS:3'Ome-m7GpppAmpG is a trinucleotide cap with LNA, boosting translation; useful in mRNA vaccines and gene therapy.Fórmula:C33H45N15O24P4Cor e Forma:SolidPeso molecular:1159.69TFMU-ADPr triethylamine
TFMU-ADPr triethylamine is a substrate for PARG activity measurement, releasing a fluorophore to indicate PAR hydrolase activity.Fórmula:C25H26F3N5O16P2·5C6H15NCor e Forma:SolidPeso molecular:1024.42CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Fórmula:C24H22FN7O2Cor e Forma:SolidPeso molecular:459.48Pseudouridimycin
CAS:Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.Fórmula:C17H26N8O9Pureza:98%Cor e Forma:SolidPeso molecular:486.44
