Imunologia e Inflamação

Keap1-Nrf2-IN-10 (compound 15) is a potent inducer of NQO1 and efficaciously mitigates oxidative stress in gamma-irradiated mice by reducing MDA and ROS levels

<p>NT-0796 is an inflammasome NLRP3 inhibitor that inhibits NLRP3 activation.NT-0796 is a potential NDT-19795 delivery vector.</p>

Heneicosapentaenoic Acid (HPA) is a fatty acid found in small amounts in Bryopsis pennata Lamouroux green algae and fish oils, with a structure similar to eicosapentaenoic acid (EPA), but with an additional carbon at the carboxyl end, resulting in the first double bond being in the Δ6 position. HPA is important for researching the impact of double bond positions in n-3 fatty acids, as it integrates into phospholipids and triacylglycerol in vivo as effectively as EPA and docosahexaenoic acid (DHA), while strongly inhibiting the synthesis of arachidonic acid from linoleic acid. Despite being a poor substrate for prostaglandin H (PGH) synthase and 5-lipoxygenase, HPA can rapidly deactivate PGH synthase. HPA methyl ester, in certain formulations, acts as a prodrug to enhance cellular uptake of HPA before being converted into free acid by esterases, and serves as a useful reference standard.

Antitumor agent-49 (Compound 10), a harmine derivative-furoxan hybrid featuring nitric oxide (NO) donating properties, exhibits cytotoxic effects against HepG2

<p>FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells.</p>

DXP, a lipophilic prodrug of Dexamethasone, has 47x less glucocorticoid receptor affinity; it's an agonist & anti-inflammatory.

<p>GW274150 phosphate is a selective, orally active iNOS inhibitor with an IC50 of 0.2 μM. It mitigates experimental renal ischaemia-reperfusion injury.</p>

Compound 166, also referred to as compound 3, exhibits potent anticancer properties, demonstrating significant inhibitory activity against Caco-2 cells with an

Anti-inflammatory agent 63 exhibits potent inhibitory activity (EC50 = 5.33±0.57 μM) against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in

6-PPD (Antioxidant 4020) is an antioxidant and the most commonly used additive in rubber. It can induce neurodegeneration in Caenorhabditis elegans.

6-Hydroxy Etodolac, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac, causes false positives in diazo diagnostic tests for urinary bilirubin.

4-(3,4-Difluorobenzo)curcumin (CDF) is a semisynthetic coumarin noted for its antiparasitic and anticancer properties.

Kuwanon T, an isoprenylated flavonoid extracted from the root bark of Morus alba, exhibits protective effects against t-BHP-induced oxidative stress, presenting

STING agonist-3: non-nucleotide, selective, anti-tumor with pEC50=7.5, pIC50=9.5, could enhance cancer therapy.

STING agonist-19 serves as a precursor for the synthesis of immune-stimulating antibody conjugates (ISACs).

IL-17A antagonist 3 is an IL-17A antagonist.

Bucolome (Paramidine) is a CYP2C9 inhibitor with uricosuric and anti-inflammatory activity.

HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells.

CD73-IN-10, a potent inhibitor of CD73, aids in creating cancer drugs by hindering adenosine synthesis, which fosters tumor growth.

Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.