Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(111 produtos)
- CDK(525 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(46 produtos)
- DYRK(49 produtos)
- Dinamina(26 produtos)
- Ferroptose(225 produtos)
- HSP(180 produtos)
- Integrinas(256 produtos)
- Cinesina(87 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(283 produtos)
- PKC(111 produtos)
- PLK(25 produtos)
- ROCK(66 produtos)
- Rho(2 produtos)
- Wee1(14 produtos)
- c-Myc(75 produtos)
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Foram encontrados 3749 produtos de "Ciclo celular/Ponto de verificação"
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Purine riboside triphosphate
CAS:Purine riboside triphosphate resembles adenosine; inhibits cancer cell growth by blocking RNA/DNA synthesis.Fórmula:C10H15N4O13P3Cor e Forma:SolidPeso molecular:492.17Bromochloroacetonitrile
CAS:Bromochloroacetonitrile, a water disinfection by-product, is mutagenic and can break DNA strands.Fórmula:C2HBrClNCor e Forma:SolidPeso molecular:154.39UnyLinker 12 TEA
UnyLinker 12 TEA is a versatile linker used in the synthesis of oligoribonucleotides.Fórmula:C39H35NO10C6H15NCor e Forma:SolidPeso molecular:778.34655Abemaciclib metabolite M18
CAS:Abemaciclib M18 (LSN3106729), a potent CDK inhibitor with antitumor action, used in a PROTAC to degrade CDK4/6.Fórmula:C25H28F2N8OPureza:98%Cor e Forma:SolidPeso molecular:494.5413-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Fórmula:C12H19F2N6O12P3Cor e Forma:SolidPeso molecular:570.23Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Fórmula:C21H25FN4O2Cor e Forma:SolidPeso molecular:384.45Pseudouridimycin
CAS:Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.Fórmula:C17H26N8O9Pureza:98%Cor e Forma:SolidPeso molecular:486.44Ac-MRGDH-NH2
<p>Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.</p>Fórmula:C25H41N11O8SCor e Forma:SolidPeso molecular:655.727AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.615'-O-DMTr-5-MedC (Ac)-methyl phosphonamidite
5’-O-DMTr-5-MedC (Ac)-methyl phosphonamidite, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignanciesFórmula:C40H51N4O7PCor e Forma:SolidPeso molecular:730.83Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Fórmula:C23H20F2N2O4Pureza:98%Cor e Forma:SolidPeso molecular:426.41EFdA-TP
CAS:<p>EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.</p>Fórmula:C12H15FN5O12P3Cor e Forma:SolidPeso molecular:533.1956-Amino-4-methoxy-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
6-Amino-4-methoxy-2-(β-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits widespread antitumor efficacy, particularly againstFórmula:C11H17N5O5Cor e Forma:SolidPeso molecular:299.28N1-Methyl-2'-β-C-methyl adenosine
N1-Methyl-2’-beta-C-methyl adenosine, a purine nucleoside analog, exhibits broad antitumor activity, particularly against indolent lymphoid malignancies.Fórmula:C12H17N5O4Cor e Forma:SolidPeso molecular:295.29αVβ8-IN-1
CAS:<p>αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).</p>Fórmula:C25H32ClN5O4Cor e Forma:SolidPeso molecular:502.012'-(2-Nitrobenzyl)-ATP trisodium
2'-(2-Nitrobenzyl)-ATP trisodium is an rATP analogue that acts as a transcription terminator. It inhibits T7 RNA polymerase from continuing RNA chain extension.Fórmula:C17H18N6Na3O15P3Cor e Forma:SolidPeso molecular:707.97361Demycarosyl-3D-β-D-digitoxosylmithramycin SK
CAS:Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity.Fórmula:C50H72O23Cor e Forma:SolidPeso molecular:1041.099-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine
9-(5(R)-C-Methyl-2,3,5-tri-O-benzoyl-D-ribofuranosyl)-6-chloropurine: A purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis.Fórmula:C32H25ClN4O7Cor e Forma:SolidPeso molecular:613.02JH-XVI-178
CAS:JH-XVI-178: potent CDK8/19 inhibitor with good pharmacokinetics, low clearance, moderate oral bioavailability.Fórmula:C22H22ClN7OCor e Forma:SolidPeso molecular:435.92PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Cor e Forma:Odour Solid
