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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3739 produtos de "Ciclo celular/Ponto de verificação"

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  • AR-13324 M1 metabolite
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    AR-13324 M1 metabolite

    CAS:
    <p>AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.</p>
    Fórmula:C19H19N3O2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:321.37

    Ref: TM-T10358L

  • Logotipo do CymitQuimica
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    CDK8-IN-9

    <p>CDK8-IN-9, potent CDK8 inhibitor (IC50: 48.6 nM), curbs tumor growth, useful for colorectal cancer research.</p>
    Cor e Forma:Solid

    Ref: TM-T64245

  • Logotipo do CymitQuimica
    Targetmol
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    Dyrk1A/α-synuclein-IN-1

    Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM).
    Fórmula:C20H21N5O3S
    Cor e Forma:Solid
    Peso molecular:411.48

    Ref: TM-T62096

  • PARG-IN-7
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    PARG-IN-7

    CAS:
    PARG-IN-7 (Example 38) is a Poly ADP-ribose glycohydrolase (PARG) inhibitor with an IC50 of less than 0.1 μM. It reduces the viability of HCC1806-XRCC1 knockdown (KD) cells, exhibiting an IC50 of less than 1 μM. PARG-IN-7 is applicable in cancer research.
    Fórmula:C22H24F2N8O3S2
    Cor e Forma:Solid
    Peso molecular:550.61

    Ref: TM-T212151

  • Adafosbuvir
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    Adafosbuvir

    CAS:
    Adafosbuvir has antiviral activity.
    Fórmula:C22H29FN3O10P
    Cor e Forma:Solid
    Peso molecular:545.457

    Ref: TM-T26560

  • CDK8-IN-5
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    CDK8-IN-5

    CAS:
    CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.
    Fórmula:C26H22N2O4
    Cor e Forma:Solid
    Peso molecular:426.46

    Ref: TM-T62310

  • Logotipo do CymitQuimica
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    PROTAC CDK12/13 Degrader-1

    PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.
    Cor e Forma:Solid

    Ref: TM-T64284

  • DHX9-IN-9
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    DHX9-IN-9

    CAS:
    <p>DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].</p>
    Fórmula:C21H21ClFN5O3S2
    Cor e Forma:Solid
    Peso molecular:510

    Ref: TM-T86205

  • Zorubicin
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    Zorubicin

    CAS:
    <p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>
    Fórmula:C34H35N3O10
    Cor e Forma:Solid
    Peso molecular:645.66

    Ref: TM-T69130

  • LNA-AMP
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    LNA-AMP

    CAS:
    LNA-AMP is a nucleotide analog used in the synthesis of oligonucleotides.
    Fórmula:C11H14N5O7P
    Cor e Forma:Solid
    Peso molecular:359.23

    Ref: TM-TSW-00964

  • RAD51-IN-5
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    RAD51-IN-5

    CAS:
    RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)
    Fórmula:C26H38N4O5S2
    Cor e Forma:Solid
    Peso molecular:550.73

    Ref: TM-T63892

  • CHK-IN-1
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    CHK-IN-1

    CAS:
    CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.
    Fórmula:C18H19ClFN5OS
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:407.89

    Ref: TM-T13148

  • Logotipo do CymitQuimica
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    MtTMPK-IN-5

    <p>MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.</p>
    Fórmula:C21H23N5O2
    Cor e Forma:Solid
    Peso molecular:377.44

    Ref: TM-T61573

  • EFdA-TP tetrasodium
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    EFdA-TP tetrasodium

    CAS:
    EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.
    Fórmula:C12H11FN5Na4O12P3
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:621.12

    Ref: TM-T72461

  • CDK7-IN-18
    Targetmol
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    CDK7-IN-18

    CAS:
    CDK7-IN-18: potent, pyrimidine-based CDK7 inhibitor with cancer research potential.
    Fórmula:C22H24F3N7OS
    Pureza:99.28%
    Cor e Forma:Solid
    Peso molecular:491.53

    Ref: TM-T63301

  • Logotipo do CymitQuimica
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    CDK1-IN-4

    CDK1-IN-4 inhibits CDK1 (IC50: 44.52 nM), CDK2/CDK5 less potently, impacts cell cycle, used in cancer studies.
    Fórmula:C26H24ClN5S
    Cor e Forma:Solid
    Peso molecular:474.02

    Ref: TM-T63080

  • ATIC-IN-2
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    ATIC-IN-2

    CAS:
    <p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>
    Fórmula:C4H4N4O3S
    Cor e Forma:Solid
    Peso molecular:188.165

    Ref: TM-T204433

  • CTX-712
    Targetmol
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    CTX-712

    CAS:
    <p>CTX-712 is a potent inhibitor of cdc2-like kinase ( CLK ). CTX-712 inhibits inhibits cancer survival and cancer cell growth.</p>
    Fórmula:C19H17FN8O2
    Cor e Forma:Solid
    Peso molecular:408.39

    Ref: TM-T62049

  • PAIR2
    Targetmol
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    PAIR2

    CAS:
    PAIR2 is a selective IRE1α RNase partial antagonist, blocking its ATP site and preventing KIRA from hindering XBP1 splicing.
    Fórmula:C27H26F4N6O3S
    Cor e Forma:Solid
    Peso molecular:590.59

    Ref: TM-T64183

  • CDK12/13 ligand 1
    Targetmol
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    CDK12/13 ligand 1

    CAS:
    ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.
    Fórmula:C26H26BrN5O
    Cor e Forma:Solid
    Peso molecular:504.42

    Ref: TM-T201159