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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3480 produtos de "Ciclo celular/Ponto de verificação"

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  • (R)-Simurosertib
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    (R)-Simurosertib

    CAS:
    <p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>
    Fórmula:C17H19N5OS
    Pureza:99.89%
    Cor e Forma:Solid
    Peso molecular:341.43

    Ref: TM-T12642

  • PD-L1-IN-3
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    PD-L1-IN-3

    CAS:
    <p>PD-L1-IN-3 is a PD-1/PD-L1 inhibitor for the study of tumors and immune diseases.</p>
    Fórmula:C19H15ClFN2OS
    Pureza:99.47%
    Cor e Forma:Soild
    Peso molecular:373.85

    Ref: TM-T79314

  • CCT129202
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    CCT129202

    CAS:
    <p>CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.</p>
    Fórmula:C23H25ClN8OS
    Pureza:98.14%
    Cor e Forma:Solid
    Peso molecular:497.02

    Ref: TM-T6435

  • LNA-Adenosine
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    LNA-Adenosine

    CAS:
    <p>LNA-Adenosine (LNA-A) is a nucleoside analogue that acts as a ligand for adenosine A3 receptors.</p>
    Fórmula:C11H13N5O4
    Pureza:99.15%
    Cor e Forma:Solid
    Peso molecular:279.25

    Ref: TM-T32826

  • αvβ1 integrin-IN-1
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    αvβ1 integrin-IN-1

    CAS:
    <p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>
    Fórmula:C26H34N6O6S
    Pureza:99.74% - >99.99%
    Cor e Forma:Solid
    Peso molecular:558.65

    Ref: TM-T13473

  • Sorivudine
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    Sorivudine

    CAS:
    <p>Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.</p>
    Fórmula:C11H13BrN2O6
    Pureza:99.74%
    Cor e Forma:Solid
    Peso molecular:349.13

    Ref: TM-T16911

  • Lomibuvir
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    Lomibuvir

    CAS:
    <p>Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.</p>
    Fórmula:C25H35NO4S
    Pureza:99.83%
    Cor e Forma:Solid
    Peso molecular:445.61

    Ref: TM-T6729

  • Aurora inhibitor 1
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    Aurora inhibitor 1

    CAS:
    <p>Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).</p>
    Fórmula:C23H25N9S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:459.57

    Ref: TM-T10412

  • CDK2/4-IN-2
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    CDK2/4-IN-2

    CAS:
    <p>CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.</p>
    Fórmula:C18H20F3N7O3S2
    Cor e Forma:Solid
    Peso molecular:503.52

    Ref: TM-T200624

  • CDK2-IN-40
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    CDK2-IN-40

    CAS:
    <p>CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.</p>
    Fórmula:C16H21N7O2
    Cor e Forma:Solid
    Peso molecular:343.384

    Ref: TM-T205452

  • MU147
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    MU147

    CAS:
    <p>MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.</p>
    Fórmula:C19H13N3O3S
    Cor e Forma:Solid
    Peso molecular:363.39

    Ref: TM-T205293

  • CHK1 inhibitor
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    CHK1 inhibitor

    CAS:
    <p>CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.</p>
    Fórmula:C17H21BrN4O
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:377.28

    Ref: TM-T10793

  • TA-316
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    TA-316

    CAS:
    <p>Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.</p>
    Fórmula:C28H25BrN4O5S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:641.56

    Ref: TM-T13769

  • TREX1-IN-3
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    TREX1-IN-3

    CAS:
    <p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>
    Fórmula:C24H19ClN6O4
    Cor e Forma:Solid
    Peso molecular:490.898

    Ref: TM-T205254

  • HPH-15
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    HPH-15

    CAS:
    <p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>
    Fórmula:C19H31N3S4
    Cor e Forma:Solid
    Peso molecular:429.73

    Ref: TM-T205327

  • Logotipo do CymitQuimica
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    DNA gyrase B-IN-1

    <p>DNA gyrase B-IN-1, a potent inhibitor of P. aeruginosa DNA gyrase B, has IC50 of 2.2 μM with high affinity and stability.</p>
    Fórmula:C23H18ClF3N6O4S
    Cor e Forma:Solid
    Peso molecular:566.94

    Ref: TM-T64012

  • MY05
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    MY05

    CAS:
    <p>MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).</p>
    Fórmula:C19H11ClN4O
    Cor e Forma:Solid
    Peso molecular:346.77

    Ref: TM-T206537

  • PD-L1-IN-7
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    PD-L1-IN-7

    CAS:
    <p>PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.</p>
    Fórmula:C46H50N6O7
    Cor e Forma:Solid
    Peso molecular:798.93

    Ref: TM-T89952

  • GTSE1-IN-1
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    GTSE1-IN-1

    CAS:
    <p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>
    Fórmula:C21H24FN7
    Cor e Forma:Solid
    Peso molecular:393.46

    Ref: TM-T200127

  • Zeltociclib
    Targetmol
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    Zeltociclib

    CAS:
    <p>Zeltociclib is an inhibitor of cyclin-dependent kinases (CDKs) with anti-tumor properties.</p>
    Fórmula:C18H20F3N4O2P
    Cor e Forma:Solid
    Peso molecular:412.346

    Ref: TM-T205641