Imunologia e Inflamação
Os inibidores de imunologia e inflamação são compostos que modulam a resposta imunológica e os processos inflamatórios. Esses inibidores são cruciais para estudar os mecanismos de regulação imunológica, autoimunidade e inflamação crônica, bem como para desenvolver tratamentos para doenças inflamatórias, alergias e distúrbios relacionados ao sistema imunológico. Ao direcionar vias-chave no sistema imunológico, esses inibidores podem ajudar a reduzir respostas imunológicas excessivas ou inadequadas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Subcategorias de "Imunologia e Inflamação"
- CCR(136 produtos)
- CXCR(149 produtos)
- Parede celular(5 produtos)
- Receptor IL(112 produtos)
- IκB/IKK(59 produtos)
- LTR(3 produtos)
- MALT(23 produtos)
- MRP(6 produtos)
- NADPH-oxidase(1 produtos)
- NF-κB(443 produtos)
- NOD(18 produtos)
- NOS(63 produtos)
- Nrf2(78 produtos)
- PGE Sintase(31 produtos)
- ROS(69 produtos)
- TGF-beta/Smad(58 produtos)
- TLR(66 produtos)
- Tiorredoxina(12 produtos)
- gp120/CD4(4 produtos)
Exibir 11 mais subcategorias
Foram encontrados 3054 produtos de "Imunologia e Inflamação"
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Cryptopleurine
CAS:<p>Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.</p>Fórmula:C24H27NO3Pureza:98%Cor e Forma:SolidPeso molecular:377.48E 5090
CAS:E5090 is a novel orally active inhibitor of IL-1 generation. It also has anti-inflammatory properties.Fórmula:C19H20O5Pureza:98%Cor e Forma:SolidPeso molecular:328.36COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Fórmula:C25H21N3O3SCor e Forma:SolidPeso molecular:443.52IACS-8779 disodium
CAS:<p>IACS-8779 disodium: potent STING agonist, strong systemic anti-tumor effects, effective in melanoma model.</p>Fórmula:C21H23N9Na2O10P2S2Cor e Forma:SolidPeso molecular:733.52CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Fórmula:C6H6S3Cor e Forma:SolidPeso molecular:174.307COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Fórmula:C17H19NO3Cor e Forma:SolidPeso molecular:285.34COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Fórmula:C15H10ClIN2OCor e Forma:SolidPeso molecular:396.61Cyclic-di-GMP sodium
<p>c-di-GMP sodium: STING activator, regulates bacteria biofilm, motility, virulence.</p>Fórmula:C20H24N10NaO14P2Cor e Forma:SolidPeso molecular:713.08464cGAS-IN-4
CAS:<p>cGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS). In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.</p>Fórmula:C19H18Cl2N4O3Cor e Forma:SolidPeso molecular:421.277NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Cor e Forma:SolidPeso molecular:454.97Antioxidant agent-3
<p>Antioxidant agent-3 shows strong DPPH and ABTS+ radical scavenging (IC50: 26.58, 30.31 μM). Boosts ROS, SOD, GSH; lowers LDH in H2O2-exposed HepG2 cells.</p>Fórmula:C18H14O8Cor e Forma:SolidPeso molecular:358.3COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Fórmula:C19H14ClN5S2Cor e Forma:SolidPeso molecular:411.93SARM1-IN-4
CAS:<p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>Fórmula:C13H17F2N3O2Cor e Forma:SolidPeso molecular:285.29CD73-IN-2
<p>CD73-IN-2 is a potent inhibitor of CD73 (IC50: 0.09 nM).</p>Fórmula:C17H25ClN5O7PCor e Forma:SolidPeso molecular:477.84AIM4
CAS:<p>AIM4 is a compound known for inhibiting TDP-43 aggregation. It demonstrates good biocompatibility and anti-inflammatory activity, making it a valuable agent in research for diseases such as amyotrophic lateral sclerosis (ALS).</p>Fórmula:C25H23Br2N5O4Cor e Forma:SolidPeso molecular:617.289Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Fórmula:C31H37ClFN5O5Cor e Forma:SolidPeso molecular:614.11FAPI-74
CAS:<p>FAPI-74 is a PET (positron emission tomography) tracer involved in early FAPI-PET imaging.FAPI-74 can be used to study cancer tumors and degenerative diseases.</p>Fórmula:C36H49N9O8Cor e Forma:SolidPeso molecular:735.83COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Fórmula:C25H23N5O4S2Cor e Forma:SolidPeso molecular:521.61Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Fórmula:C22H20O12Cor e Forma:SolidPeso molecular:476.39OP-5244 sodium
<p>OP-5244 sodium: potent oral CD73 inhibitor (IC50: 0.25 nM), potential in cancer research by hindering adenosine, reversing immunosuppression.</p>Fórmula:C19H28ClN5NaO9PCor e Forma:SolidPeso molecular:559.87
