Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase(111 produtos)
- CDK(522 produtos)
- Ciclo celular/Parada(4 produtos)
- Chk(46 produtos)
- DYRK(49 produtos)
- Dinamina(26 produtos)
- Ferroptose(225 produtos)
- HSP(180 produtos)
- Integrinas(256 produtos)
- Cinesina(85 produtos)
- LIM Quinase(19 produtos)
- Microtúbulo associado(285 produtos)
- PKC(111 produtos)
- PLK(25 produtos)
- ROCK(67 produtos)
- Rho(2 produtos)
- Wee1(14 produtos)
- c-Myc(75 produtos)
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Foram encontrados 3739 produtos de "Ciclo celular/Ponto de verificação"
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Antibacterial agent 271
Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.Cor e Forma:Odour SolidPKMYT1-IN-8
<p>PKMYT1-IN-8 (Compound 137) is an inhibitor of PKMYT1, with an IC50 value of 9 nM. It also inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2, exhibiting IC50 values of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. Additionally, PKMYT1-IN-8 suppresses the proliferation of cancer cells OVCAR3 with a GI50 of 2.02 μM.</p>Fórmula:C17H16F3N5O2Cor e Forma:SolidPeso molecular:379.3366-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits broad antitumor activity byFórmula:C15H17N5O6Cor e Forma:SolidPeso molecular:363.33MU1920
<p>MU1920 is an ATP-competitive, selective inhibitor of haspin with an IC50 of 6 nM. In mouse plasma and microsomes, it demonstrates favorable pharmacokinetic properties and metabolic stability. Although it lacks significant anticancer activity, MU1920 is suitable for developing chemical probes.</p>Fórmula:C17H15N5SCor e Forma:SolidPeso molecular:321.4Diopterin
CAS:Diopterin is a folic acid analog.Fórmula:C24H26N8O9Cor e Forma:SolidPeso molecular:570.51Surovatamig
Surovatamig is a bispecific antibody of the (H-γ4_L-κ)_VH-G4(h-CH2-CH3) type, targeting CD3D/CD3E/CD19.Farletuzumab
CAS:Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.36 kDa3'-Deoxy-GTP trisodium
<p>3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, functions as an RNA chain terminator, thereby inhibiting RNA synthesis. It is capable of suppressing dengue virus DENV NS5 RdRp with an IC50 value of 0.02 μM.</p>Cor e Forma:Odour SolidCDK9 ligand 3
CAS:<p>CDK9ligand 3 is a ligand for CDK9 and can be utilized in the synthesis of PROTAC degraders, specifically PROTAC CDK9degrader-11.</p>Fórmula:C18H18BrCl2N5O3Cor e Forma:SolidPeso molecular:503.177PARP-1-IN-32
CAS:PARP-1-IN-32 (compound 15) is an inhibitor of poly (ADPribose) polymerase-1 (PARP-1), specifically designed for use in cancer research.Fórmula:C21H16N2O5Peso molecular:376.36CTP Synthetase-IN-1 Ammonium salt
<p>CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infections</p>Fórmula:C20H22F3N7O3S2Pureza:99.97%Cor e Forma:SolidPeso molecular:529.56KIF18A-IN-6
CAS:KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor that suppresses KIF18A microtubule-dependent ATPase activity with an IC50 of 0.016 μM.Fórmula:C28H37N3O5S2Pureza:97.59%Peso molecular:559.74CDK1-IN-2
CAS:CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM.Fórmula:C17H11ClN2OPureza:98.53%Cor e Forma:SoildPeso molecular:294.73c-Myc inhibitor 10
CAS:<p>c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.</p>Fórmula:C28H38N6O3Cor e Forma:SolidPeso molecular:506.64KWR137
<p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>Fórmula:C33H31ClF3N9O4Cor e Forma:SolidPeso molecular:710.105TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Fórmula:C23H22Cl2FN5O3Pureza:99.65%Cor e Forma:SolidPeso molecular:506.36PROTAC CDK9 degrader-8
<p>PROTAC CDK9 Degrader-8 (Compound 21) is a potent degrader of CDK9 with an IC50 of 0.01 μM, utilized in cancer research [1].</p>Fórmula:C44H52Cl2N10O7Pureza:98%Cor e Forma:SolidPeso molecular:903.852-Amino-3',5'-di-O-acetyl-N6,N6-dimethyl-2'-O-methyladenosine
2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine is an adenosine analog.Fórmula:C17H24N6O6Cor e Forma:SolidPeso molecular:408.41LSN3106729 hydrochloride
CAS:LSN3106729 hydrochloride, an Abemaciclib metabolite, is a CDK-inhibiting antitumor PROTAC CDK4/6 degrader.Fórmula:C25H29ClF2N8OCor e Forma:SoildPeso molecular:531.00H122
H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Fórmula:C45H45ClFN5O8Cor e Forma:SolidPeso molecular:838.319
