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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3477 produtos de "Ciclo celular/Ponto de verificação"

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  • 7-Methylguanosine 5′-monophosphate
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    7-Methylguanosine 5′-monophosphate

    CAS:
    <p>7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.</p>
    Fórmula:C11H16N5O8P
    Cor e Forma:Solid
    Peso molecular:377.25

    Ref: TM-TSW-00951

  • CDK2-IN-39
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    CDK2-IN-39

    CAS:
    <p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>
    Fórmula:C14H15N3O4S
    Cor e Forma:Solid
    Peso molecular:321.352

    Ref: TM-T204890

  • CDK4/6-IN-3
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    CDK4/6-IN-3

    CAS:
    <p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: &lt;0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>
    Fórmula:C25H31FN8
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:462.57

    Ref: TM-T10737

  • Logotipo do CymitQuimica
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    MtTMPK-IN-8

    <p>MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.</p>
    Fórmula:C24H24N6O7
    Cor e Forma:Solid
    Peso molecular:508.48

    Ref: TM-T63491

  • Metesind Glucuronate
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    Metesind Glucuronate

    CAS:
    <p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>
    Fórmula:C29H34N4O10S
    Cor e Forma:Solid
    Peso molecular:630.67

    Ref: TM-T24454

  • AB25583
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    AB25583

    CAS:
    <p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>
    Fórmula:C22H17ClN4O3S
    Cor e Forma:Solid
    Peso molecular:452.91

    Ref: TM-T200101

  • LIMK1 inhibitor 2
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    LIMK1 inhibitor 2

    CAS:
    <p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>
    Fórmula:C10H11N3OS
    Cor e Forma:Solid
    Peso molecular:221.279

    Ref: TM-T204765

  • MKLP2-IN-1
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    MKLP2-IN-1

    CAS:
    <p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>
    Fórmula:C23H19BrFN3O2
    Cor e Forma:Solid
    Peso molecular:468.318

    Ref: TM-T205538

  • Logotipo do CymitQuimica
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    Antibacterial agent 110

    <p>Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).</p>
    Fórmula:C22H21N5O4S
    Cor e Forma:Solid
    Peso molecular:451.5

    Ref: TM-T62740

  • CDK4/9-IN-1
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    CDK4/9-IN-1

    CAS:
    <p>CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.</p>
    Fórmula:C22H34N6O2
    Cor e Forma:Solid
    Peso molecular:414.544

    Ref: TM-T205312

  • Logotipo do CymitQuimica
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    Antiangiogenic agent 2

    <p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>
    Fórmula:C26H26FN3O4
    Cor e Forma:Solid
    Peso molecular:463.5

    Ref: TM-T62931

  • Valopicitabine dihydrochloride
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    Valopicitabine dihydrochloride

    CAS:
    <p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Fórmula:C15H25ClN4O6
    Cor e Forma:Solid
    Peso molecular:392.84

    Ref: TM-T29094

  • CDK7-IN-17
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    CDK7-IN-17

    CAS:
    <p>CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.</p>
    Fórmula:C24H26F3N6OP
    Cor e Forma:Solid
    Peso molecular:502.47

    Ref: TM-T63410

  • JY-3-094
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    JY-3-094

    CAS:
    <p>JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.</p>
    Fórmula:C13H8N4O5
    Pureza:98.72%
    Cor e Forma:Solid
    Peso molecular:300.23

    Ref: TM-T86777

  • CDK7/12-IN-1
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    CDK7/12-IN-1

    CAS:
    <p>CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.</p>
    Fórmula:C25H34N8O
    Cor e Forma:Solid
    Peso molecular:462.59

    Ref: TM-T62926

  • 8-Oxo-dATP
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    8-Oxo-dATP

    CAS:
    <p>8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.</p>
    Fórmula:C10H12Li4N5O13P3
    Cor e Forma:Solid
    Peso molecular:530.913

    Ref: TM-T206632

  • 5-Methylcytosine hydrochloride
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    5-Methylcytosine hydrochloride

    CAS:
    <p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>
    Fórmula:C5H8ClN3O
    Cor e Forma:Solid
    Peso molecular:161.59

    Ref: TM-T201054

  • IIP0943
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    IIP0943

    CAS:
    <p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>
    Fórmula:C26H28N6O3S
    Cor e Forma:Solid
    Peso molecular:504.604

    Ref: TM-T206115

  • 12(S)-HETE
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    12(S)-HETE

    CAS:
    <p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>
    Fórmula:C20H32O3
    Cor e Forma:Solid
    Peso molecular:320.47

    Ref: TM-T37047

  • NSC 641396
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    NSC 641396

    CAS:
    <p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>
    Fórmula:C18H13NO3
    Cor e Forma:Solid
    Peso molecular:291.301

    Ref: TM-T204449