Dano de DNA/Reparo de DNA
Os inibidores de dano/ reparo do DNA são compostos que interferem nos processos envolvidos na detecção e reparo de danos ao DNA. Esses inibidores são fundamentais para estudar os mecanismos de estabilidade genômica, mutagênese e resposta ao dano ao DNA. Eles também são importantes na pesquisa do câncer, pois muitos tumores dependem de vias específicas de reparo de DNA para sobreviver. Ao inibir essas vias, os inibidores de dano/reparo de DNA podem aumentar a eficácia da quimioterapia e da radioterapia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade de dano/reparo de DNA para apoiar sua pesquisa em biologia molecular, oncologia e farmacologia.
Subcategorias de "Dano de DNA/Reparo de DNA"
- ATM/ATR(71 produtos)
- Alquilação de DNA(11 produtos)
- DNA Metiltransferase(422 produtos)
- DNA girase(11 produtos)
- DNA-PK(51 produtos)
- MTH1(1 produtos)
- Nucleosídeo Antimetabólito/Análogo(1.388 produtos)
- Transcriptase reversa(43 produtos)
- Sirtuína(88 produtos)
- Telomerase(33 produtos)
- Topoisomerase(136 produtos)
Exibir 3 mais subcategorias
Foram encontrados 958 produtos de "Dano de DNA/Reparo de DNA"
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1-Hydroxyanthraquinone
CAS:<p>1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities.</p>Fórmula:C14H8O3Pureza:99.56%Cor e Forma:Orange Red Needles Red-Orange To Fine Yellow CrystalsPeso molecular:224.21Rubitecan
CAS:<p>Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.</p>Fórmula:C20H15N3O6Pureza:97.54%Cor e Forma:Yellow Amorphous PowderPeso molecular:393.35AG14361
CAS:<p>AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).</p>Fórmula:C19H20N4OPureza:98.7% - 99.93%Cor e Forma:SolidPeso molecular:320.39Gatifloxacin hydrochloride
CAS:<p>Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.</p>Fórmula:C19H23ClFN3O4Pureza:99.85% - 99.89%Cor e Forma:SolidPeso molecular:411.86EIDD-1931
CAS:<p>EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Fórmula:C9H13N3O6Pureza:99.14% - 99.73%Cor e Forma:SolidPeso molecular:259.22CXD101
CAS:<p>CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101(CXD-101) has no activity against HDAC class II</p>Fórmula:C24H29N5OPureza:99.82%Cor e Forma:SolidPeso molecular:403.521-Oleoyl lysophosphatidic acid sodium
CAS:<p>1-Oleoyl lysophosphatidic acid sodium (1-Oleoyl lysophosphatidic acid sodium salt) salt is an Endogenous agonist of LPA1 and LPA2</p>Fórmula:C21H40O7P·NaPureza:98.75% - 99.24%Cor e Forma:SolidPeso molecular:458.51MK-4827 Racemate
CAS:<p>MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for</p>Fórmula:C19H20N4OPureza:99.86%Cor e Forma:SolidPeso molecular:320.39Cycloastragenol
CAS:<p>Cycloastragenol, a saponin from Astragalus, could be a new depression treatment.</p>Fórmula:C30H50O5Pureza:99.85% - 99.92%Cor e Forma:SolidPeso molecular:490.71GNE-3511
CAS:<p>GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.</p>Fórmula:C23H26F2N6OPureza:98.3% - 99.51%Cor e Forma:SolidPeso molecular:440.49PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Cor e Forma:SolidPeso molecular:389.889-Hydroxycamptothecin
CAS:<p>9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.</p>Fórmula:C20H16N2O5Pureza:98.28%Cor e Forma:SolidPeso molecular:364.35Xanthosine 5'-monophosphate sodium salt
CAS:<p>Xanthosine 5'-monophosphate sodium salt (L-XMP Sodium) is an intermediate in purine metabolism.</p>Fórmula:C10H11N4Na2O9PPureza:99% - 99.77%Cor e Forma:SolidPeso molecular:408.17Deoxycytidine triphosphate
CAS:<p>dCTP is a nucleotide used in DNA synthesis, PCR, cDNA creation, and sequencing.</p>Fórmula:C9H16N3O13P3Pureza:99.68%Cor e Forma:SolidPeso molecular:467.16NKL 22
CAS:<p>NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.</p>Fórmula:C19H23N3O2Pureza:96.16% - 96.24%Cor e Forma:SolidPeso molecular:325.4AGK7
CAS:<p>AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.</p>Fórmula:C23H13Cl2N3O2Pureza:98.31%Cor e Forma:SolidPeso molecular:434.27MN-64
CAS:<p>MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.</p>Fórmula:C18H16O2Pureza:99.5% - 99.93%Cor e Forma:SolidPeso molecular:264.32E7449
CAS:<p>E7449 is a potent inhibitor of PARP1, PARP2, TNKS1, and TNKS2 with IC50s of 2, 1, ~50, and ~50 nM respectively.</p>Fórmula:C18H15N5OPureza:97.13%Cor e Forma:SolidPeso molecular:317.34Methotrexate disodium
CAS:<p>Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor</p>Fórmula:C20H20N8Na2O5Pureza:99.77% - 99.96%Cor e Forma:SolidPeso molecular:498.4AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4AZ6102
CAS:<p>AZ6102: Potent TNKS1/2 inhibitor, 100x selective over PARPs, IC50 = 5 nM in DLD-1 Wnt pathway.</p>Fórmula:C25H28N6OPureza:97.98% - 99.91%Cor e Forma:SolidPeso molecular:428.53OUL35
