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Ciclo celular/Ponto de verificação

Ciclo celular/Ponto de verificação

Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.

Subcategorias de "Ciclo celular/Ponto de verificação"

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Foram encontrados 3739 produtos de "Ciclo celular/Ponto de verificação"

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  • Polθ-IN-6
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    Polθ-IN-6

    CAS:
    Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.
    Fórmula:C25H23N3O3S
    Cor e Forma:Solid
    Peso molecular:445.53

    Ref: TM-T200918

  • WRN inhibitor 12
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    WRN inhibitor 12

    CAS:
    WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.
    Fórmula:C33H33ClF3N9O5
    Cor e Forma:Solid
    Peso molecular:728.12

    Ref: TM-T201316

  • Lobucavir
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    Lobucavir

    CAS:
    <p>Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).</p>
    Fórmula:C11H15N5O3
    Cor e Forma:Solid
    Peso molecular:265.27

    Ref: TM-T200820

  • DNA Gyrase-IN-13
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    DNA Gyrase-IN-13

    CAS:
    <p>DNA Gyrase-IN-13 (compound 1b) is an inhibitor of DNA gyrase with bacteriostatic properties. It exhibits an IC50 of 1.81 μM against Staphylococcus aureus DNA gyrase.</p>
    Fórmula:C15H21N3O3S
    Cor e Forma:Solid
    Peso molecular:323.41

    Ref: TM-T201341

  • Methyl 3-oxodecanoate
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    Methyl 3-oxodecanoate

    CAS:
    <p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>
    Fórmula:C11H20O3
    Cor e Forma:Solid
    Peso molecular:200.275

    Ref: TM-T206384

  • MTH1 activator-1
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    MTH1 activator-1

    CAS:
    MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.
    Fórmula:C29H23F3N4O2
    Cor e Forma:Solid
    Peso molecular:516.514

    Ref: TM-T204503

  • WRN inhibitor 11
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    WRN inhibitor 11

    CAS:
    WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.
    Fórmula:C34H35ClF3N9O5
    Cor e Forma:Solid
    Peso molecular:742.15

    Ref: TM-T201262

  • TA-316
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    TA-316

    CAS:
    Agent induces megakaryocytes/platelets from stem cells to treat thrombopenia.
    Fórmula:C28H25BrN4O5S2
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:641.56

    Ref: TM-T13769

  • WEE1-IN-11
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    WEE1-IN-11

    CAS:
    WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.
    Fórmula:C26H29FN8OS2
    Cor e Forma:Solid
    Peso molecular:552.69

    Ref: TM-T200924

  • CDK2-IN-31
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    CDK2-IN-31

    CAS:
    CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.
    Fórmula:C37H52N6O5
    Cor e Forma:Solid
    Peso molecular:660.85

    Ref: TM-T201156

  • MY05
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    MY05

    CAS:
    MY05 selectively targets c-MYC within cells and disrupts the interaction between MYC and MAX. It binds to intracellular c-MYC, modulating its thermal stability, reducing the transcriptional targets of c-MYC, and exhibiting anticancer activity (TNBC, triple-negative breast cancer).
    Fórmula:C19H11ClN4O
    Cor e Forma:Solid
    Peso molecular:346.77

    Ref: TM-T206537

  • BWC0977
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    BWC0977

    CAS:
    BWC0977 is an effective topoisomerase inhibitor that disrupts bacterial DNA replication by targeting both DNA gyrase and topoisomerase IV. The minimum inhibitory concentration (MIC90) of BWC0977 against MDR (multi-drug resistant) Gram-negative bacteria ranges from 0.03 to 2 µg/mL.
    Fórmula:C22H21FN6O5
    Cor e Forma:Solid
    Peso molecular:468.44

    Ref: TM-T201074

  • CTPS1-IN-1
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    CTPS1-IN-1

    CAS:
    CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.
    Fórmula:C21H22N6O4S2
    Pureza:99.46%
    Cor e Forma:Solid
    Peso molecular:486.57

    Ref: TM-T86105

  • Elacytarabine
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    Elacytarabine

    CAS:
    Elacytarabine (M7594 0037), a lipid-conjugated derivative of the nucleoside analog cytarabine, is an antineoplastic drug. It has cytotoxicity in solid tumors.
    Fórmula:C27H45N3O6
    Pureza:97.69%
    Cor e Forma:Solid
    Peso molecular:507.66

    Ref: TM-T15009

  • HRO761
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    HRO761

    CAS:
    HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
    Fórmula:C31H31ClF3N9O5
    Pureza:98.74% - 99.62%
    Cor e Forma:Solid
    Peso molecular:702.08

    Ref: TM-T72107

  • GFB-12811
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    GFB-12811

    CAS:
    GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.
    Fórmula:C22H23F4N5O
    Pureza:98.88%
    Cor e Forma:Solid
    Peso molecular:449.44

    Ref: TM-T62695

  • LY3143921 hydrate
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    LY3143921 hydrate

    CAS:
    LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].
    Fórmula:C16H14FN5O2
    Pureza:98.43%
    Cor e Forma:Solid
    Peso molecular:327.31

    Ref: TM-T9064

  • SR 11302
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    SR 11302

    CAS:
    SR 11302 is an inhibitor of activator protein-1 (AP-1).
    Fórmula:C26H32O2
    Pureza:98.65%
    Cor e Forma:Solid
    Peso molecular:376.53

    Ref: TM-T23384

  • INCB086550
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    INCB086550

    CAS:
    INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.
    Fórmula:C41H39N7O4
    Pureza:98.49%
    Cor e Forma:Solid
    Peso molecular:693.79

    Ref: TM-T36899

  • Troxacitabine
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    Troxacitabine

    CAS:
    Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.
    Fórmula:C8H11N3O4
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:213.19

    Ref: TM-T17175

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