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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3480 produtos de "Ciclo celular/Ponto de verificação"

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  • TY-011
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    TY-011

    CAS:
    <p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>
    Fórmula:C18H16ClN5
    Cor e Forma:Solid
    Peso molecular:337.81

    Ref: TM-T89833

  • Logotipo do CymitQuimica
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    ddCTP trisodium

    <p>ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.</p>
    Fórmula:C9H13N3Na3O12P3
    Cor e Forma:Solid
    Peso molecular:517.1

    Ref: TM-T63602

  • FR-β ligand 1
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    FR-β ligand 1

    CAS:
    <p>FR-β ligand 1 (III) is a ligand that specifically targets folate receptors, exhibiting antitumor activity, high selectivity, and strong affinity.</p>
    Fórmula:C22H25N5O6
    Cor e Forma:Solid
    Peso molecular:455.46

    Ref: TM-T207453

  • CHK1-IN-4
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    CHK1-IN-4

    CAS:
    <p>CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.</p>
    Fórmula:C18H18BrN7O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:444.29

    Ref: TM-T10792

  • DL-Alanosine
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    DL-Alanosine

    CAS:
    <p>DL-Alanosine is an amino acid analog with antitumor activity.</p>
    Fórmula:C3H7N3O4
    Cor e Forma:Solid
    Peso molecular:149.105

    Ref: TM-T205451

  • LIMK1 inhibitor 1
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    LIMK1 inhibitor 1

    CAS:
    <p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>
    Fórmula:C12H15N3S2
    Cor e Forma:Solid
    Peso molecular:265.398

    Ref: TM-T204784

  • RNAP-σ interaction inhibitor-1
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    RNAP-σ interaction inhibitor-1

    CAS:
    <p>RNAP-σ interaction inhibitor-1 (compound 5d) acts as an inhibitor of the interaction between RNA polymerase and the sigma factor. It exhibits activity against Streptococci with a minimum inhibitory concentration (MIC) ranging from 1-2 µg/mL.</p>
    Fórmula:C19H11Cl3N2O6S2
    Cor e Forma:Solid
    Peso molecular:533.79

    Ref: TM-T207529

  • TREX1-IN-4
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    TREX1-IN-4

    CAS:
    <p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>
    Fórmula:C24H19ClN6O4
    Cor e Forma:Solid
    Peso molecular:490.898

    Ref: TM-T205208

  • Cdc7-IN-8
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    Cdc7-IN-8

    CAS:
    <p>Cdc7-IN-8, inhibits Cdc7 kinase, key in DNA replication, and is promising for cancer research. (WO2021032170A1)</p>
    Fórmula:C19H21N5O2
    Cor e Forma:Solid
    Peso molecular:351.40

    Ref: TM-T61224

  • Pseudouridine 5'-OTBDPS
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    Pseudouridine 5'-OTBDPS

    CAS:
    <p>Pseudouridine5'-OTBDPS [5-(5-O-TBDPS-β-D-ribofuranosyl)uracil] is an intermediate of Pseudouridine.</p>
    Fórmula:C25H30N2O6Si
    Cor e Forma:Solid
    Peso molecular:482.60

    Ref: TM-TSW-00962

  • APE1-IN-3
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    APE1-IN-3

    CAS:
    <p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>
    Fórmula:C17H16O4
    Cor e Forma:Solid
    Peso molecular:284.31

    Ref: TM-T89919

  • GSK3-IN-10
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    GSK3-IN-10

    CAS:
    <p>GSK3-IN-10 (Compound 4) is a multi-target inhibitor primarily affecting GSK3α and GSK3β with IC50 values of 1.0 nM and 2.0 nM, respectively. It inhibits the activation of β-catenin, enhances neuronal survival, and provides protective effects against endoplasmic reticulum stress.</p>
    Fórmula:C17H18F2N4O3
    Cor e Forma:Solid
    Peso molecular:364.347

    Ref: TM-T206481

  • MU1409
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    MU1409

    CAS:
    <p>MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.</p>
    Fórmula:C20H14BrN3O3S
    Cor e Forma:Solid
    Peso molecular:456.312

    Ref: TM-T205338

  • Logotipo do CymitQuimica
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    Aurora/LIM kinase-IN-1

    <p>Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.</p>
    Fórmula:C16H20N6O
    Cor e Forma:Solid
    Peso molecular:312.37

    Ref: TM-T60783

  • N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine
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    N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine

    CAS:
    <p>N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that resembles the natural nucleotide adenosine in structure. It acts as an activator of ribonucleotide reductase, facilitating the conversion of ribonucleotides into deoxyribonucleotides.</p>
    Fórmula:C38H35N5O6
    Cor e Forma:Solid
    Peso molecular:657.714

    Ref: TM-T206424

  • TASIN-30
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    TASIN-30

    CAS:
    <p>TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.</p>
    Fórmula:C18H30N2O3S
    Cor e Forma:Solid
    Peso molecular:354.51

    Ref: TM-T89927

  • DYRK1-IN-1
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    DYRK1-IN-1

    CAS:
    <p>DYRK1-IN-1: Selective DYRK1A inhibitor with IC50 of 220 nM, good permeability, CNS penetrant for research, no P-glycoprotein issues.</p>
    Fórmula:C12H12N6
    Cor e Forma:Solid
    Peso molecular:240.26

    Ref: TM-T60334

  • LNA-UTP
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    LNA-UTP

    CAS:
    <p>LNA-UTP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Fórmula:C10H15N2O15P3
    Cor e Forma:Solid
    Peso molecular:496.15

    Ref: TM-TSW-00943

  • Logotipo do CymitQuimica
    Targetmol
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    2'-F-AMP

    CAS:
    <p>2'-F-AMP is a nucleotide analogue used in the synthesis of oligonucleotides.</p>
    Fórmula:C10H13FN5O6P
    Peso molecular:349.21

    Ref: TM-TSW-00945

  • CDK12/13 ligand 1
    Targetmol
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    CDK12/13 ligand 1

    CAS:
    <p>ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.</p>
    Fórmula:C26H26BrN5O
    Cor e Forma:Solid
    Peso molecular:504.42

    Ref: TM-T201159