CAS:<p>OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.</p>Fórmula:C14H12N2O3Pureza:99.2%Cor e Forma:SolidPeso molecular:256.26AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Fórmula:C16H12N2O3Pureza:98.69%Cor e Forma:SolidPeso molecular:280.28Clofibrate
CAS:<p>Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.</p>Fórmula:C12H15ClO3Pureza:98.77%Cor e Forma:Oil LiquidPeso molecular:242.70Selisistat S-enantiomer
CAS:<p>Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.</p>Fórmula:C13H13ClN2OPureza:99.86%Cor e Forma:SolidPeso molecular:248.71Suramin Sodium Salt
CAS:<p>Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.</p>Fórmula:C51H34N6Na6O23S6Pureza:97.47% - 99.97%Cor e Forma:WhitePeso molecular:1429.15Citarinostat
CAS:<p>ACY-241 (Citarinostat), a potent oral HDAC inhibitor, may induce tumor cell death and block growth by altering gene expression.</p>Fórmula:C24H26ClN5O3Pureza:98.06% - 99.06%Cor e Forma:SolidPeso molecular:467.95Pamiparib
CAS:<p>Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor. It has potent PARP trapping, and capability to penetrate the brain.</p>Fórmula:C16H15FN4OPureza:99.69%Cor e Forma:SolidPeso molecular:298.31Fluzoparib
CAS:<p>Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.</p>Fórmula:C22H16F4N6O2Pureza:98.53% - 99.63%Cor e Forma:SolidPeso molecular:472.4Bisantrene
CAS:<p>Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.</p>Fórmula:C22H22N8Pureza:96.07% - 98.57%Cor e Forma:SolidPeso molecular:398.46DMNB
CAS:<p>DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.</p>Fórmula:C9H9NO5Pureza:97.87%Cor e Forma:Yellow SolidPeso molecular:211.17Bobcat339
CAS:<p>Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.</p>Fórmula:C16H12ClN3OPureza:97.79% - 99.24%Cor e Forma:SolidPeso molecular:297.74CGK733
CAS:<p>CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.</p>Fórmula:C23H18Cl3FN4O3SPureza:98% - 99.67%Cor e Forma:SolidPeso molecular:555.84AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Fórmula:C22H24N4O4Pureza:99.79% - 99.95%Cor e Forma:SolidPeso molecular:408.452-Aminopurine
CAS:<p>2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.</p>Fórmula:C5H5N5Pureza:99.51%Cor e Forma:White To Light Yellow Crystal PowderPeso molecular:135.13Compound 401
CAS:<p>Compound 401 (2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one) is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR but not PI3K.</p>Fórmula:C16H15N3O2Pureza:99.73% - 99.78%Cor e Forma:SolidPeso molecular:281.31Selisistat R-enantiomer
CAS:<p>Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).</p>Fórmula:C13H13ClN2OPureza:99.8%Cor e Forma:SolidPeso molecular:248.71G007-LK
CAS:<p>G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.</p>Fórmula:C25H16ClN7O3SPureza:97.63% - 98.17%Cor e Forma:SolidPeso molecular:529.96Trabectedin
CAS:<p>Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research.</p>Fórmula:C39H43N3O11SPureza:≥98%Cor e Forma:SolidPeso molecular:761.84Niraparib tosylate monohyrate
CAS:Niraparib (MK-4827), a PARP inhibitor, boosts DNA breaks to trigger genomic instability and apoptosis, offering anti-cancer effects.Fórmula:C26H30N4O5SPureza:97.7% - 98.41%Cor e Forma:SolidPeso molecular:510.61Isosteviol
CAS:<p>Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.</p>Fórmula:C20H30O3Pureza:99.72% - 99.97%Cor e Forma:SolidPeso molecular:318.45SW044248
CAS:<p>SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.</p>Fórmula:C22H23N5O2SPureza:99.56% - 99.87%Cor e Forma:SolidPeso molecular:421.52CM-272
CAS:<p>CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.</p>Fórmula:C28H38N4O3Pureza:97.83%Cor e Forma:SolidPeso molecular:478.63LY294002
CAS:<p>LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).</p>Fórmula:C19H17NO3Pureza:98% - 99.96%Cor e Forma:Pale Yellow SolidPeso molecular:307.34Torin 2
CAS:<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Fórmula:C24H15F3N4OPureza:98.31% - 99.32%Cor e Forma:SolidPeso molecular:432.4Cardioxane
CAS:<p>Cardioxane (ADR-529) is a cardio-protective drug.</p>Fórmula:C11H16N4O4·HClPureza:98.08%Cor e Forma:SolidPeso molecular:304.73Adefovir
CAS:<p>Adefovir: acyclic nucleoside phosphonate, reverse transcriptase inhibitor for hepatitis B and herpes treatment.</p>Fórmula:C8H12N5O4PPureza:99.56%Cor e Forma:White To Off-White PowderPeso molecular:273.19PJ34 hydrochloride
CAS:<p>PJ34 hydrochloride (PJ34 HCl) is a potent specific inhibitor of PARPl/2.</p>Fórmula:C17H18ClN3O2Pureza:98.87% - ≥95%Cor e Forma:SolidPeso molecular:331.8SRT 2104
CAS:<p>SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.</p>Fórmula:C26H24N6O2S2Pureza:98.34% - 99.82%Cor e Forma:SolidPeso molecular:516.64Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Fórmula:C21H25F3N6O2Pureza:99.88%Cor e Forma:SolidPeso molecular:450.46
